Calorie restriction–the SIR2 connection

Cited by (793)

Items 101–200 of 793

1. A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
   Jian Yuan, Katherine Minter‐Dykhouse, Zhenkun Lou · 2009 · The Journal of Cell Biology
2. The ups and downs of SIRT1
   Hye-Sook Kwon, Mélanie Ott · 2008 · Trends in Biochemical Sciences
3. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
   Ilhem Messaoudi, Jessica Warner, Miranda B. Fischer, Buyng Park, Brenna J. Hill, Julie A. Mattison, Mark A. Lane, George S. Roth, Donald K. Ingram, Louis J. Picker et al. · 2006 · Proceedings of the National Academy of Sciences
4. Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans
   Dana L. Miller, Mark B. Roth · 2007 · Proceedings of the National Academy of Sciences
5. Small-Molecule Allosteric Activators of Sirtuins
   David A. Sinclair, Leonard Guarente · 2011 · The Annual Review of Pharmacology and Toxicology
6. SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
   Petra Šimić, Eric O. Williams, Eric L. Bell, Jing Gong, Michael S. Bonkowski, Leonard Guarente · 2013 · Cell Reports
7. The Role of Oxidative Stress and Inflammation in Cardiovascular Aging
   Junzhen Wu, Shijin Xia, Bill Kalionis, Wenbin Wan, Tao Sun · 2014 · BioMed Research International
8. Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
   Daniel L. Smith, Julie M. McClure, Mirela Matecic, Jeffrey S. Smith · 2007 · Aging Cell
9. Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes
   Kitada, Munehiro, Takeda, Ai, Nagai, Takako, Ito, Hiroki, Kanasaki, Keizo, Koya, Daisuke · 2011 · Experimental Diabetes Research
10. SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
    Ran Zhang, Hou‐Zao Chen, Jinjing Liu, Yuyan Jia, Zhu‐Qin Zhang, Ruifeng Yang, Yuan Zhang, Jing Xu, Yu-Sheng Wei, De‐Pei Liu et al. · 2009 · Journal of Biological Chemistry
11. Growth and aging: a common molecular mechanism
    Mikhail V. Blagosklonny, Michael N. Hall · 2009 · Aging
12. The impact of low-protein high-carbohydrate diets on aging and lifespan
    Le Couteur, David G., Solon-Biet, Samantha, Cogger, Victoria C., Mitchell, Sarah J., Senior, Alistair, de Cabo, Rafael, Raubenheimer, David, Simpson, Stephen J. · 2016 · Cellular and Molecular Life Sciences
13. Isoflavones Promote Mitochondrial Biogenesis
    Kyle A. Rasbach, Rick G. Schnellmann · 2008 · Journal of Pharmacology and Experimental Therapeutics
14. An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms
    David Rauh, Frank F. Fischer, M. Gertz, Mahadevan Lakshminarasimhan, Tim Bergbrede, Firouzeh Aladini, Christian Kambach, Christian F. W. Becker, Johannes Zerweck, Mike Schutkowski et al. · 2013 · Nature Communications
15. Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
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16. N-Lysine Propionylation Controls the Activity of Propionyl-CoA Synthetase
    Jane Garrity, Jeffrey G. Gardner, William F. Hawse, Cynthia Wolberger, Jorge C. Escalante‐Semerena · 2007 · Journal of Biological Chemistry
17. Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis
    Tao, Randa, Vassilopoulos, Athanassios, Parisiadou, Loukia, Yan, Yufan, Gius, David · 2014 · Antioxidants & Redox Signaling
18. Resveratrol in prevention and treatment of common clinical conditions of aging.
    M. Andrea Markus, Brian J. Morris · 2008 · Europe PMC (PubMed Central)
19. NAD + metabolism: A therapeutic target for age-related metabolic disease
    Mouchiroud, Laurent, Houtkooper, Riekelt H., Auwerx, Johan · 2013 · Critical Reviews in Biochemistry and Molecular Biology
20. CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions
    Eduardo N. Chini · 2009 · Current Pharmaceutical Design
21. SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression
    Toshinori Iwahara, Roberto Bonasio, Varun K. Narendra, Danny Reinberg · 2012 · Molecular and Cellular Biology
22. Worming pathways to and from DAF-16/FOXO
    Arnab Mukhopadhyay, Seung Wook Oh, Heidi A. Tissenbaum · 2006 · Experimental Gerontology
23. Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast
    Matt R. Kaeberlein, Di Hu, Emily O. Kerr, Mitsuhiro Tsuchiya, Eric A. Westman, Nick Dang, Stanley Fields, Brian Keith Kennedy · 2005 · PLoS Genetics
24. Molecular bases of progeroid syndromes
    Navarro, Claire L., Cau, Pierre, Lévy, Nicolas · 2006 · Human Molecular Genetics
25. Epigenetic regulation of caloric restriction in aging
    Yuanyuan Li, Michael G. Daniel, Trygve O. Tollefsbol · 2011 · BMC Medicine
26. MicroRNA Regulation of SIRT1
    Munekazu Yamakuchi · 2012 · Frontiers in Physiology
27. SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
    Jing Huang, Qini Gan, Limin Han, Jian Li, Hai Zhang, Ying Sun, Zongyu Zhang, Tanjun Tong · 2008 · PLoS ONE
28. A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice
    Kevin L. Quick, Sameh Saad Ali, Robert H. Arch, Chengjie Xiong, David F. Wozniak, Laura L. Dugan · 2006 · Neurobiology of Aging
29. miR-34a Regulates Mouse Neural Stem Cell Differentiation
    Márcia M. Aranha, Daniela Maria dos Santos, Susana Solá, Clifford J. Steer, Cecília M. P. Rodrigues · 2011 · PLoS ONE
30. Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
    Carlos Escande, Claudia C.S. Chini, Verónica Nin, Katherine Minter Dykhouse, Colleen M. Novak, James A. Levine, Jan van Deursen, Gregory James Gores, Junjie Chen, Zhenkun Lou et al. · 2010 · Journal of Clinical Investigation
31. High-throughput analysis of yeast replicative aging using a microfluidic system
    Myeong Chan Jo, Wei Liu, Liang Gu, Weiwei Dang, Lidong Qin · 2015 · Proceedings of the National Academy of Sciences
32. The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
    Valerie Vanhooren, Claude Libert · 2012 · Ageing Research Reviews
33. SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
    Yu Wang, Yan Qi Liang, Paul M. Vanhoutte · 2010 · FEBS Letters
34. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
    Xueying Deng, Lulu Chen, N Li · 2007 · Liver International
35. Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
    Lilly Bourguignon, Weiliang Xia, Gabriel Wong · 2008 · Journal of Biological Chemistry
36. Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the multifunctional enzyme CD38
    Pınar Aksoy, Carlos Escande, Thomas A. White, Michael Thompson, Sandra M. Soares, Juan Claudio Benech, Eduardo N. Chini · 2006 · Biochemical and Biophysical Research Communications
37. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery
    Javed Khan, F. Forouhar, Xiao Tao, Liang Tong · 2007 · Expert Opinion on Therapeutic Targets
38. NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
    Tianle Yang, Anthony A. Sauve · 2006 · The AAPS Journal
39. Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
    Sergio Portal‐Núñez, Pedro Esbrit, María José Alcaraz, Raquel Largo · 2015 · Biochemical Pharmacology
40. Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies
    Shanjean Lee, Nicole J. Van Bergen, George Y. X. Kong, Vicki Chrysostomou, Hayley S. Waugh, Evelyn C. O’Neill, Jonathan Guy Crowston, Ian Andrew Trounce · 2010 · Experimental Eye Research
41. Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism
    Laurène Vetterli, Thierry Brun, Laurianne Giovannoni, Domenico Bosco, Pierre Maechler · 2010 · Journal of Biological Chemistry
42. Compensatory ingestion upon dietary restriction in Drosophila melanogaster
    Gil B. Carvalho, Pankaj Kapahi, Seymour Benzer · 2005 · Nature Methods
43. Sirtuin 1 regulation of developmental genes during differentiation of stem cells
    Vincenzo Calvanese, Ester Lara, Beatriz Suárez-Álvarez, Raed Abu Dawud, Mercedes Vázquez–Chantada, Maria Luz Martínez‐Chantar, Nieves Embade, Pilar López‐Nieva, Angélica Horrillo, Abdelkrim Hmadcha et al. · 2010 · Proceedings of the National Academy of Sciences
44. p66Shc-generated Oxidative Signal Promotes Fat Accumulation
    Berniakovich, Ina, Trinei, Mirella, Stendardo, Massimo, Migliaccio, Enrica, Minucci, Saverio, Bernardi, Paolo, Pelicci, Pier Giuseppe, Giorgio, Marco · 2008 · Journal of Biological Chemistry
45. Novel Role of the SIRT1 in Endocrine and Metabolic Diseases
    Lu, Chenxi, Zhao, Huadong, Liu, Yanqing, Yang, Zhi, Yao, Hairong, Liu, Tong, Gou, Tiantian, Wang, Li, Zhang, Juan, Tian, Ye et al. · 2023 · International Journal of Biological Sciences
46. Deacetylases and NF- κ B in Redox Regulation of Cigarette Smoke-Induced Lung Inflammation: Epigenetics in Pathogenesis of COPD
    Saravanan Rajendrasozhan, Se‐Ran Yang, Indika Edirisinghe, Hongwei Yao, David Adenuga, Irfan Rahman · 2008 · Antioxidants and Redox Signaling
47. Antioxidant Therapy in Alzheimers Disease: Theory and Practice
    Gjumrakch Aliev, Mark E. Obrenovich, V. Prakash Reddy, Justin C. Shenk, Paula Isabel Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith, George L. Perry · 2008 · Mini-Reviews in Medicinal Chemistry
48. Circadian Rhythms, Aging, and Life Span in Mammals
    Froy, Oren · 2011 · Physiology
49. Significance of wine and resveratrol in cardiovascular disease: French paradox revisited.
    Ramesh Vidavalur, Hajime Otani, Pawan K. Singal, Nilanjana Maulik · 2006 · PubMed Central
50. The controversial world of sirtuins
    Weiwei Dang · 2012 · Drug Discovery Today Technologies
51. Calorie restriction and the exercise of chromatin
    Alejandro Vaquero, Danny Reinberg · 2009 · Genes & Development
52. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress
    Özkan Özden, Seong‐Hoon Park, Hyunseok Kim, Haiyan Jiang, Mitchell C. Coleman, Douglas R. Spitz, David R. Gius · 2011 · Aging
53. Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy
    Guoxiang Liu, Seong‐Hoon Park, Marta Imbesi, William J. Nathan, Xianghui Zou, Yueming Zhu, Haiyan Jiang, Loukia Parisiadou, David R. Gius · 2016 · Antioxidants and Redox Signaling
54. G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity
    Chen-Tseh Zhu, Paul Ingelmo, David M. Rand · 2014 · PLoS Genetics
55. Neuronal protection by sirtuins in Alzheimer's disease
    Thimmappa S. Anekonda, P. Hemachandra Reddy · 2005 · Journal of Neurochemistry
56. An anti-aging drug today: from senescence-promoting genes to anti-aging pill
    Mikhail V. Blagosklonny · 2007 · Drug Discovery Today
57. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
    Hong Xia Fan, Haichun Yang, You Li, Yingying Wang, Wenjuan He, Chuan‐Ming Hao · 2013 · Kidney International
58. The plasma membrane redox system in aging
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59. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
    Norifumi Fujita, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda · 2010 · Journal of Orthopaedic Research®
60. Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)
    Kazuyoshi Kuwano, Jun Araya, Hiromichi Hara, Shunsuke Minagawa, Naoki Takasaka, Saburo Ito, Kenji Kobayashi, Katsutoshi Nakayama · 2016 · Respiratory Investigation
61. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss
    Tatsuya Yamasoba, Shinichi Someya, Chikako Yamada, Richard H. Weindruch, Tomas A. Prolla, Masaru Tanokura · 2006 · Hearing Research
62. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway
    Guangli Wang, Yu‐Cai Fu, Wencan Xu, Ya-Qing Feng, Shi-Rong Fang, Xiaohui Zhou · 2009 · Biochemical and Biophysical Research Communications
63. SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
    Seong‐Hoon Park, Özkan Özden, Guoxiang Liu, Ha Yong Song, Yueming Zhu, Yufan Yan, Xianghui Zou, Hong-Jun Kang, Haiyan Jiang, Daniel R. Principe et al. · 2016 · Cancer Research
64. Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma
    L Wei, Yu Zhou, Q Dai, C Qiao, Li Zhao, H Hui, Na Lu, Q-L Guo · 2013 · Cell Death and Disease
65. SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells
    Tetsuro Koyama, Shinji Kume, Daisuke Koya, Shin‐ichi Araki, Keiji Isshiki, Masami Chin‒Kanasaki, Toshiro Sugimoto, Masakazu Haneda, Takeshi Sugaya, Atsunori Kashiwagi et al. · 2011 · Free Radical Biology and Medicine
66. Epigenetics of Aging and Alzheimer’s Disease: Implications for Pharmacogenomics and Drug Response
    Ramón Cacabelos, Clara Torrellas · 2015 · International Journal of Molecular Sciences
67. Aging and longevity in the simplest animals and the quest for immortality
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68. Effect of feeding regimens on circadian rhythms: Implications for agingand longevity
    Oren Froy, Ruth Miskin · 2010 · Aging
69. Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.
    Bosch-Presegué, Laia, Raurell-Vila, Helena, Marazuela-Duque, Anna, Kane-Goldsmith, Noriko, Valle, Adamo, Oliver, Jordi, Serrano, Lourdes, Vaquero, Alejandro · 2011 · Molecular Cell
70. Histone deacetylase inhibitors: insights into mechanisms of lethality
    Roberto R. Rosato, Steven Grant · 2005 · Expert Opinion on Therapeutic Targets
71. N-Myc Down-regulated Gene 1 Modulates the Response of Term Human Trophoblasts to Hypoxic Injury
    Baosheng Chen, D. Michael Nelson, Yoel Sadovsky · 2005 · Journal of Biological Chemistry
72. The Whitening of Brown Fat and Its Implications for Weight Management in Obesity
    Ippei Shimizu, Kenneth X. Walsh · 2015 · Current Obesity Reports
73. SIRT 5‐mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer
    Liang Shi, Hui Yan, Shuxian An, Mengqin Shen, Wenzhi Jia, Ruixue Zhang, Li Zhao, Gang Huang, Jianjun Liu · 2018 · Molecular Oncology
74. Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy
    Jun Wang, Jin‐Tai Yu, Meng‐Shan Tan, Teng Jiang, Lan Tan · 2013 · Ageing Research Reviews
75. Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.
    Tao Wu, Yuhua Liu, Yu‐Cai Fu, Xingmu Liu, Xiao-hui Zhou · 2014 · PubMed
76. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
    Wei Jiang, Xuemei Zhang, Jie Hao, Jieliang Shen, Fang Ji, Wen Dong, Dawu Wang, Xiaojun Zhang, Wei Shui, Yi Luo et al. · 2014 · Scientific Reports
77. Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice
    Jung Hwan Hwang, Dong Wook Kim, Eun Jin Jo, Yong Kyung Kim, Young Suk Jo, Ji Hoon Park, Sang Ku Yoo, Myung Kyu Park, Tae Hwan Kwak, Young Lim Kho et al. · 2009 · Diabetes
78. Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging
    Erich Birelli Tahara, Mario Henrique de Barros, Graciele Almeida de Oliveira, Luís Eduardo Soares Netto, Alicia Juliana Kowaltowski · 2006 · The FASEB Journal
79. Antioxidant and Anti-Inflammatory Effects of Resveratrol in Airway Disease
    Lisa G. Wood, Peter A. B. Wark, Manohar L. Garg · 2010 · Antioxidants and Redox Signaling
80. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
    M.-H. Moon, Jae‐Kyo Jeong, Y.-J. Lee, Jae‐Won Seol, Chris Jackson, S.-Y. Park · 2012 · Osteoarthritis and Cartilage
81. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
    Gräff, Johannes, Kahn, Martin, Samiei, Alireza, Gao, Jun, Ota, Kristie T., Rei, Damien, Tsai, Li-Huei · 2013 · The Journal of Neuroscience
82. Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy
    Yujun George Zheng, Jiang Wu, Ziyue Chen, Masha Goodman · 2008 · Medicinal Research Reviews
83. Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase
    Emmanuel S. Burgos, Vern L. Schramm · 2008 · Biochemistry
84. Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
    Chao Liu, Zhenhua Song, Lina Wang, Haiyan Yu, Weixiao Liu, Yongliang Shang, Zhiliang Xu, Haichao Zhao, Fengyi Gao, Jiamin Wen et al. · 2016 · Development
85. Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease
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86. Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression
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87. Structure and activity of enzymes that remove histone modifications
    Marc A. Holbert, Ronen Marmorstein · 2005 · Current Opinion in Structural Biology
88. Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1
    Benedetto Grimaldi, Yasukazu Nakahata, Milota Kaluzová, Satoru Masubuchi, Paolo Sassone‐Corsi · 2008 · The International Journal of Biochemistry & Cell Biology
89. Crystal structure analysis of human Sirt2 and its ADP-ribose complex
    S. Moniot, Mike Schutkowski, Clemens Steegborn · 2013 · Journal of Structural Biology
90. Untitled work
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91. High glucose downregulates endothelial progenitor cell number via SIRT1
    Maria Luisa Balestrieri, Monica Rienzo, Francesca Felice, Raffaele Rossiello, Vincenzo Grimaldi, Lara Milone, Amelia Casamassimi, Luigi Servillo, Bartolomeo Farzati, Alfonso Giovane et al. · 2008 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
92. Epigenetics and cancer
    Rajnee Kanwal, Sanjay Gupta · 2010 · Journal of Applied Physiology
93. Sirt1 activation by resveratrol is substrate sequence-selective
    Mahadevan Lakshminarasimhan, David Rauh, Mike Schutkowski, Clemens Steegborn · 2013 · Aging
94. SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis
    Kayvan Zainabadi, Cassie J. Liu, Alison L. M. Caldwell, Leonard Guarente · 2017 · PLoS ONE
95. SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
    Xing‐Jie Liang, Toren Finkel, Ding‐Wu Shen, Jun‐Jie Yin, Adorján Aszalós, Michael M. Gottesman · 2008 · Molecular Cancer Research
96. SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    Hongzhe Li, Grace K. Rajendran, Ninning Liu, Carol B. Ware, Brian P. Rubin, Yansong Gu · 2007 · Breast Cancer Research
97. miR-486-5p Induces Replicative Senescence of Human Adipose Tissue-Derived Mesenchymal Stem Cells and Its Expression Is Controlled by High Glucose
    Yeon Jeong Kim, Soo Hyun Hwang, Sun Young Lee, Keun Koo Shin, Hyun Hwa Cho, Yong Chan Bae, Jin Sup Jung · 2011 · Stem Cells and Development
98. Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice
    Pu Wu, Qian Shen, Suzhen Dong, Zhiliang Xu, Joe Z. Tsien, Yinghe Hu · 2007 · Neurobiology of Aging
99. Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.
    Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett, Matt R. Kaeberlein · 2015 · Cold Spring Harbor Perspectives in Medicine
100. Resveratrol inhibits insulin responses in a SirT1-independent pathway
     Jiandi Zhang · 2006 · Biochemical Journal