The DOI matches its Crossref record; 86 of the 87 references it cites were found in a registry or an index.
Dragging Ras Back in the Ring
Open accessAbstract
Ras proteins play a major role in human cancers but have not yielded to therapeutic attack. Ras-driven cancers are among the most difficult to treat and often excluded from therapies. The Ras proteins have been termed "undruggable," based on failures from an era in which understanding of signaling transduction, feedback loops, redundancy, tumor heterogeneity, and Ras' oncogenic role was poor. Structures of Ras oncoproteins bound to their effectors or regulators are unsolved, and it is unknown precisely how Ras proteins activate their downstream targets. These knowledge gaps have impaired development of therapeutic strategies. A better understanding of Ras biology and biochemistry, coupled with new ways of targeting undruggable proteins, is likely to lead to new ways of defeating Ras-driven cancers.
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In the citing paper
“Clinical trials involving inhibitors against RAF and MEK have not received approval for treating KRAS-mutant cancers [46].”
From KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance (2024) · cites this paper as [46]
In the citing paper
“Clinically active, covalent KRASG12C inhibitors have provided the first opportunity to directly target this key oncoprotein (Canon et al., 2019; Hallin et al., 2020; Stephen et al., 2014).”
From SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling (2021) · cites this paper as Stephen et al., 2014
In the citing paper
“Although frequently observed in cancer, not only is the basis for the specific frequencies of KRAS G12X mutations poorly understood [47], but also the effects of these specific mutations on a molecular scale are not clear.”
Citations
Cites
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1 of the 87 references couldn’t be matched to a known paper.
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Drugging the undruggable RAS: Mission Possible?
Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., & Der, C. J. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4389 · Cited by 1,997
RAS Proteins and Their Regulators in Human Disease
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Self-citationDistinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
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Dang, C. V., Reddy, E. P., Shokat, K. M., & Soucek, L. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.36 · Cited by 927
Metadata
- Authors
- Stephen, A. G., Esposito, D., Bagni, R. K., & McCormick, F.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- University of California, San Francisco (US)
- Corresponding author
- McCormick, Frank
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 25
- Issue
- 3
- Pages
- 272-281
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2022920832
- Cited by
- 795
- References
- 87
- Citations by year
- 2026: 25 · 2025: 34 · 2024: 44 · 2023: 36 · 2022: 59 · 2021: 63 · 2020: 67 · 2019: 84 · 2018: 95 · 2017: 94 · 2016: 82 · 2015: 80 · 2014: 31
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Frederick National Laboratory for Cancer Research
- National Institutes of Health
- University of California, San Francisco
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- Ras proteins, RAS-driven cancers, undruggable proteins, Ras signaling, Ras effectors, RAS inhibitors, cancer therapy
- MeSH terms
- Animals, Guanosine Diphosphate, Guanosine Triphosphate, Humans, Neoplasms, Protein Processing, Post-Translational, Retroviridae Infections, Tumor Virus Infections, Signal Transduction, Oncogene Protein p21(ras), Proto-Oncogene Proteins p21(ras), Mice
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