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Cited by 366

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

Open access
Paroo, Zain, Ye, Xuecheng, Chen, She, Liu, Qinghua·2009·Cell
DOI 10.1016/j.cell.2009.06.044
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Abstract

SUMMARY MicroRNA (miRNA) govern an expanding number of biological and disease processes. Understanding the mechanisms by which the miRNA pathway is regulated, therefore, represents an important area of investigation. We determined that the human miRNA-generating complex is comprised of Dicer and phospho-TRBP isoforms. Phosphorylation of TRBP is mediated by the mitogen activated protein kinase (MAPK) Erk. Expression of phospho-mimic TRBP and TRBP phosphorylation enhanced miRNA production by increasing stability of the miRNA-generating complex. Mitogenic signaling in response to serum and the tumor promoter PMA was dependent on TRBP phosphorylation. These effects were accompanied by a coordinated increase in levels of growth promoting miRNA and reduced expression of let-7 tumor suppressor miRNA. Conversely, pharmacological inhibition of MAPK/Erk resulted in an anti-growth miRNA profile. Taken together, these studies indicate that the MAPK/Erk pathway regulates the miRNA machinery and suggest a general principle, wherein signaling systems target the miRNA pathway to achieve biological responses.

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Metadata

Authors
Paroo, Z., Ye, X., Chen, S., & Liu, Q.
Venue
Cell
Publisher
Elsevier BV
Published
2009-10
Volume
139
Issue
1
Pages
112-122
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2009.06.044
OpenAlex
W2047256111
Cited by
366
References
7
FWCI
11.27
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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