Oxidative Stress, Chronic Disease, and Muscle Wasting

Moylan, Jennifer S.; Reid, Michael B.

doi:10.1002/mus.20743

Cited by 416Muscle Physiology and DisordersNutrition and Health in AgingExercise and Physiological Responses

Oxidative Stress, Chronic Disease, and Muscle Wasting

Moylan, Jennifer S., Reid, Michael B.·2007·Muscle & Nerve

DOI 10.1002/mus.20743

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Abstract

Underlying the pathogenesis of chronic disease is the state of oxidative stress. Oxidative stress is an imbalance in oxidant and antioxidant levels. If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensues. In some cases, oxidative stress is assigned a causal role in disease pathogenesis, whereas in others the link is less certain. Along with underlying oxidative stress, chronic disease is often accompanied by muscle wasting. It has been hypothesized that catabolic programs leading to muscle wasting are mediated by oxidative stress. In cases where disease is localized to the muscle, this concept is easy to appreciate. Transmission of oxidative stress from diseased remote organs to skeletal muscle is thought to be mediated by humoral factors such as inflammatory cytokines. This review examines the relationship between oxidative stress, chronic disease, and muscle wasting, and the mechanisms by which oxidative stress acts as a catabolic signal.

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Oxidative stress is a major trigger of imbalance between protein synthesis and degradation leading to muscle atrophy.
“Oxidative stress, characterized by increased reactive oxygen species (ROS) production and impairment of antioxidant defense systems, is also a major trigger of imbalance between protein synthesis and degradation leading to muscle atrophy [10,11].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [10]

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Authors: Moylan, J. S., & Reid, M. B.
Affiliations: University of Kentucky (US)
Corresponding author: Reid, Michael B.
ORCID: Moylan, Jennifer S.
Reid, Michael B.
Venue: Muscle & Nerve
Publisher: Wiley
Published: 2007-01-31
Volume: 35
Issue: 4
Pages: 411-429
ISSN: 0148-639X (ISSN-L)
1097-4598
DOI: 10.1002/mus.20743
OpenAlex: W1964166589
Cited by: 416
References: 295
Citations by year: 2026: 13 · 2025: 17 · 2024: 23 · 2023: 21 · 2022: 23 · 2021: 17 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 23 · 2016: 27 · 2015: 22 · 2014: 26 · 2013: 21 · 2012: 19
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Muscle & Nerve (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL59878, R01HL059878)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: oxidative stress, chronic disease, muscle atrophy, sarcopenia, inflammatory cytokines, antioxidant defense, oxidative damage, pathogenesis, skeletal muscle
MeSH terms: Antioxidants, Chemotaxis, Leukocyte, Chronic Disease, Humans, Inflammation, Muscular Atrophy, Nitric Oxide, Cytokines, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal

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Oxidative Stress, Chronic Disease, and Muscle Wasting

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