Cited by 601Immune cells in cancerAngiogenesis and VEGF in CancerCancer, Stress, Anesthesia, and Immune Response

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Cancer related inflammation: The macrophage connection

Sica, Antonio, Allavena, Paola, Mantovani, Alberto·2008·Cancer Letters

DOI 10.1016/j.canlet.2008.03.028

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Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

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Authors: Sica, A., Allavena, P., & Mantovani, A.
Affiliations: Fondazione Humanitas per la Ricerca (IT)
University of Milan (IT)
Corresponding author: Allavena, Paola
ORCID: Sica, Antonio
Allavena, Paola
Mantovani, Alberto
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2008-08
Volume: 267
Issue: 2
Pages: 204-215
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2008.03.028
OpenAlex: W2141487097
Cited by: 601
References: 96
Citations by year: 2026: 10 · 2025: 17 · 2024: 22 · 2023: 36 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 35 · 2014: 47 · 2013: 35 · 2012: 37
FWCI: 3.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: tumor-associated macrophages, tumor inflammation, tumor microenvironment, macrophage polarization, tumor progression, angiogenesis, immunosuppression, growth factors, carcinogenesis, therapeutic target
MeSH terms: Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, NF-kappa B, Cell Polarity, Disease Progression, STAT3 Transcription Factor, Hypoxia-Inducible Factor 1, alpha Subunit

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