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Cited by 259Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAluminum toxicity and tolerance in plants and animals

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Metal-associated amyloid-β species in Alzheimer's disease

Pithadia, Amit S, Lim, Mi Hee·2012·Current Opinion in Chemical Biology
DOI 10.1016/j.cbpa.2012.01.016
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Abstract

Highly concentrated metals such as Cu, Zn, and Fe are found in amyloid-β (Aβ) plaques within the brain of Alzheimer's disease (AD). In vitro and in vivo studies have suggested that metal binding to Aβ could facilitate Aβ aggregation and generate reactive oxygen species (ROS), which could contribute to the neuropathogenesis of AD. The connection between metal-Aβ interaction/reactivity and AD development, however, has not been clearly revealed owing to the complexity of the disease. In this review, metal-Aβ interaction/reactivity and its relation to neurotoxicity are briefly discussed. Additionally, our review illustrates the recent progress of small molecules, capable of targeting metal-Aβ species and modulating their interaction/reactivity, which could offer a promising approach to interrogate their role in AD.

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Research works printed but not linked: 31

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Metadata

Authors
Pithadia, A. S., & Lim, M. H.
Affiliations
University of Michigan (US)
Corresponding author
Lim, Mi Hee
ORCID
Lim, Mi Hee
Venue
Current Opinion in Chemical Biology
Publisher
Elsevier BV
Published
2012-04
Volume
16
Issue
1-2
Pages
67-73
ISSN
1367-5931 (ISSN-L)
DOI
10.1016/j.cbpa.2012.01.016
OpenAlex
W1984223653
Cited by
259
References
48
Citations by year
2026: 3 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 17 · 2020: 21 · 2019: 28 · 2018: 30 · 2017: 25 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 20 · 2012: 8
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Current Opinion in Chemical Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords
Alzheimer's disease, amyloid-beta, metal ion binding, copper, zinc, iron, amyloid plaques, amyloid-beta aggregation, reactive oxygen species, neurotoxicity, metal chelators
MeSH terms
Alzheimer Disease, Amyloid, Humans, Metals, Reactive Oxygen Species

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