Hdac3 is essential for the maintenance of chromatin structure and genome stability
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Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. These defects corresponded to increases in histone H3K9,K14ac; H4K5ac; and H4K12ac in late S phase of the cell cycle, and histone deposition marks were retained in quiescent Hdac3-null cells. Liver-specific deletion of Hdac3 culminated in hepatocellular carcinoma. Whereas HDAC3 expression was downregulated in only a small number of human liver cancers, the mRNA levels of the HDAC3 cofactor NCOR1 were reduced in one-third of these cases. siRNA targeting of NCOR1 and SMRT (NCOR2) increased H4K5ac and caused DNA damage, indicating that the HDAC3/NCOR/SMRT axis is critical for maintaining chromatin structure and genomic stability.
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HDAC3 is required for genome maintenance and DNA replication in hematopoietic cells.
“HDAC3 was found to be required for genome maintenance and DNA replication in hematopoietic cells (27, 28); therefore, HDAC3 inhibition is suspected to be responsible for bone marrow toxicity seen with nonselective HDAC inhibitors (29).”
From TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes <i>STK11</i> -Mutant Tumors to Anti–PD-1 Immunotherapy (2025) · cites this paper as [28]
The Results (‘Hdac3 is required for genomic stability’; page not provided) report increased chromosome breaks and gaps after Hdac3 deletion in mouse embryonic fibroblasts, and the paper states that Hdac3 is essential for efficient DNA replication. The cited copy does not establish those requirements in hematopoietic cells; its Discussion mentions bone-marrow cells only when considering possible effects of HDAC inhibitors. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHDAC3 affects genome instability.
“Preliminary studies have shown that HDAC3 affects genome instability.”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Bhaskara et al., 2010
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“HDAC3 was found to be required for genome maintenance and DNA replication in hematopoietic cells (27, 28); therefore, HDAC3 inhibition is suspected to be responsible for bone marrow toxicity seen with nonselective HDAC inhibitors (29).”
- Authors
- Bhaskara, S., Knutson, S. K., Jiang, G., Chandrasekharan, M. B., Wilson, A. J., Zheng, S., Yenamandra, A., Locke, K., Yuan, J.-L., Bonine-Summers, A. R., Wells, C. E., Kaiser, J. F., Washington, M. K., Zhao, Z., Wagner, F. F., Sun, Z.-W., Xia, F., Holson, E. B., Khabele, D., & Hiebert, S. W.
- Affiliations
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
- Broad Institute (US)
- Corresponding author
- Hiebert, Scott W.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 18
- Issue
- 5
- Pages
- 436-447
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3004468
- OpenAlex
- W2059002036
- Cited by
- 353
- References
- 65
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 23 · 2023: 23 · 2022: 17 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 28 · 2017: 28 · 2016: 26 · 2015: 19 · 2014: 27 · 2013: 28 · 2012: 31
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30 CA 68485, R01CA141071, R01CA109355, F32CA138091, R01CA077274, R01CA064140, T32CA009582, P30CA068485, R01 CA64140, R01-CA77274)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK58404, P30DK058404)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- HDAC3, chromatin structure, genome stability, DNA replication, DNA damage response, DNA repair, heterochromatin, histone acetylation, histone H3K9 acetylation, histone deposition, hepatocellular carcinoma, NCOR1, SMRT, histone deacetylase
- MeSH terms
- Histone Deacetylase 3, Acetylation, Animals, Chromatin, DNA Damage, DNA Repair, DNA Replication, Carcinoma, Hepatocellular, Histone Deacetylases, Histones, Humans, Liver Neoplasms, Experimental, RNA, Messenger, Down-Regulation, Gene Expression Regulation, Neoplastic, S Phase, RNA Interference, Chromatin Assembly and Disassembly, Genomic Instability, Cell Line, Tumor, Mice, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Co-Repressor 2
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