Cited by 793Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

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Calorie restriction–the SIR2 connection

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Guarente, Leonard, Picard, Frédéric·2005·Cell

DOI 10.1016/j.cell.2005.01.029

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Abstract

A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast and Drosophila. We then describe the physiological changes in mammals during calorie restriction and how they may lead to the observed health benefits. We summarize the roles of mammalian Sirt1 in mediating these changes in tissues and endocrine systems and propose that Sirt1 regulates calorie restriction by sensing low calories and triggering physiological changes linked to health and longevity.

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Authors: Guarente, L., & Picard, F.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Guarente, Leonard
ORCID: Guarente, Leonard
Picard, Frédéric
Venue: Cell
Publisher: Elsevier BV
Published: 2005-02
Volume: 120
Issue: 4
Pages: 473-482
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2005.01.029
OpenAlex: W2078023359
Cited by: 793
References: 81
Citations by year: 2026: 4 · 2025: 7 · 2024: 14 · 2023: 8 · 2022: 11 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 24 · 2017: 27 · 2016: 40 · 2015: 41 · 2014: 37 · 2013: 48 · 2012: 61
FWCI: 7.51
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3088 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: caloric restriction, Sir2, SIRT1, NAD+-dependent deacetylase, longevity, aging, healthspan, yeast, Drosophila, mammals, hormonal regulation, physiological adaptation
MeSH terms: Animals, Drosophila, Insulin, Longevity, Saccharomyces cerevisiae, Signal Transduction, Heredodegenerative Disorders, Nervous System, Caloric Restriction, Sirtuins, PPAR gamma, Mice, Sirtuin 1

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Calorie restriction–the SIR2 connection

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