Novel Role of the SIRT1 in Endocrine and Metabolic Diseases

Biochemical and Biophysical Research Communications

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Mechanism of Human SIRT1 Activation by Resveratrol

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

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Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

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Calorie restriction–the SIR2 connection

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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

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The biochemistry of sirtuins

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Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

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Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

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Endocrine functions of bile acids

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Follicle dynamics and anovulation in polycystic ovary syndrome

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Resveratrol (RV): A pharmacological review and call for further research

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Hypertension-induced cognitive impairment: From pathophysiology to public health

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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetesPreprint

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Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary

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Sirtuin Functions in Health and Disease

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SIRT1 is downregulated by autophagy in senescence and ageing

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Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

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SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

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How does SIRT1 affect metabolism, senescence and cancer?

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Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

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Melatonin prevents D rp1‐mediated mitochondrial fission in diabetic hearts through SIRT 1‐ PGC 1α pathway

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Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

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Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

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SIRT1 and insulin resistance

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Sirtuin activators and inhibitors

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Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBPPreprint

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Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

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Biological & pharmaceutical bulletin

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Sirt1 activation protects the mouse renal medulla from oxidative injury

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Metformin for the treatment of the polycystic ovary syndrome

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Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

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Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective

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Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

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Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis

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The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

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Sirtuin 1 in lipid metabolism and obesity

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Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

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Shear stress, SIRT1, and vascular homeostasis

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Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

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Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm

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SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

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Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

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Mechanisms Underlying Caloric Restriction and Lifespan Regulation

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Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

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Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

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Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through <scp>SIRT1</scp>

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The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism

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SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

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Role of Transcription Factor Acetylation in Diabetic Kidney Disease

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Hypertension

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AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

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SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

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Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

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Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway

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The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats

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The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD

Sato, Y., Feig, D. I., Stack, A. G., Kang, D., Lanaspa, M. A., Ejaz, A. A., Sánchez‐Lozada, L. G., Kuwabara, M., Borghi, C., & Johnson, R. J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0174-z · Cited by 199 · see citing works

The Role of Sirtuins in the Control of Metabolic Homeostasis

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Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-catenin

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SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

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SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

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Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor

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Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

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Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

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Post-translational Regulation of Runx2 in Bone and Cartilage

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Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism

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SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents

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The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

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Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

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Transcription Factor Runx2 and its Application to Bone Tissue Engineering

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Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

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Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension

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Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes

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Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

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Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis

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Histone Modifications as an Intersection Between Diet and Longevity

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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

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Cloning and Characterization of Four SIR Genes of Saccharomyces cerevisiae

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Novel Role of Silent Information Regulator 1 in Myocardial Ischemia

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Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis

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Role of Sirtuin 1 in the Regulation of Hepatic Gene Expression by Thyroid Hormone

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GABAergic Excitation of Vasopressin Neurons

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SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

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Genetic screening in arterial hypertension

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Neuroimmune crosstalk in the pathophysiology of hypertension

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Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ

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A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells

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Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

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Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll‐like receptor 4

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Current role of neprilysin inhibitors in hypertension and heart failure.

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Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

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Estrogen-SIRT1 Axis Plays a Pivotal Role in Protecting Arteries Against Menopause-Induced Senescence and Atherosclerosis

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17‐ β Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting SIRT1 / AMPK / H3 acetylation

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Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes

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Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development

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The Sirtuin1 Activator SRT3025 Down-Regulates Sclerostin and Rescues Ovariectomy-Induced Bone Loss and Biomechanical Deterioration in Female Mice

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Underutilization of Aspirin for Primary Prevention of Cardiovascular Disease Among HIV-Infected Patients

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Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease

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The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

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Adipose Tissue and FoxO1: Bridging Physiology and Mechanisms

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Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy

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Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis

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Grape Seed Proanthocyanidin Extracts Enhance Endothelial Nitric Oxide Synthase Expression through 5′-AMP Activated Protein Kinase/Surtuin 1–Krüpple Like Factor 2 Pathway and Modulate Blood Pressure in Ouabain Induced Hypertensive Rats

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A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging

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Follicle dynamics and anovulation in polycystic ovary syndrome

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Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

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Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS

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Doses of Quercetin in the Range of Serum Concentrations Exert Delipidating Effects in 3T3-L1 Preadipocytes by Acting on Different Stages of Adipogenesis, but Not in Mature Adipocytes

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Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction

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Device Therapy of Hypertension

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Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway

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Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis

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Upregulation of SIRT1 inhibits H2O2‑induced osteoblast apoptosis via FoxO1/β‑catenin pathway

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Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats

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SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway

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Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease

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Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1

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Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension

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Targeting Sirtuin-1 in Huntington’s Disease: Rationale and Current Status

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Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1

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SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness

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Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression

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SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription

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NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications

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Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts

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TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage

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NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway

Zhou, L., Zhang, S., Bolor-Erdene, E., Wang, L., Ding, T., & Mei, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1974265 · Cited by 50 · see citing works

Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms

Abiri, B., Sarbakhsh, P., & Vafa, M. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1945859 · Cited by 50 · see citing works

Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.

Tao, X., Zhang, X., Ge, S., Zhang, E., & Zhang, B. (2015) · PubMed Central · Cited by 49 · see citing works

SIRT1 Deacetylates FOXA2 and Is Critical for Pdx1 Transcription and β-Cell Formation

Wang, R., Xu, X., Kim, H., Xiao, Z., & Deng, C. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7529 · Cited by 49 · see citing works

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting

Lee, J., Kang, H. S., Park, H. Y., Moon, Y.-A., Kang, Y. N., Oh, B., Song, D., Bae, J., & Im, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-10523-7 · Cited by 48 · see citing works

SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency

Chen, H., Hu, X., Yang, R., Wu, G., Tan, Q., Goltzman, D., & Miao, D. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.48169 · Cited by 48 · see citing works

GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity

Prud’homme, G. J., Glinka, Y., Udovyk, O., Hasilo, C. P., Paraskevas, S., & Wang, Q. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.135 · Cited by 47 · see citing works

Resveratrol promotes white adipocytes browning and improves metabolic disorders in Sirt1‐dependent manner in mice

Li, Z., Zhang, Z., Ke, L., Sun, Y., Li, W., Feng, X., Zhu, W., & Chen, S. (2020) · The FASEB Journal · doi:10.1096/fj.201902222r · Cited by 47 · see citing works

Selective Inhibition by Grape Seed Proanthocyanidin Extracts of Cell Adhesion Molecule Expression Induced by Advanced Glycation End Products in Endothelial Cells

Zhang, F.-L., Gao, H., Wu, J., Ma, Y., You, B.-A., Li, B., & Xuan, J.-H. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000242058.72471.0c · Cited by 46 · see citing works

Fucosterol, isolated from Ecklonia stolonifera, inhibits adipogenesis through modulation of FoxO1 pathway in 3T3-L1 adipocytes

Lee, J.-H., Jung, H. A., Kang, M. J., Choi, J. S., & Kim, G. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12684 · Cited by 46 · see citing works

Putrescine delays postovulatory aging of mouse oocytes by upregulating PDK4 expression and improving mitochondrial activity

Xu, W., Li, L., Sun, J., Zhu, S., Yan, Z., Gao, L., Gao, C., Cui, Y., & Mao, C. (2018) · Aging · doi:10.18632/aging.101699 · Cited by 46 · see citing works

Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)

Estienne, A., Bongrani, A., Ramé, C., Kurowska, P., Błaszczyk, K., Rak, A., Ducluzeau, P., Froment, P., & Dupont, J. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111113 · Cited by 46 · see citing works

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

Pinho, A. V., Bensellam, M., Wauters, E., Rees, M., Giry-Laterrière, M., Mawson, A., Ly, L. Q., Biankin, A. V., Wu, J., Laybutt, D. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128012 · Cited by 45 · see citing works

Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR‐106b Expression and Up‐Regulating SIRT1

Chen, D., & Yang, K. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26089 · Cited by 45 · see citing works

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

Wu, H., Wu, J., Zhou, S., Huang, W., Li, Y., Zhang, H., Wang, J., & Jia, Y. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0672 · Cited by 45 · see citing works

Fucoidan ameliorates pancreatic β‐cell death and impaired insulin synthesis in streptozotocin‐treated β cells and mice via a Sirt‐1‐dependent manner

Yu, W., Chen, Y., Hwang, P., Chen, T., & Chou, T. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700136 · Cited by 44 · see citing works

Susceptibility gene discovery for common metabolic and endocrine traits

McCarthy, M. I. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0280001 · Cited by 42 · see citing works

ADIPOSE TISSUE DYSFUNCTION IN OBESITY, DIABETES, AND VASCULAR DISEASES

Carlin, B. W., & Roitman, J. L. (2009) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/01.hcr.0000348169.97212.87 · Cited by 42 · see citing works

Prepregnancy Consumption of Fruits and Fruit Juices and the Risk of Gestational Diabetes Mellitus

Chen, L., Hu, F. B., Yeung, E. H., Tobias, D. K., Willett, W. C., & Zhang, C. (2012) · Diabetes Care · doi:10.2337/dc11-2105 · Cited by 41 · see citing works

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway

Chini, C. C. S., Espíndola‐Netto, J. M., Mondal, G., Guerrico, A. M. G., Nin, V., Escande, C., Sola‐Penna, M., Zhang, J., Billadeau, D. D., & Chini, E. N. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1760 · Cited by 41 · see citing works

Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts

Wang, Y., Mei, R., Hao, S., Luo, P., Wang, P., Almatari, Y., Guo, L., & Guo, L. P. (2021) · Aging · doi:10.18632/aging.203639 · Cited by 41 · see citing works

SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats

Chen, Y.-R., Lai, Y.-L., Lin, S., Li, X.-T., Fu, Y., & Xu, W. (2013) · Molecular Biology Reports · doi:10.1007/s11033-012-2412-3 · Cited by 40 · see citing works

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

Gilbert, R. E., Thai, K., Advani, S. L., Cummins, C. L., Kepecs, D. M., Schroer, S. A., Woo, M., & Zhang, Y. (2015) · Diabetologia · doi:10.1007/s00125-014-3485-4 · Cited by 40 · see citing works

The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1‐bone morphogenic protein 2 longevity axis

Zhao, M., Ko, S., Garrett, I. R., Mundy, G. R., Gutierrez, G. E., & Edwards, J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14477 · Cited by 40 · see citing works

NADPH Oxidase Isoforms Are Involved in Glucocorticoid-Induced Preosteoblast Apoptosis

Bai, S., Xu, Q., Li, H., Qin, Y., Song, L., Wang, C., Cui, W., Zheng, Z. P., Yan, D., Li, Z., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9192413 · Cited by 40 · see citing works

Adiponectin/SIRT1 Axis Induces White Adipose Browning After Vertical Sleeve Gastrectomy of Obese Rats with Type 2 Diabetes

Liu, L., Zhang, T., Hu, J., Ma, R., He, B., Wang, M., & Wang, Y. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04295-4 · Cited by 40 · see citing works

Treating hyperuricemia related non-alcoholic fatty liver disease in rats with resveratrol

Xu, K., Liu, S., Zhao, X. D., Zhang, X., Fu, X., Zhou, Y., Xu, K., Miao, L., Li, Z., Li, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.039 · Cited by 38 · see citing works

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

Gurt, I., Artsi, H., Cohen‐Kfir, E., Hamdani, G., Ben-Shalom, G., Feinstein, B., El-Haj, M., & Dresner–Pollak, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134391 · Cited by 37 · see citing works

The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus

Qiu, Y., Zhou, X., Liu, Y. S., Tan, S., & Li, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632383 · Cited by 37 · see citing works

SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression

Feng, T., Liu, P., Wang, X., Luo, J., Zuo, X., Jiang, X., Liu, C., Li, Y., Li, N., Chen, M., et al. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.04.039 · Cited by 36 · see citing works

Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation.

Zhang, L., Bao, D.-M., Li, P., Lu, Z., Pang, L., Chen, Z., Guo, H., Gao, Z.-H., & Jin, Q. (2018) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2018.05.030 · Cited by 36 · see citing works

Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia

Xu, W.-A., Yin, L., Pan, H., Shi, L., Xu, L., Zhang, X., & Duan, J. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.09.024 · Cited by 35 · see citing works

Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences

Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052600 · Cited by 138 · see citing works

SIRT1: Harnessing multiple pathways to hinder NAFLD

Tian, C., Huang, R., & Xiang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107155 · Cited by 77 · see citing works

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

Farid, H. A., Sayed, R. H., El-Shamarka, M. E.-S., Abdel‐Salam, O. M. E., & Sayed, N. S. E. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01305-x · Cited by 52 · see citing works

Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44 · see citing works

Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis

Almalki, W. H., & Almujri, S. S. (2024) · Biogerontology · doi:10.1007/s10522-024-10153-3 · Cited by 44 · see citing works

Resveratrol attenuates high glucose-induced inflammation and improves glucose metabolism in HepG2 cells

Tshivhase, A. M., Matsha, T. E., & Raghubeer, S. (2024) · Scientific Reports · doi:10.1038/s41598-023-50084-6 · Cited by 38 · see citing works

Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases

Luo, Z., Liu, Y., Wang, X., Fan, F., Yang, Z., & Luo, D. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116554 · Cited by 48 · see citing works

Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway

Liu, T., Zhu, S., Yang, Y., Qin, W., Wang, Z., Zhao, Z., Liu, T., Wang, X., Duan, T., Liu, Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116110 · Cited by 33 · see citing works

The relationship between SIRT1 and inflammation: a systematic review and meta-analysis

Sun, H., Li, D., Wei, C., Liu, L., Xin, Z., Gao, H., & Gao, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465849 · Cited by 31 · see citing works

Sirt1-mediated deacetylation of PGC-1α alleviated hepatic steatosis in type 2 diabetes mellitus via improving mitochondrial fatty acid oxidation

Pang, J., Yin, L., Jiang, W., Wang, H., Cheng, Q., Jiang, Z., Cao, Y., Zhu, X., Li, B., Qian, S., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111478 · Cited by 30 · see citing works

Bushen Jianpi Tiaoxue Decoction (BJTD) ameliorates oxidative stress and apoptosis induced by uterus ageing through activation of the SIRT1/NRF2 pathway

Zhang, J., Hu, H., Zhu, Y., Jin, Y., Zhang, H., Fan, R., Ye, Y., Xin, X., & Dong, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156288 · Cited by 28 · see citing works

Interplay between maternal nutrition and epigenetic programming on offspring hypertension

Tain, Y., & Hsu, C. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109604 · Cited by 25 · see citing works

Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention

Mohammadi, S., Moghadam, M. D., Nasiriasl, M., Akhzari, M., & Barazesh, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328268507231218051058 · Cited by 22 · see citing works

Mechanisms and effects of metformin on skeletal muscle disorders

Shang, R., & Miao, J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1275266 · Cited by 21 · see citing works

SIRT1: a novel regulator in colorectal cancer

Dong, W., Lu, J., Li, Y., Zeng, J., Du, X., Yu, A., Zhao, X., Chi, F., Xi, Z., & Cao, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117176 · Cited by 19 · see citing works

Adipose mesenchymal stem cell-derived exosomes rescue mitochondrial function through SIRT1 to improve diabetic wound healing

Bai, X., Li, Y., Wang, P., Xu, Z., Wei, J., He, T., & Han, J. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf017 · Cited by 21 · see citing works

Changes of Signaling Pathways in Hypothalamic Neurons with Aging

Masliukov, P. M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100523 · Cited by 17 · see citing works

The role of SIRT1 in kidney diseases

Wang, W. J., Hu, Y., Ding, N., Wei, J., & Li, C. (2024) · International Urology and Nephrology · doi:10.1007/s11255-024-04162-x · Cited by 17 · see citing works

Maternal exercise represses Nox4 via SIRT1 to prevent vascular oxidative stress and endothelial dysfunction in SHR offspring

Zhang, Y., Shan, M., Ding, X., Sun, H., Qiu, F., & Shi, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1219194 · Cited by 17 · see citing works

SIRT1 inhibitors within Qing-Luo-Yin alleviated white adipose tissues-mediated inflammation in antigen-induced arthritis mice

Ye, P., Wang, Q., Liu, C., Li, G., Olatunji, O. J., Lin, J.-T., & Zuo, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155132 · Cited by 17 · see citing works

ED-71 ameliorates OVX-induced osteoporosis by regulating calcium homeostasis and SIRT1-mediated mitochondrial function, alleviating osteoblast senescence and suppressing osteoclastogenesis

Zhang, Y., Cui, Y., Sun, C., Guo, J., & Li, M. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111713 · Cited by 16 · see citing works

Potential role of SIRT1 in cell ferroptosis

Zhang, Y., Kong, F., Li, N., Tao, L., Zhai, J., Ma, J., & Zhang, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1525294 · Cited by 16 · see citing works

Sirtuin 1 and Hormonal Regulations in Aging

Keremidarska‐Markova, M., Sazdova, I., Mladenov, M. I., Pilicheva, B., Zagorchev, P. I., & Gagov, H. (2024) · Applied Sciences · doi:10.3390/app142412051 · Cited by 16 · see citing works

Effect and mechanism of resveratrol against polycystic ovary syndrome: a review

Chang, H., Shi, B., Wang, Y., Lu, F., Guan, M., & Wu, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1529231 · Cited by 14 · see citing works

Astragaloside IV Inhibits the Pyroptosis in the Acute Kidney Injury through Targeting the SIRT1/FOXO3a Axis

Zha, C., Qi, Y., Xing, F., & Li, J. (2024) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c24-00151 · Cited by 14 · see citing works

Semaglutide attenuates pathological electrophysiological remodeling in diabetic cardiomyopathy via restoring Cx43 expression

Yan, M., Lin, K., Huang, D., Li, J., Qu, X., & Chen, K. (2024) · Endocrine · doi:10.1007/s12020-024-03823-2 · Cited by 13 · see citing works

SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion

Yang, K., Zheng, Q., Luo, M., Zhang, R., Zhao, S., Kang, L., Lei, X., & Dong, W. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.05.400 · Cited by 12 · see citing works

Involvement of SIRT1-mediated cellular immune response in cancer

Liu, N., Li, J., Dai, H., Liang, X., & Fan, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117482 · Cited by 12 · see citing works

Mechanisms of SIRT3 Regulation of Aging and Aging-Related Diseases and Advances in Drug Therapy

Yang, J., Lu, Y., Zhao, Y. C., & Wang, X. (2025) · Gerontology · doi:10.1159/000547549 · Cited by 13 · see citing works

Sirtuins as Therapeutic Targets for Treating Cancer, Metabolic Diseases, and Neurodegenerative Diseases

Akantibila, M., & Carabetta, V. J. (2025) · Pharmaceuticals · doi:10.3390/ph18111723 · Cited by 11 · see citing works

Harnessing SIRT1 activators for effective PCOS treatment: A new frontier

Moharir, S. R., Talamadla, M. K., Bhardwaj, P., Banerjee, A., Dey, R. J., & Sekhar, K. V. G. C. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118361 · Cited by 11 · see citing works

Organic photoelectrochemical transistor biosensor for the detection of histone deacetylase Sirt1 based on the cleavage of deacetylated peptide chain by recombinant lysine endopeptidase

Gao, L., Zhang, H., Zhou, Y., Yin, H., Cao, L., Hu, Z., Zhang, M., & Ai, S. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136144 · Cited by 10 · see citing works

Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment

De-Leon-Covarrubias, U. E., Perez‐Trujillo, J. J., Villa‐Cedillo, S. A., Martínez-Pérez, A. G., Montes-de-Oca-Saucedo, C. R., Loera‐Arias, M. D. J., García‐García, A., Cárdenas, O. S., & Montes‐de‐Oca‐Luna, R. (2024) · Metabolites · doi:10.3390/metabo14080418 · Cited by 10 · see citing works

Maternal Dietary Strategies for Improving Offspring Cardiovascular–Kidney–Metabolic Health: A Scoping Review

Tain, Y., & Hsu, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189788 · Cited by 11 · see citing works

Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration

Ding, Z., Du, W., Huang, J., Han, J., Bai, J., Yang, G., Zhang, Y., & Ding, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113700 · Cited by 10 · see citing works

Transcriptional Signatures and Network-Based Approaches Identified Master Regulators Transcription Factors Involved in Experimental Periodontitis Pathogenesis

Vicencio, E., Nuñez-Belmar, J., Cárdenas, J. P., Cortés, B. I., Martín, A. J. M., Maracaja‐Coutinho, V., Rojas, A., Cafferata, E. A., González, L., Vernal, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914835 · Cited by 10 · see citing works

Polysaccharide of Atractylodes macrocephala Koidz alleviated fructose-induced salt-sensitive hypertension and renal injury via suppressing SIRT1/Nlrp3/caspase-1 pathway in mice

Deng, Q., Lu, S.-Y., Li, Y., Quan, H., Li, W., Hu, X., Wang, L., & Zhu, Q. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120063 · Cited by 9 · see citing works

RNA Modification in Metabolism

Liu, Y., Sun, Z., Gui, D., Zhao, Y., & Xu, Y. (2025) · MedComm · doi:10.1002/mco2.70135 · Cited by 8 · see citing works

Sirtuins in Central Nervous System Tumors—Molecular Mechanisms and Therapeutic Targeting

Nowacka, A., Śniegocka, M., Śniegocki, M., & Ziółkowska, E. (2025) · Cells · doi:10.3390/cells14141113 · Cited by 8 · see citing works

Histone deacetylases in myocardial infarction: Orchestrating programmed cell death pathways and emerging therapeutic opportunities

Wen, H., Hun, M., He, Q., Huang, L., Wu, X., Wei, M., Shi, J., Zhao, M., & He, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118367 · Cited by 8 · see citing works

Sirtuins in Parkinson's disease: Molecular mechanisms and pathophysiological roles

Li, X., Luo, X., Cao, X., Thomas, E. R., Wang, W., Zhou, X., Zhou, S., Wu, A., Gao, R., Liu, K., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102902 · Cited by 8 · see citing works

SIRT1 and ZNF350 as novel biomarkers for osteoporosis: a bioinformatics analysis and experimental validation

Zhu, N., Hou, J., Si, J., Yang, N., Chen, B., Xu, W., & Zhu, L. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09406-8 · Cited by 8 · see citing works

Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state

Gao, Q., Jiang, Y., Song, Z., Ren, H., Kong, Y., Wang, C., Zheng, M., Shan, C., & Yang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-67755-7 · Cited by 8 · see citing works

Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer

Karunakar, K. K., Cheriyan, B. V., Velmurugan, R., Gopalakrishnan, M., & Karthikha, V. S. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100527 · Cited by 8 · see citing works

Mechanisms and Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury in Diabetic States

Xue, J., Zhuang, J., Wang, X., Meng, T., Wu, J. Q., Zhang, X., & Zhang, G. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00272 · Cited by 8 · see citing works

Targeting mitochondrial dysfunction: an innovative strategy for treating renal fibrosis

Wu, Y.-J., Yang, Y., Yan, Y.-L., Yang, H.-Y., & Du, J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05297-w · Cited by 7 · see citing works

Neuronal glycolysis meets mitophagy to govern organismal wellbeing

Jiménez-Blasco, D., Lapresa, R., Agulla, J., Almeida, Á., & Bolaños, J. P. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.05.005 · Cited by 8 · see citing works

Association between mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) and PCOS

Huang, L.-Y., Qin, X., Tian, C., Ling, S., Luo, X., Huang, B., Ling, Y., Zhong, S., Li, Z., & Li, Q. (2025) · European journal of medical research · doi:10.1186/s40001-025-02862-3 · Cited by 7 · see citing works

Co-treatments of vitamin D and mesenchymal stem cells effectively alleviate the diabetic kidney disease through attenuating the SIRT1-mediated pathways

Zhao, X., He, S., Luo, X., Zhang, X., Jiang, X., Liang, Y., Tang, T., Qi, K., Wang, Y., Zhang, Y., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04579-w · Cited by 7 · see citing works

Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes

Timasheva, Y., Balkhiyarova, Z., Avzaletdinova, D. S., Вячеславовна, М. Т., Korytina, G. F., Nouwen, A., Prokopenko, I., & Kochetova, O. V. (2024) · Nutrients · doi:10.3390/nu16081166 · Cited by 8 · see citing works

(Poly)phenols and diabetes: From effects to mechanisms by systematic multigenomic analysis

Farrim, M. I. D. J. D., Gomes, A. M., Menezes, R., & Milenković, D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102557 · Cited by 7 · see citing works

The AMPK-SIRT1 Axis: Redefining type 2 diabetes mellitus management

Kemelo, M. K., & Moseki, P. (2025) · Results in Chemistry · doi:10.1016/j.rechem.2025.102139 · Cited by 6 · see citing works

Alpha‐Linolenic Acid Supplementation Improves Testosterone Production in an Aged Breeder Rooster Model: Role of Mitochondrial Modulation and SIRT1 Activation

Long, C., Zhi-xian, Z., Willing, B. P., Sheng, X., Wang, X., Xiao, L., & Qi, X. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400522 · Cited by 6 · see citing works

Maternal exercise represses FGF21 via SIRT1 to improve the phenotypic transformation of vascular smooth muscle in hypertensive offspring

Shan, M., Qiu, F., Li, P., Zhang, Y., & Shi, L. (2024) · Hypertension Research · doi:10.1038/s41440-024-01991-2 · Cited by 6 · see citing works

Molecular mechanisms and targeted therapy of progranulin in metabolic diseases

Wang, X., Liang, Y., Yang, F., Shi, Y., Shao, R., Jing, R., Yang, T., Chu, Q., An, D., Qi, Z., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1553794 · Cited by 7 · see citing works

Disruption of the SIRT1/PI3K/AKT Signaling Axis Mediates Fluoride-Induced Cardiotoxicity: Evidence from in Vitro and Zebrafish Models

Guo, L., Yang, B., Chen, F., Yuan, X., Cheng, J., Chen, X., Zhou, Y., Yang, X., Li, Y., Liu, Y., et al. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04828-2 · Cited by 5 · see citing works

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Gan, D., Ran, Y., Pan, H., Yan, Q., Zhang, W., Zhou, B., Xu, P., Liao, R., Xue, H., Jiang, W. M., et al. (2025) · Advanced Science · doi:10.1002/advs.202510103 · Cited by 5 · see citing works

The Role of SIRT1–BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells

Yang, B., Wang, F., Xu, Y., Yuan, X., Yang, Y., Chen, X., Tian, T., Chen, F., Tang, D., He, Z., et al. (2025) · Biological Trace Element Research · doi:10.1007/s12011-024-04503-y · Cited by 5 · see citing works

Sodium-Glucose Transporter-2 Inhibitors (SGLT2i) and Myocardial Ischemia: Another Compelling Reason to Consider These Agents Regardless of Diabetes

Piccirillo, F., Lanciotti, M., Nusca, A., Frau, L., Spanò, A., Liporace, P., Ussia, G. P., & Grigioni, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052103 · Cited by 6 · see citing works

Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Zhang, X., Guo, Q., Fang, J., Cheng, Q., Zhu, Z., Yu, Q., Wang, H., Hong, Y., Liu, C., Yang, H., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03401-2 · Cited by 5 · see citing works

Neuroprotective effects of SIRT1 in human RGCs derived from iPSCs following oxidative stress induction at early and late stages of differentiation

Alhadi, S. A., Camacho, D., Chaqour, B., Rossman, J., Pham, J., Shindler, K. S., & Ross, A. G. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110526 · Cited by 5 · see citing works

Cathelicidin-BF regulates the AMPK/SIRT1/NF-κB pathway to ameliorate murine osteoarthritis: In vitro and in vivo studie

Zhou, H., Zou, L., Ren, H., Shen, Z., Lin, Y., Cai, H., & Zhang, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112201 · Cited by 5 · see citing works

Circulating exosome-mediated AMPKα–SIRT1 pathway regulates lipid metabolism disorders in calf hepatocytes

Zhang, D., Ding, H., Liu, C., Huang, Y., Tai, W., Feng, S., Wang, X., Zhao, C., & Li, Y. (2024) · Research in Veterinary Science · doi:10.1016/j.rvsc.2024.105177 · Cited by 5 · see citing works

The effect of weight loss therapies on sirtuin 1 regulation: a systematic review and meta-analysis of randomized controlled trials

Sohouli, M. H., Eslamian, G., Rohani, P., Zand, H., & Guimarães, N. S. (2024) · BMC Nutrition · doi:10.1186/s40795-024-00921-2 · Cited by 4 · see citing works

Puerarin prevents cadmium-induced endoplasmic reticulum stress via SIRT1-dependent PERK-CHOP pathway in HepG2 cells

Huang, D., Qiu, M., Luo, K., Zhu, Y., Zhang, S., He, Z., Hu, X., & Zhaohui, C. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025039 · Cited by 4 · see citing works

Estrogen, Epigenetics, and Cardiometabolic Health: Mechanisms and Therapeutic Strategies in Postmenopausal Women

Edwards, A., Singh, P., Shah, V., Chander, V., & Mishra, S. (2026) · Cells · doi:10.3390/cells15060529 · Cited by 4 · see citing works

Ionic liquid mediated synthesis of TiO2-ZnO-BMIMBr nanocomposite for electrochemical sensing of neurotransmitter

Khairnar, A. P., Tawade, A. K., Kamble, B. B., Khune, H. S., Powar, A. A., Sharma, K. K. K., Patil, M. R., Tayade, S. N., & Patil, V. S. (2023) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-023-09956-w · Cited by 4 · see citing works

SIRT1-dependent regulation of mitochondrial metabolism participates in miR-30a-5p-mediated cardiac remodeling post-myocardial infarction

Wu, C., Hong, Y., Zhang, X., Li, J.-Z., Li, Y.-T., Xie, J., Wang, R., Wang, Y., & Li, G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.030 · Cited by 4 · see citing works

Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review

Budziak, S., Kloza, M., Krzyżewska, A., & Baranowska‐Kuczko, M. (2025) · Molecules · doi:10.3390/molecules30183740 · Cited by 3 · see citing works

The natural β-glucan polysaccharide laminarin ameliorates microglial inflammation by metabolic reprogramming through the sirtuin 1/AMP-activated protein kinase axis

Moon, C. Y., Shin, S., Lee, J., Kim, S., Lee, S., & Kang, H. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152488 · Cited by 3 · see citing works

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD

Xu, Y., Hu, T., Jiang, P., Wang, X., Yao, J., Shen, H., Zhang, Z., Zheng, B., Wang, T., Ren, Y., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1480847 · Cited by 3 · see citing works

Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review)

Zhou, Q., Gao, W., Zhang, W., Tang, S., Fu, H., & Pan, P. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13573 · Cited by 3 · see citing works

Association between miR-138-5p, miR-132-3p, SIRT1, STAT3, and CD36 and atherogenic indices in blood mononuclear cells from patients with atherosclerosis

Ehsani, S., Mard‐Soltani, M., Ahmadpour, F., & Shahsavari, G. (2023) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-023-00464-4 · Cited by 3 · see citing works

SIRT1 Serum Concentrations in Lipodystrophic Syndromes

Salvatori, L., Ceccarini, G., Magno, S., Tozzi, R., Contini, S., Pelosini, C., Santini, F., Gnessi, L., & Mariani, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094785 · Cited by 2 · see citing works

Phase Separation in Biological Systems: Implications for Disease Pathogenesis

Dave, R., Pandey, K., Patel, R. B., Solanki, R., Gour, N., & Bhatia, D. D. (2025) · ChemBioChem · doi:10.1002/cbic.202400883 · Cited by 2 · see citing works

Effects and potential mechanisms of Alismatis Rhizoma extracts on glucose and lipid metabolism: A systematic review and meta-analysis of rodent studies

Di, Z., Zhang, B., Tan, H., Dai, Q., Du, X. M., Tao, J., Ding, R., Yue, R., & Yang, H. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120386 · Cited by 2 · see citing works

Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota

Xu, Y., Jiang, J., Li, T., Yan, Q., Jiang, Z., & Yang, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.067 · Cited by 2 · see citing works

SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies

Liu, H., Ouyang, Y., & Ge, H. (2025) · Human Cell · doi:10.1007/s13577-025-01285-w · Cited by 2 · see citing works

Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis

Wang, X., Ma, M., Zhu, L.-C., Dai, L.-F., Qin, C., Shao, S., Xu, X.-W., Gao, R.-X., & Zhang, Z.-H. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i39.110115 · Cited by 2 · see citing works

Discovery of citrinin derivatives with SIRT1 agonist activity from Penicillium citrinum TJ507

Zhang, Y., Huang, X., Wei, J., Zhou, J., Chen, M., 张金龙, Tang, Y., Qi, C., & Zhang, Y. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109473 · Cited by 2 · see citing works

Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation

Yang, J., Wang, A., Qi, Z., Xu, P., Pan, H., Song, W., Wang, K., & Lin, D. (2026) · Burns · doi:10.1016/j.burns.2026.107872 · Cited by 2 · see citing works

Epigenetic regulation and posttranslational modifications of FXR: underlying mechanisms and implications in digestive diseases

Mi, Q.-R., Wu, C.-Q., Lv, C., Zhao, K.-E., Liu, Z., Xu, P., & Li, L. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01726-0 · Cited by 2 · see citing works

Succinate Mediates Immune‐Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen‐Induced Retinopathy

Shen, T., Lin, R., Zheng, T., Yu, J., & Cai, W. (2026) · The FASEB Journal · doi:10.1096/fj.202503858rr · Cited by 2 · see citing works

Modulation of mitochondrial biogenesis by flavonoids via SIRT1 signalling in metabolic syndrome: a systematic review

Sahariah, P., Saikia, L. P., Bharali, A., Law, D. S. N., Sen, S., & Dutta, P. P. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11599-z · Cited by 2 · see citing works

Targeting Autophagy to Restore Intestinal Integrity in Sepsis: Resveratrol’s NOX1/SIRT1-Mediated Protective Effect

Zhang, W., Yu, J., Shi, Z., Jiao, Y., Lai, Z., Chi, J., Li, J., & Meng, J. (2026) · Pharmacology · doi:10.1159/000550966 · Cited by 2 · see citing works

Molecular mechanisms underlying Parkinson’s disease and role of phytochemicals, α-synuclein, sirtuins, and incretin mimetics in potential therapy

Juthi, S. S., Ansari, P., Ahmed, M. F., Khan, J. T., Seidel, V., Kumar, S., Kumari, R., McKillop, A. M., Abdel‐Wahab, Y. H. A., & Flatt, P. R. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1798309 · Cited by 2 · see citing works

An updated review of male subfertility and leydig cell senescence under oxidative stress: Pathophysiology, mechanisms, and emerging antioxidant and nanotherapeutic approaches

Mansour, D. A., Hassan, A. A., & Baraka, S. M. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103559 · Cited by 2 · see citing works

Molecular Interplay between hypertension and dyslipidemia in cardiovascular pathogenesis: toward precision-based therapeutic strategies

Cao, B., Pei, J., Kong, L., Han, Y., Yan, G., & Wang, X. P. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1783567 · Cited by 2 · see citing works

Effects of 8-Week High-Intensity Interval Training Intervention Regulating the SIRT1/PGC1α Pathway on Hippocampal Neuron Injury and Cognitive Impairment in Obese Rats

Cui, K., Zhang, J., Wei, H., Meng, Y., Li, C., Liao, R., Miao, J., & Su, H. (2025) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2025.107548 · Cited by 2 · see citing works

Metadichol® a Sirtuin Modulator for Anti-Aging TherapiesPreprint

Raghavan, P. R. (2023) · Research Square · doi:10.21203/rs.3.rs-3199226/v2 · Cited by 2 · see citing works

Sirtuins and Melatonin: Linking Chronobiology to Inflammation and Aging

Ungurianu, A., Drăgoi, C. M., Nicolae, A. C., Dumitrescu, I.-B., Grădinaru, D., & Margina, D. M. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1003914 · Cited by 1 · see citing works

Gut microbiota-derived TMAO and SIRT1/HMGB1 Axis: unveiling mechanisms of renal impairment in beta-thalassemia major

Saad, K., Elgalaly, N. A., Ahmad, A. R., Elhoufey, A. A., Jaber, H., & Elgenidy, A. (2024) · Pediatric Research · doi:10.1038/s41390-024-03747-7 · Cited by 1 · see citing works

Antioxidant and Analgesic Effect of Melatonin Involving Sirtuin 1: A Randomised Pilot Clinical Study

Perrone, S., Carloni, S., Benedetti, S., Weiss, M., Marseglia, L. M., Dell’Orto, V., Beretta, V., Pappagallo, N., Pagliarini, M., Albertini, M. C., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70605 · Cited by 1 · see citing works

Capsaicin counteracts dexamethasone-induced osteoporosis and metabolic disturbances in rats: role of AMPK/SIRT1/β-catenin/RUNX2 pathway

Habiba, E. S., Fathelbab, M. H., Omar, E. M., El-Alkamy, A., Omar, W. E., & Harby, S. A. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10460-0 · Cited by 1 · see citing works

Exercise mimetics: A new strategy for treating metabolic diseases?

Li, M., Wei, A., & Wang, T. (2025) · Science & Sports · doi:10.1016/j.scispo.2025.08.003 · Cited by 1 · see citing works

Dihydro-R demonstrates innate immunity against Adenovirus-7 by suppressing the NF-κB/JAK-STAT pathway in a SIRT1-dependent manner

Wang, C., Li, X. A., Wang, C., Ye, Y., Zhao, M., Guo, M., Xu, T., Kuang, L., Yan, Y., Liang, W., et al. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102387 · Cited by 1 · see citing works

Exploring plant-based metallic nanoparticles for advanced medicinal application in diabetes

Priya, Chaudhary, A., Rejeeth, C., Kumar, S., Ding, X., & Sharma, A. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100243 · Cited by 1 · see citing works

SIRT1-mediated FABP4 destabilization attenuates fibrosis and ferroptosis in non-alcoholic fatty liver disease

Qiu, H., Chen, K., Qiu, Y., Yang, Y., Wang, T., Wang, W., & Jiang, L. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-02029-8 · Cited by 1 · see citing works

Resolvin D1 alleviates liver inflammation and fibrosis through SIRT1-mediated NF-κB and TGF-β1/Smads pathways

Li, J., Zhao, L., Xi, Y., & Xiaoling, D. (2026) · Journal of Inflammation · doi:10.1186/s12950-026-00492-y · Cited by 1 · see citing works

Sirtuin 1 enhances alveolar bone repair by regulating glycolytic metabolism via the Wnt/β-catenin pathway

Shan, Z., Zhang, Z., Xia, Y., Wu, C., Yuan, L., Wang, Y., Ma, J., & Zhang, Y. (2026) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjag055 · Cited by 1 · see citing works

SIRT1 in Metabolic Health and Disease

Boutant, M., & Cantó, C. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_4 · Cited by 3 · see citing works

SIRT1 and metabolic syndrome

Mac‐Marcjanek, K., Wójcik, M., & Cypryk, K. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works

SIRT1 in metabolic syndrome: Where to target matters

Wang, Y., Xu, C., Liang, Y., & Vanhoutte, P. M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.009 · Cited by 51 · see citing works

SIRT1 and insulin resistance

Cao, Y., Jiang, X., Ma, H., Wang, Y., Xue, P., & Liu, Y. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.08.022 · Cited by 152 · see citing works

The Versatility of Sirtuin-1 in Endocrinology and Immunology

Rasha, F. A., Mims, B. M., Castro‐Piedras, I., Barnes, B. J., Grisham, M. B., Rahman, R. L., & Pruitt, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.589016 · Cited by 35 · see citing works