Application of liquid biopsy in bone and soft tissue sarcomas: Present and future
Abstract
Bone and soft tissue sarcomas account for approximately 1% of adult solid malignancies and 20% of pediatric solid malignancies. Sarcomas are divided into more than 50 subtypes. Each subtype is highly heterogeneous and characterized by significant morphological and phenotypic variability. Currently, sarcoma characterization is based on tissue biopsies. However, primary and invasive tissue biopsies may not accurately reflect the current disease condition following treatment as is may cause marked changes to the tumor cells. Liquid biopsy offers an alternative minimally invasive approach to provide dynamic tumor information, allowing for the application of precision medicine in the treatment of sarcomas. Recently, there have been numerous blood-based tumor components identified by liquid biopsy in sarcomas, including circulating tumor cells, circulating cell-free nucleic acids, tumor-derived exosomes and metabolites in circulation. Here, we summarize the current evolving technologies and then elaborate on emerging novel concepts that may further propel the field of liquid biopsy in sarcomas. We address the applications in the context of our current knowledge about liquid biopsy in sarcomas and highlight the potential of translating these recent advances into the clinic for more effective management strategies for sarcoma patients.
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Studies in pediatric sarcomas link ctDNA detection to poorer clinical outcomes.
“This concept is supported by studies in pediatric sarcomas linking ctDNA detection to poorer clinical outcomes, as well as by methodological advances that allow reliable identification of sarcoma-associated genomic alterations, including characteristic translocations and copy-number changes [40].”
Methodological advances allow reliable identification of sarcoma-associated genomic alterations, including characteristic translocations and copy-number changes.
“This concept is supported by studies in pediatric sarcomas linking ctDNA detection to poorer clinical outcomes, as well as by methodological advances that allow reliable identification of sarcoma-associated genomic alterations, including characteristic translocations and copy-number changes [40].”
The strongest value of liquid biopsy in pediatric sarcoma may lie in serial surveillance, where rising ctDNA (or miRNA) could flag molecular relapse earlier than conventional detection.
“Nevertheless, the finding emphasizes a central clinical opportunity for liquid biopsy in pediatric sarcoma: rather than expecting end-of-therapy levels to mirror response categories, the strongest value may lie in serial surveillance, where rising ctDNA (or miRNA) could flag molecular relapse earlier than conventional detection.”
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Self-citationMicroRNA‐1 (miR‐1) inhibits chordoma cell migration and invasion by targeting slug
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Self-citationCRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells
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Self-citationDetection of circulating tumor cells in liquid biopsy from Ewing sarcoma patients
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MicroRNA-155 expression is independently predictive of outcome in chordoma
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Self-citationmiR-497 as a potential serum biomarker for the diagnosis and prognosis of osteosarcoma.
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Self-citationCirculating tumour-derived DNA in metastatic soft tissue sarcoma
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Self-citationTargeted Chemotherapy in Bone and Soft-Tissue Sarcoma
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SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN OSTEOSARCOMA
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Self-citationSERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA
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Advances in immune checkpoint inhibitors for bone sarcoma therapy
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Gibt es eine Magic Bullet für Sarkome?
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Application of Modified Closed Biopsy in Rabbit Model of VX2 Transplanted Bone TumorPreprint
Lei-peng, B., xing, L. J., wei, K. L., ying, C. H., & Yu, J. S. (2021) · Research Square · doi:10.21203/rs.3.rs-141172/v1
Stratégies et techniques de biopsie pour suspicion de tumeur osseuse
de Remaurin, X. D. C., Larousserie, F., Talabard, M.-P., Biau, D. J., & Anract, P. (2025) · EMC - Techniques chirurgicales - Orthopédie - Traumatologie · doi:10.1016/s0246-0467(25)47782-4
Pleural metastasis of bone and soft tissue sarcomas: A review
Yang, Y., Xie, L., Sun, X., Xu, J. H., & Ren, G. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.101062
A metabolic crosstalk between liposarcoma and skeletal muscle sustains tumor growth
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Estrategias y técnicas de biopsia ante la sospecha de un tumor óseo
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Precision oncology in the treatment of patients with bone sarcomas: an up-to-date narrative review
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- Authors
- Li, X., Seebacher, N. A., Hornicek, F. J., Xiao, T., & Duan, Z.
- Affiliations
- Central South University (CN)
- University of California, Los Angeles (US)
- Second Xiangya Hospital of Central South University (CN)
- Corresponding author
- Duan, Zhenfeng
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 439
- Pages
- 66-77
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2890290594
- Cited by
- 53
- References
- 137
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 10
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Scholarship Council (201606370194)
- Sarcoma Foundation of America (222433)
- National Cancer Institute
- National Institutes of Health (CA151452-01)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- liquid biopsy, bone sarcoma, soft tissue sarcoma, circulating tumor cells, cell-free DNA, circulating tumor DNA, tumor-derived exosomes, precision medicine
- MeSH terms
- Cell-Free Nucleic Acids, Liquid Biopsy, Bone and Bones, Bone Neoplasms, Forecasting, Humans, Neoplastic Cells, Circulating, Sarcoma, Soft Tissue Neoplasms, Biomarkers, Tumor, Exosomes
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