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Metal-associated amyloid-β species in Alzheimer's disease
Abstract
Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-β (Aβ) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding to Aβ could facilitate Aβ aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD. The connection between metal-Aβ interaction/reactivity and AD development, however, has not been clearly revealed owing to the complexity of the disease. In this review, metal-Aβ interaction/reactivity and its relation to neurotoxicity are briefly discussed. Additionally, our review illustrates the recent progress of small molecules, capable of targeting metal-Aβ species and modulating their interaction/reactivity, which could offer a promising approach to interrogate their role in AD.
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“Recent efforts to control abnormal Aβ–metal interactions have focused on small molecules, bifunctional chelators (BFCs), that have binding affinity for both metal ions and Aβ aggregates.20,25,27−30”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [29]
Citations
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“Overall, rather than a static process, amyloid aggregation is iterative, dynamic, and environment-dependent[22,23,35,24 – 30,34 ], leading to an energy landscape with multiple local minima, each corresponding to”
Metadata
- Authors
- Pithadia, A. S., & Lim, M. H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Lim, Mi Hee
- ORCID
- Lim, Mi Hee
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 16
- Issue
- 1-2
- Pages
- 67-73
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W1984223653
- Cited by
- 259
- References
- 48
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 17 · 2020: 21 · 2019: 28 · 2018: 30 · 2017: 25 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 20 · 2012: 8
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- Alzheimer's disease, amyloid-beta, metal ion binding, copper, zinc, iron, amyloid plaques, amyloid-beta aggregation, reactive oxygen species, neurotoxicity, metal chelators
- MeSH terms
- Alzheimer Disease, Amyloid, Humans, Metals, Reactive Oxygen Species
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