Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

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Strength in Numbers: A Giant NIR‐II AIEgen with One‐for‐All Phototheranostic Features for Exceptional Orthotopic Bladder Cancer Treatment

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Engineering of exosome-liposome hybrid-based theranostic nanomedicines for NIR-II fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma

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Regulated cell death mechanisms in mitochondria-targeted phototherapy

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Tuning Second Near-Infrared Fluorescence Activation by Regulating the Excited-State Charge Transfer Dynamics Change Ratio

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Dynamic Regulation of Radical Photochromism and Photoluminescence via Polymer Polarity

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Reprogrammed glycolysis-induced augmentation of NIR-II excited photodynamic/photothermal therapy

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An Ultrasound‐Activated Supramolecular Modulator Enhancing Autophagy to Prevent Ventricular Arrhythmias Post‐Myocardial Infarction

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Construction of Through‐Space Charge‐Transfer Nanoparticles for Facilely Realizing High‐Performance NIR‐II Cancer Phototheranostics

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Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging

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Organoboron-embedded functional materials: recent developments in photovoltaic and luminescence properties

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Tissue‐seeking dyes for in vivo applications

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Advanced optical imaging technology in the near infrared window for cell tracking in vivo

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Current Status and Future Developments in NIR‐II‐emitting Organic Small Molecule Fluorophores for Bioimaging and Phototherapy

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Early Diagnosis of Liver Injury and Real‐Time Evaluation of Photothermal Therapy Efficacy with a Viscosity‐Responsive NIR‐II Smart Molecule

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Far-red/NIR BODIPY probes in focus: tailored strategies for organelle-specific imaging and biomedical applications

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Molecular fluorophore dimerization: a new paradigm for precision phototheranostics

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Polydopamine-based surface coating fabrication on titanium implant by combining a photothermal agent and TiO2 nanosheets for efficient photothermal antibacterial therapy and promoted osteogenic activity

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Recent advances of versatile fluorophores for multifunctional biomedical imaging in the NIR-II region

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Modifications and applications of heptamethine cyanine (Cy7) dyes as near-infrared photosensitizers

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Robust organic radical cations with near-unity absorption across solar spectrum

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Engineering near-infrared organic small molecules for photodynamic therapy

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Organic small-molecule NIR-II fluorophores for tumor phototheranostics

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A photoactivatable tumor‐targeting in situ nanovaccine for large‐volume tumor therapy

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Machine Learning‐Assisted Design and Discovery of High‐Performance Cyanine‐Based Photosensitizers for Integrated Theranostic Applications

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π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light

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BODIPY based nanomedicine for cancer imaging and phototherapy

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The controllable of BODIPY dimers without installing blocking groups as both fluorescence and singlet oxygen generators

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Engineering iridium(III) complexes for enhancing electron transfer-based photodynamic therapy

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Insight into the enhanced performance of the 1-phenylethyl segment in an aza-BODIPY system

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Zero-trigger ultrafast charge-transfer J-aggregates via Se/π-directed assembly enable synchronous ROS/heat amplification for NIR-II photoimmunotherapy

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Advances in the near-infrared Ⅱ for in vivo fluorescence imaging applications: A review

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Activatable Heavy-Atom-Free Photosensitizer with Large Stokes Shift and a NIR-II Emission Harnessing Rhodamine Ring-Opening Strategy

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Molecular Engineering of a Tumor‐Targeting Thione‐Derived Diketopyrrolopyrrole Photosensitizer to Attain NIR Excitation Over 850 nm for Efficient Dual Phototherapy

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Advances in hydrogels combined with photothermal/photodynamic therapy for bacterial infection

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Self-assembled metal-based photosensitizers for photodynamic therapy: Mechanisms, applications, and future perspectives

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Molecular Engineering of 2′, 7′‐Dichlorofluorescein to Unlock Efficient Superoxide Anion NIR‐II Fluorescent Imaging and Tumor Photothermal Therapy

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Protein‐Interference‐Free and Kidney‐Targeting NIR Fluorophores for Accurate in Vivo Imaging of H 2 S 2 during Kidney Ferroptosis

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From X‐ To J‐Aggregation: Subtly Managing Intermolecular Interactions for Superior Phototheranostics with Precise 1064 nm Excitation

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Tracking In Vivo Lipolysis of Lipid Nanocarriers Using NIR‐II Polarity‐Sensitive Fluorescent Probes

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Recent Advances for Synthesis and Bioapplications of Polymethine Cyanines

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Valence state engineering in multi-heteroatom-doped PAHs: a strategy for tunable photophysical properties and phototheranostic potentials

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Introducing of an Unexplored Aza-BODIPY Diradicaloids with 4-(2,6-Ditert-butyl)phenoxyl Radicals Located in 1,7-Positions of the Aza-BODIPY Core

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Recent Advances in NIR-II Molecular Aggregates and Applications in the Biomedical Field

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Rational Design of Organic NIR-II fluorophores for advanced Photothermal and photodynamic therapy

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Stereospecific alkenylation of carboranes: copper-catalyzed access to pyridylcarboranyl alkenes

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Protein-anchored near-infrared heptamethine cyanine photosensitizer with ultralong retention for phototherapy of large tumors

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NIR-II absorbing aza-BODIPY with the D-A-A’ framework for PTT/PDT co-therapy

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Designing next generation of photosensitizers: recent advances in NIR-II triggered organic photodynamic nanomedicines

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A near-infrared ratiometric fluorescent probe for ferroptosis related hydrogen polysulfides imaging in arthritis

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Timed photothermal therapy combining fluorescence-on chemotherapy maximizes tumor treatment

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Synthesis and solvatochromism of a NIR II emissive amphiphilic aza-BODIPY dye and its application as a colorimetric and fluorometric probe in sequential detection of Cu 2+ and PO 4 3−

Liu, M., Kuang, X., Su, J., Pan, H., Hao, M., & Chen, Z. (2025) · RSC Advances · doi:10.1039/d5ra06752a · Cited by 6

NIR-II organic fluorophores integrated with blood–brain barrier-penetrating strategies for brain disease theranostics

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NIR-II fluorescence imaging for diagnostics and therapy of non-cancer diseases

Sohail, M., Ahmad, H., Shah, I. A., Javed, M. U., Iqbal, M. S., Yan, Y., Wang, X., Wang, H., Afzal, A., & Guo, B. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.217751 · Cited by 6

Design strategies and recent advances in activatable small molecule therapeutics

Garcia, M. G., Ozcelik, A. B., Sahin, E., Girgin, F., Buyuktokatli, E., Karakaya, A., Efe, M. S., & Erbaş-Çakmak, S. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.217834 · Cited by 6

Functional Metal Complexes for Solar–Light‐Driven Energy Conversion

Qin, Y., Luo, D., Zhang, M., & Wong, W. (2026) · Advanced Materials · doi:10.1002/adma.202518393 · Cited by 6

A protein structure-dependent fluorescent probe for hemoglobin monitoring and controllable imaging in living cells

Yan, X.-T., Chang, K.-L., Huang, Z.-B., Xu, Y., Li, Z., Liu, W., & Wang, Q. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137868 · Cited by 6

Next-generation Nanomaterial-based phototherapeutic strategies for tumor: from NIR responsiveness to smart activation

Zhang, H., Tang, X., & Jiang, Z. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2532357 · Cited by 6

A near-infrared II fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor

Zhang, M., Jin, L., Zhu, Y., Kou, J., Liu, B., Chen, J., Zhong, X., Wu, X., Zhang, J., & Ren, W. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110772 · Cited by 5

Embedding oxygen heterocycles into BODIPY to enhance intersystem crossing for photodynamic therapy

Zhang, Y., Cui, Z., Širůček, J., Jacquemin, D., Guennic, B. L., Sun, X., Jiang, X., & Qin, G. W. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00427f · Cited by 5

Tetris-like acceptor engineering: evolution of NIR-II aggregation-induced emission luminogens for one-for-all phototheranostics of orthotopic breast cancer

You, C., Xiang, S., Zhu, J., Tian, Y., Wang, L., Tang, B. Z., & Wang, D. (2026) · Science China Chemistry · doi:10.1007/s11426-025-3257-5 · Cited by 5

Triple-Targeted Peptide–Photosensitizer–Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma

He, X., Liang, X., Yu, J., Rong, J., Hu, J., Xu, C., Cai, Z., Chen, J., Zhang, Y., Pu, X., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c01282 · Cited by 5

Harnessing the energy gap law for high NIR-II quantum yield at the molecular and aggregate levels

Qin, Y., Wang, D., & Tang, B. Z. (2026) · Materials Horizons · doi:10.1039/d6mh00129g · Cited by 7

Synergism of rotary motor and twisted framework in NIR absorbing aza-BODIPY for photothermal-photodynamic therapy

Zhang, Y., Fan, L., Du, C., Sun, C., Qin, G. W., Jiang, X., & Liu, H. (2025) · Materials Today Chemistry · doi:10.1016/j.mtchem.2025.102547 · Cited by 5

A versatile 980 nm excitable small molecule for short-wave infrared fluorescence imaging guided type-I photodynamic/photothermal therapy

Wang, Q., Tang, Y., Yang, G., Tao, Z., Li, S., Wang, R., Li, M., Geng, R., Hai, J., & Lu, F. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137807 · Cited by 5

Upconversion boosts visible-light-absorbing photothermal agent for 1064-nm-driven photothermal/NO therapy

Chen, X., Lyu, M., Liu, J., Li, C., Yang, M., Wang, J., Zhang, S., Sun, J., Kwok, R. T. K., Lam, J. W. Y., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100247 · Cited by 4

Multichromophoric Macrocycle Nanoparticles for Mitigating Cyanine Limit and Efficient Aqueous Photocatalysis via Sequential Energy Transfer

Gupta, V., & Sengupta, S. (2025) · Aggregate · doi:10.1002/agt2.70232 · Cited by 4

Photoactivatable in-cell synthesis of near infrared trimethine cyanines using benzo[cd]indolium derivatives for imaging mitochondria

Heng, H., Xu, P., Wang, Z., Ou, X., Chen, J., Chen, Y., Xia, Y., & Feng, F. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.112316 · Cited by 4

Multifunctional boron-dipyrromethene platforms for disease diagnosis and therapy: Advances in bioimaging, and phototherapeutics

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Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy

Liu, Y., Gou, S., Wang, H., Wu, Y., Yang, M., Li, X., Li, H., Zheng, Z., Yuan, Z., & Gao, J. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118081 · Cited by 4

Bright and stable dye-doped fluorescent polystyrene microspheres: quantitative lateral flow immunoassay for detecting serum amyloid A

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Water-Soluble NIR-II Photothermal Agent for Sprayable Skin Cancer Therapy

Zhao, L., Zhu, H., Ye, Q., Wang, Z., Pang, D., Ding, D., & Liu, S. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02623 · Cited by 4

Modern Cyanine Dye‐Based Photosensitizers for Medical Applications

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Switching between type I/II photosensitization processes for of an unconventional dye as modulated by the tumor microenvironment for inducing immunogenic death

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Dynamic Regulation of Radical Photochromism and Photoluminescence via Polymer Polarity

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