Cited by 276Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

The DOI matches its Crossref record; 91 of the 92 references it cites were found in a registry or an index.

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

Tang, Xiaoqiang·2013·Cancer Letters

DOI 10.1016/j.canlet.2013.01.024

Open this paper in CoChat — free account

Abstract

Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and facilitate tumor development. Clinical evidences compellingly indicate the association between high TAMs influx and poor prognosis in patients with breast cancers. The pan-macrophage marker CD68 is now generally utilized to identify TAMs in diagnostic biopsy samples, and some other TAM-related biomarkers are also utilized in prognosis prediction, including CD163, vascular endothelial growth factor (VEGF), hypoxia-inducible factors (HIFs), proliferating cellular nuclear antigen (PCNA), ferritin light chain (FTL) and C-C motif chemokine ligand 18 (CCL18). In this review, we highlight the recent progress made in understanding the relationship between TAMs and clinicopathological parameters in human breast cancer and address the potential value of TAMs as diagnostic and prognostic biomarkers.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2013.01.024

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Retracted: Immunotherapy of metastatic breast cancer patients with vitamin D‐binding protein‐derived macrophage activating factor (GcMAF)
Yamamoto, N., Suyama, H., Yamamoto, N., & Ushijima, N. (2007) · International Journal of Cancer · doi:10.1002/ijc.23107 · Cited by 62
Retracted
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer
Berry, D. A., Cronin, K. A., Plevritis, S. K., Fryback, D. G., Clarke, L. D., Zelen, M., Mandelblatt, J. S., Yakovlev, A. Y., Habbema, J. D. F., & Feuer, E. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050518 · Cited by 2,456
Breast cancer statistics, 2013
Desantis, C. E., Ma, J., Bryan, L. N., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21203 · Cited by 2,142
Breast Cancer Statistics
Ma, J., & Jemal, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5647-6_1 · Cited by 1,918
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715
The role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642

Show all 92 references

Research works printed but not linked: 1

Laoui, 2011, Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions, Int. J. Dev. Biol., 55, 861, 10.1387/ijdb.113371dl · DOI

Sorted by citations

Tumor-associated macrophages: from basic research to clinical application
Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
Li, X., Shao, C., Shi, Y., & Han, W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0578-4 · Cited by 389
Macrophages: Their Emerging Roles in Bone
Sinder, B. P., Pettit, A. R., & McCauley, L. K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2735 · Cited by 309
Iron Metabolism in Cancer
Wang, Y., Lei, Y., Ding, J. P., & Chen, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010095 · Cited by 301
Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268
“Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”
Background
High numbers of macrophages, especially M2‐like ( CD 163‐positive), correlate with hyaluronan accumulation and poor outcome in breast cancer
Tiainen, S., Tumelius, R., Rilla, K. J., Hämäläinen, K. M., Tammi, M., Tammi, R., Kosma, V., Oikari, S., & Auvinen, P. (2014) · Histopathology · doi:10.1111/his.12607 · Cited by 234
Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication
Burugu, S., Asleh, K., & Nielsen, T. O. (2016) · Breast Cancer · doi:10.1007/s12282-016-0698-z · Cited by 234
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function
Zhang, L., & Han, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.101 · Cited by 213
Intratumoral Immunization: A New Paradigm for Cancer Therapy
Marabelle, A., Kohrt, H. E. K., Caux, C., & Levy, R. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2116 · Cited by 221
Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets
Luo, X., Wu, K., & He, X. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01968-w · Cited by 210
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells
Song, Y., Tang, C., & Yin, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.017 · Cited by 189
Targeting the Stat6 pathway in tumor‐associated macrophages reduces tumor growth and metastatic niche formation in breast cancer
Binnemars‐Postma, K., Bansal, R., Storm, G., & Prakash, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700629r · Cited by 188
Macrophage Polarization: Anti-Cancer Strategies to Target Tumor-Associated Macrophage in Breast Cancer: A NTI-C ANCER S TRATEGIESTO T ARGET TAMs IN B REAST C ANCER
Tariq, M., Zhang, J., Liang, G., Ding, L., He, Q., & Yang, B. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25895 · Cited by 178
PET Imaging of Tumor-Associated Macrophages with 89 Zr-Labeled High-Density Lipoprotein Nanoparticles
Pérez‐Medina, C., Tang, J., Abdel-Atti, D., Hogstad, B., Mérad, M., Fisher, E. A. A., Fayad, Z. A., Lewis, J. S., Mulder, W. J. M., & Reiner, T. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.158956 · Cited by 168
Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer
Cullis, J. E., Siolas, D., Avanzi, A., Barui, S., Maitra, A., & Bar‐Sagi, D. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0125 · Cited by 165
The Human Cytomegalovirus, from Oncomodulation to Oncogenesis
Herbein, G. (2018) · Viruses · doi:10.3390/v10080408 · Cited by 160
Tumor infiltrating lymphocytes in early breast cancer
Pruneri, G., Vingiani, A., & Denkert, C. (2017) · The Breast · doi:10.1016/j.breast.2017.03.010 · Cited by 149
High-Infiltration of Tumor-Associated Macrophages Predicts Unfavorable Clinical Outcome for Node-Negative Breast Cancer
Zhang, Y., Cheng, S., Zhang, M., Zhen, L., Pang, D., Zhang, Q., & Li, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076147 · Cited by 144
Prognostic and predictive value of tumor-infiltrating lymphocytes in breast cancer: a systematic review and meta-analysis
Yu, X., Zhang, Z., Wang, Z., Wu, P., Qiu, F., & Huang, J. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1391-y · Cited by 137
Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes
Caspani, E. M., Crossley, P. H., Redondo-Garcia, C., & Martı́nez, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101402 · Cited by 144
Prognostic Value of Tumor-Associated Macrophages According to Histologic Locations and Hormone Receptor Status in Breast Cancer
Gwak, J. M., Jang, M. H., Kim, D. I., Seo, A. N., & Park, S. Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125728 · Cited by 128
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
Mehraj, U., Ganai, R. A., Macha, M. A., Hamid, A., Zargar, M. A., Bhat, A. A., Nasser, M. W., Haris, M., Batra, S. K., Alshehri, B., et al. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00634-9 · Cited by 128
The Contribution of the Immune System in Bone Metastasis Pathogenesis
Xiang, L., & Gilkes, D. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040999 · Cited by 118
Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a
Zhou, Y., Zhao, W., Mao, L., Wang, Y., Xia, L., Cao, M., Shen, J., & Chen, J. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.08.017 · Cited by 115
Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion
Li, K., Wei, L., Huang, Y., Wu, Y., SU, M., Pang, X., Wang, N., Ji, F., Zhong, C., & Chen, T. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3483 · Cited by 116
Noninvasive Imaging of CD206-Positive M2 Macrophages as an Early Biomarker for Post-Chemotherapy Tumor Relapse and Lymph Node Metastasis
Zhang, C., Yu, X., Gao, L., Zhao, Y., Lai, J., Lu, D., Bao, R., Jia, B., Zhong, L., Wang, F., et al. (2017) · Theranostics · doi:10.7150/thno.20999 · Cited by 113
Nanomedicine Strategies to Target Tumor-Associated Macrophages
Binnemars‐Postma, K., Storm, G., & Prakash, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050979 · Cited by 112
CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers
Pelekanou, V., Villarroel‐Espíndola, F., Schalper, K. A., Pusztai, L., & Rimm, D. L. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1076-x · Cited by 109
Usefulness of lymphocyte-to-monocyte, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios as prognostic markers in breast cancer patients treated with neoadjuvant chemotherapy
Hernández, C. M., Piñero, A., Vázquez, P. J. G., Fernández, P. J. G., Merino, G. R., Alonso-Romero, J. L., & Paricio, P. P. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1732-0 · Cited by 105
Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment
Yang, L., Sun, J., Liu, Q., Zhu, R., Yang, Q., Hua, J., Zheng, L., Li, K., Wang, S., & Li, A. (2019) · Advanced Science · doi:10.1002/advs.201802012 · Cited by 101
Metformin and cancer immunity
Ma, R., Yi, B., Riker, A. I., & Xi, Y. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00508-0 · Cited by 104
The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis
Tian, T., Wang, M., Lin, S., Guo, Y., Dai, Z., Liu, K., Yang, P., Dai, C., Zhu, Y., Zheng, Y., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.018 · Cited by 103
Small oral squamous cell carcinomas with nodal lymphogenic metastasis show increased infiltration of M2 polarized macrophages – An immunohistochemical analysis
Weber, M., Büttner-Herold, M. J., Hyckel, P., Möbius, P., Distel, L. V., Ries, J., Amann, K., Neukam, F. W., & Wehrhan, F. (2014) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2014.01.035 · Cited by 96
Small cell lung cancer: Recruitment of macrophages by circulating tumor cells
Hamilton, G., Rath, B., Klameth, L., & Hochmair, M. J. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1093277 · Cited by 94
CD68- and CD163-positive tumor-associated macrophages in triple negative cancer of the breast
Jamiyan, T., Kuroda, H., Yamaguchi, R., Abe, A., & Hayashi, M. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02855-z · Cited by 92
Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy
Umemoto, Y., Okano, S., Matsumoto, Y., Nakagawara, H., Matono, R., Yoshiya, S., Yamashita, Y., Yoshizumi, T., Ikegami, T., Soejima, Y., et al. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0933-3 · Cited by 92
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladder tumors is associated with BCG immunotherapy failure
Lima, L., Oliveira, D. S., Tavares, A., Amaro, T., Cruz, R., Oliveira, M. J., Ferreira, J. A., & Santos, L. L. (2013) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2013.10.012 · Cited by 90
The number and localization of CD68+ and CD163+ macrophages in different stages of cutaneous melanoma
Salmi, S., Siiskonen, H., Sironen, R. K., Tyynelä-Korhonen, K., Hirschovits-Gerz, B., Valkonen, M., Auvinen, P., & Pasonen‐Seppänen, S. (2018) · Melanoma Research · doi:10.1097/cmr.0000000000000522 · Cited by 90
Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer
Fortis, S. P., Sofopoulos, M., Sotiriadou, N. N., Haritos, C., Vaxevanis, C., Anastasopoulou, E. A., Janssen, N., Arnogiannaki, N., Ardavanis, A. S., Pawelec, G., et al. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0240-7 · Cited by 89
Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype
Eisel, D., Das, K., Dickes, E., König, R., Osen, W., & Eichmüller, S. B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00219 · Cited by 83
Prognostic Significance of Preoperative Lymphocyte-Monocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma
Han, L., Jia, Y., Song, Q., Wang, J., Wang, N., & Cheng, Y. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.6.2245 · Cited by 86
Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages
Alaluf, E., Vokaer, B., Detavernier, A., Azouz, A., Splittgerber, M., Carrette, A., Boon, L., Libert, F., Soares, M. P., Moine, A. L., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133929 · Cited by 86
In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging
Szulczewski, J. M., Inman, D. R., Entenberg, D. R., Ponik, S. M., Aguirre‐Ghiso, J. A., Castracane, J., Condeelis, J. S., Eliceiri, K. W., & Keely, P. J. (2016) · Scientific Reports · doi:10.1038/srep25086 · Cited by 83
Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC)
Bielecka, Z. F., Czarnecka, A. M., Solarek, W., Kornakiewicz, A., & Szczylik, C. A. (2014) · Current Signal Transduction Therapy · doi:10.2174/1574362409666140206223014 · Cited by 80
Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness
Takeuchi, H., Tanaka, M., TANAKA, A., Tsunemi, A., & Yamamoto, H. (2016) · Oncology Letters · doi:10.3892/ol.2016.4392 · Cited by 79
Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance
Jiang, S., Deng, T., Cheng, H., Liu, W., Shi, D., Yuan, J., He, Z., Wang, W., Chen, B., Ma, L., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02756-4 · Cited by 79
Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells
Li, H., Yang, B. L., Huang, J., Lin, Y. S., Xiang, T., Wan, J., Li, H., Chouaı̈b, S., & Ren, G. (2015) · Oncotarget · doi:10.18632/oncotarget.4936 · Cited by 79
Stromal Infiltration of Tumor-Associated Macrophages Conferring Poor Prognosis of Patients with Basal-Like Breast Carcinoma
Yang, M., Li, Z., Ren, M., Li, S., Zhang, L., Zhang, X., & Liu, F. (2018) · Journal of Cancer · doi:10.7150/jca.25155 · Cited by 79
Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas
Weber, M., Iliopoulos, C., Möbius, P., Büttner-Herold, M. J., Amann, K., Ries, J., Preidl, R. H. M., Neukam, F. W., & Wehrhan, F. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.001 · Cited by 79
Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients
Liu, H., Wang, J., Zhang, M., Xuan, Q., Wang, Z., Lian, X., & Zhang, Q. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4394-2 · Cited by 77
Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
Gómez, V., Eykyn, T. R., Mustapha, R., Flores‐Borja, F., Male, V. H., Barber, P. R., Patsialou, A., Green, R. J., Panagaki, F., Li, C. W., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aax4585 · Cited by 77
"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma
Clawson, G. A., Matters, G. L., Xin, P., McGovern, C. O., Wafula, E. K., dePamphilis, C. W., Meckley, M., Wong, J. Y., Stewart, L., D’Jamoos, C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184451 · Cited by 74
Macrophages Support Splenic Erythropoiesis in 4T1 Tumor-Bearing Mice
Liu, M., Jin, X., He, X., Pan, L., Zhang, X., & Zhao, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121921 · Cited by 72
Quantifying tumor associated macrophages in breast cancer: a comparison of iron and fluorine-based MRI cell tracking
Makela, A. V., Gaudet, J. M., & Foster, P. J. (2017) · Scientific Reports · doi:10.1038/srep42109 · Cited by 78
The Oncogenic Potential of Human Cytomegalovirus and Breast Cancer
Herbein, G., & Kumar, A. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00230 · Cited by 72
Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer
Sun, X., Gao, D., Gao, L., Zhang, C., Yu, X., Jia, B., Wang, F., & Liu, Z. (2015) · Theranostics · doi:10.7150/thno.11546 · Cited by 74
Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages
An, G., Wu, F., Huang, S., Lu, F., Bai, J., Gu, S., & Zhao, X. (2019) · Oncology Reports · doi:10.3892/or.2019.7344 · Cited by 71
Tumor-Associated Macrophages are Correlated with Tamoxifen Resistance in the Postmenopausal Breast Cancer Patients
Xuan, Q., Wang, J., Nanding, A., Wang, Z., Liu, H., Lian, X., & Zhang, Q. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-013-9740-z · Cited by 70
Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration—A Review of the Literature
Mamilos, A., Winter, L., Schmitt, V. H., Barsch, F., Grevenstein, D., Wagner, W. L., Babel, M., Keller, K., Schmitt, C., Gürtler, F., et al. (2023) · Cells · doi:10.3390/cells12020276 · Cited by 75
Human cytomegalovirus in cancer: the mechanism of HCMV-induced carcinogenesis and its therapeutic potential
Yu, C., He, S., Zhu, W., Ru, P., Ge, X., & Govindasamy, K. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1202138 · Cited by 69
Targeting myeloid cells using nanoparticles to improve cancer immunotherapy
Amoozgar, Z., & Goldberg, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.007 · Cited by 69
Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
Norton, K., Jin, K., & Popel, A. S. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.05.003 · Cited by 66
Circulating tumor cell interactions with macrophages: implications for biology and treatment
Hamilton, G., & Rath, B. (2017) · Translational Lung Cancer Research · doi:10.21037/tlcr.2017.07.04 · Cited by 65
Pretreatment neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte, and neutrophil/monocyte ratios and outcome in elderly breast cancer patients
Losada, B., Guerra, J. A., Malón, D., Jara, C., Rodriguez, L., & Barco, S. D. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1999-9 · Cited by 65
Current understandings and clinical translation of nanomedicines for breast cancer therapy
Jiang, Y., Jiang, Z., Wang, M., & Ma, L. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114034 · Cited by 67
Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments
Yokoi, K., Tanei, T., Godin, B., van de Ven, A. L., Hanibuchi, M., Matsunoki, A., Alexander, J. F., & Mauro Ferrari, B. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.11.015 · Cited by 64
Fourteen composite probiotics alleviate type 2 diabetes through modulating gut microbiota and modifying M1/M2 phenotype macrophage in db/db mice
Wang, Y., Wu, Y., Sailike, J., Sun, X., Abuduwaili, N., Tuoliuhan, H., MuLaTiAize, Y., & Nabi, X. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105150 · Cited by 64
The Immune Microenvironment in Multiple Myeloma: Friend or Foe?
Lopes, R., Caetano, J., Ferreira, B. V., Barahona, F., Carneiro, E. A., & Joao, C. M. (2021) · Cancers · doi:10.3390/cancers13040625 · Cited by 64
Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy
Zhu, L., Zhao, Y., Liu, T., Chen, M., Qian, W. P., Jiang, B., Barwick, B. G., Zhang, L., Styblo, T. M., Li, X., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c07440 · Cited by 63
Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin
Pincus, S. H., Bhaskaran, M., Brey, R. N., Didier, P. J., Doyle‐Meyers, L. A., & Roy, C. J. (2015) · Toxins · doi:10.3390/toxins7062121 · Cited by 60
The role of inflammation in progression of breast cancer: Friend or foe? (Review)
Allen, M. D., & Jones, J. L. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3075 · Cited by 60
Photoimmunotherapy with cetuximab-conjugated gold nanorods reduces drug resistance in triple negative breast cancer spheroids with enhanced infiltration of tumor-associated macrophages
Emami, F., Pathak, S., Nguyen, T. T., Shrestha, P. S., Maharjan, S., Kim, J. O., Jeong, J., & Yook, S. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.001 · Cited by 59
Macrophage colony-stimulating factor and cancer: a review
Chockalingam, S., & Ghosh, S. S. (2014) · Tumor Biology · doi:10.1007/s13277-014-2627-0 · Cited by 58
Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy
Jhaveri, K. L., Teplinsky, E., Silvera, D., Valeta-Magara, A., Arju, R., Giashuddin, S. M., Sarfraz, Y., Alexander, M., Darvishian, F., Levine, P. H., et al. (2015) · Clinical Breast Cancer · doi:10.1016/j.clbc.2015.11.006 · Cited by 58
VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages
Zhang, Y., Guo, Q., Zhang, Z., Bai, N., Liu, Z., Xiong, M., Wei, Y., Xiang, R., & Tan, X. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0036 · Cited by 55
Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women
Bower, J. E., Shiao, S. L., Sullivan, P., Lamkin, D. M., Atienza, R., Mercado, F., Arevalo, J. M. G., Asher, A., Ganz, P. A., & Cole, S. W. (2018) · JNCI Cancer Spectrum · doi:10.1093/jncics/pky029 · Cited by 55
Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner.
Xu, J., Yu, Y., He, X., Niu, N., Li, X., Zhang, R., Hu, J., Ma, J., Yu, X., Sun, Y., et al. (2019) · PubMed Central · Cited by 54
Double-crosser of the Immune System: Macrophages in Tumor Progression and Metastasis
Mir, M. A., & Mehraj, U. (2019) · Current Immunology Reviews · doi:10.2174/1573395515666190611122818 · Cited by 54
The role of macrophages in the tumor microenvironment and tumor metabolism
Sadhukhan, P., & Seiwert, T. Y. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00988-2 · Cited by 52
Circulating microRNA-451 as a predictor of resistance to neoadjuvant chemotherapy in breast cancer
Gu, X., Xue, J., Han, S., Qian, S., & Zhang, W. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160578 · Cited by 51
Nanomedicines for dysfunctional macrophage-associated diseases
He, H., Ghosh, S., & Yang, H. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.032 · Cited by 52
Oxidative Modification of the Potential G-Quadruplex Sequence in the PCNA Gene Promoter Can Turn on Transcription
Redstone, S. C. J., Fleming, A. M., & Burrows, C. J. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00332 · Cited by 54
c‐Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment
Ding, Y., Hao, K., Li, Z., Ma, R., Zhou, Y. L., Zhou, Z., Wei, M., Liao, Y., Dai, Y., Yang, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29317 · Cited by 52
TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer
Bron, S., Henry, L., Hull, E. F.-V., Turrini, R., Vanhecke, D., Guex, N., Ifticene‐Treboux, A., Iancu, E. M., Semilietof, A., Rufer, N., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1073882 · Cited by 48
Metabolic dysfunction and early‐onset colorectal cancer – how macrophages build the bridge
Scheurlen, K. M., Billeter, A. T., O'Brien, S. J., & Galandiuk, S. (2020) · Cancer Medicine · doi:10.1002/cam4.3315 · Cited by 44
Tumor-Infiltrating Lymphocytes and Immune Response in HER2-Positive Breast Cancer
Luque, M., Sanz-Álvarez, M., Morales-Gallego, M., Madoz‐Gúrpide, J., Zazo, S., Domínguez, C., Cazorla, A., Izarzugaza, Y., Arranz, J. L., Cristóbal, I., et al. (2022) · Cancers · doi:10.3390/cancers14246034 · Cited by 44
Tumor associated macrophages deliver iron to tumor cells via Lcn2.
Duan, X., He, K., Li, J., Cheng, M. S., Song, H., Liu, J., & Liu, P. (2018) · Europe PMC (PubMed Central) · Cited by 43
Relationship between migraine headache and hematological parameters
SARIÇAM, G. (2020) · Acta Neurologica Belgica · doi:10.1007/s13760-020-01362-x · Cited by 48
Biodistribution and PET Imaging of a Novel [68Ga]-Anti-CD163-Antibody Conjugate in Rats with Collagen-Induced Arthritis and in Controls
Eichendorff, S., Svendsen, P., Bender, D., Keiding, S., Christensen, E. I., Deleuran, B. W., & Moestrup, S. K. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0768-6 · Cited by 44
Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2
Qin, S., Wang, Z., Huang, C., Huang, P., & Li, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955841 · Cited by 42
Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth
Pestell, T. G., Jiao, X., Kumar, M., Peck, A. R., di Prisco, M., Deng, S., Li, Z., Ertel, A., Casimiro, M. C., Ju, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19953 · Cited by 44
Frontiers in intravital multiphoton microscopy of cancer
Perrin, L., Bayarmagnai, B., & Gligorijevic, B. (2019) · Cancer Reports · doi:10.1002/cnr2.1192 · Cited by 42
A review concerning the breast cancer-related tumour microenvironment
Rodríguez-Bejarano, O. H., Parra-López, C., & Patarroyo, M. A. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104389 · Cited by 47
CD204-Expressing Tumor-Associated Macrophages Are Associated With Malignant, High-Grade, and Hormone Receptor–Negative Canine Mammary Gland Tumors
Seung, B., Lim, H., Shin, J.-I., Kim, H.-W., Cho, S., Kim, S., & Sur, J. (2018) · Veterinary Pathology · doi:10.1177/0300985817750457 · Cited by 41
Prognostic role of immune infiltrates in breast ductal carcinoma in situ
Chen, X., Yeong, J. P.-S., Thike, A. A., Bay, B., & Tan, P. H. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05272-2 · Cited by 41
Low pretreatment lymphocyte/monocyte ratio is associated with the better efficacy of neoadjuvant chemotherapy in breast cancer patients
Peng, Y., Chen, R., Qu, F., Ye, Y., Fu, Y., Tang, Z., Wang, Y., Zong, B., Yu, H., Luo, F., et al. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1680057 · Cited by 41
Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions
Yang, S., Wang, M., Hua, Y., Li, J., Zheng, H., Cui, M., Huang, N., Liu, Q., & Liao, Q. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216610 · Cited by 43
CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer
Buldakov, M. A., Zavyalova, M. V., Krakhmal, N. V., Телегина, Н. С., Vtorushin, S. V., Larionova, I., Riabov, V., Yin, S., Song, B., Чердынцева, Н. В., et al. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.09.011 · Cited by 40
Increased circulating M2-like monocytes in patients with breast cancer
Zhang, B., Cao, M., He, Y., Liu, Y., Zhang, G., Yang, C., Du, Y., Xu, J., Hu, J., & Gao, F. (2017) · Tumor Biology · doi:10.1177/1010428317711571 · Cited by 40
Promising Colorectal Cancer Biomarkers for Precision Prevention and Therapy
Turano, M., Delrio, P., Rega, D., Cammarota, F., Polverino, A., Duraturo, F., Izzo, P., & Rosa, M. D. (2019) · Cancers · doi:10.3390/cancers11121932 · Cited by 40

Authors: Tang, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Tang, Xiaoqiang
ORCID: Tang, Xiaoqiang
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2013-05
Volume: 332
Issue: 1
Pages: 3-10
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2013.01.024
OpenAlex: W2077731584
Cited by: 276
References: 92
Citations by year: 2026: 4 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 30 · 2019: 24 · 2018: 21 · 2017: 26 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 9
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Tsinghua University
West China Hospital, Sichuan University
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: tumor-associated macrophages, breast cancer, tumor microenvironment, M2 macrophages, CD68, prognostic factors, diagnostic biomarkers, CD163, vascular endothelial growth factor, hypoxia-inducible factor, PCNA, ferritin light chain, CCL18, TAM infiltration
MeSH terms: CD68 Molecule, Animals, Biopsy, Breast Neoplasms, Female, Humans, Macrophages, Predictive Value of Tests, Prognosis, Biomarkers, Tumor, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks