The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Cancer related inflammation: The macrophage connection
Abstract
Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Self-citationAngiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
Paik, S., Shak, S., Tang, G., Kim, C., Baker, J. B., Cronin, M. T., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,321
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Self-citationInvolvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 601
Modulation of Tumor Angiogenesis by a Host Anti-Tumor Response in Colorectal Cancer
Britzen‐Laurent, N., Schellerer, V. S., Strzl, R. S. C. M., & Naschberger, E. (2012) · InTech eBooks · doi:10.5772/28931 · Cited by 1
Extracellular matrix in tumours as a source of additional neoplastic lesions - a review
MADEJ, J. A. (2014) · Journal of Veterinary Research · doi:10.2478/bvip-2014-0001 · Cited by 1
Immunotherapeutic Strategies for Colon Cancer: Monoclonal Antibody Therapy
Thara, E., & Barzi, A. (2015) · Current Colorectal Cancer Reports · doi:10.1007/s11888-015-0260-y · Cited by 1
The Tumor Microenvironment as Target for New Cancer Therapies
Schwendener, R. A., & Mete, S. (2014) · Cited by 1
Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression
Lutgendorf, S. K., Costanzo, E. S., & Sood, A. K. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0019 · Cited by 1
Modulation of immune functions by oestrogens. Part I
Wilczyński, J. R. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Shaping Tumor Associated Macrophages: The Role of NF-κB
Soper, R., & Hagemann, T. (2010) · Springer eBooks · doi:10.1007/978-90-481-9531-2_6 · Cited by 1
Sweat Gland Tumor Microenvironment
Handaya, A. Y., Anwar, S. L., Fauzi, A. R., & Werdana, V. A. P. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-59038-3_16 · Cited by 1
Rathod, S., Aggarwal, V., Upadhyay, A., & Choudhari, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_7 · Cited by 1
Genetic Susceptibility and High Risk Groups for Pancreatic Cancer
Greenhalf, W., & Neoptolemos, J. P. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_24 · Cited by 1
Lin, A., Mou, W., Zhu, L., Yang, T., Zhou, C., Zhang, J., & Luo, P. (2023) · Cancer Innovation · doi:10.1002/cai2.84 · Cited by 1
Molecular warriors: Proteases as sentinels in the war against cancer diagnosis and prognosis
Dasari, N., Panda, S., Ahmed, N., & Pindiprolu, S. K. S. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-30098-1.00020-3 · Cited by 1
Protein Therapeutics in Oncology
Corbley, M. J. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1216-8_8 · Cited by 1
Heavy Metal-Induced Carcinogenicity: Depleted Uranium and Heavy-Metal Tungsten Alloy
Kalinich, J. F. (2011) · Springer eBooks · doi:10.1007/978-94-007-0428-2_10 · Cited by 1
[Effect of macrophages on ulcerative colitis-associated carcinogenesis].
Wang, W., Zhou, Y., Li, X., & Shen, S. (2012) · PubMed · doi:10.3969/j.issn.1672-7347.2012.06.017 · Cited by 1
Distinct Pattern of CC Chemokine 2 and 5 in Post-Transurethral Resection of Bladder Cancer
Moogooei, M., Hassanshahi, G., Khorramdelazad, H., Moogooei, M., & Fattahpour, S. (2016) · journal of ilam university of medical sciences · doi:10.18869/acadpub.sjimu.24.1.144 · Cited by 1
Immunology and Immunotherapy of Ovarian Cancer
Wilczyński, J. R., Nowak, M., & Wilczyński, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-57949-4_20 · Cited by 1
Obesity in Children and Adolescents
Fox, C. K., Ryder, J. R., Gross, A. C., & Kelly, A. S. (2019) · Endocrinology · doi:10.1007/978-3-319-46933-1_27 · Cited by 1
Aspects of Tumour Targeting : Preclinical Studies on Human Malignant Cells in vitro
Wester, M. D. (2009) · Cited by 1
Lira, R. B. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-06012017-092200 · Cited by 1
Understanding the interaction between mycoplasma bovis and bovine respiratory macrophages
Maina, T. (2019) · Cited by 1
Secreted Growth Factors as Therapeutic Targets
Teicher, B. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_31
Discovery and application of colorectal cancer protein markers for disease stratification
Zhou, J. (2013) · The Sydney eScholarship Repository (The University of Sydney)
The Role of Prostaglandin E2/EP4 Prostanoid Receptor Signaling in Colorectal Carcinogenesis
Chandramouli, A. (2009) · UA Campus Repository (The University of Arizona)
THE CONTRIBUTION OF INFLAMMATORY PATHWAY SIGNALING AND MICRORNA CHANGES TO COLON CANCER PROGRESSION
Onyeagucha, B. C. (2013) · UA Campus Repository (The University of Arizona)
Tumor Microenvironment, Angiogenesis Biology, and Targeted Therapy
Heymach, J. V., & Cascone, T. (2014) · Lung Cancer · doi:10.1002/9781118468791.ch33
Phenotype and function of tumour-derived CD4+ T lymphocytes in colorectal cancer
Hamilton, E. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Bengtsson, Å. (2009) · Lund University Publications (Lund University)
6.1.1 UNDERSTANDING DISEASE THROUGH SYSTEMS THINKING
Smith, G. R. (2014) · INCOSE International Symposium · doi:10.1002/j.2334-5837.2014.tb03162.x
Tumor Immunotherapy by Utilizing a Double-Edged Sword, Chemokines
Mukaida, N., Sasaki, S., & Baba, T. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7876-8_4
Mburu, Y. K. (2011) · D-Scholarship@Pitt (University of Pittsburgh)
A New Approach to Cancer Therapy: The Tumor Microenvironment as Target
Schwendener, R. A., & Mete, S. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-102646
Modulation of immune functions by oestrogens. Part II Immunomodulacyjna rola estrogenów. Czêœæ II
Wilczyński, J. R., & Szpakowski, M. (2010)
The anti-inflammatory effects of ethanol extract of Allium Hookeri cultivated in
Bae, G.-C., & Bae, D.-Y. (2012)
Traumatic brain injury and brain tumour
Wicher, G., & Nilsson, K. (2012)
Novel Treatment Modalities for High-Risk Neuroblastoma : Studies in Animal Models
Fuchs, D. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Recent Publications in this Series
Juuri, E., Makkonen, M., & Liu, P. (2014)
TINT Tumor Indicating Normal Tissue : new field of diagnostic biomarkers for prostate cancer
Adamo, H. H. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Macrophages: Tissue-Resident Determinants of Immunomodulation
Foey, A. (2016) · Immunotherapy Open Access · doi:10.4172/2471-9552.1000e102
Differential Activation of Macrophages in Tumors
Outram, S. P., & Leibovich, S. J. (2013) · CRC Press eBooks · doi:10.1201/b14842-5
The Contribution of Inflammatory Cells to the Progression of Prostate Cancer
Jones, K. J. (2016) · Atlanta University Center Robert W. Woodruff Library (Atlanta University Center Robert W. Woodruff Library)
Delving, L. K. D. O. B. (2015) · Americanae (AECID Library)
Characterization of a Novel Dendritic Cell Population
Mikhailova, A. (2012) · TSpace (University of Toronto)
Chaniad, P., Trakunram, K., Geater, S. L., Keeratichananont, W., Thongsuksai, P., & Raungrut, P. (2017) · International Conference on Biomedical and Bioinformatics Engineering (ICBBE) · doi:10.1145/3168776.3168788
A sinalização via receptor A2A contribui para suscetibilidade ao carcinoma mamário experimental
Rodríguez, G. R. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2017.tde-27072016-154619
Nano-carrier Macrophage Interaction: Role of Secondary Toxicity
Sarfraz, M. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r30863b2k
The Tumor Suppressor RASSF1A Links Inflammation and Cancer
Gordon, M. (2015) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r39w0945j
Targeting and inhibition of tumor-associated macrophages in breast cancer
Binnemars‐Postma, K. (2017) · doi:10.3990/1.9789036544627
최윤선, 이평재, 김용민, & 김이화 (2018) · Daehan miyong hakoeji · doi:10.15810/jic.2018.14.2.008
Khan, K. A. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
A Tumor-derived Niche Cell Promotes Tumor Growth in Medulloblastoma
Ventura, P. B. (2015) · doi:10.18130/v3754q
O papel de galectina-3 no desenvolvimento de carcinoma espinocelular de pele
de Siqueira, K. P. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.25.2019.tde-14052019-175435
IL-33 no carcinoma espinocelular de pele
Boas, V. G. V. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.25.2019.tde-14052019-180319
Caracterização da resposta inflamatória nos carcinomas mamários em cadelas
Lima, A. E. (2011) · Americanae (AECID Library)
Macrophage Density Correlates with Severity of Uterine Cervix Neoplasia
Lucian, R., Mazuru, V., Șaptefrați, L., & David, V. (2011)
Abuduwaili, M., Xing, Z., Fei, Y., Xia, B., Zhu, J., & Su, A. (2021) · Research Square · doi:10.21203/rs.3.rs-727962/v1
Easterling, R. S. (2013) · The Knowledge Bank (The Ohio State University)
Frontiers in Clinical Drug Research - Anti-Cancer Agents
Schwendener, R. A., & Mete, S. (2013) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816080579861130101
Leitsch, D. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737595422.793582798
Antiangiogenic drugs as chemosensitizers in hematological tumors
Desantis, V., Lamanuzzi, A., Saltarella, I., Frassanito, M. A., Vacca, A., Montagnani, M., & Ribatti, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90190-1.00010-x
Dulal, D., Boring, A. R., Terrero, D., Tiwari, A. K., & Raman, D. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_20
Chemokines and Chemokine Receptors in Cancer: An Update
Elemam, N. M., & Maghazachi, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_26-1
Data from Blockade of a Chemokine, CCL2, Reduces Chronic Colitis-Associated Carcinogenesis in Mice
Popivanova, B. K., Kostadinova, F. I., Furuichi, K., Shamekh, M. M., Kondo, T., Wada, T., Egashira, K., & Mukaida, N. (2023) · doi:10.1158/0008-5472.c.6499829.v1
Du, F., Nakamura, Y., Tan, T.-L., Lee, P., Lee, R. H., Yu, B., & Jamora, C. (2023) · doi:10.1158/0008-5472.c.6501221.v1
Du, F., Nakamura, Y., Tan, T.-L., Lee, P., Lee, R. H., Yu, B., & Jamora, C. (2023) · doi:10.1158/0008-5472.c.6501221
The Role of Inflammatory Biomarkers in Predicting the Prognosis of Gastric Cancer
刘, 娜. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13122802
Huo, Q., Li, Z., Chen, S., Wang, J., Li, J., & Xie, N. (2021) · Figshare · doi:10.6084/m9.figshare.14643017
Panda, V. K. (2023) · International Journal of Science and Research (IJSR) · doi:10.21275/sr23731232223
Distribution Width (RDW) between Benign Endometrial Disease and Malignant Endometrial Disease
Islam, J., Ferdous, J., Khatoon, F., Amatullah, M., Nihar, F., Akter, N., Naher, S., Liza, M., Sayed, S., Yasmin, L., et al. (2024) · Scholars International Journal of Obstetrics and Gynecology · doi:10.36348/sijog.2024.v07i12.011
TEAD inhibition alters the lung immune microenvironment and attenuates metastasisPreprint
Rahhal, R., Schmidt, M. O., Moussa, M., Asemi, T., Battina, R., Kiliti, A. J., Wellstein, A., Riegel, A. T., & Sharif, G. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.639326
Chemokines and Chemokine Receptors in Cancer: An Update
Elemam, N. M., & Maghazachi, A. A. (2025) · Springer eBooks · doi:10.1007/978-3-032-00749-0_26
Yuan, G., Cui, R., Xu, Y., Luo, Z., Zhang, X., Jiang, O., & Si, G. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.114150
Jardim, M. G. D. (2014) · Americanae (AECID Library)
Huo, Q., Li, Z., Chen, S., Wang, J., li, J., & Xie, N. (2021) · Figshare · doi:10.6084/m9.figshare.14643014
Tunalı, G., Yanık, H., Ozturk, S. C., Canlı, S. D., Efthymiou, G., Yilmaz, K. B., Obberghen‐Schilling, E. V., & Esendağlı, G. (2024) · Figshare · doi:10.6084/m9.figshare.26575391
Zhou, Y., Gao, H., Shan, L., Zhu, L., Yang, J., Wang, B., Zhang, J., Ran, R., Tian, Q., Liu, P., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01252-6
Wang, M., Feng, L., Wu, P., Liu, Y., Zhang, H., Ma, Y., Ren, H., Jin, X., Zhou, X., & Jiang, W. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743681
Rôle des mastocytes dans le développement des astrocytomes humains : implication du récepteur CD47
Boukhari, A. A. (2012) · theses.fr (ABES) · doi:10.70675/3c922fc3z5510z47b6zba8ezeb4143cfb7ba
Pleiotropism of MyD88, as Determined by its Multiple Protein-Protein Interactions
Sabeh, R. E. (2014) · theses.fr (ABES) · doi:10.70675/7ab5dd24z6801z49fcza7e9zc657eed7c6ea
Characterization of a novel antibody targeting tumor-associated macrophages
Domagala, M. (2022) · theses.fr (ABES) · doi:10.70675/b4720b22z5236z4e41za89dz1f8d16c27670
Morel, V. (2021) · theses.fr (ABES) · doi:10.70675/31e506dazce13z4d4cz8c40z9823077c170b
Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerabilityPreprint
Pallarés-Moratalla, C., Guyot, M., Gopalan, K. S., Robl, B., Idkowiak, J., Dehairs, J., Ravoet, N., Nowak, K. A., Dubroja, N., Weng, L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.24.720633
Chronic Hepatitis and Women’s Health: Unresolved Effects on Reproductive and Hormonal Function
Sawhney, A. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017212
Macrophage lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
Pallarés-Moratalla, C., Guyot, M., Gopalan, K. S., Robl, B., Idkowiak, J., Dehairs, J., Ravoet, N., Hendriks, T., Nowak, K. A., Lakić, N. D., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.10.006
BindingDB Entry 50001624: Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides.
BindingDB (2020) · UC San Diego · doi:10.7270/q2p84fdv
Ovarian Cancer Therapy Today and Tomorrow: Unmet Needs, Innovations, and Clinical Pathways
Tannous, J. C., Maimaitiming, D., Yeku, O., Xu, L., & Amoozgar, Z. (2026) · Gynecologic Cancer · doi:10.3390/gynecolcancer1010002
The Role of MACIR Gene in Regulation of Immune Response and Pathogenesis of Disease
Plewa, P., Figiel, K., Jędrasiak, A., Ostałowska, H., Szulc, J., Krawczyk, I., & Pawlik, A. (2026) · Genes · doi:10.3390/genes17111364
Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations
Baronzio, G., Freitas, I., Fiorentini, G., Crugnola, A. R., Hager, E. D., Ceppodomo, D., & Kiselevsky, M. V. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9576-4_9
Metadata
- Authors
- Sica, A., Allavena, P., & Mantovani, A.
- Affiliations
- Fondazione Humanitas per la Ricerca (IT)
- University of Milan (IT)
- Corresponding author
- Allavena, Paola
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 267
- Issue
- 2
- Pages
- 204-215
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2141487097
- Cited by
- 601
- References
- 96
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 22 · 2023: 36 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 35 · 2014: 47 · 2013: 35 · 2012: 37
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- tumor-associated macrophages, tumor inflammation, tumor microenvironment, macrophage polarization, tumor progression, angiogenesis, immunosuppression, growth factors, carcinogenesis, therapeutic target
- MeSH terms
- Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, NF-kappa B, Cell Polarity, Disease Progression, STAT3 Transcription Factor, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review