Calorie restriction–the SIR2 connection

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Oxidative Stress, Caloric Restriction, and Aging

Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133

Thomas, Springfield, Illinois

MAGOUN, H. N. (1965) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-196504000-00011 · Cited by 2,932

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264

SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status

Song, H. Y., Biancucci, M., Kang, H.-J., O'Callaghan, C., Park, S., Principe, D. R., Jiang, H., Yan, Y., Satchell, K. J. F., Raparia, K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12015 · Cited by 41

Sirtuins are not conserved longevity genes

Brenner, C. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac025 · Cited by 43

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

Peng, C., Chang, Y.-L., Kao, C.-L., Tseng, L.-M., Wu, C.-C., Chen, Y., Tsai, C.-Y., Woung, L., Liu, J., Chiou, S., et al. (2010) · Sensors · doi:10.3390/s100606172 · Cited by 42

A novel gene, ecl1+, extends the chronological lifespan in fission yeast

Ohtsuka, H., Mita, S., Ogawa, Y., Azuma, K., Ito, H., & Aiba, H. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2008.00379.x · Cited by 42

Molecular pathology of aging and its implications for senescent coronary atherosclerosis

McEwen, J. E., Zimniak, P., Mehta, J. L., & Reis, R. J. S. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000175517.50181.89 · Cited by 41

Resveratrol, by Modulating RNA Processing Factor Levels, Can Influence the Alternative Splicing of Pre-mRNAs

Markus, M. A., Marques, F. Z., & Morris, B. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028926 · Cited by 42

The potential role of epigenetic responses to diet in ageing

Ford, D., Ions, L. J., Alatawi, F. S., & Wakeling, L. A. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000851 · Cited by 42

Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1

Lai, S., Liu, Y.-S., Lu, D., & Tsai, C. (2019) · Nutrients · doi:10.3390/nu11061343 · Cited by 41

Inflammaging in Endemic Areas for Infectious Diseases

Batista, M. A., Calvo-Fortes, F., Silveira‐Nunes, G., Camatta, G. C., Speziali, E., Turroni, S., Teixeira‐Carvalho, A., Martins‐Filho, O. A., Neretti, N., Maioli, T. U., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579972 · Cited by 43

Pioglitazone: an anti-diabetic compound with anti-aging properties

Jafari, M., Khodayari, B., Felgner, J. S., Bussel, I. I., Rose, M. R., & Mueller, L. D. (2007) · Biogerontology · doi:10.1007/s10522-007-9105-7 · Cited by 41

Current Views of the Structure of the Mammalian Mitochondrial Ribosome

Koc, E. C., Haque, M. E., & Spremulli, L. L. (2010) · Israel Journal of Chemistry · doi:10.1002/ijch.201000002 · Cited by 40

Acute and long-term nutrient-led modifications of gene expression: Potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function

Holness, M. J., Caton, P., & Sugden, M. C. (2010) · Nutrition · doi:10.1016/j.nut.2009.09.012 · Cited by 44

Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma

Kang, Y., Jung, W. Y., Lee, H., Lee, E., Kim, A., & Kim, B. (2012) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2012.46.6.523 · Cited by 40

EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation

Silva, J., Aivio, S., Knobel, P. A., Bailey, L. J., Casali, A., Vinaixa, M., Garcı́a-Cao, I., Coyaud, É., Jourdain, A. A., Pérez-Ferreros, P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0016-9 · Cited by 43

Cell Injury, Cell Death, and Adaptations

(2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1781-5.00001-5 · Cited by 41

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

Zhu, Y., Yan, Y., Gius, D. R., & Vassilopoulos, A. (2013) · Current Opinion in Oncology · doi:10.1097/01.cco.0000432527.49984.a3 · Cited by 43

Nutrients and Epigenetics

Choi, S.-W., & Friso, S. (2009) · CRC Press eBooks · doi:10.1201/9781420063561 · Cited by 39

Sirtuin‐mediated deacetylation pathway stabilizes Werner syndrome protein

Kahyo, T., Mostoslavsky, R., Goto, M., & Setou, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.031 · Cited by 40

Role of Sirtuins in Stem Cell Differentiation

Rodríguez, R. M. A., Fernández, A. F., & Fraga, M. F. (2013) · Genes & Cancer · doi:10.1177/1947601913479798 · Cited by 39

Caloric restriction maintains stem cells through niche and regulates stem cell aging

Maharajan, N., Vijayakumar, K. A., Jang, C. H., & Cho, G. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01846-1 · Cited by 38

dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction

Parashar, V., & Rogina, B. (2009) · Aging · doi:10.18632/aging.100061 · Cited by 39

Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders

Lardenoije, R., Pishva, E., Lunnon, K., & van den Hove, D. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.008 · Cited by 37

Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases

Wang, F., & Chen, H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.537519 · Cited by 40

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

Lakshminarasimhan, M., Curth, U., Moniot, S., Mosalaganti, S., Raunser, S., & Steegborn, C. (2013) · Bioscience Reports · doi:10.1042/bsr20120121 · Cited by 39

Circadian aspects of energy metabolism and aging

Froy, O. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.002 · Cited by 41

Physiology of Skin Aging

Robert, L., Labat‐Robert, J., & Robert, A. M. (2011) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2011.09.006 · Cited by 36

Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components

Keijer, J., & van Schothorst, E. M. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f39f95 · Cited by 36

SIRT1 improves VSMC functions in atherosclerosis

Zhang, M.-J., Zhou, Y., Chen, L., Wang, X., Long, C.-Y., ., Y. P., Gao, C., Li, J.-C., & Zhang, L. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.02.003 · Cited by 37

Zinc Transporters in the Mouse Placenta Show a Coordinated Regulatory Response to Changes in Dietary Zinc Intake

Helston, R. M., Phillips, S. R., McKay, J. A., Jackson, K. A., Mathers, J. C., & Ford, D. (2006) · Placenta · doi:10.1016/j.placenta.2006.07.002 · Cited by 36

Transition State of ADP-Ribosylation of Acetyllysine Catalyzed by Archaeoglobus fulgidus Sir2 Determined by Kinetic Isotope Effects and Computational Approaches

Cen, Y., & Sauve, A. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910342d · Cited by 36

Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1

Mahani, F. D., Khaksari, M., & Raji-Amirhasani, A. (2021) · International Urology and Nephrology · doi:10.1007/s11255-020-02761-y · Cited by 34

Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice

Shiozaki, M., Hayakawa, N., Shibata, M., Koike, M., Uchiyama, Y., & Gotow, T. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0847-6 · Cited by 35

Calorie restriction increases primordial follicle reserve in mature female chemotherapy-treated rats

Xiang, Y.-F., Xu, J., Li, L., Lin, X.-H., Chen, X., Zhang, X., Fu, Y., & Luo, L. (2011) · Gene · doi:10.1016/j.gene.2011.11.019 · Cited by 35

Aging: past, present and future

Blagosklonny, M. V., Campisi, J., & Sinclair, D. A. (2009) · Aging · doi:10.18632/aging.100009 · Cited by 35

Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress

Luo, W., Cao, J., Li, J., & He, W. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.11.002 · Cited by 35

Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure

Mu, W., Zhang, Q., Tang, X., Fu, W., Zheng, W., Lu, Y., Li, H., Wei, Y., Li, L., She, Z., et al. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4687-1 · Cited by 34

Metabolism, longevity and epigenetics

Cosentino, C., & Mostoslavsky, R. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1295-3 · Cited by 35

Rat models of caloric intake and activity: relationships to animal physiology and human health

Young, G. S., & Kirkland, J. B. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-082 · Cited by 35

Reactive Oxygen Species and Aging: Evolving Questions

Dugan, L. L., & Quick, K. L. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.26.pe20 · Cited by 34

Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells

Borji, M., Nourbakhsh, M., Shafiee, S. M., Owji, A. A., Abdolvahabi, Z., Hesari, Z., Ilbeigi, D., Seiri, P., & Yousefi, Z. (2019) · Biochemical Genetics · doi:10.1007/s10528-019-09905-5 · Cited by 33

Transcription‐blocking DNA damage in aging: a mechanism for hormesis

Schumacher, B. (2009) · BioEssays · doi:10.1002/bies.200900107 · Cited by 33

The Telomere–Telomerase Axis and the Heart

Kajstura, J., Rota, M., Urbanek, K., Hosoda, T., Bearzi, C., Anversa, P., Bolli, R., & Leri, A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2125 · Cited by 33

Expression profiling in the aging brain: A perspective

Galvin, J. E., & Ginsberg, S. D. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.009 · Cited by 32

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Zhang, N., Li, Z., Xu, K., Wang, Y., & Wang, Z. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00085 · Cited by 32

Endothelial Cell Aging: How miRNAs Contribute?

Yamakuchi, M., & Hashiguchi, T. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7070170 · Cited by 32

microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer

Yang, A., Wang, X., Yu, C., Jin, Z., Lingxia, W., Cao, J., Wang, Q., Zhang, M., Zhang, L., Zhang, L., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.6501 · Cited by 31

MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death

Jiao, D., Zhang, H., Jiang, Z., Huang, W., Liu, Z., Wang, Z., Wang, Y., & Wu, H. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1667-0 · Cited by 32

NO Targets SIRT1

Potente, M., & Dimmeler, S. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.173682 · Cited by 32

Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction

Ions, L. J., Wakeling, L. A., Bosomworth, H. J., Hardyman, J. E. J., Escolme, S. M., Swan, D., Valentine, R. A., Mathers, J. C., & Ford, D. (2012) · AGE · doi:10.1007/s11357-012-9485-8 · Cited by 30

Environmental Challenge, Epigenetic Plasticity and the Induction of Altered Phenotypes in Mammals

Lillycrop, K. A., & Burdge, G. C. (2014) · Epigenomics · doi:10.2217/epi.14.51 · Cited by 30

Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

Broxmeyer, H. E., Liu, Y., Kapur, R., Orschell, C. M., Aljoufi, A., Ropa, J. P., Trinh, T. L. P., Burns, S. S., & Capitano, M. L. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10065-y · Cited by 30

Factors involved in rosuvastatin induction of insulin sensitization in rats fed a high fat diet

Heras, N. D. L., Valero‐Muñoz, M., Ballesteros, S., Gómez‐Hernández, A., Martín‐Fernández, B., Blanco‐Rivero, J., Cachofeiro, V., Benito, M., Balfagón, G., & Lahera, V. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.11.009 · Cited by 30

Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1

Lee, C.-H., Su, S., Chiang, C., Chien, C., Hsu, C., Yu, T.-Y., Huang, S., Shieh, Y., Kao, H.-W., Tsai, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22546 · Cited by 30

Hypoxia modifies the feeding preferences of Drosophila. Consequences for diet dependent hypoxic survival

Vigne, P., & Frelin, C. (2010) · BMC Physiology · doi:10.1186/1472-6793-10-8 · Cited by 29

Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, L. J., & Bohr, V. A. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa392 · Cited by 29

Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?

Poljšak, B., Kovač, V., & Milisav, I. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8819627 · Cited by 33

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

Yan, L., Park, J. Y., Dillinger, J., Lorenzo, M. S. D., Yuan, C., Lai, L., Wang, C., Ho, D. W. T., Tian, B., Stanley, W. C., et al. (2012) · Aging Cell · doi:10.1111/acel.12013 · Cited by 29

Pma1, a P-type Proton ATPase, Is a Determinant of Chronological Life Span in Fission Yeast

Ito, H., Oshiro, T., Fujita, Y., Kubota, S., Naito, C., Ohtsuka, H., Murakami, H., & Aiba, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.175562 · Cited by 29

Effects of Age on Meiosis in Budding Yeast

Boselli, M. G., Rock, J. M., Ünal, E., Levine, S. S., & Amon, A. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.013 · Cited by 31

Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function

Skrovanek, S. M., Valenzano, M. C., & Mullin, J. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2007 · Cited by 29

Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets

Lakshminarasimhan, M., & Steegborn, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.024 · Cited by 28

Molecular control of circadian metabolic rhythms

Li, S., & Lin, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00467.2009 · Cited by 28

DNA Damage Response and Cell Cycle Regulation in Pluripotent Stem Cells

Chen, A. C. H., Peng, Q., Fong, S. W., Lee, K. C., Yeung, W. S. B., & Lee, Y. L. (2021) · Genes · doi:10.3390/genes12101548 · Cited by 28

HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases

Ruggieri, E., Domenico, E. D., Locatelli, A. G., Isopo, F., Damanti, S., LORENZO, R. D., Milan, E., Musco, G., Rovere, P. Q., Cenci, S., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102550 · Cited by 27

Protective effect of SIRT3 on acute lung injury by increasing manganese superoxide dismutase-mediated antioxidation

Tian, Y., & Zhang, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8469 · Cited by 27

Sirt1 Inhibits Resistin Expression in Aortic Stenosis

Carter, S., Miard, S., Roy-Bellavance, C., Boivin, L., Li, Z., Pîbarot, P., Mathieu, P., & Picard, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035110 · Cited by 27

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro

de Cabo, R., Liu, L., Ali, A., Price, N. D., Zhang, J., Wang, M., Lakatta, E. G., & Irusta, P. M. (2015) · Aging · doi:10.18632/aging.100719 · Cited by 27

Antioxidant Diets and Functional Foods Promote Healthy Aging and Longevity Through Diverse Mechanisms of Action

Wichansawakun, S., & Buttar, H. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813148-0.00032-3 · Cited by 31

The Role of Resveratrol in Cancer Management: From Monotherapy to Combination Regimens

Ribeiro, E., & Vale, N. (2024) · Targets · doi:10.3390/targets2040018 · Cited by 28

Transcriptional and epigenetic effects of Vitis vinifera L. leaf extract on UV-stressed human dermal fibroblasts

Letsiou, S., Kapazoglou, A., Tsaftaris, A. S., Spanidi, E., & Gardikis, Κ. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05645-7 · Cited by 27

An automated compound screening for anti-aging effects on the function of C. elegans sensory neurons

Bazopoulou, D., Chaudhury, A. R., Pantazis, A. K., & Chronis, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-09651-x · Cited by 27

Tetrahydroxystilbene Glucoside Delayed Senile Symptoms in Old Mice via Regulation of the AMPK/SIRT1/PGC-1α Signaling Cascade

Ning, Z., Li, Y., Liu, D., Orgah, J. O., Zhu, J., Wang, Y., & Zhu, Y. (2018) · Gerontology · doi:10.1159/000487360 · Cited by 26

Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: Scientific interventions for anti-aging

Anton, B. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s866 · Cited by 26

A Low Protein Diet Increases the Hypoxic Tolerance in Drosophila

Vigne, P., & Frelin, C. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000056 · Cited by 27

Epigenetic alterations due to diet andHelicobacter pyloriinfection in gastric carcinogenesis

Nardone, G., & Compare, D. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.2.243 · Cited by 26

The dysfunctional lipids in prostate cancer.

Dang, Q., Chen, Y., & Hsieh, J. (2019) · PubMed Central · Cited by 25

Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Bartfai, T., & Conti, B. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00184 · Cited by 25

Curing units' ability to cure restorative composites and dual-cured composite cements under composite overlay.

Park, S. H., Kim, S.-S., Cho, Y.-S., Lee, C.-K., & Noh, B.-D. (2004) · PubMed · Cited by 25

Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjögren’s syndrome

Inoue, H., Kishimoto, A., Ushikoshi‐Nakayama, R., Hasaka, A., Takahashi, A., Ryo, K., Muramatsu, T., Ide, F., Mishima, K., & Saito, I. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-31 · Cited by 27

Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction

Park, S., Komatsu, T., Kim, S. E., Tanaka, K., Hayashi, H., Mori, R., & Shimokawa, I. (2017) · Aging Cell · doi:10.1111/acel.12558 · Cited by 27

Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury

Andrianova, N. V., Jankauskas, S. S., Zorova, L. D., Pevzner, I. B., Popkov, V. A., Silachev, D. N., Plotnikov, E. Y., & Zorov, D. B. (2018) · Cells · doi:10.3390/cells7100178 · Cited by 24

The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)

Khan, M., Park, S., Kim, H., Lee, K.-J., Kim, D. H., Baek, S.-H., & Hong, S. (2019) · Nutrients · doi:10.3390/nu11050983 · Cited by 25

Activating SIRT1: a new strategy to prevent atherosclerosis?

Brandes, R. P. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn245 · Cited by 25

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

Chen, Y., Xiao, H., Liu, Z., Teng, F., Yang, A., Geng, B., Sheng, X., & Xia, Y. (2024) · Biomolecules · doi:10.3390/biom14080970 · Cited by 29

Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China

Yao, Y., Liu, L., Guo, G., Zeng, Y., & Ji, J. S. (2021) · Environmental Health · doi:10.1186/s12940-021-00718-x · Cited by 24

Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions

Mousa, S. A., Gallati, C., Simone, T. M., Dier, E., Yalçın, M., Dyskin, E., Sudha, T., Hanko, C., & Rebbaa, A. (2009) · Aging · doi:10.18632/aging.100035 · Cited by 23

The sirtuins in the pathogenesis of cancer

Voelter‐Mahlknecht, S., & Mahlknecht, U. (2010) · Clinical Epigenetics · doi:10.1007/s13148-010-0008-0 · Cited by 24

Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress

Vatner, S. F., Yan, L., Ishikawa, Y., Vatner, D. E., & Sadoshima, J. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-0957 · Cited by 26

Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence

Bouklas, T., Jain, N., & Fries, B. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00098 · Cited by 25

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H:quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials

Kim, S., Lee, S., Cho, J., Yoon, S. H., Jang, I., & Yu, K. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s151269 · Cited by 24

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder

Wang, Z., Liang, Y., Zhang, L., Zhang, N., Liu, Q., & Wang, Z. (2018) · Aging · doi:10.18632/aging.101559 · Cited by 24

Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men

Artsi, H., Gurt, I., El-Haj, M., Müller, R., Kuhn, G. A., Ben-Shalom, G., Cohen‐Kfir, E., Abramowitz, E., Kandel, L., Safran, O., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00126 · Cited by 25

Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

Suchard, M. S., & Savulescu, D. M. (2021) · FEBS Journal · doi:10.1111/febs.15807 · Cited by 23

Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review

Yadegar, S., Mohammadi, F., Yadegar, A., Naeini, A. M., Ayati, A., Milan, N., Tayebi, A., Seyedi, S. A., Nabipoorashrafi, S. A., Rabizadeh, S., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8171 · Cited by 23

Honeybees and cell lines as models of DNA methylation and aging in response to diet

Ford, D. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.010 · Cited by 23

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

Makino, N., Oyama, J., Maeda, T., Koyanagi, M., Higuchi, Y., Shimokawa, I., Mori, N., & Furuyama, T. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2615-8 · Cited by 23

NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way

Poljšak, B. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1975 · Cited by 24

SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

Wakeling, L. A., Ions, L. J., Escolme, S. M., Cockell, S., Su, T., Dey, M., Hampton, E. V., Jenkins, G., Wainwright, L., McKay, J. A., et al. (2015) · Human Genomics · doi:10.1186/s40246-015-0036-0 · Cited by 22

Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing

Badiola, I., Santaolalla, F., García-Gallastegui, P., del Rey, A. S., Unda, F. J., & Ibarretxe, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.004 · Cited by 22

A label-free fluorescence DNA probe based on ligation reaction with quadruplex formation for highly sensitive and selective detection of nicotinamide adenine dinucleotide

Zhao, J., Zhang, L., Jiang, J., Shen, G., & Yu, R. (2012) · Chemical Communications · doi:10.1039/c2cc30540b · Cited by 21

Increase in Activity During Calorie Restriction Requires Sirt1

Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science · doi:10.1126/science.1118357 · Cited by 419

Sirt1 as a key regulator orchestrating the response to caloric restriction

Moynihan, K. A., & Imai, S. (2006) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2006.02.005 · Cited by 10

Calorie restriction and SIR2 genes—Towards a mechanism

Guarente, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.013 · Cited by 160

Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation

Wang, Y. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.5.321 · Cited by 68

SIR2: a potential target for calorie restriction mimetics

Chen, D., & Guarente, L. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.004 · Cited by 187