The DOI matches its Crossref record; 91 of the 92 references it cites were found in a registry or an index.
Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer
Abstract
Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and facilitate tumor development. Clinical evidences compellingly indicate the association between high TAMs influx and poor prognosis in patients with breast cancers. The pan-macrophage marker CD68 is now generally utilized to identify TAMs in diagnostic biopsy samples, and some other TAM-related biomarkers are also utilized in prognosis prediction, including CD163, vascular endothelial growth factor (VEGF), hypoxia-inducible factors (HIFs), proliferating cellular nuclear antigen (PCNA), ferritin light chain (FTL) and C-C motif chemokine ligand 18 (CCL18). In this review, we highlight the recent progress made in understanding the relationship between TAMs and clinicopathological parameters in human breast cancer and address the potential value of TAMs as diagnostic and prognostic biomarkers.
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“Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [56]
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Tumor-associated macrophages: from basic research to clinical application
Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 389
Macrophages: Their Emerging Roles in Bone
Sinder, B. P., Pettit, A. R., & McCauley, L. K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2735 · Cited by 309
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Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268
“Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”
Background
Metadata
- Authors
- Tang, X.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Tang, Xiaoqiang
- ORCID
- Tang, Xiaoqiang
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 332
- Issue
- 1
- Pages
- 3-10
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2077731584
- Cited by
- 276
- References
- 92
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 30 · 2019: 24 · 2018: 21 · 2017: 26 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 9
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tsinghua University
- West China Hospital, Sichuan University
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor-associated macrophages, breast cancer, tumor microenvironment, M2 macrophages, CD68, prognostic factors, diagnostic biomarkers, CD163, vascular endothelial growth factor, hypoxia-inducible factor, PCNA, ferritin light chain, CCL18, TAM infiltration
- MeSH terms
- CD68 Molecule, Animals, Biopsy, Breast Neoplasms, Female, Humans, Macrophages, Predictive Value of Tests, Prognosis, Biomarkers, Tumor, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Tumor Microenvironment
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