Sarcoma treatment in the era of molecular medicine
Open accessAbstract
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult‐to‐treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The seed and soil phenomenon in osteosarcoma is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration and drug resistance, and contributes to intrinsic heterogeneity.
“This seed and soil phenomenon is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration, and drug resistance 15,51,52,53 and contributes to their intrinsic heterogeneity 54,55 .”
From Osteosarcoma (2022) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Mu, J., Sun, P., Ma, Z., & Sun, P. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2170-4 · Cited by 36 · see citing works
RetractedThéry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works
Self-citation3D bioprinting of tissues and organs
Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034 · see citing works
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143 · see citing works
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Galon, J., & Bruni, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0007-y · Cited by 3,414 · see citing works
DNA methylation-based classification of central nervous system tumours
Capper, D., Jones, D., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chávez, L., Reuß, D., et al. (2018) · Nature · doi:10.1038/nature26000 · Cited by 3,046 · see citing works
Self-citationA view on drug resistance in cancer
Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770 · see citing works
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma
Andtbacka, R. H. I., Kaufman, H. L., Collichio, F. A., AMATRUDA, T. T., Senzer, N. N., Chesney, J. A., Delman, K. A., S̄pitler, L. E., Puzanov, I. J., Agarwala, S. S., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3377 · Cited by 2,646 · see citing works
The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Rotter-Maskowitz, A., Weiser, R., Mallel, G., Gigi, E., et al. (2020) · Science · doi:10.1126/science.aay9189 · Cited by 2,464 · see citing works
Self-citationPatient-derived organoids model treatment response of metastatic gastrointestinal cancers
Vlachogiannis, G., Hedayat, S., Vatsiou, A., Jamin, Y., Fernández-Mateos, J., Khan, K., Lampis, A., Eason, K., Huntingford, I., Burke, R., et al. (2018) · Science · doi:10.1126/science.aao2774 · Cited by 2,096 · see citing works
B cells are associated with survival and immunotherapy response in sarcoma
Petitprez, F., de Reyniès, A., Keung, E. Z., Chen, T. W.-W., Sun, C.-M., Calderaro, J., Jeng, Y.-M., Hsiao, L.-P., Lacroix, L., Bougoüin, A., et al. (2020) · Nature · doi:10.1038/s41586-019-1906-8 · Cited by 1,942 · see citing works
The Epidemiology of Osteosarcoma
Ottaviani, G., & Jaffe, N. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_1 · Cited by 1,793 · see citing works
Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy
Ribas, A., Dummer, R., Puzanov, I., VanderWalde, A., Andtbacka, R. H. I., Michielin, O., Olszanski, A. J., Malvehy, J., Cebon, J., Fernandez, E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.027 · Cited by 1,520 · see citing works
Visvader, J. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,509 · see citing works
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M., & Shendure, J. (2016) · Cell · doi:10.1016/j.cell.2015.11.050 · Cited by 1,462 · see citing works
Tumor Antigen Escape from CAR T-cell Therapy
Majzner, R. G., & Mackall, C. L. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0442 · Cited by 1,203 · see citing works
Judson, I. R., Verweij, J., Gelderblom, H. A. J., Hartmann, J. T., Schöffski, P., Blay, J., Kerst, J. M., Šufliarský, J., Whelan, J. S., Hohenberger, P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70063-4 · Cited by 1,185 · see citing works
Liquid biopsy and minimal residual disease - latest advances and implications for cure
Pantel, K., & Alix-Panabières, C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0187-3 · Cited by 1,110 · see citing works
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G.-H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0349 · Cited by 1,092 · see citing works
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Abeshouse, A., Adebamowo, C., Adebamowo, S. N., Akbani, R., Akeredolu, T., Ally, A., Anderson, M. L., Anur, P., Appelbaum, E. L., Armenia, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.014 · Cited by 1,069 · see citing works
Ahmed, N., Brawley, V. S., Hegde, M., Robertson, C., Ghazi, A., Gerken, C., Liu, E., Dakhova, O., Ashoori, A., Corder, A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.0225 · Cited by 1,004 · see citing works
Genetic and transcriptional evolution alters cancer cell line drug response
Ben-David, U., Siranosian, B., Ha, G., Tang, H., Oren, Y., Hinohara, K., Strathdee, C. A., Dempster, J., Lyons, N. J., Burns, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0409-3 · Cited by 931 · see citing works
Helleday, T. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.07.001 · Cited by 859 · see citing works
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
Behjati, S., Tarpey, P. S., Presneau, N., Scheipl, S., Pillay, N., Van Loo, P., Wedge, D. C., Cooke, S. L., Gundem, G., Davies, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2814 · Cited by 854 · see citing works
Corless, C. L., Schroeder, A., Griffith, D., Town, A., McGreevey, L. S., Harrell, P. M., Shiraga, S., Bainbridge, T., Morich, J. R., & Heinrich, M. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.14.068 · Cited by 848 · see citing works
Clark, J., Rocques, P. J., Crew, A. J., Gill, S., SHIPLEY, J. M., Chan, A. M.-L., Gusterson, B. A., & Cooper, C. S. (1994) · Nature Genetics · doi:10.1038/ng0894-502 · Cited by 772 · see citing works
Casali, P. G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovée, J. V. M. G., Brodowicz, T., Broto, J. M., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy095 · Cited by 749 · see citing works
Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis
Eyler, C. E., & Rich, J. N. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.1829 · Cited by 742 · see citing works
Shern, J. F., Chen, L., Chmielecki, J., Wei, J. S., Patidar, R., Rosenberg, M. W., Ambrogio, L., Auclair, D., Wang, J., Song, Y. K., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0639 · Cited by 742 · see citing works
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration
Gaspar, N., Hawkins, D. S., Dirksen, U., Lewis, I. J., Ferrari, S., Deley, M. L., Kovar, H., Grimer, R. J., Whelan, J. S., Claude, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.5256 · Cited by 725 · see citing works
Descriptive epidemiology of sarcomas in Europe: Report from the RARECARE project
Stiller, C. A., Trama, A., Serraino, D., Rossi, S., Navarro, C., Chirlaque, M. D., & Casali, P. G. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.09.011 · Cited by 693 · see citing works
Majzner, R. G., Theruvath, J. L., Nellan, A., Heitzeneder, S., Cui, Y., Mount, C. W., Rietberg, S. P., Linde, M. H., Xu, P., Rota, C., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0432 · Cited by 681 · see citing works
The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors.
Mankin, H. J., Lange, T. A., & Spanier, S. S. (1982) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198264080-00002 · Cited by 650 · see citing works
PD-L1 expression and prognostic impact in glioblastoma
Nduom, E. K.-E., Wei, J., Yaghi, N. K., Huang, N., Kong, L.-Y., Gabrusiewicz, K. R., Ling, X., Zhou, S., Ivan, C., Chen, J. Q., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov172 · Cited by 600 · see citing works
Tirode, F., Surdez, D., Ma, X., Parker, M. D., Deley, M. L., Bahrami, A., Zhang, Z., Lapouble, E., Grossetête, S., Rusch, M., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0622 · Cited by 569 · see citing works
Next-generation sequencing in liquid biopsy: cancer screening and early detection
Chen, M., & Zhao, H. (2019) · Human Genomics · doi:10.1186/s40246-019-0220-8 · Cited by 561 · see citing works
Jayasingam, S., Citartan, M., Thang, T. H., Zin, A. A. M., Kai, C.-E.-A., & Ch'ng, E. S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01512 · Cited by 554 · see citing works
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 549 · see citing works
Rougraff, B. T., Simon, M. A., Kneisl, J. S., Greenberg, D. B., & Mankin, H. J. (1994) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199405000-00004 · Cited by 534 · see citing works
Buddingh, E. P., Kuijjer, M. L., Duim, R. A. J., Bürger, H., Agelopoulos, K., Myklebost, O., Serra, M., Mertens, F., Hogendoorn, P. C. W., Lankester, A. C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2047 · Cited by 508 · see citing works
Genetically engineered mouse models in oncology research and cancer medicine
Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502 · see citing works
Perry, J. A., Kiezun, A., Tonzi, P., Van Allen, E. M., Carter, S. L., Baca, S. C., Cowley, G. S., Bhatt, A. S., Rheinbay, E., Pedamallu, C. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419260111 · Cited by 481 · see citing works
Lysosomes as mediators of drug resistance in cancer
Zhitomirsky, B., & Assaraf, Y. G. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.11.004 · Cited by 480 · see citing works
Osteosarcoma, Chondrosarcoma, and Chordoma
Whelan, J. S., & Davis, L. E. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.75.1743 · Cited by 477 · see citing works
Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur.
Simon, M. A., Aschliman, M. A., Thomas, N., & Mankin, H. J. (1986) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198668090-00005 · Cited by 469 · see citing works
Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project
Stiller, C. A., Trama, A., Brewster, D., Verne, J., Bouchardy, C., Navarro, C., Chirlaque, M. D., Marcos‐Gragera, R., Visser, O. J., Serraino, D., et al. (2014) · Cancer Epidemiology · doi:10.1016/j.canep.2014.09.009 · Cited by 463 · see citing works
Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications
Jeyaram, A., & Jay, S. M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0160-y · Cited by 461 · see citing works
Limb-Salvage Treatment Versus Amputation for Osteosarcoma of the Distal End of the Femur
Simon, M. A., Aschliman, M. A., Thomas, N. J., & Mankin, H. J. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.8712.cl · Cited by 452 · see citing works
Genome-Informed Targeted Therapy for Osteosarcoma
Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452 · see citing works
Riggi, N., Knoechel, B., Gillespie, S. M., Rheinbay, E., Boulay, G., Suvà, M. L., Rossetti, N. E., Boonseng, W. E., Oksuz, O., Cook, E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.004 · Cited by 447 · see citing works
Biological Laser Printing: A Novel Technique for Creating Heterogeneous 3-dimensional Cell Patterns
Barron, J. A., Wu, P., Ladouceur, H. D., & Ringeisen, B. R. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000031751.67267.9f · Cited by 437 · see citing works
Inferring expressed genes by whole-genome sequencing of plasma DNA
Ulz, P., Thallinger, G., Auer, M., Graf, R., Kashofer, K., Jahn, S. W., Abete, L., Pristauz, G., Petru, E., Geigl, J. B., et al. (2016) · Nature Genetics · doi:10.1038/ng.3648 · Cited by 432 · see citing works
D’Angelo, S. P., Melchiori, L., Merchant, M. S., Bernstein, D. B., Glod, J. W., Kaplan, R. N., Grupp, S. A., Tap, W. D., Chagin, K., Binder, G. K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1417 · Cited by 432 · see citing works
Bioprinting for vascular and vascularized tissue biofabrication
Datta, P., Ayan, B., & Ozbolat, I. T. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.035 · Cited by 431 · see citing works
Advances in sarcoma genomics and new therapeutic targets
Taylor, B. S., Barretina, J. G., Maki, R. G., Antonescu, C. R., Singer, S., & Ladanyi, M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3087 · Cited by 428 · see citing works
Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts
Hoffman, R. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3972 · Cited by 424 · see citing works
A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype
Naumov, G. N., Bender, E., Zurakowski, D., Kang, S.-Y., Sampson, D., Flynn, E., Watnick, R. S., Straume, O., Akslen, L. A., Folkman, J., et al. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj068 · Cited by 423 · see citing works
Michel, B. C., D’Avino, A. R., Cassel, S. H., Mashtalir, N., McKenzie, Z. M., McBride, M. J., Valencia, A. M., Zhou, Q., Bocker, M., Soares, L. M. M., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0221-1 · Cited by 423 · see citing works
Blay, J., Serrano, C., Heinrich, M. C., Zalcberg, J. R., Bauer, S., Gelderblom, H. A. J., Schöffski, P., Jones, R. L., Attia, S., D’Amato, G. Z., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30168-6 · Cited by 422 · see citing works
Ma, X., Liu, J., Zhu, W. Z., Tang, M., Lawrence, N., Yu, C., Gou, M., & Chen, S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.011 · Cited by 408 · see citing works
Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas
Toulmonde, M., Penel, N., Adam, J., Chevreau, C., Blay, J., Cesne, A. L., Bompas, E., Piperno-Neumann, S., Cousin, S., Grellety, T., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.1617 · Cited by 402 · see citing works
Dickson, M. A., Tap, W. D., Keohan, M. L., D'Angelo, S. P., Gounder, M. M., Antonescu, C. R., Landa, J., Qin, L.-X., Rathbone, D. D., Condy, M. M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.5476 · Cited by 399 · see citing works
Doebele, R. C., Davis, L. E., Vaishnavi, A., Le, A. T., Estrada‐Bernal, A., Keysar, S. B., Jimeno, A., Varella‐Garcia, M., Aisner, D. L., Li, Y., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0443 · Cited by 398 · see citing works
Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome
Baldini, N., Scotlandi, K., Bròdano, G. B., Manara, M. C., Maurici, D., Bacci, G., Bertoni, F., Picci, P., Sottili, S., Campanacci, M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332103 · Cited by 396 · see citing works
Self-citationHistone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lü, C., Jain, S. U., Hoelper, D., Béchet, D., Molden, R. C., Ran, L., Murphy, D. A., Venneti, S., Hameed, M., Pawel, B., et al. (2016) · Science · doi:10.1126/science.aac7272 · Cited by 392 · see citing works
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
Lawson, M. A., McDonald, M. M., Kovačić, N., Khoo, W. H., Terry, R. L., Down, J. M., Kaplan, W. H., Paton‐Hough, J., Fellows, C., Pettitt, J. A., et al. (2015) · Nature Communications · doi:10.1038/ncomms9983 · Cited by 385 · see citing works
The expanding landscape of ‘oncohistone’ mutations in human cancers
Nacev, B. A., Feng, L., Bagert, J. D., Lemiesz, A. E., Gao, J., Soshnev, A. A., Kundra, R., Schultz, N., Muir, T. W., & Allis, C. D. (2019) · Nature · doi:10.1038/s41586-019-1038-1 · Cited by 384 · see citing works
Pathology image analysis using segmentation deep learning algorithms
Wang, S., Yang, D. M., Rong, R., Zhan, X., & Xiao, G. (2019) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.05.007 · Cited by 382 · see citing works
Improved survival using specialized multidisciplinary board in sarcoma patients
Blay, J., Soibinet, P., Penel, N., Bompas, E., Duffaud, F., Stoeckle, E., Mir, O., Adam, J., Chevreau, C., Bonvalot, S., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx484 · Cited by 370 · see citing works
Autophagy, cancer stem cells and drug resistance
Smith, A. G., & Macleod, K. F. (2018) · The Journal of Pathology · doi:10.1002/path.5222 · Cited by 364 · see citing works
Targeting Cancer Cell Dormancy
Recasens, A., & Munoz, L. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.004 · Cited by 356 · see citing works
Gene expression profiling of human sarcomas: insights into sarcoma biology.
Baird, K., Davis, S., Antonescu, C. R., Harper, U. L., Walker, R. L., Chen, Y., Glatfelter, A. A., Duray, P. H., & Meltzer, P. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1699 · Cited by 353 · see citing works
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
Kovac, M., Blattmann, C., Ribi, S., Smida, J., Mueller, N. S., Engert, F., Castro-Giner, F., Weischenfeldt, J., Kovacova, M., Krieg, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms9940 · Cited by 353 · see citing works
Self-citationOsteoblasts are target cells for transformation in c-fos transgenic mice
Grigoriadis, A. E., Schellander, K., Wang, Z., & Wagner, E. F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.685 · Cited by 349 · see citing works
Self-citationMulti-omic measurements of heterogeneity in HeLa cells across laboratories
Liu, Y., Mi, Y., Mueller, T., Kreibich, S., Williams, E. G., Van Drogen, A., Borel, C., Frank, M., Germain, P.-L., Bludau, I., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0037-y · Cited by 338 · see citing works
Transcriptomic definition of molecular subgroups of small round cell sarcomas
Watson, S., Perrin, V., Guillemot, D., Reynaud, S., Coindre, J., Karanian, M., Guinebretière, J., Fréneaux, P., Loarer, F. L., Bouvet, M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5053 · Cited by 335 · see citing works
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid Tumors
Merchant, M. S., Wright, M., Baird, K., Wexler, L. H., Rodriguez-Galindo, C., Bernstein, D., Delbrook, C., Lodish, M., Bishop, R., Wolchok, J. D., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0491 · Cited by 331 · see citing works
Heinrich, M. C., Jones, R. L., von Mehren, M., Schöffski, P., Serrano, C., Kang, Y., Cassier, P. A., Mir, O., Eskens, F. A. L. M., Tap, W. D., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30269-2 · Cited by 325 · see citing works
PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability
Gryder, B. E., Yohe, M. E., Chou, H.-C., Zhang, X., Marques, J. G., Wachtel, M., Schaefer, B. W., Sen, N., Song, Y., Gualtieri, A., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1297 · Cited by 317 · see citing works
Musa, J., Aynaud, M.-M., Mirabeau, O., Delattre, O., & Grünewald, T. G. P. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.244 · Cited by 315 · see citing works
Self-citationHSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
Xiao, X., Wang, W., Li, Y., Yang, D., Li, X., Shen, C., Liu, Y., Ke, X., Guo, S., & Guo, Z. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0880-6 · Cited by 313 · see citing works
Keller, C., Arenkiel, B. R., Coffin, C. M., Bardeesy, N. M., DePinho, R. A., & Capecchi, M. R. (2004) · Genes & Development · doi:10.1101/gad.1244004 · Cited by 304 · see citing works
Cancer stem cells in osteosarcoma
Brown, H. K., Tellez-Gabriel, M., & Heymann, D. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.11.019 · Cited by 303 · see citing works
Self-citationIntegrative genomic and transcriptomic analysis of leiomyosarcoma
Chudasama, P., Mughal, S. S., Sanders, M. A., Hübschmann, D., Chung, I., Deeg, K. I., Wong, S.-H., Rabe, S., Hlevnjak, M., Zapatka, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02602-0 · Cited by 303 · see citing works
D’Angelo, S. P., Shoushtari, A. N., Agaram, N. P., Kuk, D., Qin, L., Carvajal, R. D., Dickson, M. A., Gounder, M. M., Keohan, M. L., Schwartz, G. K., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.11.001 · Cited by 300 · see citing works
From the archives of the AFIP. Extraskeletal osseous and cartilaginous tumors of the extremities.
Kransdorf, M. J., & Meis, J. M. (1993) · Radiographics · doi:10.1148/radiographics.13.4.8356273 · Cited by 292 · see citing works
Orthotopic patient-derived xenografts of paediatric solid tumours
Stewart, E., Federico, S. M., Chen, X., Shelat, A. A., Bradley, C., Gordon, B., Karlstrom, A., Twarog, N. R., Clay, M. R., Bahrami, A., et al. (2017) · Nature · doi:10.1038/nature23647 · Cited by 286 · see citing works
A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.
Suzuki, K., Fueyo-Margareto, J., Krasnykh, V. N., Reynolds, P. N., Curiel, D. T., & Alemany, R. (2001) · PubMed · Cited by 286 · see citing works
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Fang, D., Gan, H., Lee, J., Han, J., Wang, Z., Riester, S. M., Jin, L. G., Chen, J., Zhou, H., Wang, J., et al. (2016) · Science · doi:10.1126/science.aae0065 · Cited by 285 · see citing works
Kim, J. R., Moon, Y. J., Kwon, K. S., Bae, J. S., Wagle, S., Kim, K. M., Park, H. S., Lee, H., Moon, W. S., Chung, M. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082870 · Cited by 284 · see citing works
Causes, consequences, and therapy of tumors acidosis
Pillai, S., Damaghi, M., Marunaka, Y., Spugnini, E. P., Fais, S., & Gillies, R. J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09792-7 · Cited by 282 · see citing works
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 280 · see citing works
Self-citationRiggi, N., Suvà, M.-L., Vito, C. D., Provero, P., Stehle, J., Baumer, K., Cironi, L., Janiszewska, M., Petricevic, T., Suvà, D., et al. (2010) · Genes & Development · doi:10.1101/gad.1899710 · Cited by 279 · see citing works
Pollack, S. M., He, Q., Yearley, J. H., Emerson, R., Vignali, M., Zhang, Y., Redman, M. W., Baker, K. K., Cooper, S., Donahue, B., et al. (2017) · Cancer · doi:10.1002/cncr.30726 · Cited by 274 · see citing works
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Vaira, V., Fedele, G., Pyne, S., Fasoli, E., Zadra, G., Bailey, D., Snyder, E. L., Faversani, A., Coggi, G., Flavin, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907676107 · Cited by 269 · see citing works
Koirala, P., Roth, M. E., Gill, J., Piperdi, S., Chinai, J. M., Geller, D. S., Hoang, B. H., Park, A., Fremed, M. A., Zang, X., et al. (2016) · Scientific Reports · doi:10.1038/srep30093 · Cited by 267 · see citing works
Nemunaitis, J. J., Tong, A. W., Nemunaitis, M., Senzer, N. N., Phadke, A. P., Bedell, C., Adams, N., Zhang, Y.-A., Maples, P. B., Chen, S., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.262 · Cited by 266 · see citing works
Behjati, S., Tarpey, P. S., Haase, K., Ye, H., Young, M. D., Alexandrov, L. B., Farndon, S. J., Collord, G., Wedge, D. C., Martincorena, I., et al. (2017) · Nature Communications · doi:10.1038/ncomms15936 · Cited by 261 · see citing works
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M. K., Hadler, J. S., Surdez, D., Guillemot, D., Lapouble, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4273 · Cited by 254 · see citing works
Self-citationCao, Y., OʼReilly, M., Marshall, B., Flynn, E. A., Ji, R. W., & Folkman, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1558 · Cited by 251 · see citing works
Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E. J., Placantonakis, D. G., Mansukhani, A., & Basilico, C. (2015) · Nature Communications · doi:10.1038/ncomms7411 · Cited by 248 · see citing works
Demetri, G. D., Chawla, S. P., Ray-Coquard, I., Le Cesne, A., Staddon, A. P., Milhem, M. M., Penel, N., Riedel, R. F., Bui-Nguyen, B., Cranmer, L. D., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.5766 · Cited by 245 · see citing works
Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., LaRue, R. S., Temiz, N. A., Molyneux, S. D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3293 · Cited by 240 · see citing works
Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M. K., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.042 · Cited by 240 · see citing works
Self-citation3D printing of biomimetic microstructures for cancer cell migration
Huang, T. Q., Qu, X., Liu, J., & Chen, S. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9812-6 · Cited by 238 · see citing works
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
Basu-Roy, U., Seo, E., Ramanathapuram, L. V., Rapp, T. B., Perry, J. A., Orkin, S. H., Mansukhani, A., & Basilico, C. (2011) · Oncogene · doi:10.1038/onc.2011.405 · Cited by 238 · see citing works
Circulating Tumor Cells: A Review of Non–EpCAM-Based Approaches for Cell Enrichment and Isolation
Gabriel, M. T., Calleja, L. R., Chalopin, A., Ory, B., & Heymann, D. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.249706 · Cited by 238 · see citing works
Self-citationHeymann, M.-F., Lézot, F., & Heymann, D. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2017.10.011 · Cited by 233 · see citing works
Self-citationGaude, E., Schmidt, C., Gammage, P. A., Dugourd, A. J. F., Blacker, T. S., Peak‐Chew, S., Sáez-Rodríguez, J., O'Neill, J. S., Szabadkai, G., Minczuk, M. A., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.034 · Cited by 229 · see citing works
Laser Printing of Single Cells: Statistical Analysis, Cell Viability, and Stress
Barron, J. A., Krizman, D. B., & Ringeisen, B. R. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-8971-x · Cited by 227 · see citing works
Jaboin, J. J., Wild, J., Hamidi, H., Khanna, C., Kim, C. J., Robey, R. W., Bates, S. E., & Thiele, C. J. (2002) · PubMed · Cited by 226 · see citing works
Liquid Biopsy: Current Status and Future Perspectives
Mader, S., & Pantel, K. (2017) · Oncology Research and Treatment · doi:10.1159/000478018 · Cited by 226 · see citing works
Bone microenvironment signals in osteosarcoma development
Alfranca, A., Martínez-Cruzado, L., Tornín, J., Abarrategi, A., Amaral, A. T., de Álava, E., Menéndez, P. R., Garcı́a-Castro, J., & Rodrı́guez, R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1918-y · Cited by 225 · see citing works
Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Salanti, A., Clausen, T. M., Agerbæk, M. Ø., Al-Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.003 · Cited by 221 · see citing works
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Brien, G. L., Remillard, D., Shi, J., Hemming, M. L., Chabon, J., Wynne, K. J., Dillon, E., Cagney, G., van Mierlo, G., Baltissen, M. P. A., et al. (2018) · eLife · doi:10.7554/elife.41305 · Cited by 217 · see citing works
Musculoskeletal Tumors: How to Use Anatomic, Functional, and Metabolic MR Techniques
Fayad, L. M., Jacobs, M. A., Wang, X., Carrino, J. A., & Bluemke, D. A. (2012) · Radiology · doi:10.1148/radiol.12111740 · Cited by 217 · see citing works
Keung, E. Z., Burgess, M., Salazar, R., Parra, E. R., Rodrigues-Canales, J., Bolejack, V., Van Tine, B. A., Schuetze, S. M., Attia, S., Riedel, R. F., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1824 · Cited by 215 · see citing works
Osteosarcoma: Cells‐of‐Origin, Cancer Stem Cells, and Targeted Therapies
Abarrategi, A., Tornín, J., Martínez-Cruzado, L., Hamilton, A., Martínez‐Campos, E., Rodrigo, J. P., González, M. V., Baldini, N., Garcı́a-Castro, J., & Rodrı́guez, R. (2016) · Stem Cells International · doi:10.1155/2016/3631764 · Cited by 211 · see citing works
Self-citationVolckmar, A., Sültmann, H., Riediger, A. L., Fioretos, T., Schirmacher, P., Endris, V., Stenzinger, A., & Dietz, S. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22517 · Cited by 207 · see citing works
Synovial Sarcoma Is a Stem Cell Malignancy
Naka, N., Takenaka, S., Araki, N., Miwa, T., Hashimoto, N., Yoshioka, K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., et al. (2010) · Stem Cells · doi:10.1002/stem.452 · Cited by 205 · see citing works
Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
Angelis, M. L. D., Francescangeli, F., Torre, F. L., & Zeuner, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00626 · Cited by 203 · see citing works
Ségaliny, A. I., Mohamadi, A., Dizier, B., Lokajczyk, A., Brion, R., Lanel, R., Amiaud, J., Charrier, C., Boisson‐Vidal, C., & Heymann, D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29376 · Cited by 199 · see citing works
Self-citationBelluco, C., Nitti, D., Frantz, M., Toppan, P., Basso, D., Plebani, M., Lise, M., & Jessup, J. M. (2000) · Annals of Surgical Oncology · doi:10.1007/s10434-000-0133-7 · Cited by 196 · see citing works
Italiano, A., Mauro, I. D., Rapp, J., Pierron, G., Auger, N., Alberti, L., Chibon, F., Escande, F., Voegeli, A., Ghnassia, J., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00583-5 · Cited by 191 · see citing works
Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression
Casadei, L., Calore, F., Creighton, C. J., Guescini, M., Batte, K., Iwenofu, O. H., Zewdu, A., Braggio, D., Bill, K. L. J., Fadda, P., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2984 · Cited by 191 · see citing works
(2003) · PubMed · Cited by 190 · see citing works
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression
Baglio, S. R., Lagerweij, T., Pérez-Lanzón, M., Ho, X. D., Léveillé, N., Melo, S. A., Cleton-Jansen, A.-M., Jordanova, E. S., Roncuzzi, L., Greco, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2726 · Cited by 187 · see citing works
Self-citationPreoperative serum vascular endothelial growth factor can predict stage in colorectal cancer.
Kumar, H., Heer, K., Lee, P. W. R., Duthie, G. S., MacDonald, A. W., Greenman, J., Kerin, M. J., & Monson, J. R. T. (1998) · PubMed · Cited by 187 · see citing works
Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
Vallette, F. M., Olivier, C., Lézot, F., Oliver, L., Cochonneau, D., Lalier-Bretaudeau, L., Cartron, P., & Heymann, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.004 · Cited by 184 · see citing works
Self-citationTargeting the DNA Repair Pathway in Ewing Sarcoma
Stewart, E. A., Goshorn, D. R., Bradley, C. L., Griffiths, L. M., Benavente, C. A., Twarog, N. R., Miller, G. M., Caufield, W. V., Freeman, B. B., Bahrami, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.028 · Cited by 179 · see citing works
Gomez‐Brouchet, A., Illac, C., Gilhodes, J., Bouvier, C., Aubert, S., Guinebretière, J., Marie, B., Larousserie, F., Entz‐Werlé, N., Pinieux, G. D. B. D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1331193 · Cited by 179 · see citing works
Endo, H., & Inoue, M. (2018) · Cancer Science · doi:10.1111/cas.13917 · Cited by 178 · see citing works
Longo, D. L., Sun, P. Z., Consolino, L., MICHELOTTI, F. C., Uggeri, F., & Aime, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5059313 · Cited by 176 · see citing works
Self-citationDysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma
Dumars, C., Ngyuen, J.-M., Gaultier, A., Lanel, R., Corradini, N., Gouin, F., Heymann, D., & Heymann, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13055 · Cited by 174 · see citing works
Self-citationTreatment pathway of bone sarcoma in children, adolescents, and young adults
Reed, D. R., Hayashi, M., Wagner, L. M., Binitie, O. T., Steppan, D. A., Brohl, A. S., Shinohara, E. T., Bridge, J. A., Loeb, D. M., Borinstein, S. C., et al. (2017) · Cancer · doi:10.1002/cncr.30589 · Cited by 174 · see citing works
Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Satelli, A., Mitra, A., Cutrera, J. J., Devarie, M., Xia, X., Ingram, D. R., Dibra, D., Somaiah, N., Torres, K. E., Ravi, V., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1739 · Cited by 173 · see citing works
Mesenchymal stroma: Role in osteosarcoma progression
Cortini, M., Avnet, S., & Baldini, N. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.07.024 · Cited by 171 · see citing works
Self-citationRole of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
Kilic, M., Kasperczyk, H., Fulda, S., & Debatin, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210008 · Cited by 167 · see citing works
Advances in immune checkpoint inhibitors for bone sarcoma therapy
Thanindratarn, P., Dean, D. C., Nelson, S. D., Hornicek, F. J., & Duan, Z. (2019) · Journal of bone oncology · doi:10.1016/j.jbo.2019.100221 · Cited by 166 · see citing works
Biology of Bone Sarcomas and New Therapeutic Developments
Brown, H. K., Schiavone, K., Gouin, F., Heymann, M.-F., & Heymann, D. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0372-2 · Cited by 163 · see citing works
Self-citationImaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH
Anemone, A., Consolino, L., Arena, F., Capozza, M., & Longo, D. L. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09782-9 · Cited by 163 · see citing works
Self-citationHistone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Gryder, B. E., Pomella, S., Sayers, C. M., Wu, X., Song, Y., Chiarella, A. M., Bagchi, S., Chou, H.-C., Sinniah, R., Walton, A., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0534-4 · Cited by 162 · see citing works
Cripe, T. P., Ngo, M. C., Geller, J. I., Louis, C. U., Currier, M. A., Racadio, J. M., Towbin, A. J., Rooney, C. M., Pelusio, A., Moon, A., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.243 · Cited by 160 · see citing works
Local Recurrence of Disease after Unplanned Excisions of High-grade Soft Tissue Sarcomas
Potter, B. K., Adams, S. C., Pitcher, D. J., & Temple, T. H. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0529-4 · Cited by 160 · see citing works
The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
Banito, A., Li, X., Laporte, A. N., Roe, J., Sánchez-Vega, F., Huang, C., Dancsok, A. R., Hatzi, K., Chen, C.-C., Tschaharganeh, D. F., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.018 · Cited by 158 · see citing works
Self-citationDudeck, O., Zeile, M., Pink, D., Pech, M., Tunn, P., Reichardt, P., Ludwig, W., & Hamm, B. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21358 · Cited by 157 · see citing works
In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging
Longo, D. L., Bartoli, A., Consolino, L., Bardini, P., Arena, F., Schwaiger, M., & Aime, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0825 · Cited by 157 · see citing works
Self-citationPatient‐derived xenografts for individualized care in advanced sarcoma
Stebbing, J., Paz, K., Schwartz, G. K., Wexler, L. H., Maki, R. G., Pollock, R. E., Morris, R., Cohen, R., Shankar, A., Blackman, G., et al. (2014) · Cancer · doi:10.1002/cncr.28696 · Cited by 156 · see citing works
Han, Q., Shi, H., & Liu, F. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.01.023 · Cited by 149 · see citing works
Shulman, D. S., Klega, K., Imamovic-Tuco, A., Clapp, A., Nag, A., Thorner, A. R., Van Allen, E., Ha, G., Lessnick, S. L., Gorlick, R., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0212-9 · Cited by 149 · see citing works
Lamoureux, F., Baud’huin, M., Calleja, L. R., Jacques, C., Berreur, M., Rédiní, F., Lecanda, F., Bradner, J. E., Heymann, D., & Ory, B. (2014) · Nature Communications · doi:10.1038/ncomms4511 · Cited by 148 · see citing works
Self-citationSannino, G., Marchetto, A., Kirchner, T., & Grünewald, T. G. P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0032 · Cited by 145 · see citing works
Self-citationStreby, K. A., Geller, J. I., Currier, M. A., Warren, P. S., Racadio, J. M., Towbin, A. J., Vaughan, M. R., Triplet, M., Ott-Napier, K., Dishman, D. J., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2900 · Cited by 144 · see citing works
Modeling sarcomagenesis using multipotent mesenchymal stem cells
Rodrı́guez, R., Rubio, R., & Menéndez, P. R. (2011) · Cell Research · doi:10.1038/cr.2011.157 · Cited by 143 · see citing works
Honoki (2010) · Oncology Reports · doi:10.3892/or_00000885 · Cited by 143 · see citing works
Killander, D., Dohlwitz, A., Engstedt, L., Franzén, S., Gahrton, G., GULLBRING, B., Holm, G., Holmgren, A., Höglund, S., KILLANDER, A., et al. (1976) · Cancer · doi:10.1002/1097-0142(197601)37:1 · Cited by 143 · see citing works
Kovatcheva, M., Liu, D. D., Dickson, M. A., Klein, M. E., O’Connor, R., Wilder, F. O., Socci, N. D., Tap, W. D., Schwartz, G. K., Singer, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3364 · Cited by 142 · see citing works
Koelsche, C., Mynarek, M., Schrimpf, D., Bertero, L., Serrano, J., Sahm, F., Reuß, D., Hou, Y., Baumhoer, D., Vokuhl, C., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1871-6 · Cited by 142 · see citing works
Self-citationCain, D. M., Wacnik, P. W., Turner, M., Wendelschafer‐Crabb, G., Kennedy, W. R., Wilcox, G. L., & Simone, D. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09367.2001 · Cited by 141 · see citing works
Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
Bonuccelli, G., Avnet, S., Grisendi, G., Salerno, M., Granchi, D., Dominici, M., Kusuzaki, K., & Baldini, N. (2014) · Oncotarget · doi:10.18632/oncotarget.2243 · Cited by 140 · see citing works
Self-citationFritzsching, B., Fellenberg, J., Moskovszky, L. E., Sápi, Z., Krenács, T., Machado, I., Poeschl, J., Lehner, B., Szendrői, M., Bosch, A. L., et al. (2015) · OncoImmunology · doi:10.4161/2162402x.2014.990800 · Cited by 140 · see citing works
Tarnowski, M., Grymula, K., Liu, R., Tarnowska, J., Drukala, J., Ratajczak, J., Mitchell, R. A., Ratajczak, M. Z., & Kucia, M. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0288 · Cited by 136 · see citing works
Avnet, S., Pompo, G. D., Chano, T., Errani, C., Ibrahim‐Hashim, A., Gillies, R. J., Donati, D. M., & Baldini, N. (2016) · International Journal of Cancer · doi:10.1002/ijc.30540 · Cited by 133 · see citing works
Self-citationUndifferentiated Sarcomas Develop through Distinct Evolutionary Pathways
Steele, C. D., Tarabichi, M., Oukrif, D., Webster, A. P., Ye, H., Fittall, M. W., Lombard, P., Martincorena, I., Tarpey, P. S., Collord, G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.02.002 · Cited by 132 · see citing works
Genomic landscape of liposarcoma
Kanojia, D., Nagata, Y., Garg, M., Lee, D. H., Sato, A., Yoshida, K., Sato, Y., Sanada, M., Mayakonda, A., Bartenhagen, C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6464 · Cited by 132 · see citing works
A Mouse Model of Rhabdomyosarcoma Originating from the Adipocyte Lineage
Hatley, M. E., Tang, W., Garcia, M. R., Finkelstein, D., Millay, D. P., Liu, N., Graff, J. M., Galindo, R. L., & Olson, E. N. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.004 · Cited by 131 · see citing works
East Siberian Arctic inland waters emit mostly contemporary carbon
Dean, J. F., Meisel, O. H., Rosco, M. M., Marchesini, L. B., Garnett, M. H., Lenderink, H., van Logtestijn, R. S. P., Borges, A. V., Bouillon, S., Lambert, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15511-6 · Cited by 131 · see citing works
Cats, Cancer and Comparative Oncology
Cannon, C. M. (2015) · Veterinary Sciences · doi:10.3390/vetsci2030111 · Cited by 128 · see citing works
Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen‐Rhoades, W., Fan, T., Khanna, C., Sweet‐Cordero, E. A., Cash, T., et al. (2019) · Cancer · doi:10.1002/cncr.32351 · Cited by 127 · see citing works
Self-citationVaupel, P. W., Okunieff, P., Kallinowski, F., & Neuringer, L. J. (1989) · Radiation Research · doi:10.2307/3577798 · Cited by 126 · see citing works
Unplanned Excision of Soft-Tissue Sarcomas
Pretell-Mazzini, J. A., Barton, M. D., Conway, S. A., & Temple, H. T. (2015) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.n.00649 · Cited by 123 · see citing works
Zebrafish xenograft models of cancer and metastasis for drug discovery
Brown, H. K., Schiavone, K., Tazzyman, S. J., Heymann, D., & Chico, T. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1297416 · Cited by 122 · see citing works
Self-citationRodríguez-García, A., Giménez-Alejandre, M., Rojas, J. J., Moreno, R., Bazán‐Peregrino, M., Cascalló, M., & Alemany, R. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2213 · Cited by 119 · see citing works
Rutkowski, P. L., Kaminska, J. A., Kowalska, M. M., Ruka, W., & Steffen, J. A. (2003) · Journal of Surgical Oncology · doi:10.1002/jso.10305 · Cited by 117 · see citing works
Ghilardi, J. R., Freeman, K. T., Jiménez‐Andrade, J. M., Mantyh, W. G., Bloom, A. P., Kuskowski, M. A., & Mantyh, P. W. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-87 · Cited by 117 · see citing works
Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma
Lamora, A., Talbot, J., Bougras-Cartron, G., Amiaud, J., Leduc, M., Chesneau, J., Taurelle, J., Stresing, V., Deley, M. L., Heymann, M., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3191 · Cited by 114 · see citing works
Self-citationProlonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis
Almog, N., Henke, V. G., Flores, L. M., Hlatky, L., Kung, A. L., Wright, R. D., Berger, R., Hutchinson, L., Naumov, G. N., Bender, E. R., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-3946fje · Cited by 112 · see citing works
Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling
Martins‐Neves, S. R., Paiva‐Oliveira, D. I., Wijers‐Koster, P. M., Abrunhosa, A., Ribeiro, C., Bovée, J. V. M. G., Cleton-Jansen, A., & Gomes, C. M. F. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.013 · Cited by 112 · see citing works
Riethmüller, G., & Klein, C. A. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0386 · Cited by 112 · see citing works
Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment
Indraccolo, S., Stievano, L., Minuzzo, S. A., Tosello, V., Esposito, G., Piovan, E., Zamarchi, R., Chieco‐Bianchi, L., & Amadori, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506200103 · Cited by 112 · see citing works
Sundara, Y. T., Kostine, M., Cleven, A. H. G., Bovée, J. V. M. G., Schilham, M. W., & Cleton-Jansen, A.-M. (2017) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-016-1925-3 · Cited by 111 · see citing works
Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity
Gabriel, M. T., Heymann, M., & Heymann, D. (2019) · Theranostics · doi:10.7150/thno.34337 · Cited by 111 · see citing works
Self-citationVakkila, J., Jaffe, R., Michelow, M., & Lotze, M. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1824 · Cited by 110 · see citing works
Zhang, H., Wu, H., Zheng, J., Yu, P., Xu, L., Jiang, P., Gao, J., Wang, H., & Zhang, Y. (2012) · Stem Cells · doi:10.1002/stem.1298 · Cited by 109 · see citing works
Koelsche, C., Hartmann, W., Schrimpf, D., Stichel, D., Jabar, S., Ranft, A., Reuß, D., Sahm, F., Jones, D., Bewerunge‐Hudler, M., et al. (2018) · Modern Pathology · doi:10.1038/s41379-018-0045-3 · Cited by 108 · see citing works
Self-citationRugo, H. S., Jacobs, I. A., Sharma, S., Scappaticci, F. A., Paul, T. A., Jensen-Pergakes, K., & Malouf, G. G. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01379-x · Cited by 108 · see citing works
The Role of 18 F-FDG-PET/CT in Pediatric Sarcoma
Harrison, D. J., Parisi, M. T., & Shulkin, B. L. (2017) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.12.004 · Cited by 107 · see citing works
Traub, F., Griffin, A. M., Wunder, J. S., & Ferguson, P. C. (2018) · Cancer · doi:10.1002/cncr.31648 · Cited by 106 · see citing works
Advances in limb salvage treatment of osteosarcoma
Yang, Y., Han, L., He, Z., Li, X., Yang, S., Yang, J., Zhang, Y., Li, D., Yang, Y., & Yang, Z. (2017) · Journal of bone oncology · doi:10.1016/j.jbo.2017.11.005 · Cited by 105 · see citing works
CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma
Shiraishi, D., Fujiwara, Y., Horlad, H., Saito, Y., Iriki, T., Tsuboki, J., Pan, C., Nakagata, N., Mizuta, H., Bekki, H., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2011 · Cited by 105 · see citing works
Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma
Santoro, M., Lamhamedi-Cherradi, S.-E., Menegaz, B. A., Ludwig, J. A., & Mikos, A. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506684112 · Cited by 104 · see citing works
Wei, S., Henderson‐Jackson, E., Qian, X., & Bui, M. M. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2016-0417-ra · Cited by 103 · see citing works
Targetable Alterations in Adult Patients With Soft-Tissue Sarcomas
Lucchesi, C., Khalifa, E., Laizet, Y., Soubeyran, I., Mathoulin‐Pélissier, S., Chomienne, C., & Italiano, A. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.0723 · Cited by 102 · see citing works
Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas
Dancsok, A. R., Setsu, N., Gao, D., Blay, J., Thomas, D. M., Maki, R. G., Nielsen, T. O., & Demicco, E. G. (2019) · Modern Pathology · doi:10.1038/s41379-019-0312-y · Cited by 101 · see citing works
Therapeutic implications of tumor interstitial acidification
Kolosenko, I., Avnet, S., Baldini, N., Viklund, J., & Milito, A. D. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.01.008 · Cited by 100 · see citing works
Self-citationQue, Y., Xiao, W. L., Guan, Y., Liang, Y., Yan, S., Chen, H.-Y., Li, Q.-Q., Xu, B.-S., Zhou, Z., & Zhang, X. (2017) · Journal of Cancer · doi:10.7150/jca.18683 · Cited by 100 · see citing works
Mesenchymal stem cell transformation and sarcoma genesis
Xiao, W., Mohseny, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · Clinical Sarcoma Research · doi:10.1186/2045-3329-3-10 · Cited by 99 · see citing works
Ehnman, M., Missiaglia, E., Folestad, E. B., Selfe, J., Strell, C., Thway, K., Brodin, B. A., Pietras, K., SHIPLEY, J. M., Östman, A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1646 · Cited by 98 · see citing works
Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma
Smida, J., Xu, H., Zhang, Y., Baumhoer, D., Ribi, S., Kovac, M. B., von Luettichau, I., Bielack, S., O’Leary, V. B., Leib‐Mösch, C., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30778 · Cited by 98 · see citing works
Cortini, M., Massa, A., Avnet, S., Bonuccelli, G., & Baldini, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166500 · Cited by 97 · see citing works
Self-citation
Flagged first, then by citations
2 of the 457 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Heymann D (2014) Bone Cancer. Academic Press, San Diego, California, USA
Cited by
Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
Self-citationCruz, A. S., Mendes‐Frias, A., Oliveira, A. I., Dias, L., Matos, A. R., Carvalho, A., Capela, C., Pedrosa, J., Castro, A. G., & Silvestre, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613422 · Cited by 355 · see citing works
Naringenin: A potential flavonoid phytochemical for cancer therapy
Motallebi, M., Bhia, M., Rajani, H. F., Bhia, I., Tabarraei, H., Mohammadkhani, N., Pereira‐Silva, M., Kasaii, M. S., Nouri-Majd, S., Mueller, A., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120752 · Cited by 336 · see citing works
Self-citationEwing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
Zöllner, S. K., Amatruda, J. F., Bauer, S., Collaud, S., de Álava, E., DuBois, S. G., Hardes, J., Hartmann, W., Kovar, H., Metzler, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081685 · Cited by 275 · see citing works
Self-citationAccelerating antibiotic discovery through artificial intelligence
Melo, M. C. R., Maasch, J. R. M. A., & de la Fuente-Nunez, C. (2021) · Communications Biology · doi:10.1038/s42003-021-02586-0 · Cited by 234 · see citing works
Future Directions in the Treatment of Osteosarcoma
Smrke, A., Anderson, P. M., Gulia, A., Gennatas, S., Huang, P. H., & Jones, R. L. (2021) · Cells · doi:10.3390/cells10010172 · Cited by 225 · see citing works
Panez-Toro, I., Muñoz-García, J., Vargas-Franco, J. W., Renodon‐Cornière, A., Heymann, M., Lézot, F., & Heymann, D. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00803-9 · Cited by 132 · see citing works
Self-citationStem cell membrane-coated abiotic nanomaterials for biomedical applications
Ferreira-Faria, I., Yousefiasl, S., Macário‐Soares, A., Pereira‐Silva, M., Peixoto, D., Zafar, H., Raza, F., Faneca, H., Veiga, F., Hamblin, M. R., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.012 · Cited by 119 · see citing works
Self-citationDrug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies
Hattinger, C. M., Patrizio, M. P., Fantoni, L., Casotti, C., Riganti, C., & Serra, M. (2021) · Cancers · doi:10.3390/cancers13122878 · Cited by 110 · see citing works
Bacteria as a treasure house of secondary metabolites with anticancer potential
Mohan, C. D., Rangappa, S., Nayak, S. C., Jadimurthy, R., Wang, L., Sethi, G., Garg, M., & Rangappa, K. S. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.006 · Cited by 100 · see citing works
Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
Zarrabi, A., Perrin, D., Kavoosi, M., Sommer, M., Sezen, S., Mehrbod, P., Bhushan, B., Machaj, F., Rosik, J., Kawalec, P., et al. (2023) · Cancers · doi:10.3390/cancers15215269 · Cited by 88 · see citing works
Chondrosarcoma-from Molecular Pathology to Novel Therapies
Zając, A. E., Kopeć, S., Szostakowski, B., Spalek, M. J., Fiedorowicz, M., Bylina, E., Filipowicz, P., Szumera‐Ciećkiewicz, A., Tysarowski, A., Czarnecka, A. M., et al. (2021) · Cancers · doi:10.3390/cancers13102390 · Cited by 84 · see citing works
Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level
Pillozzi, S., Bernini, A., Palchetti, I., Crociani, O., Antonuzzo, L., Campanacci, D. A., & Scoccianti, G. (2021) · Cancers · doi:10.3390/cancers13123044 · Cited by 76 · see citing works
The landscape of drug sensitivity and resistance in sarcoma
Shihabi, A. A., Tebon, P. J., Nguyen, H. T. L., Chantharasamee, J., Sartini, S., Davarifar, A., Jensen, A. Y., Diaz-Infante, M. B., Cox, H., Gonzalez, A. E., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.08.010 · Cited by 75 · see citing works
Rosa, R. L., Rossi, E., Feist, A. M., Johansen, H. K., & Molin, S. (2021) · Nature Communications · doi:10.1038/s41467-021-23451-y · Cited by 72 · see citing works
Magno, L., Bunney, T. D., Mead, E., Svensson, F., & Bictash, M. N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00436-5 · Cited by 64 · see citing works
Patient-derived tumor organoids: A preclinical platform for personalized cancer therapy
Taurin, S., Alzahrani, R., Aloraibi, S., Ashi, L., AlHarmi, R. A. R., & Hassani, N. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102226 · Cited by 54 · see citing works
Tessaro, F. H. G., Ko, E. Y., Simone, M. C. D., Piras, R., Broz, M. T., Goodridge, H. S., Balzer, B. L., Shiao, S. L., & Guarnerio, J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110977 · Cited by 50 · see citing works
Current State of Immunotherapy and Mechanisms of Immune Evasion in Ewing Sarcoma and Osteosarcoma
Evdokimova, V. E., Gassmann, H., Radvanyi, L. G., & Burdach, S. E. G. (2022) · Cancers · doi:10.3390/cancers15010272 · Cited by 54 · see citing works
Self-citationRetroperitoneal Sarcoma Care in 2021
Schmitz, E. M., & Nessim, C. (2022) · Cancers · doi:10.3390/cancers14051293 · Cited by 52 · see citing works
Cancer Stem Cells as a Source of Drug Resistance in Bone Sarcomas
Menéndez, S. T., Gallego, B., Murillo, D., Rodríguez, A., & Rodrı́guez, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122621 · Cited by 48 · see citing works
Cidre‐Aranaz, F., Watson, S., Amatruda, J. F., Nakamura, T., Delattre, O., de Álava, E., Dirksen, U., & Grünewald, T. G. P. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00393-3 · Cited by 48 · see citing works
Self-citationMorice, S., Mullard, M., Brion, R., Dupuy, M., Renault, S., Tesfaye, R. A., Royer, B. B.-L., Ory, B., Rédiní, F., & Verrecchia, F. (2020) · Cancers · doi:10.3390/cancers12123847 · Cited by 44 · see citing works
Self-citationWakamatsu, T., Ogawa, H., Yoshida, K., Matsuoka, Y., Shizuma, K., Imura, Y., Tamiya, H., Nakai, S., Yagi, T., Nagata, S., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.893592 · Cited by 43 · see citing works
Artificial intelligence and the future of life sciences
Leite, M. L., Costa, L. S. D. L., Cunha, V. A., Kreniski, V., Filho, M. D. O. B., da Cunha, N. B., & Costa, F. F. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.002 · Cited by 46 · see citing works
Jarak, I., Pereira‐Silva, M., Paiva‐Santos, A. C., Veiga, F., Cabral, H., & Figueiras, A. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101217 · Cited by 40 · see citing works
Self-citationLavaud, M., Mullard, M., Tesfaye, R. A., Amiaud, J., Legrand, M., Danieau, G., Brion, R., Morice, S., Regnier, L., Dupuy, M., et al. (2021) · Cells · doi:10.3390/cells10092268 · Cited by 38 · see citing works
Self-citationVanni, S., Fausti, V., Fonzi, E., Liverani, C., Miserocchi, G., Spadazzi, C., Cocchi, C., Calabrese, C., Gurrieri, L., Riva, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086926 · Cited by 37 · see citing works
Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma
Morales‐Molina, Á., Gambera, S., Leo, A., & Garcı́a-Castro, J. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001703 · Cited by 37 · see citing works
Self-citationTargeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials
Tang, F., Tie, Y., Wei, Y.-Q., Tu, C., & Wei, X. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188606 · Cited by 37 · see citing works
Rufo, N., Korovesis, D., Eygen, S. V., Derua, R., Garg, A. D., Finotello, F., Vara‐Pérez, M., Rožanc, J., Dewaele, M., de Witte, P. A. M., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00853-5 · Cited by 37 · see citing works
The Role of Keratin17 in Human Tumours
Zhang, H., Zhang, Y., Xia, T., Lu, L., Luo, M., Chen, Y., Liu, Y., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.818416 · Cited by 38 · see citing works
ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis
YAN, H. H., Jung, K. H., Lee, J. E., Son, M. K., Fang, Z., Park, J. H., Kim, S., Kim, J., Lim, J. H., & Hong, S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.07.036 · Cited by 36 · see citing works
Next-generation sequencing for the management of sarcomas with no known driver mutations
Vyse, S., Thway, K., Huang, P. H., & Jones, R. L. (2021) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000741 · Cited by 36 · see citing works
Prokakis, E., Dyas, A., Grün, R., Fritzsche, S., Bedi, U., Kazerouni, Z. B., Kosinsky, R. L., Johnsen, S. A., & Wegwitz, F. (2021) · Oncogene · doi:10.1038/s41388-021-01814-5 · Cited by 35 · see citing works
Avnet, S., Lemma, S., Cortini, M., Pompo, G. D., Perut, F., Lipreri, M. V., Roncuzzi, L., Columbaro, M., Errani, C., Longhi, A., et al. (2021) · Cancers · doi:10.3390/cancers13225855 · Cited by 36 · see citing works
Self-citationAcid Microenvironment in Bone Sarcomas
Pompo, G. D., Cortini, M., Baldini, N., & Avnet, S. (2021) · Cancers · doi:10.3390/cancers13153848 · Cited by 32 · see citing works
Self-citationLi, W., Liu, W., Memon, F. H., Wang, B., Xu, C., Dong, S., Wang, H., Hu, Z., Quan, X., Deng, Y., et al. (2022) · Computational Intelligence and Neuroscience · doi:10.1155/2022/2220527 · Cited by 32 · see citing works
The emerging role of cancer nanotechnology in the panorama of sarcoma
Mercatali, L., Vanni, S., Miserocchi, G., Liverani, C., Spadazzi, C., Cocchi, C., Calabrese, C., Gurrieri, L., Fausti, V., Riva, N., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.953555 · Cited by 33 · see citing works
Sarcoma care in the era of precision medicine
Wallander, K., Öfverholm, I., Boye, K., Tsagkozis, P., Papakonstantinou, A., Lin, Y., & Haglund de Flon, F. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13717 · Cited by 30 · see citing works
Targeting metastasis in paediatric bone sarcomas
Bull, E. C., Singh, A., Harden, A. M., Soanes, K., Habash, H., Toracchio, L., Carrabotta, M., Schreck, C., Shah, K. M., Riestra, P. V., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02365-z · Cited by 30 · see citing works
Self-citationKrysztofiak, A., Szymonowicz, K., Hlouschek, J., Xiang, K., Waterkamp, C., Larafa, S., Goetting, I., Vega-Rubín-de-Celis, S., Theiß, C., Matschke, V., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103366 · Cited by 29 · see citing works
PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas
Mancarella, C., Morrione, A., & Scotlandi, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216346 · Cited by 28 · see citing works
Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions
Boyce-Fappiano, D. R., Damron, E. P., Farooqi, A. S., Mitra, D., Conley, A. P., Somaiah, N., Araujo, D. M., Livingston, J. A., Ratan, R., Keung, E. Z.-Y., et al. (2022) · Advances in Radiation Oncology · doi:10.1016/j.adro.2022.100913 · Cited by 27 · see citing works
Lanzi, C., Arrighetti, N., Pasquali, S., & Cassinelli, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115727 · Cited by 27 · see citing works
Koumarianou, A. A., & Durán, J. (2021) · Cancers · doi:10.3390/cancers13030363 · Cited by 26 · see citing works
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy
Sousa, L. M., Almeida, J. S., Fortes-Andrade, T., Santos-Rosa, M., Freitas-Tavares, P., Casanova, J., & Rodrigues‐Santos, P. (2021) · Cancers · doi:10.3390/cancers13153885 · Cited by 26 · see citing works
Mithramycin delivery systems to develop effective therapies in sarcomas
Estupiñán, Ó., Niza, E., Bravo, I., Rey, V., Tornín, J., Gallego, B., Clemente-Casares, P., Morís, F., Ocaña, A., Blanco‐Lorenzo, V., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01008-x · Cited by 26 · see citing works
YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522
Green, D., Singh, A., Tippett, V. L., Tattersall, L., Shah, K. M., Siachisumo, C., Ward, N. J., Thomas, P., Carter, S., Jeys, L. M., et al. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100474 · Cited by 24 · see citing works
Cold plasma and inhibition of STAT3 selectively target tumorigenicity in osteosarcoma
Tornín, J., Mateu‐Sanz, M., Rey, V., Murillo, D., Huergo, C., Gallego, B., Rodríguez, A., Rodrı́guez, R., & Canal, C. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102685 · Cited by 25 · see citing works
Pathogenetic and molecular classifications of soft tissue and bone tumors: A 2024 update
Patrichi, A. I., & Gurzu, S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155406 · Cited by 24 · see citing works
Neoadjuvant Chemotherapy for Adults with Osteogenic Sarcoma
Robinson, M. J., & Davis, E. J. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01269-2 · Cited by 24 · see citing works
G1-phase progression in pluripotent stem cells
ter Huurne, M., & Stunnenberg, H. G. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03797-8 · Cited by 22 · see citing works
Advances in sarcoma molecular diagnostics
Wang, X. Q., Goytain, A., Dickson, B. C., & Nielsen, T. O. (2022) · Genes Chromosomes and Cancer · doi:10.1002/gcc.23025 · Cited by 22 · see citing works
The Role of CDK Pathway Dysregulation and Its Therapeutic Potential in Soft Tissue Sarcoma
Thiel, J. T., Daigeler, A., Kolbenschlag, J., Rachunek, K., & Hoffmann, S. (2022) · Cancers · doi:10.3390/cancers14143380 · Cited by 22 · see citing works
Noncanonical roles of p53 in cancer stemness and their implications in sarcomas
Curylova, L., Ramos, H., Saraiva, L., & Skoda, J. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.037 · Cited by 21 · see citing works
B7-H3-targeting Fc-optimized antibody for induction of NK cell reactivity against sarcoma
Hagelstein, I., Engel, M., Hinterleitner, C., Manz, T., Märklin, M., Jung, G., Salih, H. R., & Zekri, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1002898 · Cited by 20 · see citing works
Walshe, N., Fennelly, M., Hellebust, S., Wenger, J., Sodeau, J. R., Prentice, M. B., Grice, C., Jordan, V., Comerford, J., Downey, V., et al. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.769238 · Cited by 19 · see citing works
Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma
Jubelin, C., Muñoz-García, J., Cochonneau, D., Moranton, E., Heymann, M., & Heymann, D. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2021.130 · Cited by 19 · see citing works
Self-citationHeymann, C. J. F., Bobin‐Dubigeon, C., Muñoz-García, J., Cochonneau, D., Ollivier, E., Heymann, M., & Heymann, D. (2022) · Journal of bone oncology · doi:10.1016/j.jbo.2022.100451 · Cited by 19 · see citing works
Self-citationCombinatorial strategies to potentiate the efficacy of HDAC inhibitors in fusion-positive sarcomas
Lanzi, C., & Cassinelli, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114944 · Cited by 18 · see citing works
Baelen, J., Dewaele, B., Dêbiec‐Rychter, M., Sciot, R., Schöffski, P., Hompes, D., Sinnaeve, F., Wafa, H., & Bempt, I. V. (2024) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2024.02.003 · Cited by 18 · see citing works
Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes
Goya‐Jorge, E., Rampal, C., Loones, N., Barigye, S. J., Carpio, L. E., Gozalbes, R., Ferroud, C., Veitía, M. S., & Giner, R. M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112777 · Cited by 18 · see citing works
Evaluation of virucidal activity of residual quaternary ammonium-treated surfaces on SARS-CoV-2
Caschera, A. G., McAuley, J., Kim, Y., Purcell, D. F. J., Rymenants, J., & Foucher, D. A. (2021) · American Journal of Infection Control · doi:10.1016/j.ajic.2021.10.021 · Cited by 18 · see citing works
Li, X., Zhang, Z., Liang, B., Ye, F., & Gong, W. (2021) · The Journal of Antibiotics · doi:10.1038/s41429-021-00471-w · Cited by 18 · see citing works
A novel tumor inhibitory hybridoma monoclonal antibody with dual specificity for HER3 and HER2
Hassani, D., Amiri, M. M., Mohammadi, M., Yousefi, P., Judaki, M. A., Mobini, M., Golsaz‐Shirazi, F., Jeddi‐Tehrani, M., & Shokri, F. (2021) · Current Research in Translational Medicine · doi:10.1016/j.retram.2021.103277 · Cited by 17 · see citing works
Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations
Imle, R., Kommoss, F. K. F., & Banito, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081578 · Cited by 16 · see citing works
Self-citationZou, Z., Sun, W. Y., Xu, Y., Liu, W., Zhong, J., Lin, X., & Chen, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.946022 · Cited by 17 · see citing works
The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas
Holzmayer, S. J., Liebel, K., Hagelstein, I., Salih, H. R., & Märklin, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1391954 · Cited by 17 · see citing works
Estupiñán, Ó., Rendueles, C., Suárez, P., Rey, V., Murillo, D., Morís, F., Gutiérrez, G., Blanco‐López, M. C., Matos, M., & Rodrı́guez, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071358 · Cited by 17 · see citing works
Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models
Gallego, B., Murillo, D., Rey, V., Huergo, C., Estupiñán, Ó., Rodríguez, A., Tornín, J., & Rodrı́guez, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126425 · Cited by 16 · see citing works
Regorafenib for the Treatment of Sarcoma
Blay, J., Duffaud, F., George, S., Maki, R. G., & Penel, N. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-00990-0 · Cited by 17 · see citing works
Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma
Walker, R. L., Hornicek, F. J., & Duan, Z. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116342 · Cited by 16 · see citing works
Luongo, M., Laurenziello, P., Cesta, G., Bochicchio, A. M., Omer, L. C., Falco, G., Milone, M. R., Cibarelli, F., Russi, S., & Laurino, S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02083-y · Cited by 16 · see citing works
Schöffski, P., Bahleda, R., Wagner, A. J., Burgess, M. A., Junker, N., Chisamore, M. J., Peterson, P. M., Szpurka, A. M., Ceccarelli, M., & Tap, W. D. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0742 · Cited by 15 · see citing works
Leng, D., Yang, Z., Sun, H., Song, C., Huang, C., Ip, K. U., Chen, G., Deng, C., Zhang, X. D., & Zhao, Q. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3396 · Cited by 15 · see citing works
Patients’ Experiences of a Sarcoma Diagnosis: A Process Mapping Exercise of Diagnostic Pathways
Martin, S., Clark, S. E., Gerrand, C., Gilchrist, K., Lawal, M., Maio, L., Martins, A. P., Storey, L., Taylor, R. M., Wells, M., et al. (2023) · Cancers · doi:10.3390/cancers15153946 · Cited by 15 · see citing works
Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities
Jeong, S., Afroz, S., Kang, D., Noh, J., Suh, J., Kim, J. H., You, H. J., Kang, H. G., Kim, Y., & Kim, J. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0079 · Cited by 15 · see citing works
Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics
Lee, C., The, M., Meng, C., Bayer, F. P., Putzker, K., Müller, J., Streubel, J., Woortman, J., Sakhteman, A., Moritz, R., et al. (2023) · Molecular Systems Biology · doi:10.1038/s44320-023-00004-7 · Cited by 15 · see citing works
Barghi, F., Shannon, H. E., Saadatzadeh, M. R., Bailey, B. J., Riyahi, N., Bijangi‐Vishehsaraei, K., Just, M., Ferguson, M. J., Pandya, P. H., & Pollok, K. E. (2022) · Cancers · doi:10.3390/cancers14153611 · Cited by 15 · see citing works
Chodyla, M.-K., Demircioğlu, A., Schaarschmidt, B. M., Bertram, S., Morawitz, J., Bauer, S., Podleska, L. E., Rischpler, C., Forsting, M., Herrmann, K., et al. (2021) · Cancers · doi:10.3390/cancers13112753 · Cited by 15 · see citing works
MEK1/2 activity modulates TREM2 cell surface recruitment
Schapansky, J., Grinberg, Y. Y., Osiecki, D. M., Freeman, E. A., Walker, S. G., Karran, E. H., Gopalakrishnan, S. M., & Talanian, R. V. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014352 · Cited by 14 · see citing works
Hagelstein, I., Lutz, M. S., Schmidt, M. J., Heitmann, J. S., Malenke, E., Zhou, Y., Clar, K. L., Kopp, H., Jung, G., Salih, H. R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653081 · Cited by 14 · see citing works
Gong, H., Jiang, A., Jiang, R., Wang, Y., Zhang, D., Wu, Z., & Xiao, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5687238 · Cited by 14 · see citing works
RetractedStillger, M. N., Li, M. J., Hönscheid, P., von Neubeck, C., & Föll, M. C. (2024) · PROTEOMICS · doi:10.1002/pmic.202300001 · Cited by 15 · see citing works
Rey, V., Tornín, J., Alba‐Linares, J. J., Robledo, C., Murillo, D., Rodríguez, A., Gallego, B., Huergo, C., Viera, C., Braña, A., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105090 · Cited by 16 · see citing works
Self-citationPrime Editing: An Emerging Tool in Cancer Treatment
Sen, D., Sarkar, S., & Mukhopadhyay, P. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00580-3 · Cited by 13 · see citing works
Giusti, V., Miserocchi, G., Sbanchi, G., Pannella, M., Hattinger, C. M., Cesari, M., Fantoni, L., Guerrieri, A. N., Bellotti, C., Vita, A. D., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081921 · Cited by 12 · see citing works
Тодосенко, Н. М., Хлусов, И. А., Yurova, K. A., Геннадьевна, Х. О., & Litvinova, L. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108993 · Cited by 12 · see citing works
Clinical Differences Among Histological Categories of Sarcoma: Insights from 97,062 Patients
Han, Y., Shah, A., Yao, Y., Mutter, R. W., & Xu‐Welliver, M. (2025) · Cancers · doi:10.3390/cancers17101706 · Cited by 11 · see citing works
Retrospective immunohistochemical investigation of suspected non-visceral leiomyosarcoma in dogs
Brady, R. V., Rebhun, R. B., Skorupski, K. A., Burton, J. H., Al‐Nadaf, S., Choi, E., & Willcox, J. L. (2022) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/10406387221083570 · Cited by 11 · see citing works
Tu, C., Liu, B., Li, C., Feng, C., Wang, H., Zhang, H., He, S., & Li, Z. (2023) · MedComm · doi:10.1002/mco2.369 · Cited by 10 · see citing works
Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling
Silva, F. L. T., Euzébio, M. F., Ruas, J. S., Franco, M. T., Cassone, A. E., Junqueira, T., Lucon, D. R., Cardinalli, I. A., Pereira, L. H., Zenatti, P. P., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-13159-9 · Cited by 10 · see citing works
Primary central nervous system sarcomas in adults: A systematic review
Haider, A. S., Palmisciano, P., Sagoo, N. S., Bin-Alamer, O., Ahmadieh, T. Y. E., Pan, E., & Garzón-Muvdi, T. (2022) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2022.107127 · Cited by 10 · see citing works
Proof of concept for the use of trained sniffer dogs to detect osteosarcoma
Ortal, A., Rodríguez, A., Solís-Hernández, M. P., de Prado, M., Rey, V., Tornín, J., Estupiñán, Ó., Gallego, B., Murillo, D., Huergo, C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11013-1 · Cited by 10 · see citing works
Moyers, J. T., Pestana, R. C., Roszik, J., Hong, D. S., Naing, A., Fu, S., Piha-Paul, S. A., Yap, T. A., Karp, D. D., Rodon, J. A., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2509 · Cited by 10 · see citing works
Zhang, L., Zhang, G., Zheng, H., Jiang, B., Ju, Y., Duan, Q., An, L., & Shi, H. (2023) · Brain Tumor Pathology · doi:10.1007/s10014-023-00471-8 · Cited by 10 · see citing works
Sharma, S. R., Paonessa, N. E., Casadei, L., de Faria, F. C., Pollock, R. E., & Grignol, V. P. (2021) · Journal of Surgical Oncology · doi:10.1002/jso.26680 · Cited by 10 · see citing works
Current challenges and practical aspects of molecular pathology for bone and soft tissue tumors
de Álava, E. (2024) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-024-03736-5 · Cited by 9 · see citing works
Kyriazoglou, A. I., Pagkali, A., Kotsantis, I., Economopoulou, P., Kyrkasiadou, M., Moutafi, M. K., Gavrielatou, N., Anastasiou, Μ., Boulouta, A., Pantazopoulos, A., et al. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102716 · Cited by 9 · see citing works
- Authors
- Grünewald, T. G., Alonso, M., Avnet, S., Banito, A., Burdach, S., Cidre‐Aranaz, F., Di Pompo, G., Distel, M., Dorado‐Garcia, H., Garcia‐Castro, J., González‐González, L., Grigoriadis, A. E., Kasan, M., Koelsche, C., Krumbholz, M., Lecanda, F., Lemma, S., Longo, D. L., Madrigal‐Esquivel, C., Morales‐Molina, Á., Musa, J., Ohmura, S., Ory, B., Pereira‐Silva, M., Perut, F., Rodriguez, R., Seeling, C., Al Shaaili, N., Shaabani, S., Shiavone, K., Sinha, S., Tomazou, E. M., Trautmann, M., Vela, M., Versleijen‐Jonkers, Y. M., Visgauss, J., Zalacain, M., Schober, S. J., Lissat, A., English, W. R., Baldini, N., & Heymann, D.
- Affiliations
- German Cancer Research Center (DE)
- Universidad de Navarra (ES)
- Istituto Ortopedico Rizzoli (IT)
- Technical University of Munich (DE)
- Pathologisches Institut (DE)
- Instituto de Salud Carlos III (ES)
- King's College London (GB)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Erlangen (DE)
- Centro de Investigación Médica Aplicada (ES)
- Institute of Biostructure and Bioimaging (IT)
- University of Sheffield (GB)
- Heidelberg University (DE)
- Inserm (FR)
- University of Coimbra (PT)
- Universität Ulm (DE)
- University of Groningen (NL)
- University of Helsinki (FI)
- University of Münster (DE)
- Radboud University Medical Center (NL)
- Duke University (US)
- University Children's Hospital Zurich (CH)
- Institut de Cancérologie de l'Ouest (FR)
- Corresponding author
- Grünewald, Thomas GP
- Baldini, Nicola
- Heymann, Dominique
- ORCID
- Grünewald, Thomas GP
- Alonso, Marta
- Avnet, Sofia
- Banito, Ana
- Burdach, Stefan
- Cidre‐Aranaz, Florencia
- Distel, Martin
- González‐González, Laura
- Grigoriadis, Agamemnon E
- Kasan, Merve
- Koelsche, Christian
- Krumbholz, Manuela
- Lecanda, Fernando
- Lemma, Silvia
- Longo, Dario L
- Morales‐Molina, Álvaro
- Musa, Julian
- Ohmura, Shunya
- Ory, Benjamin
- Pereira‐Silva, Miguel
- Perut, Francesca
- Rodriguez, Rene
- Seeling, Carolin
- Shaabani, Shabnam
- Sinha, Snehadri
- Tomazou, Eleni M
- Trautmann, Marcel
- Versleijen‐Jonkers, Yvonne MH
- Visgauss, Julia
- Schober, Sebastian J
- Lissat, Andrej
- English, William R
- Baldini, Nicola
- Heymann, Dominique
- Venue
- EMBO Molecular Medicine
- Published
- 2020-10-13
- Volume
- 12
- Issue
- 11
- Pages
- e11131-e11131
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC7645378
- OpenAlex
- W3092176105
- Cited by
- 319
- References
- 457
- Citations by year
- 2026: 40 · 2025: 50 · 2024: 55 · 2023: 66 · 2022: 50 · 2021: 53 · 2020: 5
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-16-IDEX-0007)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- sarcoma, soft tissue sarcoma, bone sarcoma, sarcoma subtypes, multimodal therapy, combination chemotherapy, hyperthermia, immunotherapy, targeted therapy, prognostic factors, predictive biomarkers, pediatric sarcoma, secondary malignancies, therapeutic target
- MeSH terms
- Adolescent, Bone Neoplasms, Child, Humans, Sarcoma, Osteosarcoma, Soft Tissue Neoplasms, Molecular Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review