Cited by 276Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

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Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

Tang, Xiaoqiang·2013·Cancer Letters

DOI 10.1016/j.canlet.2013.01.024

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Abstract

Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and facilitate tumor development. Clinical evidences compellingly indicate the association between high TAMs influx and poor prognosis in patients with breast cancers. The pan-macrophage marker CD68 is now generally utilized to identify TAMs in diagnostic biopsy samples, and some other TAM-related biomarkers are also utilized in prognosis prediction, including CD163, vascular endothelial growth factor (VEGF), hypoxia-inducible factors (HIFs), proliferating cellular nuclear antigen (PCNA), ferritin light chain (FTL) and C-C motif chemokine ligand 18 (CCL18). In this review, we highlight the recent progress made in understanding the relationship between TAMs and clinicopathological parameters in human breast cancer and address the potential value of TAMs as diagnostic and prognostic biomarkers.

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1 retracted

Retracted: Immunotherapy of metastatic breast cancer patients with vitamin D‐binding protein‐derived macrophage activating factor (GcMAF)
Yamamoto, N., Suyama, H., Yamamoto, N., & Ushijima, N. (2007) · International Journal of Cancer · doi:10.1002/ijc.23107 · Cited by 62
Retracted
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer
Berry, D. A., Cronin, K. A., Plevritis, S. K., Fryback, D. G., Clarke, L. D., Zelen, M., Mandelblatt, J. S., Yakovlev, A. Y., Habbema, J. D. F., & Feuer, E. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050518 · Cited by 2,456
Breast cancer statistics, 2013
Desantis, C. E., Ma, J., Bryan, L. N., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21203 · Cited by 2,142
Breast Cancer Statistics
Ma, J., & Jemal, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5647-6_1 · Cited by 1,918
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715
The role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642
Breast cancer statistics, 2011
Desantis, C. E., Siegel, R. L., Bandi, P., & Jemal, A. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20134 · Cited by 1,338
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Movahedi, K., Laoui, D., Gysemans, C. A., Baeten, M., Stangé, G. M., den Bossche, J. V., Mack, M., PIPELEERS, D. G., Veld, P. I. '., BAETSELIER, P. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4672 · Cited by 1,268
Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma
Steidl, C., Lee, T., Shah, S. P., Farinha, P., Han, G., Nayar, T., Delaney, A., Jones, S. J., Iqbal, J., Weisenburger, D. D., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0905680 · Cited by 1,262
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
Leek, R., Lewis, C. E., Whitehouse, R. M., Greenall, M. J., Clarke, J., & Harris, A. L. (1996) · PubMed · Cited by 1,187
Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S. K., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,089
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044
Heterogeneity in breast cancer
Polyák, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci60534 · Cited by 1,038
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
Medrek, C., Pontén, F., Jirström, K., & Leandersson, K. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-306 · Cited by 676
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1439 · Cited by 652
CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
Chen, J., Yao, Y., Gong, C., Yu, F., Su, S., Chen, J., Liu, B., Deng, H., Wang, F., Lin, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.006 · Cited by 645
Targeting tumor-associated macrophages as a novel strategy against breast cancer
Luo, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27648 · Cited by 551
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
Shree, T., Olson, O. C., Elie, B. T., Kester, J. C., Garfall, A. L., Simpson, K., Bell-McGuinn, K. M., Zabor, E. C., Brogi, E., & Joyce, J. A. (2011) · Genes & Development · doi:10.1101/gad.180331.111 · Cited by 541
Leukocyte composition of human breast cancer
Ruffell, B., Au, A., Rugo, H. S., Esserman, L. J., Hwang, E. S., & Coussens, L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104303108 · Cited by 489
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A., & Tahara, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106645108 · Cited by 479
Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer
Lin, E. Y., & Pollard, J. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0912 · Cited by 463
Identification and manipulation of tumor associated macrophages in human cancers
Heusinkveld, M., & van der Burg, S. H. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-216 · Cited by 451
Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
Leek, R., Landers, R. J., Harris, A. L., & Lewis, C. E. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690158 · Cited by 450
Differential regulation of iron homeostasis during human macrophage polarized activation
Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438
Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms
Biswas, S. K., Sica, A., & Lewis, C. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2011 · Cited by 432
Macrophages define the invasive microenvironment in breast cancer
Pollard, J. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107762 · Cited by 414
Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density
Tsutsui, S., Yasuda, K., Suzuki, K., Tahara, K., Higashi, H., & Era, S. (2005) · Oncology Reports · doi:10.3892/or.14.2.425 · Cited by 368
Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression
Sallari, R. C., Zhang, X., Wright, J. B., Bailey, S. D., Cole, M. D., Eeckhoute, J., Moore, J. H., & Lupien, M. (2012) · Nature Genetics · doi:10.1038/ng.2416 · Cited by 354
Tumor-Associated Macrophages in Breast Cancer
Leek, R., & Harris, A. L. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1020304003704 · Cited by 353
Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
Robinson, B. D., Sica, G., Liu, Y.-F., Rohan, T. E., Gertler, F. B., Condeelis, J. S., & Jones, J. G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2179 · Cited by 345
MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles
Daldrup-Link, H. E., Golovko, D. M., Ruffell, B., DeNardo, D. G., Castaneda, R., Ansari, C., Rao, J., Tikhomirov, G. A., Wendland, M. F., Corot, C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3420 · Cited by 307
Polarization dictates iron handling by inflammatory and alternatively activated macrophages
Corna, G., Campana, L., Pignatti, E., Castiglioni, A., Tagliafico, E., Bosurgi, L., Campanella, A., Brunelli, S., Manfredi, A. A., Apostoli, P., et al. (2010) · Haematologica · doi:10.3324/haematol.2010.023879 · Cited by 304 · cited 1×
“The molecular signature of the M1 macrophages show changes in gene expression (FTL repression and FTH induction) that favors iron sequestration in the reticuloendothelial system, whereas the M2 macrophages have an expression profile (FTL up-regulation and FTH down-regulation) that enhances iron release [70,71].”
Background
Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions
Laoui, D., Movahedi, K., Overmeire, E. V., den Bossche, J. V., Schouppe, E., Mommer, C., Nikolaou, A., Morias, Y., BAETSELIER, P. D., & Ginderachter, J. A. V. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113371dl · Cited by 302
Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway
Yang, J., Liao, D., Chen, C., Liu, Y., Chuang, T.-H., Xiang, R., Markowitz, D., Reisfeld, R. A., & Luo, Y. (2013) · Stem Cells · doi:10.1002/stem.1281 · Cited by 301
High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer.
Foekens, J. A., Peters, H. A., Grebenchtchikov, N. I., Look, M. P., Gelder, M. E. M., Geurts-Moespot, A. J., van der Kwast, T., Sweep, F. C. G. J., & Klijn, J. G. M. (2001) · PubMed · Cited by 294
Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages
Movahedi, K., Schoonooghe, S., Laoui, D., Houbracken, I., Waelput, W., Breckpot, K., Bouwens, L., Lahoutte, T., BAETSELIER, P. D., Raes, G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2994 · Cited by 292
Anti‐tumour strategies aiming to target tumour‐associated macrophages
Tang, X., Mo, C., Wang, Y., Wei, D., & Xiao, H. (2012) · Immunology · doi:10.1111/imm.12023 · Cited by 288
Self-citation
Tumour-infiltrating macrophages and clinical outcome in breast cancer
Mahmoud, S., Lee, A. H. S., Paish, E. C., Macmillan, R. D., Ellis, I. O., & Green, A. R. (2011) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2011-200355 · Cited by 277
Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome
Campbell, M. J., Tonlaar, N., Garwood, E. R., Huo, D., Moore, D. H., Khramtsov, A., der Au, A., Baehner, F. L., Chen, Y., Malaka, D. O., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1154-y · Cited by 267
Expression of CD68 in Non‐Myeloid Cell Types
Gottfried, E., Kunz‐Schughart, L. A., Weber, A., Rehli, M., Peuker, A., Müller, A., Kastenberger, M., Brockhoff, G., Andreesen, R., & Kreutz, M. P. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02091.x · Cited by 261
Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors
Ojalvo, L. S., Whittaker, C. A., Condeelis, J. S., & Pollard, J. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902360 · Cited by 248
Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
Shabo, I., Stål, O., Olsson, H., Doré, S., & Svanvik, J. (2008) · International Journal of Cancer · doi:10.1002/ijc.23527 · Cited by 225
High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors.
Ojalvo, L., King, W., Cox, D., & Pollard, J. (2009) · American Journal of Pathology · doi:10.2353/ajpath.2009.080676 · Cited by 223
Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer
Yang, L. P. H., Peng, X.-H., Wang, Y. A., Wang, X., Cao, Z., Ni, C., Karna, P., Zhang, X., Wood, W. C., Gao, X., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3289 · Cited by 216
Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
Leek, R., Landers, R. J., Fox, S. B., Ng, F. C., Harris, A. L., & Lewis, C. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.373 · Cited by 207
Macrophage migration and gene expression in response to tumor hypoxia
Murdoch, C., & Lewis, C. E. (2005) · International Journal of Cancer · doi:10.1002/ijc.21422 · Cited by 203
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M., Welm, B. E., Bainbridge, E. D., Peeters, G., Krummel, M. F., & Werb, Z. (2008) · Disease Models & Mechanisms · doi:10.1242/dmm.000596 · Cited by 199
Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.
Leek, R., Talks, K., Pezzella, F., Turley, H., Campo, L., Brown, N. S., Bicknell, R., Taylor, M., Gatter, K. C., & Harris, A. L. (2002) · PubMed · Cited by 199
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors.
Brown, N. S., Jones, A., Fujiyama, C., Harris, A. L., & Bicknell, R. (2000) · PubMed · Cited by 187
Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy
Meng, Y., Beckett, M. A., Liang, H. L., Mauceri, H. J., van Rooijen, N., Cohen, K. S., & Weichselbaum, R. R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2995 · Cited by 186
Molecular interactions in the Vogelstein model of colorectal carcinoma
Arends, J. W. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200003)190:4 · Cited by 184
Macrophages in human breast disease: a quantitative immunohistochemical study
Kelly, P., Davison, R., Bliss, E., & McGee, J. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.36 · Cited by 168
Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages
Eubank, T. D., Roberts, R. D., Khan, M., Curry, J. M., Nuovo, G. J., Kuppusamy, P., & Marsh, C. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1405 · Cited by 166
Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma
Valković, T., Dobrila, F., Melato, M., Sasso, F., Rizzardi, C., & Jonjić, N. (2001) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280100458 · Cited by 152
Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics
Mukhtar, R. A., Nseyo, O., Campbell, M. J., & Esserman, L. J. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.97 · Cited by 142
89 Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging
Keliher, E. J., Yoo, J., Nahrendorf, M., Lewis, J. S., Marinelli, B. S., Newton, A., Pittet, M. J., & Weissleder, R. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200405d · Cited by 136
Expression of Vascular Notch Ligand Delta-Like 4 and Inflammatory Markers in Breast Cancer
Jubb, A. M., Soilleux, E. J., Turley, H., Steers, G., Parker, A., Low, I., Blades, J. S., Li, J., Allen, P. W., Leek, R., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090908 · Cited by 123
Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters.
Bolat, F. A., Kayaselçuk, F., Nursal, T. Z., Yağmurdur, M. C., Bal, N., & Demirhan, B. (2006) · PubMed · Cited by 122
A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages
Verdoes, M., Edgington‐Mitchell, L. E., Scheeren, F. A., Leyva, M. J., Blum, G., Weiskopf, K., Bachmann, M. H., Ellman, J. A., & Bogyo, M. S. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.03.012 · Cited by 116
Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle
Leimgruber, A., Berger, C., Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Waterman, P. R., de Figueiredo, J. L., Köhler, R. H., Elpek, N. M., Mempel, T. R., et al. (2009) · Neoplasia · doi:10.1593/neo.09356 · Cited by 112
Detection and Quantitation of Macrophage Infiltration Into Primary Human Tumors With the Use of Cell-Surface Markers 2
Wood, G. W., & Gollahon, K. A. (1977) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/59.4.1081 · Cited by 97
Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study
Jézéquel, P., Campion, L., Spyratos, F., Loussouarn, D., Campone, M., Guérin‐Charbonnel, C., Joalland, M., André, J., Descotes, F., Grenot, C., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.26397 · Cited by 85
The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer
Murri, A. M. A., Hilmy, M., Bell, J., Wilson, C., McNicol, A. M., Lannigan, A., Doughty, J., & McMillan, D. C. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604667 · Cited by 81
The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue
(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70
Determination of angiogenesis adds information to estrogen receptor status in predicting the efficacy of adjuvant tamoxifen in node-positive breast cancer patients.
Gasparini, G. M., Fox, S. B., Verderio, P., Bonoldi, E., Bevilacqua, P., Boracchi, P., Dante, S., Marubini, E., & Harris, A. L. (1996) · PubMed · Cited by 69
Shigella Mediated Depletion of Macrophages in a Murine Breast Cancer Model Is Associated with Tumor Regression
Galmbacher, K., Heisig, M., Hotz, C., Wischhusen, J., Galmiche, A., Bergmann, B., Gentschev, I., Goebel, W., Rapp, U. R., & Fensterle, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009572 · Cited by 66
Significance of thymidine phosphorylase as a marker of protumor monocytes in breast cancer.
Toi, M., Ueno, T., Matsumoto, H., Saji, H., Funata, N., Koike, M., & Tominaga, T. (1999) · PubMed · Cited by 63
Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer
Zohny, S. F., & Fayed, S. T. (2009) · Medical Oncology · doi:10.1007/s12032-009-9366-x · Cited by 54
Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity
Mukhtar, R. A., Moore, A. P., Nseyo, O., Baehner, F. L., Au, A., Moore, D. H., Twomey, P. L., Campbell, M. J., & Esserman, L. J. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1646-4 · Cited by 53
Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813
Melancon, M. P., Lü, W., Huang, Q., Thapa, P., Zhou, D., Ng, C. S., & Li, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.001 · Cited by 53
Tumour-associated macrophages in breast cancer and their prognostic correlations
Volodko, N., Reiner, A., Rudas, M., & Jakesz, R. (1998) · The Breast · doi:10.1016/s0960-9776(98)90065-0 · Cited by 53
Breast Cancer Management: Opportunities and Barriers to an Individualized Approach
Perez, E. A. (2011) · The Oncologist · doi:10.1634/theoncologist.2011-s1-20 · Cited by 52
In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis
Ch’ng, E. S., Sharif, S. E. T., & Jaafar, H. (2013) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-012-1362-4 · Cited by 40
Cellular neurothekeoma with histiocytic differentiation
Misago, N., Satoh, T., & NARISAWA, Y. (2004) · Journal of Cutaneous Pathology · doi:10.1111/j.0303-6987.2004.00223.x · Cited by 36
MR imaging of tumor-associated macrophages
Daldrup-Link, H. E., & Coussens, L. M. (2012) · OncoImmunology · doi:10.4161/onci.19456 · Cited by 34
Expression of CCL18 and interleukin-6 in the plasma of breast cancer patients as compared with benign tumor patients and healthy controls.
Nariţa, D., Șeclăman, E. P., Ursoniu, S., Ilina, R. Ş., Cireap, N., & Anghel, A.-V. (2011) · PubMed · Cited by 31
Elevated Serum Levels of Vascular Endothelial Growth Factor Are Associated With Tumor-Associated Macrophages in Primary Breast Cancer
Vicioso, L., Gonzalez, F. J., Alvarez, M., Ribelles, N., Molina, M., Márquez, A., Pérez, L. M. G., Matilla, A., & Alba, E. (2005) · American Journal of Clinical Pathology · doi:10.1309/0864af2u3lgpcf3j · Cited by 31
Longitudinal study of tumor‐associated macrophages during tumor expansion using MRI
Shih, Y. I., Hsu, Y., Duong, T. Q., Lin, S., Chow, K.-P. N., & Chang, C. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1698 · Cited by 30
Elevated Levels of Proliferating and Recently Migrated Tumor-associated Macrophages Confer Increased Aggressiveness and Worse Outcomes in Breast Cancer
Mukhtar, R. A., Moore, A. P., Tandon, V. J., Nseyo, O., Twomey, P. L., Adisa, C., Eleweke, N., Au, A., Baehner, F. L., Moore, D. H., et al. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2415-2 · Cited by 30
Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 gene
Fernández‐Navarro, P., Pita, G., Santamariña, C., Moreno, M. P., Vidal, C., Miranda-García, J., Ascunce, N., Casanova, F., Collado-García, F., Herráez, B., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.08.026 · Cited by 26
Characterisation of macrophages infiltrating human mammary carcinomas
Steele, R. J., Brown, M., & Eremin, O. (1985) · British Journal of Cancer · doi:10.1038/bjc.1985.20 · Cited by 25
Valkovic, T. et al. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinomas. Virchows Arch. 440, 583-588
Valković, T., Dobrila, F., Melato, M., Sasso, F., Rizzardi, C., & Jonjić, N. (2002) · Cited by 24
Fine-mapping of the 6q25 locus identifies a novel SNP associated with breast cancer risk in African-American women
Ruiz-Narváez, E., Rosenberg, L. A., Yao, S., Rotimi, C. N., Cupples, L. A., Bandera, E. V., Ambrosone, C. B., Adams-Campbell, L. L., & Palmer, J. R. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs334 · Cited by 23
Clinicopathologic analysis of macrophage infiltrates in breast carcinoma
Visscher, D. W., Tabaczka, P. M., Long, D., & Crissman, J. D. (1995) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80658-8 · Cited by 18
Proteomic analysis identifies candidate proteins associated with distant recurrences in breast cancer after adjuvant chemotherapy
Niméus, E., Malmström, J. A., Johnsson, A., Marko‐Varga, G., & Fernö, M. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2006.09.019 · Cited by 16
The Histiocytic Marker PG-M1 Is Helpful in Differentiating Histiocytes and Histiocytic Tumors From Melanomas
Groisman, G. M., Amar, M., & Schäfer, I. (2002) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200209000-00003 · Cited by 16
Evaluation of chromosome 6p22 as a breast cancer risk modifier locus in a follow-up study of BRCA2 mutation carriers
Study, S. (.-B. S. B. C., Purrington, K. S., HEreditary Breast and Ovarian Cancer Group Netherlands (HEBON), CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella (CONSIT Team), kConFab, Wang, X., Fredericksen, Z., Pankratz, V. S., Greene, M. H., Andrulis, I. L., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2255-6 · Cited by 4

Research works printed but not linked: 1

Laoui, 2011, Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions, Int. J. Dev. Biol., 55, 861, 10.1387/ijdb.113371dl · DOI

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Background

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Authors: Tang, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Tang, Xiaoqiang
ORCID: Tang, Xiaoqiang
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2013-05
Volume: 332
Issue: 1
Pages: 3-10
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2013.01.024
OpenAlex: W2077731584
Cited by: 276
References: 92
Citations by year: 2026: 4 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 30 · 2019: 24 · 2018: 21 · 2017: 26 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 9
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Tsinghua University
West China Hospital, Sichuan University
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: tumor-associated macrophages, breast cancer, tumor microenvironment, M2 macrophages, CD68, prognostic factors, diagnostic biomarkers, CD163, vascular endothelial growth factor, hypoxia-inducible factor, PCNA, ferritin light chain, CCL18, TAM infiltration
MeSH terms: CD68 Molecule, Animals, Biopsy, Breast Neoplasms, Female, Humans, Macrophages, Predictive Value of Tests, Prognosis, Biomarkers, Tumor, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Tumor Microenvironment

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Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

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