The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
Open accessAbstract
SUMMARY MicroRNA (miRNA) govern an expanding number of biological and disease processes. Understanding the mechanisms by which the miRNA pathway is regulated, therefore, represents an important area of investigation. We determined that the human miRNA-generating complex is comprised of Dicer and phospho-TRBP isoforms. Phosphorylation of TRBP is mediated by the mitogen activated protein kinase (MAPK) Erk. Expression of phospho-mimic TRBP and TRBP phosphorylation enhanced miRNA production by increasing stability of the miRNA-generating complex. Mitogenic signaling in response to serum and the tumor promoter PMA was dependent on TRBP phosphorylation. These effects were accompanied by a coordinated increase in levels of growth promoting miRNA and reduced expression of let-7 tumor suppressor miRNA. Conversely, pharmacological inhibition of MAPK/Erk resulted in an anti-growth miRNA profile. Taken together, these studies indicate that the MAPK/Erk pathway regulates the miRNA machinery and suggest a general principle, wherein signaling systems target the miRNA pathway to achieve biological responses.
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Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
The widespread regulation of microRNA biogenesis, function and decay
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Regulation of mRNA Translation and Stability by microRNAs
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MicroRNA regulation by RNA-binding proteins and its implications for cancer
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Metadata
- Authors
- Paroo, Z., Ye, X., Chen, S., & Liu, Q.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 139
- Issue
- 1
- Pages
- 112-122
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2047256111
- Cited by
- 366
- References
- 7
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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