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The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis
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The presence of ILVs within iridosomes supports an endosomal origin or an endosomal intermediate during iridosome formation and maturation.
“Because ILVs are a hallmark of multivesicular bodies and are commonly observed during the maturation of multiple LRO types, including melanosomes and cytotoxic granules (86–88), their presence within iridosomes supports an endosomal origin or an endosomal intermediate during iridosome formation and maturation.”
From Lysosome-related organelles orchestrate guanine crystal formation in pigment cells (2026) · cites this paper as [88]
The Introduction (page unavailable) describes ILVs in multivesicular endosomes and identifies ILV-containing stage I premelanosomes as endosomal intermediates, supporting the analogy with melanosomes. Our copy does not address cytotoxic granules or iridosomes; the proposed origin of iridosomes is the citing authors’ inference, not a finding of this source. (LLM, conf=0.85)
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Metadata
- Authors
- van Niel, G., Charrin, S., Simoes, S., Romao, M., Rochin, L., Saftig, P., Marks, M. S., Rubinstein, E., & Raposo, G.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 21
- Issue
- 4
- Pages
- 708-721
- ISSN
- 1534-5807
- PMC
- PMC3199340
- Cited by
- 950
- References
- 2
- Language
- en
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