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Calorie restriction–the SIR2 connection
Open accessAbstract
A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast and Drosophila. We then describe the physiological changes in mammals during calorie restriction and how they may lead to the observed health benefits. We summarize the roles of mammalian Sirt1 in mediating these changes in tissues and endocrine systems and propose that Sirt1 regulates calorie restriction by sensing low calories and triggering physiological changes linked to health and longevity.
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“Among 704 70-year-old Swedish men, dietary intakes of vitamin C and a-tocopherol, but not of b-carotene, were inversely associated with CRP and IL-6 concentrations measured 7 years after the dietary information was collected (780) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [780]
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Metadata
- Authors
- Guarente, L., & Picard, F.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Guarente, Leonard
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 120
- Issue
- 4
- Pages
- 473-482
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2078023359
- Cited by
- 793
- References
- 81
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 8 · 2022: 11 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 24 · 2017: 27 · 2016: 40 · 2015: 41 · 2014: 37 · 2013: 48 · 2012: 61
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- caloric restriction, Sir2, SIRT1, NAD+-dependent deacetylase, longevity, aging, healthspan, yeast, Drosophila, mammals, hormonal regulation, physiological adaptation
- MeSH terms
- Animals, Drosophila, Insulin, Longevity, Saccharomyces cerevisiae, Signal Transduction, Heredodegenerative Disorders, Nervous System, Caloric Restriction, Sirtuins, PPAR gamma, Mice, Sirtuin 1
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