The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

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High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells

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SQSTM1/p62/A170 regulates the severity of Legionella pneumophila pneumonia by modulating inflammasome activity

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Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages

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The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

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High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic cancer

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Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

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RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis

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Oncogene-mediated tumor transformation sensitizes cells to autophagy induction

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Autophagy deficiency activates rDNA transcription

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Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma

Hamedi, K. R., Harmon, K. A., Goodwin, R. L., & Arce, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.889954 · Cited by 12

Aging, cancer, and autophagy: connections and therapeutic perspectives

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Quantitative proteomics to study a small molecule targeting the loss of von Hippel–Lindau in renal cell carcinomas

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Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era

Zhang, X., Deibert, C. P., Kim, W.-J., Jaman, E., Rao, A. V., Lotze, M. T., & Amankulor, N. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0205-8 · Cited by 13

High Expression of p62 and ALDH1A3 Is Associated With Poor Prognosis in Luminal B Breast Cancer

Ozaki, A., Motomura, H., Tamori, S., Onaga, C., Nagashima, Y., KOTORI, M., Matsuda, C., MATSUDA, A., MOCHIZUKI, N., Sato, T., et al. (2022) · Anticancer Research · doi:10.21873/anticanres.15818 · Cited by 12

Intranuclear inclusions in hepatocellular carcinoma contain autophagy‐associated proteins and correlate with prolonged survival

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Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43266-283 in Glioblastoma Stem Cells

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Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance

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Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer

Chang, H., Yang, C., Loi, L., Hung, C.-H., Wu, C., & Lin, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28406 · Cited by 13

The Estrogen–Autophagy Axis: Insights into Cytoprotection and Therapeutic Potential in Cancer and Infection

Zhao, Y., Klionsky, D. J., Wang, X., Huang, Q., Deng, Z., & Xiang, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312576 · Cited by 10

Hypoxia enhances basal autophagy of epithelial‐derived ameloblastoma cells

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In vitro evaluation of autophagy and cell death induction in Panc1 pancreatic cancer by secretome of hAMSCs through downregulation of p-AKT/p-mTOR and upregulation of p-AMPK/ULK1 signal transduction pathways

Safari, F., & Dadvar, F. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102160 · Cited by 11

IKKβ targeting reduces KRAS-induced lung cancer angiogenesis in vitro and in vivo: A potential anti-angiogenic therapeutic target

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Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases

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Inhibition of p62/SQSTM1 sensitizes small‐cell lung cancer cells to cisplatin‐induced cytotoxicity by targeting NEDD9 expression

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Diluted aqueous extract of heat-not-burn tobacco product smoke causes less oxidative damage in fibroblasts than conventional cigarette

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The up-regulation of P62 levels is associated with resistance of sorafenib in hepatocarcinoma cells.

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Inhibitor of the transcription factor NF-κB, DHMEQ, enhances the effect of paclitaxel on cells of anaplastic thyroid carcinoma in vitro and in vivo

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Reduced expression of SM22 is correlated with low autophagy activity in human colorectal cancer

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Mitophagy in Viral Infections

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p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes

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The Roles of SQSTM1/p62 in Selective Autophagy and Oncogenic Signaling

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miR675 Accelerates Malignant Transformation of Mesenchymal Stem Cells by Blocking DNA Mismatch Repair

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Supramolecular Complexes in Cell Death and Inflammation and Their Regulation by Autophagy

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Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family

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Plasma Rich in Growth Factors Promotes Autophagy in ARPE19 Cells in Response to Oxidative Stress Induced by Blue Light

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The Adaptor Protein p62 Mediates Nuclear Factor κB Activation in Response to Inflammation and Facilitates the Formation of Prolabor Mediators in Human Myometrium

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Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification

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Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage

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Targeting STAT3-mediated autophagy with small molecules in cancer treatment – A comprehensive review

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Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma

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Inhibition of autophagy in peripheral blood mononuclear cells by vaginal fluid from women with a malignant adnexal mass

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‘Doubling down’ on the autophagy pathway to suppress tumor growthPreprint

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Autophagy in host-microbe interactions

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Lysosomal dysfunction-derived autophagy impairment of gingival epithelial cells in diabetes-associated periodontitis with altered protein acetylation

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Dual Role of Lysosome in Cancer Development and Progression

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A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ

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Rosmarinic acid-mediated downregulation of RIG-I and p62 in microglia confers resistance to Japanese encephalitis virus-induced inflammation

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A New Alpha in Line Between KRAS and NF-κB Activation?

Pak, C., & Miyamoto, S. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0193 · Cited by 6

Autophagy and Cancer Therapy

Thorburn, A. M., & Morgan, M. J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6561-4_10 · Cited by 6

Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer

Wang, L., Hensley, C. R., Howell, M. E. A., & Ning, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.923009 · Cited by 6

In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization

Liu, Y., Trnka, M. J., He, L., Burlingame, A. L., & Correia, M. A. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100495 · Cited by 6

TonEBP Promotes β-Cell Survival under ER Stress by Enhancing Autophagy

Kang, H. J., Yoo, E. J., Lee, H. H., An, S. M., Park, H., Lee‐Kwon, W., Choi, S. Y., & Kwon, H. M. (2020) · Cells · doi:10.3390/cells9091928 · Cited by 6

Exendin-4 Induces Cytotoxic Autophagy in Two Ovarian Cancer Cell Lines through Inhibition of Mtorc1 Mediated by Activation of AMPK and Suppression of Akt

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Analysis of differentially expressed genes responsible for the suppressive effect of anisomycin on cell proliferation of DLD-1 cells

Ushijima, H., Monzaki, R., & Funakoshi, M. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101038 · Cited by 6

IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells

Rodrigues, F. S., Miranda, V. S., Carneiro-Lobo, T., Scalabrini, L. C., Kruspig, B., Levantini, E., Murphy, D. J., & Bassères, D. S. D. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165806 · Cited by 5

Current and potential roles of RNA modification-mediated autophagy dysregulation in cancer

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Lysine-specific demethylase 1 (LSD1) participate in porcine early embryonic development by regulating cell autophagy and apoptosis through the mTOR signaling pathway

Qi, J., Zhang, S., Qu, H., Wang, Y., Dong, Y., Wei, H., Wang, Y., Sun, B., Jiang, H., Zhang, J., et al. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.05.010 · Cited by 5

Sequestosome 1/p62: a multi-domain protein with multi-faceted functions

Liu, X., Gál, J., & Zhu, H. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1217-z · Cited by 5

DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1

Zheng, Y., Xu, B., Zhao, Y., Yang, S., Wang, S., Ma, L., & Dong, L. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06735-z · Cited by 4

Immunohistochemical Expression of p62 in Feline Mammary Carcinoma and Non-Neoplastic Mammary Tissue

Magi, G. E., Mariotti, F., Pallotta, L., Cerbo, A. D., & Venanzi, F. M. (2022) · Animals · doi:10.3390/ani12151964 · Cited by 4

Combined Treatment with Bojungikgi-tang (Buzhong Yiqi Decoction) and Riluzole Attenuates Cell Death in TDP-43-Expressing Cells

Yang, E. J. (2023) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-023-3557-8 · Cited by 4

The Complex Crosstalk Between Autophagy and ROS Signalling Pathways

Airiau, K., & Djavaheri‐Mergny, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-30079-5_3 · Cited by 4

HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: Role of BCP and preCore mutations

Elizalde, M. M., Pérez, P. S., Sevic, I., Grasso, D., Ropolo, A., Barbini, L., Campos, R. H., Vaccaro, M. I., & Flichman, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197109 · Cited by 4

Autophagy-Driven Cancer Drug Development

Belaïd, A., Roméo, B., Filippakis, H., Meyer, M., Grosjean, I., Yazbeck, N., Domdom, M. A., Crépeaux, G., Gherardi, R. K., Lagadic‐Gossmann, D., et al. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00021-3 · Cited by 4

Autophagy in cancer and protein conformational disorders

Attanasio, S. (2025) · FEBS Letters · doi:10.1002/1873-3468.70061 · Cited by 5

p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis

Cai-McRae, X., & Karantza, V. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.975035 · Cited by 3

Enhanced Sensitivity to NVP-BEZ235 by Inhibition of p62/SQSTM1 in Human Bladder Cancer KoTCC-1 Cells Both In Vitro and In Vivo

Tamura, K., Watanabe, K., Matsushita, Y., Watanabe, H., Motoyama, D., Ito, T., Sugiyama, T., Otsuka, A., & Miyake, H. (2020) · In Vivo · doi:10.21873/invivo.11868 · Cited by 3

Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants

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Another Facet of Ubiquitylation: Death

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GENETIC MOUSE MODELS FOR ELUCIDATION OF AUTOPHAGY-LYSOSOMAL SYSTEMS IN NEURONS UNDER PHYSIOLOGIC AND PATHOLOGIC CONDITIONS

Komatsu, M., Koike, M., Ichimura, Y., & Uchiyama, Y. (2012) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814350457_0008 · Cited by 3

Autophagy regulates tumor growth and metastasisPreprint

Qiang, L., Zhao, B., Ming, M., Wang, N., He, T., Hwang, S., Thorburn, A. M., & He, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.31.564991 · Cited by 3

p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p

Hennig, P., Turko, P., Filippo, M. D., Levesque, M. P., Kündig, T. M., & Beer, H. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07785-9 · Cited by 2

Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state

Rosset, C., Jaeger, M. D. C., Filippi‐Chiela, E. C., Reis, L. B., Sartor, I. T. S., Netto, C. B. O., de Farias, C. B., Roesler, R., & Ashton‐Prolla, P. (2021) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2020-0475 · Cited by 2

p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation

Kondylis, V., Schneider, F., Schorn, F., Oikonomou, N., Straub, B. K., Werner, S., Rosenstiel, P. C., & Pasparakis, M. (2022) · Cancers · doi:10.3390/cancers14102436 · Cited by 2

Natural Compounds and Their Role in Autophagic Cell Signaling Pathways

Rasul, A., & Tonghui, M. (2013) · InTech eBooks · doi:10.5772/55447 · Cited by 2

Role of Autophagy in Cancer Development via Mitochondrial Reactive Oxygen Species

Liu, B., & He, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00012-0 · Cited by 2

Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q)

Fang, J., & Starczynowski, D. T. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1014219 · Cited by 2

Evidence for a Growing Involvement of Glia in Amyotrophic Lateral Sclerosis

Radford, R. A. W., Vidal-Itriago, A., Scherer, N. M., Lee, A., Graeber, M. B., Chung, R. S., & Morsch, M. (2021) · Wiley eBooks · doi:10.1002/9781119745532.ch7 · Cited by 3

Autophagy regulates rRNA synthesis

Xu, Y., & Wan, W. (2022) · Nucleus · doi:10.1080/19491034.2022.2114661 · Cited by 2

Selective Disposal of Insoluble Protein Aggregates

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Cell-Based Assays for Evaluation of Autophagy in Cancers

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P62/Sequestosome1 deficiency disrupts antioxidant and stress homeostasis during acute pancreatitis without exacerbating inflammation

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