Ciliary ectosomes: transmissions from the cell's antenna
Open accessAbstract
The cilium is the site of function for a variety of membrane receptors, enzymes and signal transduction modules crucial for a spectrum of cellular processes. Through targeted transport and selective gating mechanisms, the cell localizes specific proteins to the cilium that equip it for the role of sensory antenna. This capacity of the cilium to serve as a specialized compartment where specific proteins can be readily concentrated for sensory reception also makes it an ideal organelle to employ for the regulated emission of specific biological material and information. In this review we present and discuss an emerging body of evidence centered on ciliary ectosomes - bioactive vesicles released from the surface of the cilium.
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The mechanisms that control the balanced output of ciliary signaling described in this Review might also apply to other pathways such as Hippo and Notch signaling pathways or those regulated by receptors of extracellular matrix molecules, which also have been linked to primary cilia in various cell types and tissues.
“The mechanisms that control the balanced output of ciliary signalling described in this Review might also apply to other pathways such as Hippo and Notch signalling pathways or those regulated by receptors of extracellular matrix molecules, which also have been linked to primary cilia in various cell types and tissues 23, 291, 292.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [292]
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Cites
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works
Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,539 · see citing works
Regulation of immune responses by extracellular vesicles
Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260 · see citing works
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162 · see citing works
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, É., Pap, E., Kittel, Á., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0689-3 · Cited by 2,075 · see citing works
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057 · see citing works
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016 · see citing works
Shedding microvesicles: artefacts no more
Cocucci, E., Racchetti, G., & Meldolesi, J. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.003 · Cited by 1,742 · see citing works
Henne, W. M., Buchkovich, N. J., & Emr, S. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.05.015 · Cited by 1,505 · see citing works
Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423 · see citing works
Self-citationPKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
Mochizuki, T., Wu, G., Hayashi, T., Xenophontos, S. L., Veldhuisen, B., Saris, J. J., Reynolds, D. M., Cai, Y., Gabow, P. A., Pierides, A., et al. (1996) · Science · doi:10.1126/science.272.5266.1339 · Cited by 1,393 · see citing works
The renewal of photoreceptor cell outer segments
Young, R. W. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.33.1.61 · Cited by 1,184 · see citing works
Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147 · see citing works
Self-citationThe Ciliopathies: An Emerging Class of Human Genetic Disorders
Badano, J. L., Mitsuma, N., Beales, P. L., & Katsanis, N. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115610 · Cited by 1,144 · see citing works
The Chlamydomonas sourcebook: a comprehensive guide to biology and laboratory use
(1990) · Choice Reviews Online · doi:10.5860/choice.27-2713 · Cited by 1,075 · see citing works
A motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007 · see citing works
Self-citationHaubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004 · see citing works
Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000029587.47950.25 · Cited by 935 · see citing works
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
Redmond., T. M., Yu, S., Lee, E., Bok, D., Hamasaki, D., Chen, N., Goletz, P., Ma, J.-X., Crouch, R. K., & Pfeifer, K. (1998) · Nature Genetics · doi:10.1038/3813 · Cited by 929 · see citing works
Hughes, J. R., Ward, C. J., Peral, B., Aspinwall, R., Clark, K., Millán, J. L. S., Gamble, V., & Harris, P. C. (1995) · Nature Genetics · doi:10.1038/ng0695-151 · Cited by 896 · see citing works
Asymmetric Inheritance of Radial Glial Fibers by Cortical Neurons
Miyata, T., Kawaguchi, A., Okano, H., & Ogawa, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00420-2 · Cited by 892 · see citing works
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
Miyata, T., Kawaguchi, A., Saito, K., Kawano, M., Muto, T., & Ogawa, M. (2004) · Development · doi:10.1242/dev.01173 · Cited by 769 · see citing works
G Protein–Coupled Receptor Rhodopsin
Palczewski, K. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142743 · Cited by 764 · see citing works
Ward, C. J., Hogan, M. C., Rossetti, S., Walker, D. L., Sneddon, T. P., Wang, X., Kubly, V., Cunningham, J. M., Bacallao, R. L., Ishibashi, M., et al. (2002) · Nature Genetics · doi:10.1038/ng833 · Cited by 763 · see citing works
Gal, A., Li, Y., Thompson, D. A., Weir, J., Orth, U., Jacobson, S. G., Apfelstedt-Sylla, E., & Vollrath, D. (2000) · Nature Genetics · doi:10.1038/81555 · Cited by 679 · see citing works
Ciliopathies: an expanding disease spectrum
Waters, A. M., & Beales, P. L. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1731-7 · Cited by 676 · see citing works
THE BIOLOGICAL SIGNIFICANCE OF THE THROMBOPLASTIC PROTEIN OF BLOOD
Chargaff, E., & West, R. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34997-9 · Cited by 660 · see citing works
Weigmann, A., Corbeil, D., Hellwig, A., & Huttner, W. Β. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12425 · Cited by 601 · see citing works
Taraboletti, G., D’Ascenzo, S., Borsotti, P., Giavazzi, R., Pavan, A., & Dolo, V. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64887-0 · Cited by 588 · see citing works
Röper, K., Corbeil, D., & Huttner, W. Β. (2000) · Nature Cell Biology · doi:10.1038/35023524 · Cited by 555 · see citing works
Pazour, G. J., San Agustin, J. T., Follit, J. A., Rosenbaum, J. L., & Witman, G. B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00877-1 · Cited by 531 · see citing works
Self-citationOnuchic², L. F., Furu, L., Nagasawa, Y., Hou, X., Eggermann, T., Ren, Z., Bergmann, C., Senderek, J., Esquivel, E. L., Zeltner, R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/340448 · Cited by 505 · see citing works
Lee, T. H., D’Asti, E., Magnus, N., Al-Nedawi, K. N. I., Meehan, B., & Rak, J. W. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0250-3 · Cited by 496 · see citing works
Reiter, J. F., Blacque, O. E., & Leroux, M. R. (2012) · EMBO Reports · doi:10.1038/embor.2012.73 · Cited by 476 · see citing works
The vertebrate primary cilium is a sensory organelle
Pazour, G. J., & Witman, G. B. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00012-1 · Cited by 466 · see citing works
The Chlamydomonas sourcebook. A comprehensive guide to biology and laboratory use
Coleman, A. W. (1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90080-p · Cited by 447 · see citing works
Zhou, H., Pisitkun, T., Aponte, A. M., Yuen, P. S. T., Hoffert, J. D., Yasuda, H., Hu, X., Chawla, L. S., Shen, R., Knepper, M. A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001874 · Cited by 446 · see citing works
Kosodo, Y., Röper, K., Haubensak, W. E., Marzesco, A., Corbeil, D., & Huttner, W. Β. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600223 · Cited by 435 · see citing works
Marzesco, A., Janich, P., Wilsch‐Bräuninger, M., Dubreuil, V., Langenfeld, K., Corbeil, D., & Huttner, W. Β. (2005) · Journal of Cell Science · doi:10.1242/jcs.02439 · Cited by 433 · see citing works
Phagocytosis of Retinal Rod and Cone Photoreceptors
Kevany, B. M., & Palczewski, K. (2010) · Physiology · doi:10.1152/physiol.00038.2009 · Cited by 426 · see citing works
CIS-TRANS ISOMERS OF VITAMIN A AND RETINENE IN THE RHODOPSIN SYSTEM
Hubbard, R., & Wald, G. (1952) · Journal of General Physiology · doi:10.1085/jgp.36.2.269 · Cited by 422 · see citing works
THE RENEWAL OF PROTEIN IN RETINAL RODS AND CONES
Young, R. W., & Droz, B. (1968) · Journal of Cell Biology · doi:10.1083/jcb.39.1.169 · Cited by 401 · see citing works
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
Martı́, E., Takada, R., Bumcrot, D. A., Sasaki, H., & McMahon, A. P. (1995) · Development · doi:10.1242/dev.121.8.2537 · Cited by 383 · see citing works
THE RENEWAL OF ROD AND CONE OUTER SEGMENTS IN THE RHESUS MONKEY
Young, R. W. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.2.303 · Cited by 375 · see citing works
Characterization of PKD Protein-Positive Exosome-Like Vesicles
Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008060564 · Cited by 329 · see citing works
Intraflagellar transport and cilia-dependent diseases
Pazour, G. J., & Rosenbaum, J. L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02410-8 · Cited by 294 · see citing works
Self-citationDubreuil, V., Marzesco, A., Corbeil, D., Huttner, W. Β., & Wilsch‐Bräuninger, M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608137 · Cited by 292 · see citing works
The renal cell primary cilium functions as a flow sensor
Prætorius, H. A., & Spring, K. R. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200309000-00006 · Cited by 280 · see citing works
PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS
Young, R. W., & Bok, D. (1969) · Journal of Cell Biology · doi:10.1083/jcb.42.2.392 · Cited by 271 · see citing works
Sonic hedgehog in CNS development: one signal, multiple outputs
Martı́, E. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02062-3 · Cited by 260 · see citing works
Sensory Cilia and Integration of Signal Transduction in Human Health and Disease
Christensen, S. T., Pedersen, L. B., Schneider, L. H., & Satir, P. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00516.x · Cited by 256 · see citing works
Functions and Therapeutic Roles of Exosomes in Cancer
Tickner, J., Urquhart, A., Stephenson, S., Richard, D., & O'Byrne, K. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00127 · Cited by 250 · see citing works
Gibbs, D., Kitamoto, J., & Williams, D. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1130432100 · Cited by 250 · see citing works
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
Stoeck, A., Keller, S., Riedle, S., Sanderson, M. P., Runz, S., Naour, F. L., Gutwein, P., Ludwig, A., Rubinstein, E., & Altevogt, P. (2006) · Biochemical Journal · doi:10.1042/bj20051013 · Cited by 246 · see citing works
Biochemistry of visual pigment regeneration: the Friedenwald lecture.
Saari, J. C. (2000) · PubMed · Cited by 243 · see citing works
ESCRT-III protein requirements for HIV-1 budding
Morita, E., Sandrin, V., McCullough, J., Katsuyama, A., Baci Hamilton, I., & Sundquist, W. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.02.004 · Cited by 242 · see citing works
Membrane Fission Reactions of the Mammalian ESCRT Pathway
McCullough, J., Colf, L. A., & Sundquist, W. I. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072909-101058 · Cited by 238 · see citing works
Chapter 13 Ciliary Dysfunction in Developmental Abnormalities and Diseases
Sharma, N., Berbari, N. F., & Yoder, B. K. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00813-2 · Cited by 234 · see citing works
The Cilium Secretes Bioactive Ectosomes
Wood, C. R., Huang, K., Diener, D. R., & Rosenbaum, J. L. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.019 · Cited by 233 · see citing works
Self-citationHinds, J. W., & Ruffett, T. L. (1971) · Cell and Tissue Research · doi:10.1007/bf00391127 · Cited by 231 · see citing works
Wang, J., Silva, M., Haas, L. A., Morsci, N. S., Nguyen, K. C. Q., Hall, D. H., & Barr, M. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.002 · Cited by 226 · see citing works
Defective ingestion of rod outer segments by cultured dystrophic rat pigment epithelial cells.
Chaitin, M. H., & Hall, M. O. (1983) · PubMed · Cited by 215 · see citing works
The sensory cilia of Caenorhabditis elegans_Revised
Scholey, J. M. (2007) · WormBook · doi:10.1895/wormbook.1.126.2 · Cited by 209 · see citing works
A photic visual cycle of rhodopsin regeneration is dependent on Rgr
Chen, P., Hao, W., Rife, L. L., Wang, X. P., Shen, D., Chen, J., Ogden, T. E., Boemel, G. B. V., Wu, L., Yang, M., et al. (2001) · Nature Genetics · doi:10.1038/90089 · Cited by 208 · see citing works
Tsybovsky, Y., Molday, R. S., & Palczewski, K. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-5635-4_8 · Cited by 200 · see citing works
Cleavage of L1 in Exosomes and Apoptotic Membrane Vesicles Released from Ovarian Carcinoma Cells
Gutwein, P., Stoeck, A., Riedle, S., Gast, D., Runz, S., Condon, T. P., Marmé, A., Phong, M.-C., Linderkamp, O., Skorokhod, A., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1688 · Cited by 198 · see citing works
Doroquez, D. B., Berciu, C., Anderson, J. R., Sengupta, P., & Nicastro, D. (2014) · eLife · doi:10.7554/elife.01948 · Cited by 196 · see citing works
Wang, S., Zhang, J., Nauli, S. M., Li, X., Starremans, P. G. J. F., Luo, Y., Roberts, K. A., & Zhou, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00072-07 · Cited by 188 · see citing works
The roles of evolutionarily conserved functional modules in cilia-related trafficking
Sung, C.-H., & Leroux, M. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2888 · Cited by 186 · see citing works
The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos
Wehman, A. M., Poggioli, C., Schweinsberg, P. J., Grant, B. D., & Nance, J. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.040 · Cited by 185 · see citing works
Ginestra, A., Monea, S., Seghezzi, G., Dolo, V., Nagase, H., Mignatti, P., & Vittorelli, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17216 · Cited by 173 · see citing works
Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles
Giusti, I., D’Ascenzo, S., Millimaggi, D., Taraboletti, G., Carta, G., Franceschini, N., Pavan, A., & Dolo, V. (2008) · Neoplasia · doi:10.1593/neo.08178 · Cited by 170 · see citing works
Bridges, C. D. B. (1976) · Experimental Eye Research · doi:10.1016/0014-4835(76)90182-2 · Cited by 165 · see citing works
Membranes as the Energy Source in the Endergonic Transformation of Vitamin A to 11- cis -Retinol
Deigner, P. S., Law, W. C., Cañada, F. J., & Rando, R. R. (1989) · Science · doi:10.1126/science.2727688 · Cited by 162 · see citing works
Mechanics of Dynamin-Mediated Membrane Fission
Morlot, S., & Roux, A. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-050511-102247 · Cited by 157 · see citing works
Ectosomes as modulators of inflammation and immunity
Sadallah, S., Eken, C., & Schifferli, J. A. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04271.x · Cited by 152 · see citing works
The sensory cilia of Caenorhabditis elegans
Inglis, P. N. (2006) · WormBook · doi:10.1895/wormbook.1.126.1 · Cited by 151 · see citing works
Molecular complexes that direct rhodopsin transport to primary cilia
Wang, J., & Deretic, D. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.08.004 · Cited by 146 · see citing works
Chapter 5 Targeting Proteins to the Ciliary Membrane
Pazour, G. J., & Bloodgood, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00805-3 · Cited by 145 · see citing works
Sex determination in Chlamydomonas
Goodenough, U. W., Lin, H., & Lee, J. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.02.006 · Cited by 144 · see citing works
Bišová, K., Krylov, D. M., & Umen, J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.054155 · Cited by 140 · see citing works
Dolo, V., Ginestra, A., Cassarà, D., Violini, S., Lucania, G., Torrisi, M. R., Nagase, H., Canevari, S., Pavan, A., & Vittorelli, M. L. (1998) · PubMed · Cited by 139 · see citing works
Barr, M. M. (2006) · WormBook · doi:10.1895/wormbook.1.78.1 · Cited by 131 · see citing works
Molecular mechanisms of protein and lipid targeting to ciliary membranes
Emmer, B. T., Maric, D., & Engman, D. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.062968 · Cited by 125 · see citing works
The distribution and proportions of vitamin A compounds during the visual cycle in the rat
Zimmerman, W. F. (1974) · Vision Research · doi:10.1016/0042-6989(74)90143-6 · Cited by 125 · see citing works
Goodenough, U. W., & StClair, H. S. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.3.480 · Cited by 125 · see citing works
Bergman, K., Goodenough, U. W., Goodenough, D. A., Jawitz, J., & Martin, H. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.67.3.606 · Cited by 122 · see citing works
Shroyer, N. F., Lewis, R. A., Allikmets, R. L., Singh, N., Dean, M. C., Leppert, M., & Lupski, J. R. (1999) · Vision Research · doi:10.1016/s0042-6989(99)00037-1 · Cited by 121 · see citing works
The extracellular matrix and ciliary signaling
Seeger-Nukpezah, T., & Golemis, E. A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.06.002 · Cited by 117 · see citing works
Cell wall glycoproteins: structure and function
Roberts, K., Grief, C., Hills, G. J., & Shaw, P. (1985) · Journal of Cell Science · doi:10.1242/jcs.1985.supplement_2.6 · Cited by 116 · see citing works
Snell, W. J. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.68.1.48 · Cited by 114 · see citing works
The role of extracellular vesicles in the progression of neurodegenerative disease and cancer
Candelario, K. M., & Steindler, D. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.04.003 · Cited by 112 · see citing works
Animal Models of Retinal Disease
Fletcher, E. L., Jobling, A. I., Vessey, K. A., Luu, C. D., Guymer, R. H., & Baird, P. N. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00006-6 · Cited by 109 · see citing works
Kinoshita, T., Fukuzawa, H., Shimada, T., Saito, T., & Matsuda, Y. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4693 · Cited by 107 · see citing works
Autolyse der zellwand bei den gameten von Chlamydomonas reinhardii
Claes, H. (1971) · Archives of Microbiology · doi:10.1007/bf00424874 · Cited by 99 · see citing works
McBee, J. K., Kuksa, V., Alvarez, R., de Lera, A. R., Prezhdo, O., Haeseleer, F., Sokal, I., & Palczewski, K. (2000) · Biochemistry · doi:10.1021/bi001061c · Cited by 95 · see citing works
Quarmby, L. M. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)33002-0 · Cited by 93 · see citing works
Rat Prominin, Like Its Mouse and Human Orthologues, Is a Pentaspan Membrane Glycoprotein
Corbeil, D., Fargeas, C. A., & Huttner, W. Β. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5271 · Cited by 85 · see citing works
Matsuda, Y., Saito, T., Yamaguchi, T., & Kawase, H. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88982-7 · Cited by 75 · see citing works
Biochemistry of the Extracellular Matrix of Volvox
Sumper, M., & Hallmann, A. (1998) · International review of cytology · doi:10.1016/s0074-7696(08)61770-2 · Cited by 75 · see citing works
Epitope-Tagged Pkhd1 Tracks the Processing, Secretion, and Localization of Fibrocystin
Bakeberg, J. L., Tammachote, R., Woollard, J. R., Hogan, M. C., Tuan, H.-F., Li, M., van Deursen, J. M., Wu, Y., Huang, B. Q., Torres, V. E., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111173 · Cited by 75 · see citing works
Sensory roles of neuronal cilia: Cilia development, morphogenesis, and function in C. elegans
Bae, Y. (2008) · Frontiers in bioscience · doi:10.2741/3129 · Cited by 72 · see citing works
Goodwin, P. L. (2008) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e3282fc27fc · Cited by 69 · see citing works
The When and Where of Floor Plate Induction
Dodd, J., Jessell, T. M., & Placzek, M. (1998) · Science · doi:10.1126/science.282.5394.1654 · Cited by 66 · see citing works
Cai, Z., Feng, G., & Zhang, X. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4364-09.2010 · Cited by 63 · see citing works
Kubo, T., Kaida, S., Abe, J., Saito, T., Fukuzawa, H., & Matsuda, Y. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp016 · Cited by 62 · see citing works
Compartments within a compartment
Blacque, O. E., & Sanders, A. A. W. M. (2014) · Organogenesis · doi:10.4161/org.28830 · Cited by 61 · see citing works
The Relationship of Gamone to the Mating Reaction in Chlamydomonas moewusii
McLean, R. J. C., Laurendi, C. J., & Brown, R. M. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.7.2610 · Cited by 60 · see citing works
MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer
Chen, W., Zhong, S., Ji, M., Pan, M., Hu, Q., Lv, M., Zhou, L., Zhao, J., & Tang, J. (2013) · Tumor Biology · doi:10.1007/s13277-013-1417-4 · Cited by 55 · see citing works
Flagellum assembly and function during the Leishmania life cycle
Gluenz, E., Ginger, M. L., & McKean, P. G. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.008 · Cited by 53 · see citing works
Proteins of the Ciliary Axoneme Are Found on Cytoplasmic Membrane Vesicles during Growth of Cilia
Wood, C. R., & Rosenbaum, J. L. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.047 · Cited by 48 · see citing works
Self-citationSherlekar, A. L., Janssen, A., Siehr, M. S., Koo, P. K., Caflisch, L., Boggess, M., & Lints, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060597 · Cited by 46 · see citing works
The role of calcium in the Chlamydomonas reinhardtii mating reaction.
Goodenough, U. W., Shames, B. D., Small, L., Saito, T., Crain, R. C., Sanders, M. A., & Salisbury, J. L. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.365 · Cited by 45 · see citing works
PHYSIOLOGICAL AND BIOCHEMICAL ASPECTS OF GROWTH AND GAMETOGENESIS IN CHLAMYDOMONAS REINHARDTII*
Jones, R. F. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb45182.x · Cited by 44 · see citing works
A Role for the Membrane in Regulating Chlamydomonas Flagellar Length
Dentler, W. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053366 · Cited by 42 · see citing works
Jouvenet, N. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1035-0 · Cited by 38 · see citing works
Ott, C. M., Elia, N., Jeong, S. Y., Insinna, C., Sengupta, P., & Lippincott‐Schwartz, J. (2012) · Cilia · doi:10.1186/2046-2530-1-3 · Cited by 35 · see citing works
Matsuda, Y., Koseki, M., Shimada, T., & Saito, T. (1995) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078809 · Cited by 31 · see citing works
Cohen, E., Binet, S., & Meininger, V. (1988) · PubMed · Cited by 29 · see citing works
An Ocular Study of Pulseless Disease
DOWLING, J. L., & Smith, T. (1960) · Archives of Ophthalmology · doi:10.1001/archopht.1960.01840010238009 · Cited by 28 · see citing works
Cohen, E., Binet, S., & Meininger, V. (1988) · Biology of the Cell · doi:10.1111/j.1768-322x.1988.tb00718.x · Cited by 24 · see citing works
Protein Transport and Signal Transduction During Fertilization in Chlamydomonas
Pan, J., Misamore, M. J., Wang, Q., & Snell, W. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00105.x · Cited by 21 · see citing works
Goodenough, U. W., & Heuser, J. E. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3540756.x · Cited by 19 · see citing works
Cell-cell adhesion in conjugatingChlamydomonas gametes: a self-enhancing process
Demets, R., Tomson, A. M., Homan, W. L., Stegwee, D., & ENDE, H. V. D. (1988) · PROTOPLASMA · doi:10.1007/bf01323253 · Cited by 18 · see citing works
Schlösser, U. G. (1981) · Berichte der Deutschen Botanischen Gesellschaft · doi:10.1111/j.1438-8677.1981.tb03412.x · Cited by 10 · see citing works
Flagged first, then by citations
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Extracellular Vesicles: Unique Intercellular Delivery Vehicles
Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,419 · see citing works
Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845 · see citing works
Bergmann, C., Guay‐Woodford, L. M., Harris, P. C., Horie, S., Peters, D. J. M., & Torres, V. E. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0047-y · Cited by 835 · see citing works
Establishing and regulating the composition of cilia for signal transduction
Nachury, M. V., & Mick, D. U. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0116-4 · Cited by 397 · see citing works
An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling
Nager, A. R., Goldstein, J. S., Herranz-Pérez, V., Portran, D., Ye, F., Garcia-Verdugo, J. M., & Nachury, M. V. (2017) · Cell · doi:10.1016/j.cell.2016.11.036 · Cited by 366 · see citing works
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision
Phua, S. C., Chiba, S., Suzuki, M., Su, E., Roberson, E. C., Pusapati, G. V., Setou, M., Rohatgi, R., Reiter, J. F., Ikegami, K., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.032 · Cited by 339 · see citing works
Stem Cell Extracellular Vesicles: Extended Messages of Regeneration
Riazifar, M., Pone, E. J., Lötvall, J. O., & Zhao, W. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061616-030146 · Cited by 326 · see citing works
Ultra-High Resolution 3D Imaging of Whole Cells
Huang, F., Sirinakis, G., Allgeyer, E. S., Schroeder, L. K., Duim, W. C., Kromann, E. B., Phan, T., Rivera-Molina, F. E., Myers, J. R., Irnov, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.016 · Cited by 303 · see citing works
Szempruch, A. J., Sykes, S. E., Kieft, R., Dennison, L., Becker, A. C., Gartrell, A., Martin, W. J., Nakayasu, E. S., de Almeida, I. C., Hajduk, S. L., et al. (2016) · Cell · doi:10.1016/j.cell.2015.11.051 · Cited by 276 · see citing works
Cilia - The sensory antennae in the eye
May‐Simera, H., Nagel‐Wolfrum, K., & Uwe Wolfrum, B. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.05.001 · Cited by 159 · see citing works
Three-dimensional architecture of epithelial primary cilia
Sun, S., Fisher, R. L., Bowser, S. S., Pentecost, B. T., & Sui, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821064116 · Cited by 142 · see citing works
Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release
Salinas, R. Y., Pearring, J. N., Ding, J., Spencer, W. J., Hao, Y., & Arshavsky, V. Y. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201608081 · Cited by 129 · see citing works
Thakur, A., Ke, X., Chen, Y., Motallebnejad, P., Zhang, K., Lian, Q., & Chen, H. J. (2021) · Protein & Cell · doi:10.1007/s13238-021-00863-6 · Cited by 132 · see citing works
Sending a message: extracellular vesicles of pathogenic protozoan parasites
Szempruch, A. J., Dennison, L., Kieft, R., Harrington, J. M., & Hajduk, S. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.110 · Cited by 129 · see citing works
Matsumura, S., Minamisawa, T., Suga, K., Kishita, H., Akagi, T., Ichiki, T., Ichikawa, Y., & Shiba, K. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1579541 · Cited by 100 · see citing works
Beer, K. B., & Wehman, A. M. (2016) · Cell Adhesion & Migration · doi:10.1080/19336918.2016.1236899 · Cited by 101 · see citing works
Mechanism of ciliary disassembly
Liang, Y., Meng, D., Zhu, B., & Pan, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2148-7 · Cited by 99 · see citing works
Comparative Analysis of Ciliary Membranes and Ectosomes
Long, H., Zhang, F., Xu, N., Gai, L., Diener, D. R., Rosenbaum, J. L., & Huang, K. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.055 · Cited by 96 · see citing works
Self-citationWang, J., Kaletsky, R. L., Silva, M., Williams, A. E., Haas, L. A., Androwski, R. J., Landis, J. N., Patrick, C. T., Rashid, A., Santiago-Martinez, D., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.057 · Cited by 89 · see citing works
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding
Mirvis, M., Siemers, K. A., Nelson, W. J., & Stearns, T. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000381 · Cited by 95 · see citing works
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss
Collin, G. B., Gogna, N., Chang, B., Damkham, N., Pinkney, J., Hyde, L. F., Stone, L. V., Naggert, J. Κ., Nishina, P. M., & Krebs, M. P. (2020) · Cells · doi:10.3390/cells9040931 · Cited by 94 · see citing works
Picciotto, S., Barone, M. E., Fierli, D., Aranyos, A., Adamo, G., Božič, D., Romancino, D. P., Stanly, C., Parkes, R., Morsbach, S., et al. (2021) · Biomaterials Science · doi:10.1039/d0bm01696a · Cited by 92 · see citing works
Ciliogenesis membrane dynamics and organization
Zhao, H., Khan, Z., & Westlake, C. J. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.021 · Cited by 89 · see citing works
Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior
Barr, M. M., Garcia, L. R., & Portman, D. (2018) · Genetics · doi:10.1534/genetics.117.300294 · Cited by 81 · see citing works
Satir, P. (2017) · Cilia · doi:10.1186/s13630-017-0046-8 · Cited by 80 · see citing works
A change of heart: new roles for cilia in cardiac development and disease
Djenoune, L., Berg, K., Brueckner, M. K., & Yuan, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00635-z · Cited by 79 · see citing works
The regulation of cortical neurogenesis
Villalba, A., Götz, M., & Borrell, V. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.10.003 · Cited by 74 · see citing works
Routes and machinery of primary cilium biogenesis
Bernabé‐Rubio, M., & Alonso, M. A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2570-5 · Cited by 72 · see citing works
Neocortex expansion in development and evolution — from cell biology to single genes
Wilsch‐Bräuninger, M., Florio, M., & Huttner, W. Β. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.05.004 · Cited by 73 · see citing works
Ciliary Extracellular Vesicles: Txt Msg Organelles
Wang, J., & Barr, M. M. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0345-4 · Cited by 71 · see citing works
Trafficking to the primary cilium membrane
Mukhopadhyay, S., Badgandi, H., Hwang, S., Somatilaka, B. N., Shimada, I. S., & Pal, K. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0505 · Cited by 71 · see citing works
Dynein and intraflagellar transport
Hou, Y., & Witman, G. B. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.017 · Cited by 70 · see citing works
Wang, J., Nikonorova, I. A., Silva, M., Walsh, J. D., Tilton, P. E., Gu, A., Akella, J. S., & Barr, M. M. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.040 · Cited by 72 · see citing works
Sensing of tubular flow and renal electrolyte transport
Verschuren, E. H. J., Castenmiller, C., Peters, D. J. M., Arjona, F. J., Bindels, R. J. M., & Hoenderop, J. G. J. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0259-8 · Cited by 67 · see citing works
Cell–cell communication via ciliary extracellular vesicles: clues from model systems
Wang, J., & Barr, M. M. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170085 · Cited by 63 · see citing works
Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis
Maguire, J. E., Silva, M., Nguyen, K. C. Q., Hellen, E., Kern, A. D., Hall, D. H., & Barr, M. M. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-01-0009 · Cited by 62 · see citing works
Ballesteros, Á., & Swartz, K. J. (2022) · Science Advances · doi:10.1126/sciadv.abm5550 · Cited by 63 · see citing works
Emerging mechanisms of dynein transport in the cytoplasm versus the cilium
Roberts, A. J. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170568 · Cited by 62 · see citing works
Ott, C. M., Torres, R., Kuan, T. S., Kuan, A. T., Buchanan, J., Elabbady, L., Seshamani, S., Bodor, Á. L., Collman, F., Bock, D. D., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.04.043 · Cited by 56 · see citing works
Ferraz, L. C., Pereira, P., & Ferreira, J. V. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501349 · Cited by 54 · see citing works
Cruz, L., Romero, J. A. A., Iglesia, R. P., & Lopes, M. H. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00094 · Cited by 50 · see citing works
Cilia-based peptidergic signaling
Luxmi, R., Kumar, D., Mains, R. E., King, S. M., & Eipper, B. A. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000566 · Cited by 49 · see citing works
Getting Nervous: An Evolutionary Overhaul for Communication
Varoqueaux, F., & Fasshauer, D. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024648 · Cited by 47 · see citing works
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49 · see citing works
Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding
Wang, L., Wen, X., Wang, Z., Lin, Z., Li, C., Zhou, H., Yu, H. M., Li, Y., Cheng, Y., Chen, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31751-0 · Cited by 48 · see citing works
Sreekumar, V., & Norris, D. P. (2019) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2019.05.002 · Cited by 49 · see citing works
Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons
Razzauti, A., & Laurent, P. (2021) · eLife · doi:10.7554/elife.67670 · Cited by 46 · see citing works
PIP2 determines length and stability of primary cilia by balancing membrane turnovers
Stilling, S., Καλλιακούδας, Θ., Benninghoven-Frey, H. L., Inoue, T., & Falkenburger, B. H. (2022) · Communications Biology · doi:10.1038/s42003-022-03028-1 · Cited by 47 · see citing works
Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
Volz, A., Frei, A., Kretschmer, V., Domingues, A. M. D. J., Ketting, R. F., Ueffing, M., Boldt, K., Krämer‐Albers, E., & May‐Simera, H. (2021) · Nature Communications · doi:10.1038/s41467-021-25929-1 · Cited by 45 · see citing works
Physiologic mechanisms underlying polycystic kidney disease
Boletta, A., & Caplan, M. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00018.2024 · Cited by 47 · see citing works
Petralia, R. S., Wang, Y., Mattson, M. P., & Yao, P. J. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8358-6 · Cited by 41 · see citing works
Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
Zhang, K., Da Silva, F., Seidl, C., Wilsch-Bräuninger, M., Herbst, J., Huttner, W. B., & Niehrs, C. (2023) · Developmental Cell · doi:10.1016/j.devcel.2022.12.006 · Cited by 44 · see citing works
Nodal flow transfers polycystin to determine mouse left-right asymmetry
Tanaka, Y., Morozumi, A., & Hirokawa, N. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.06.002 · Cited by 44 · see citing works
Advances in exosomes utilization for clinical applications in cancer
Batista, I. A., Machado, J. C., & Melo, S. A. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.07.010 · Cited by 44 · see citing works
Neuron's little helper: The role of primary cilia in neurogenesis
Lepanto, P., Badano, J. L., & Zolessi, F. R. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1253363 · Cited by 44 · see citing works
Primary cilia: Versatile regulator in cartilage development
Tao, F., Jiang, T., Tao, H., Cao, H., & Xiang, W. (2020) · Cell Proliferation · doi:10.1111/cpr.12765 · Cited by 44 · see citing works
HAP2-Mediated Gamete Fusion: Lessons From the World of Unicellular Eukaryotes
Pinello, J. F., & Clark, T. G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.807313 · Cited by 42 · see citing works
Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies
Karalis, V., Donovan, K. E., & Şahin, M. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10040054 · Cited by 39 · see citing works
Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella
Lv, B., Wan, L., Taschner, M., Cheng, X., Lorentzen, E., & Huang, K. (2017) · Journal of Cell Science · doi:10.1242/jcs.200758 · Cited by 41 · see citing works
Scheidel, N., Kennedy, J., & Blacque, O. E. (2018) · The EMBO Journal · doi:10.15252/embj.201798248 · Cited by 38 · see citing works
Ritter, A., Louwen, F., & Yuan, J. (2018) · Obesity Reviews · doi:10.1111/obr.12716 · Cited by 39 · see citing works
Shedding of ciliary vesicles at a glance
Naharros, I. O., & Nachury, M. V. (2022) · Journal of Cell Science · doi:10.1242/jcs.246553 · Cited by 37 · see citing works
Membrane association and remodeling by intraflagellar transport protein IFT172
Wang, Q., Taschner, M. J., Ganzinger, K. A., Kelley, C. F., Villasenor, A., Heymann, M., Schwille, P., Lorentzen, E., & Mizuno, N. (2018) · Nature Communications · doi:10.1038/s41467-018-07037-9 · Cited by 37 · see citing works
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles
Hoang-Minh, L., Dutra‐Clarke, M., Breunig, J. J., & Sarkisian, M. R. (2018) · Cilia · doi:10.1186/s13630-018-0060-5 · Cited by 37 · see citing works
Taschner, M. J., Lorentzen, A., Mourão, A., Collins, T., Freke, G., MOULDING, D. A., Basquin, J., Jenkins, D., & Lorentzen, E. (2018) · eLife · doi:10.7554/elife.33067 · Cited by 35 · see citing works
Cilia-derived vesicles: An ancient route for intercellular communication
Luxmi, R., & King, S. M. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.014 · Cited by 36 · see citing works
Role of the polycystins as mechanosensors of extracellular stiffness
Nigro, E. A., & Boletta, A. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00545.2020 · Cited by 34 · see citing works
Teasing out function from morphology: Similarities between primary cilia and immune synapses
Douanne, T., Stinchcombe, J. C., & Griffiths, G. M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202102089 · Cited by 31 · see citing works
Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons
Ott, C. M., Constable, S., Nguyen, T., White, K., Lee, W.-C. A., Lippincott‐Schwartz, J., & Mukhopadhyay, S. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202404038 · Cited by 31 · see citing works
Unconventional Protein Secretion in Animal Cells
Ng, F., & Tang, B. L. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3804-9_2 · Cited by 31 · see citing works
Thorpe, S. D., Gambassi, S., Thompson, C. L., Chandrakumar, C., Santucci, A., & Knight, M. M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25839 · Cited by 30 · see citing works
T Cell Microvilli: Sensors or Senders?
Kim, H.-R., & Jun, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01753 · Cited by 26 · see citing works
Primary Cilia in Cystic Kidney Disease
Avasthi, P. P., Maser, R. L., & Tran, P. V. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-51436-9_11 · Cited by 28 · see citing works
Emerging Roles of Primary Cilia in Glioma
Sarkisian, M. R., & Semple‐Rowland, S. L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00055 · Cited by 27 · see citing works
Shin, T. W., Wang, H., Zhang, C., An, B., Lu, Y., Zhang, E., Lu, X., Karagiannis, E. D., Kang, J. S., Emenari, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56641-z · Cited by 26 · see citing works
Model Organisms in G Protein–Coupled Receptor Research
Langenhan, T., Barr, M. M., Bruchas, M. R., Ewer, J., Griffith, L. C., Maiellaro, I., Taghert, P. H., White, B. H., & Monk, K. R. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098764 · Cited by 25 · see citing works
Primary Cilia–An Underexplored Topic in Major Mental Illness
Pruski, M., & Lang, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00104 · Cited by 24 · see citing works
CIL:50351, Mus musculus, Spinal cord neuron
Zhang, H., Cao, X., Tang, M., Zhong, G., Si, Y., Li, H., 朱飞凤, Liao, Q., Li, L., Zhao, J., et al. (2010) · UC San Diego · doi:10.6075/j0r20zxn · Cited by 25 · see citing works
Igami, K., Uchiumi, T., Ueda, S., Kamioka, K., Setoyama, D., Gotoh, K., Akimoto, M., Matsumoto, S., & Kang, D. (2020) · PeerJ Analytical Chemistry · doi:10.7717/peerj-achem.4 · Cited by 23 · see citing works
Finetti, F., Cassioli, C., & Baldari, C. T. (2017) · F1000Research · doi:10.12688/f1000research.11944.1 · Cited by 22 · see citing works
Composition, structure and function of the eukaryotic flagellum distal tip
Croft, J. T., Zabeo, D., Subramanian, R., & Höög, J. L. (2018) · Essays in Biochemistry · doi:10.1042/ebc20180032 · Cited by 23 · see citing works
The uptake of extracellular vesicles: Research progress in cancer drug resistance and beyond
Qian, L., Chen, P., Zhang, S., Wang, Z., Guo, Y., Koutouratsas, V., Fleishman, J. S., Huang, C., & Zhang, S. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101209 · Cited by 20 · see citing works
EV duty vehicles: Features and functions of ciliary extracellular vesicles
Vinay, L., & Belleannée, C. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.916233 · Cited by 20 · see citing works
Tang, B. L. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0018 · Cited by 19 · see citing works
Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis
Molday, R. S., & Goldberg, A. F. X. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201703020 · Cited by 18 · see citing works
Transient accumulation and bidirectional movement of KIF13B in primary cilia
Juhl, A. D., Anvarian, Z., Kuhns, S., Berges, J., Andersen, J., Wüstner, D., & Pedersen, L. B. (2022) · Journal of Cell Science · doi:10.1242/jcs.259257 · Cited by 15 · see citing works
Patterns of Ciliation and Ciliary Signaling in Cancer
Kiseleva, A. A., Nikonova, A. S., & Golemis, E. A. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_36 · Cited by 17 · see citing works
Constable, S., Ott, C. M., Lemire, A. L., White, K., Xun, Y., Lim, A., Lippincott‐Schwartz, J., & Mukhopadhyay, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2408083121 · Cited by 16 · see citing works
Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential
Toriyama, M., & Ishii, K. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.621318 · Cited by 15 · see citing works
Taking a closer look at matrix vesicle biogenesis
Clews, C., Dillon, S., Nudelman, F., Farquharson, C., & Stephen, L. A. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf076 · Cited by 15 · see citing works
Hedgehog pathway, cell cycle, and primary cilium
Zhuang, T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02605-7 · Cited by 17 · see citing works
Extracellular vesicles in the retina - putative roles in physiology and disease
Kalargyrou, A. A., Guilfoyle, S. E., Smith, A. J., Ali, R. R., & Pearson, R. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1042469 · Cited by 17 · see citing works
Rediscovering Primary Cilia in Pancreatic Islets
Lee, E. Y., & Hughes, J. W. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0442 · Cited by 17 · see citing works
Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides
Phua, S. C., Nihongaki, Y., & Inoue, T. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.01.008 · Cited by 16 · see citing works
Extracellular Vesicles and Membrane Protrusions in Developmental Signaling
Gustafson, C. M., & Gammill, L. S. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10040039 · Cited by 15 · see citing works
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells
Kim, H.-R., Park, J.-S., Soh, W.-C., Kim, N.-Y., Moon, H.-Y., Lee, J., & Jun, C. (2023) · Immune Network · doi:10.4110/in.2023.23.e3 · Cited by 13 · see citing works
Self-limiting stem-cell niche signaling through degradation of a stem-cell receptor
Ladyzhets, S., Antel, M., Simao, T., Gasek, N. S., Cowan, A. E., & Inaba, M. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3001003 · Cited by 12 · see citing works
Advancements in extracellular vesicle therapy for neurodegenerative diseases
Hu, N., Chen, L., Hu, G., & Ma, R. (2025) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2025.1004104 · Cited by 11 · see citing works
Maintaining protein composition in cilia
Stephen, L. A., ElMaghloob, Y., & Ismail, S. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0168 · Cited by 11 · see citing works
Kamiya, R., Shiba, K., Inaba, K., & Kato‐Minoura, T. (2018) · ZOOLOGICAL SCIENCE · doi:10.2108/zs180025 · Cited by 10 · see citing works
- Authors
- Wood, C. R., & Rosenbaum, J. L.
- Affiliations
- Harvard University (US)
- Yale University (US)
- Corresponding author
- Wood, Christopher R.
- Rosenbaum, Joel L.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 25
- Issue
- 5
- Pages
- 276-285
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4409478
- OpenAlex
- W2066323961
- Cited by
- 153
- References
- 128
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 14 · 2015: 6
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM014642)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- cilia, extracellular vesicles, cell surface receptors, signal transduction, sensory reception, regulated secretion, vesicle release
- MeSH terms
- Extracellular Vesicles, Animals, Biological Transport, Chlamydomonas, Cilia, Humans, Proteins, Signal Transduction, Microscopy, Electron, Transmission
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