Cited by 215Cellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Lysosome-related organelles: driving post-Golgi compartments into specialisation

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Raposo, Graça, Marks, Michael S, Cutler, Daniel F·2007·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2007.05.001PMC PMC2782641

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Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

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Self-citation

Authors: Raposo, G., Marks, M. S., & Cutler, D. F.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Pennsylvania (US)
MRC Laboratory for Molecular Cell Biology (GB)
Corresponding author: Raposo, Graça
Cutler, Daniel F
ORCID: Raposo, Graça
Marks, Michael S
Cutler, Daniel F
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2007-08
Volume: 19
Issue: 4
Pages: 394-401
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/j.ceb.2007.05.001
PMC: PMC2782641
OpenAlex: W2062800617
Cited by: 215
References: 59
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 14 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 20 · 2012: 16
FWCI: 1.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Centre National de la Recherche Scientifique
National Institutes of Health (5r01ar048155-13)
Medical Research Council
National Eye Institute (R01EY015625)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR-048155)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosome-related organelles, late endosomes, lysosomes, post-Golgi trafficking, organelle biogenesis, organelle motility, lysosomal storage disease
MeSH terms: rab27 GTP-Binding Proteins, Animals, Cell Compartmentation, Golgi Apparatus, Humans, Lysosomes, Endosomes, Organelles, Melanosomes, rab GTP-Binding Proteins, Protein Sorting Signals

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Lysosome-related organelles: driving post-Golgi compartments into specialisation

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