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The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
Open accessAbstract
The balance between cell death and survival, two critical aspects of oncogenic transformation, determines the outcome of tumorigenesis. Nuclear factor-kappaB (NF-kappaB) is a critical regulator of survival; it is induced by the oncogene Ras and, when inhibited, accounts for the cell death response of Ras-transformed cells. Here, we show that the signaling adaptor p62 is induced by Ras, its levels are increased in human tumors, and it is required for Ras-induced survival and transformation. p62-/- mice are resistant to Ras-induced lung adenocarcinomas. p62 is necessary for Ras to trigger IkappaB kinase (IKK) through the polyubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), and its deficiency produces increased reactive oxygen species (ROS) levels, which account for the enhanced cell death and reduced tumorigenicity of Ras in the absence of p62.
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“ALS-associated mutations in TBK1, OPTN, SQSTM1, and VCP all affect autophagy as well as microglial function and innate immunity [192,205,206,441–443].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [442]
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Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
ras oncogenes in human cancer: a review.
Bos, J. L. (1989) · PubMed · Cited by 5,061
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
Targeting RAS signalling pathways in cancer therapy
Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,354
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792
Ubiquitin signalling in the NF-κB pathway
Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184
Maeda, S., Kamata, H., Luo, J., Leffert, H. L., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2005.04.014 · Cited by 1,160
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Items 501–543 of 543
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Ichimura, Y., & Komatsu, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6561-4_6
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Díaz-Meco, M. T., & Moscat, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-543-9_10
Self-citationManipulation of cell death pathways in cancer
Bray, K. (2011) · doi:10.7282/t3bp01xm
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Mehrpour, M., Hamaï, A., & Codogno, P. (2013) · Springer eBooks · doi:10.1007/978-94-007-6211-4_14
Biomarcadores de progressão em carcinomas orais
Cervigne, N. K. (2009) · Americanae (AECID Library)
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Wong, W. W.-L., & Silke, J. (2015)
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Peters, S., & Meylan, E. (2012) · Lung Cancer Management · doi:10.2217/lmt.12.16
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Yang, H., Williams, J. A. R., Hou, Y., Xia, M., Shi, Y., Fan, J., & Ding, W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6561-4_12
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Isaka, Y., Kimura, T., Takabatake, Y., & Takahashi, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805420-8.00011-1
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Guo, J. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00011-1
Rodrigues, F. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2018.tde-26112018-080111
Wang, M., Fukuyama, S., Kawaoka, Y., & Shoemaker, J. E. (2019) · Processes · doi:10.3390/pr7050301
Maru, Y. (2016) · Springer eBooks · doi:10.1007/978-4-431-56024-1_10
Maru, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-1757-7_10
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夏, 丹. (2019) · Advances in Clinical Medicine · doi:10.12677/acm.2019.910180
Liu, Y., Trnka, M. J., He, L., Burlingame, A. L., & Correia, M. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.13.512146
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Moradian, N., & Rezaei, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_197-1
The roles of autophagy in cancer and the therapeutic implications
Wang, R. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3021674
夏, 丹. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1551629
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Lamore, S. D. (2012) · UA Campus Repository (The University of Arizona)
Yupei, L., Jiang, Y., Jin, X., Chen, P., Heng, Y., Cai, L., Zhang, W., Li, L., & Jia, L. (2020) · Figshare · doi:10.6084/m9.figshare.12291668
Thoms, H. C., Brant, T. S., Duckett, K., Yang, Y., Dong, J., Wang, H., Derby, F., Akeke, O. F., Al‐Alayeen, F., Newell, A. S., et al. (2025) · Aging Cell · doi:10.1111/acel.70334
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Pietrocola, F. (2015) · theses.fr (ABES) · doi:10.70675/42d6808dzc206z4e0fzb806z29f806b2f781 · Cited by 1
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Ndiaye, P. D. (2017) · theses.fr (ABES) · doi:10.70675/fa7c4865z5a22z4ef6z828cz73fb034ba31d
Glutamine Metabolism: Role in Cancer Cell Proliferation and Survival
Chakraborty, A. J., Pramanik, S., Mullick, S., Nath, R., Mondal, M., Pal, R., Ashique, S., & Jana, M. (2026) · Cancer treatment and research · doi:10.1007/978-3-032-21861-2_3
Regulation of proteasome activation by a ubiquitin-independent feedback mechanismPreprint
Watson, S. J., Williamson, J. C., Gerber, P. P., Grice, G. L., Melucci, C., Duggal, A., Gawden‐Bone, C. M., Wit, N., Timms, R. T., Nathan, J. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730379
Szychowski, K. A., & Skóra, B. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117994
Hirschelmann, C., & Amponsah, P. S. (2026) · Biological Chemistry · doi:10.1515/hsz-2026-0146
BindingDB Entry 50018472: p62 as a therapeutic target for tumor.
BindingDB (2024) · UC San Diego · doi:10.7270/q2q244g8
Autophagy and Necroptosis in Cancer
Tan, M., Tan, H. K., Moad, A. I. H., & Muhammad, T. S. T. (2014) · Springer eBooks · doi:10.1007/978-3-662-44006-3_14
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Rantanen, K. (2012) · UTUPub (University of Turku)
Metadata
- Authors
- Duran, A., Linares, J. F., Galvez, A. S., Wikenheiser, K., Flores, J. M., Diaz-Meco, M. T., & Moscat, J.
- Affiliations
- University of Cincinnati (US)
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Moscat, Jorge
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 13
- Issue
- 4
- Pages
- 343-354
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1981912182
- Cited by
- 541
- References
- 51
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 18 · 2022: 30 · 2021: 35 · 2020: 41 · 2019: 39 · 2018: 41 · 2017: 51 · 2016: 41 · 2015: 38 · 2014: 41 · 2013: 45 · 2012: 29
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- Cincinnati Children's Hospital Medical Center
- University of Cincinnati
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- p62, NF-κB signaling, oncogenic Ras, carcinogenesis, cell survival, cell death, TRAF6, IκB kinase, polyubiquitination, reactive oxygen species, lung adenocarcinoma, oncogenic transformation
- MeSH terms
- Animals, Cell Survival, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Lung Neoplasms, Neoplasms, Transcription, Genetic, Signal Transduction, NF-kappa B, RNA-Binding Proteins, Reactive Oxygen Species, ras Proteins, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Mice
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