The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Circular RNAs (circRNAs) in cancer
Abstract
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on some diseases. Further studies reveal that circRNA can be used as an endogenous competitive RNA, thereby regulating the proliferation, invasion or other physiological activities of tumor cells. In addition, some circRNAs located in the nucleus can regulate the transcription of the parental gene by binding to RNA polymerase II. circRNA can also combine with proteins to influence the cell cycle. Furthermore, recent studies have shown that circRNA can encode proteins, similarly to mRNA. circRNAs are found extensively in human cells and have tissue specificity. They have the potential to be used in clinical applications as tumor markers and therapeutic targets.
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1 retracted
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
Chen, L., Zhang, S., Wu, J., Cui, J., Zhong, L., Zeng, L., & Ge, S. (2017) · Oncogene · doi:10.1038/onc.2017.89 · Cited by 392
RetractedHallmarks of Cancer: The Next Generation
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Exon-intron circular RNAs regulate transcription in the nucleus
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Circular intronic long noncoding RNAs
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Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
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Self-citationComplementary Sequence-Mediated Exon Circularization
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Self-citationRole of metabolism in cancer cell radioresistance and radiosensitization methods
Tang, L., Wei, F., Wu, Y., He, Y., Shi, L., Xiong, F., Gong, Z., Guo, C., Li, X., Deng, H., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0758-7 · Cited by 409
Self-citationEmerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 312
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Metadata
- Authors
- Zhou, R., Wu, Y., Wang, W., Su, W., Liu, Y., Wang, Y., Fan, C., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 425
- Pages
- 134-142
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2796241264
- Cited by
- 292
- References
- 96
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhou, R., Wu, Y., Wang, W., Su, W., Liu, Y., Wang, Y., Fan, C., Li, X., Li, G., Li, Y., Xiong, W., & Zeng, Z. (2018). Circular RNAs (circRNAs) in cancer. Cancer Letters. https://doi.org/10.1016/j.canlet.2018.03.035
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