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Lysosome-related organelles: driving post-Golgi compartments into specialisation
Open accessAbstract
Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.
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“In the model proposed by Raposo et al. (47,48), the coated endosome (also referred to as a stage 1 melanosome) serves as a critical sorting point between endocytic and pre-melanosomal pathways, from which macromolecules are specifically directed into melanosomal or lysosomal pathways.”
From SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis (2008) · cites this paper as [48]
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Metadata
- Authors
- Raposo, G., Marks, M. S., & Cutler, D. F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Pennsylvania (US)
- MRC Laboratory for Molecular Cell Biology (GB)
- Corresponding author
- Raposo, Graça
- Cutler, Daniel F
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 19
- Issue
- 4
- Pages
- 394-401
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC2782641
- OpenAlex
- W2062800617
- Cited by
- 215
- References
- 59
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 14 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 20 · 2012: 16
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- National Institutes of Health (5r01ar048155-13)
- Medical Research Council
- National Eye Institute (R01EY015625)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR-048155)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosome-related organelles, late endosomes, lysosomes, post-Golgi trafficking, organelle biogenesis, organelle motility, lysosomal storage disease
- MeSH terms
- rab27 GTP-Binding Proteins, Animals, Cell Compartmentation, Golgi Apparatus, Humans, Lysosomes, Endosomes, Organelles, Melanosomes, rab GTP-Binding Proteins, Protein Sorting Signals
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