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Cited by 253

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Gut microbiome and cancer immunotherapy

Open access
Li, Weina, Deng, Yu, Chu, Qian, Zhang, Peng·2019·Cancer Letters
DOI 10.1016/j.canlet.2019.01.015
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Abstract

Microbiome is becoming crucial in that the balance between human health and disease can be mediated by the gut microbiome. The gut microbiome can modulate the host immune system both locally and systemically. Cancer immunotherapy has emerged as a promising way in the treatment of patients with cancer. Accumulating evidence supports that microbiome affects the therapeutic efficacy of cancer immunotherapy, particularly immune checkpoint inhibitors. Here, we discuss the mutual relationship among gut microbiome, cancer, immunity, and cancer immunotherapy, with a focus on immunotherapy. Also, we briefly introduce the relevant challenges that affect the therapeutic efficacy and present the possible solutions. • Microbiome plays a key role in human health and disease, and gut microbiome affects immunity both locally and systemically. • Gut microbiome affects the efficacy of cancer immunotherapy, especially ICIs involving blockade of PD-1 or PD-L1 and CTLA-4. • Despite the potential of gut microbiome in immunotherapy, some challenges remain, including selection of an optimal FMT donor.

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Crossref · 10.1016/j.canlet.2019.01.015

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Metadata

Authors
Li, W., Deng, Y., Chu, Q., & Zhang, P.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2019-04
Volume
447
Pages
41-47
ISSN
0304-3835 (ISSN-L)
DOI
10.1016/j.canlet.2019.01.015
OpenAlex
W2912325577
Cited by
253
References
35
FWCI
7.88
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.