Cited by 303Cancer Cells and MetastasisSarcoma Diagnosis and TreatmentMesenchymal stem cell research

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Cancer stem cells in osteosarcoma

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Brown, Hannah K., Tellez-Gabriel, Marta, Heymann, Dominique·2017·Cancer Letters

DOI 10.1016/j.canlet.2016.11.019

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Abstract

Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.

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Authors: Brown, H. K., Tellez-Gabriel, M., & Heymann, D.
Affiliations: Inserm (FR)
Corresponding author: Brown, Hannah K.
Heymann, Dominique
ORCID: Heymann, Dominique
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2017-02
Volume: 386
Pages: 189-195
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2016.11.019
OpenAlex: W2551783204
Cited by: 303
References: 47
Citations by year: 2026: 12 · 2025: 23 · 2024: 43 · 2023: 33 · 2022: 41 · 2021: 49 · 2020: 50 · 2019: 34 · 2018: 10 · 2017: 8
FWCI: 1.74
Type: journal article
Language: en
Open access: green
inserm.hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
HAL (submittedVersion, other-oa)
Funders: Bone Cancer Research Trust (144681)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: osteosarcoma, cancer stem cells, drug resistance, carcinogenesis, metastasis, cancer stem cell isolation, molecular markers, therapeutic target, pediatric bone tumors
MeSH terms: Animals, Antineoplastic Agents, Bone Neoplasms, Cell Separation, Humans, Phenotype, Osteosarcoma, Biomarkers, Tumor, Neoplastic Stem Cells, Drug Resistance, Neoplasm

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Cancer stem cells in osteosarcoma

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