KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Open accessAbstract
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a COMPASS-like enzyme, also called MLL4) is among the most highly inactivated epigenetic modifiers in lung cancer. Here, we show that lung-specific loss of Kmt2d promotes lung tumorigenesis in mice and upregulates pro-tumorigenic programs, including glycolysis. Pharmacological inhibition of glycolysis preferentially impedes tumorigenicity of human lung cancer cells bearing KMT2D-inactivating mutations. Mechanistically, Kmt2d loss widely impairs epigenomic signals for super-enhancers/enhancers, including the super-enhancer for the circadian rhythm repressor Per2. Loss of Kmt2d decreases expression of PER2, which regulates multiple glycolytic genes. These findings indicate that KMT2D is a lung tumor suppressor and that KMT2D deficiency confers a therapeutic vulnerability to glycolytic inhibitors.
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- Authors
- Alam, H., Tang, M., Maitituoheti, M., Dhar, S. S., Kumar, M., Han, C. Y., Ambati, C. R., Amin, S. B., Gu, B., Chen, T.-Y., Lin, Y.-H., Chen, J., Muller, F. L., Putluri, N., Flores, E. R., DeMayo, F. J., Baseler, L., Rai, K., & Lee, M. G.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- Moffitt Cancer Center (US)
- National Institute of Environmental Health Sciences (US)
- Corresponding author
- Rai, Kunal
- Lee, Min Gyu
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 37
- Issue
- 4
- Pages
- 599-617.e7
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC7178078
- OpenAlex
- W3014830213
- Cited by
- 243
- References
- 102
- Citations by year
- 2026: 28 · 2025: 39 · 2024: 38 · 2023: 53 · 2022: 42 · 2021: 35 · 2020: 8
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Texas MD Anderson Cancer Center (R00CA160578)
- National Cancer Institute (P30CA016672)
- American Cancer Society (RSG-15-145-01-CDD)
- National Institutes of Health (R01CA207109, R01CA157919, R01CA207098)
- National Institute of Environmental Health Sciences (Z1AES103311-10, R35CA197452)
- Cancer Prevention and Research Institute of Texas (RP170005, 127430-RSG-15-105-01-CNE)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- KMT2D, histone methyltransferase, lung cancer, super-enhancers, enhancers, glycolysis, glycolysis inhibitors, Per2, circadian rhythm, tumor suppressor, epigenetic regulators, loss-of-function mutations, lung carcinogenesis
- MeSH terms
- Adenocarcinoma of Lung, Animals, Antimetabolites, Deoxyglucose, DNA-Binding Proteins, Enhancer Elements, Genetic, Glycolysis, Histones, Humans, Lung Neoplasms, Mice, Nude, Mutation, Neoplasm Proteins, Prognosis, Histone-Lysine N-Methyltransferase, Tumor Cells, Cultured, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Apoptosis, Mice, Knockout, Xenograft Model Antitumor Assays, Cell Proliferation, Mice, Myeloid-Lymphoid Leukemia Protein, Period Circadian Proteins
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