Cited by 2,373Cellular transport and secretionExtracellular vesicles in diseaseNeuroscience and Neuropharmacology Research

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Molecular Anatomy of a Trafficking Organelle

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Takamori, Shigeo, Holt, Matthew, Stenius, Katinka, Lemke, Edward A., Grønborg, Mads, Riedel, Dietmar, Urlaub, Henning, Schenck, Stephan, Brügger, Britta, Ringler, Philippe, Müller, Shirley A., Rammner, Burkhard, Gräter, Frauke, Hub, Jochen S., De Groot, Bert L., Mieskes, Gottfried, Moriyama, Yoshinori, Klingauf, Jürgen, Grubmüller, Helmut, Heuser, John, Wieland, Felix, Jahn, Reinhard·2006·Cell

DOI 10.1016/j.cell.2006.10.030

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Abstract

Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor compartment and fuse with an acceptor compartment. Common principles of budding and fusion have emerged, and many of the proteins involved in these events are now known. However, a detailed picture of an entire trafficking organelle is not yet available. Using synaptic vesicles as a model, we have now determined the protein and lipid composition; measured vesicle size, density, and mass; calculated the average protein and lipid mass per vesicle; and determined the copy number of more than a dozen major constituents. A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins. Synaptic vesicles are dominated by proteins, possess a surprising diversity of trafficking proteins, and, with the exception of the V-ATPase that is present in only one to two copies, contain numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.

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Authors: Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., Müller, S. A., Rammner, B., Gräter, F., Hub, J. S., De Groot, B. L., Mieskes, G., Moriyama, Y., Klingauf, J., Grubmüller, H., Heuser, J., Wieland, F., & Jahn, R.
Affiliations: Max Planck Institute for Biophysical Chemistry (DE)
Yale University (US)
Heidelberg University (DE)
University of Basel (CH)
Okayama University (JP)
Washington University in St. Louis (US)
Corresponding author: Jahn, Reinhard
ORCID: Takamori, Shigeo
Holt, Matthew
Lemke, Edward A.
Grønborg, Mads
Riedel, Dietmar
Urlaub, Henning
Schenck, Stephan
Brügger, Britta
Ringler, Philippe
Gräter, Frauke
Hub, Jochen S.
Moriyama, Yoshinori
Klingauf, Jürgen
Grubmüller, Helmut
Wieland, Felix
Jahn, Reinhard
Venue: Cell
Publisher: Elsevier BV
Published: 2006-11
Volume: 127
Issue: 4
Pages: 831-846
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2006.10.030
OpenAlex: W2144447780
Cited by: 2,373
References: 65
Citations by year: 2026: 65 · 2025: 94 · 2024: 124 · 2023: 103 · 2022: 136 · 2021: 131 · 2020: 132 · 2019: 106 · 2018: 134 · 2017: 126 · 2016: 121 · 2015: 127 · 2014: 131 · 2013: 119 · 2012: 124
FWCI: 47.65
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2450 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion, other-oa)
Max Planck Institute for Plasma Physics (submittedVersion)
GRO (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Funders: University of Cambridge
Deutsche Forschungsgemeinschaft
Forsknings- og Innovationsstyrelsen
Leibniz-Gemeinschaft
Japan Society for the Promotion of Science
Danish Agency for Science and Higher Education
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: synaptic vesicles, membrane trafficking, vesicle budding, vesicle fusion, protein composition, lipid composition, protein copy number, V-ATPase, neurotransmitter uptake
MeSH terms: Animals, Lipids, Models, Molecular, Proteins, Spectrometry, Fluorescence, Synaptic Vesicles, Protein Transport, Rats

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