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Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1
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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
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“The specificity of Bcl-2-mediated suppression of MDP-induced IL-1b production was confirmed by experiments using bacterial flagellin (Figure 5D, right), which stimulates an alternative NLR-family member (Ipaf/CLAN; Franchi et al., 2006; Miao et al., 2006) that does not bind Bcl-2 or Bcl-XL (shown).”
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Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282
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A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury
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Sensing pathogens and danger signals by the inflammasome
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Effector functions of NLRs in the intestine: innate sensing, cell death, and disease
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Metadata
- Authors
- Bruey, J.-M., Bruey-Sedano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C. L., Bailly-Maitre, B., Li, X., Osterman, A., Matsuzawa, S.-I., Terskikh, A. V., Faustin, B., & Reed, J. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 129
- Issue
- 1
- Pages
- 45-56
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2044819348
- Cited by
- 319
- References
- 5
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
