The biology of PGC-1α and its therapeutic potential
Open accessAbstract
In eukaryotes, cellular and systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. Furthermore, PGC-1alpha controls many of the phenotypic adaptations of oxidative tissues to external and internal perturbations. By contrast, dysregulated metabolic plasticity is involved in the etiology of numerous diseases. Accordingly, modulation of PGC-1alpha levels and activity has recently been proposed as a therapeutic option for several pathologies. However, pharmacological interventions aimed at PGC-1alpha have to overcome inherent limitations of targeting a coactivator protein. Here, I focus on the recent breakthroughs in the identification of physiological and pathophysiological contexts involving PGC-1alpha. In addition, perspectives regarding the therapeutic importance of PGC-1alpha-controlled cellular and systemic metabolism are outlined.
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The present study revealed novel effective and safe pharmacological modulators of PGC-1α, which determines increases in cellular energy production, neuron functionality, and viability.
“The present study revealed novel effective and safe pharmacological modulators of the transcription coactivator PGC-1α, which determines increases in cellular energy production, neuron functionality, and viability [2,5,17,80].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [2]
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- Authors
- Handschin, C.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Handschin, Christoph
- ORCID
- Handschin, Christoph
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 30
- Issue
- 6
- Pages
- 322-329
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2129451233
- Cited by
- 108
- References
- 20
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 15 · 2013: 7 · 2012: 7
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- PGC-1α, mitochondrial biogenesis, mitochondrial function, metabolic plasticity, cellular metabolism, systemic metabolism, disease therapy
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Brain Diseases, Heat-Shock Proteins, Humans, Liver Diseases, Transcription Factors
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