PGC-1α, a New Therapeutic Target in Huntington's Disease?

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Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

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Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

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Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin

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Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

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Mitochondrial Diseases of the Brain

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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

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PGC-1α and PGC-1Β Regulate Mitochondrial Density in Neurons

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Mitochondria in Huntington's disease

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PGC-1β controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis

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Regulation of mitochondrial biogenesis and PGC-1α under cellular stress

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ERRα: a metabolic function for the oldest orphan

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Structure, function, and regulation of mitofusin‐2 in health and disease

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Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease

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Neuroprotective effects of creatine

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Huntington's disease: The current state of research with peripheral tissues

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Mitochondrial Lactate Oxidation Complex and an Adaptive Role for Lactate Production

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Nature and cause of mitochondrial dysfunction in Huntington’s disease: focusing on huntingtin and the striatum

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Antioxidants in Huntington's disease

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Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

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Huntington’s Disease and Mitochondria

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Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

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PPAR: a therapeutic target in Parkinson’s disease

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Exosomes from adipose‐derived stem cells ameliorate phenotype of Huntington's disease <i>in vitro</i> model

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Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders

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Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

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The gene coding for PGC-1α modifies age at onset in Huntington's Disease

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Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease

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Neuroprotective effects of PPAR ‐γ agonist rosiglitazone in N171‐82Q mouse model of Huntington's disease

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Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications☆

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MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

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Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease

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Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

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PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

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Neuroprotective and metabolic effects of resveratrol: Therapeutic implications for Huntington's disease and other neurodegenerative disorders

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Myopathy as a first symptom of Huntington's disease in a Marathon runner

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Targeting mitochondrial dysfunction in neurodegenerative disease: Part II

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A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

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Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases

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Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

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Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

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Sumoylation Regulates Nuclear Localization of Lipin-1α in Neuronal Cells

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Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke: their molecular targets and action mechanisms

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Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

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Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia

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Energy defects in Huntington's disease: Why “in vivo” evidence matters

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Peroxisome Proliferator‐Activated Receptor‐γ in Amyotrophic Lateral Sclerosis and Huntington′s Disease

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Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington's disease

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In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

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Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

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Targeting mitochondrial dysfunction in neurodegenerative disease: Part I

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Mitochondrial therapies for Parkinson's disease

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PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

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MicroRNA-124 slows down the progression of Huntington’s disease by promoting neurogenesis in the striatum

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Potential Future Neuroprotective Therapies for Neurodegenerative Disorders and Stroke

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Rosiglitazone activation of PPARγ-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta–induced mitochondrial dysfunction and oxidative stress

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Complexity and Heterogeneity: What Drives the Ever‐changing Brain in Huntington's Disease?

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PGC‐1α: overexpression exacerbates β‐amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

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Upregulation of PGC ‐1α expression by A lzheimer's disease‐associated pathway: presenilin 1/amyloid precursor protein ( APP )/intracellular domain of APP

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The relevance of mitochondrial morphology for human disease

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Neuroprotection for Huntington’s Disease: Ready, Set, Slow

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Extracts of Adipose Derived Stem Cells Slows Progression in the R6/2 Model of Huntington's Disease

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