Cited by 893Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

Open access

Eroglu, Çagla, Allen, Nicola J., Susman, Michael W., O'Rourke, Nancy A., Park, Chan Young, Özkan, Engin, Chakraborty, Chandrani, Mulinyawe, Sara B., Annis, Douglas S., Huberman, Andrew D., Green, Eric M., Lawler, Jack, Dolmetsch, Ricardo, Garcia, K. Christopher, Smith, Stephen J., Luo, Z. David, Rosenthal, Arnon, Mosher, Deane F., Barres, Ben A.·2009·Cell

DOI 10.1016/j.cell.2009.09.025PMC PMC2791798

Open this paper in CoChat — free account Open PDF

Abstract

Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of alpha2delta-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. alpha2delta-1 overexpression increases synaptogenesis in vitro and in vivo and is required postsynaptically for thrombospondin- and astrocyte-induced synapse formation in vitro. Gabapentin antagonizes thrombospondin binding to alpha2delta-1 and powerfully inhibits excitatory synapse formation in vitro and in vivo. These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2009.09.025

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Self-citation
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Self-citation
The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel
GEE, N. S., Brown, J. P., Dissanayake, V. U. K., Offord, J., Thurlow, R. J., & Woodruff, G. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5768 · Cited by 1,182
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
Meyer‐Franke, A., Kaplan, M. R., Pfrieger, F. W., & Barres, B. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90172-8 · Cited by 849
Self-citation
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
Whittaker, C., & Hynes, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0259 · Cited by 788
Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits
Micheva, K. D., & Smith, S. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.014 · Cited by 787
Self-citation
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680

Show all 49 references

Sorted by citations

Items 401–500 of 892

Rapid Quantification of Gabapentin, Pregabalin, and Vigabatrin in Human Serum by Ultraperformance Liquid Chromatography With Mass-Spectrometric Detection
Chahbouni, A., Sinjewel, A., den Burger, J. C. G., Vos, R. M., Wilhelm, A. J., Veldkamp, A. I., & Swart, E. L. (2012) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31827788c0 · Cited by 33
Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer
Roberts, D. D., Kaur, S., & Isenberg, J. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7140 · Cited by 33
A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice
Yook, C., Kim, K., Kim, D., Kang, H., Kim, S.-G., Kim, E., & Kim, S. Y. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00241 · Cited by 33
Astroglial functions
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00008-0 · Cited by 31
Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells
Kang, S., Byun, J., Son, S. M., & Mook‐Jung, I. (2018) · Cell Death Discovery · doi:10.1038/s41420-017-0023-4 · Cited by 32
Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals
Kruyer, A., Dixon, D., Angelis, A., Amato, D., & Kalivas, P. W. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01333-5 · Cited by 33
Can glial cells save neurons in epilepsy?
Nobili, P., Nikolic, L. M., Shen, W., & Pristov, J. B. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360281 · Cited by 35
Formation of N-type (Cav2.2) voltage-gated calcium channel membrane microdomains: Lipid raft association and clustering
Robinson, P. A., Etheridge, S., Song, L., Armenise, P., Jones, O., & Fitzgerald, E. M. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.08.006 · Cited by 32
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants
Lotarski, S. M., Hain, H. S., Peterson, J., Galvin, S., Strenkowski, B. P., Donevan, S. D., & Offord, J. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.03.002 · Cited by 32
The Anti-Allodynic Gabapentinoids
Alles, S. R. A., & Smith, P. A. (2016) · The Neuroscientist · doi:10.1177/1073858416628793 · Cited by 44
From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury
Yuan, Y., Liu, H., Dai, Z., He, C., Qin, S., & Su, Z. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01258-3 · Cited by 37
α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse
Beeson, K. A., Beeson, R., Westbrook, G. L., & Schnell, E. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1514-19.2020 · Cited by 35
Glioma-Derived TSP2 Promotes Excitatory Synapse Formation and Results in Hyperexcitability in the Peritumoral Cortex of Glioma
Wang, Y.-H., Huang, T.-L., Chen, X., Yu, S., Li, W., Chen, T., Li, Y., Kuang, Y.-Q., & Shu, H. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa149 · Cited by 33
Thrombospondin‐4 promotes bladder cancer cell migration and invasion via MMP2 production
Chou, K., Chang, A., Ho, C., Tsai, T., Chen, H., Chen, P., & Hwang, T. I. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16463 · Cited by 30
Synapse Dysfunctions in Multiple Sclerosis
Schwarz, K., & Schmitz, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021639 · Cited by 36
Pregabalin Modulation of Neurotransmitter Release Is Mediated by Change in Intrinsic Activation/Inactivation Properties of Cav2.1 Calcium Channels
Guilmi, M. N. D., Urbano, F. J., Inchauspe, C. G., & Uchitel, O. D. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172171 · Cited by 31
Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins
Koh, S., Kim, N., Yin, H. H., Harris, I. R., Dejneka, N. S., & Eroğlu, Ç. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1364-15.2015 · Cited by 31
Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis
Felsted, J. A., Chien, C.-H., Wang, D., Panessiti, M., Ameroso, D., Greenberg, A. S., Feng, G., Kong, D., & Rios, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.048 · Cited by 31
The “molecular soldiers” of the CNS: astrocytes, a comprehensive review on their roles and molecular signatures
Rupareliya, V. P., Singh, A. A., Butt, A. M., A, H., & Kumar, H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176048 · Cited by 29
Distribution of thrombospondins and their neuronal receptor α2δ1 in the rat retina
Huang, J., Zhou, L., Wang, H., Luo, J., Zeng, L., Xiong, K., & Chen, D. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.03.012 · Cited by 30
Cell autonomous and noncell‐autonomous role of NF‐κB p50 in astrocyte‐mediated fate specification of adult neural progenitor cells
Cvijetic, S., Bortolotto, V., Manfredi, M., Ranzato, E., Marengo, E., Salem, R., Canonico, P. L., & Grilli, M. (2016) · Glia · doi:10.1002/glia.23085 · Cited by 30
Thrombospondin-1 as a Potential Therapeutic Target: Multiple Roles in Cancers
Wang, P., Zeng, Z., Lin, C., Wang, J., Xu, W., Ma, W., Xiang, Q., Liu, H., & Liu, S.-L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200128091506 · Cited by 30
Thoracic VGluT2+Spinal Interneurons Regulate Structural and Functional Plasticity of Sympathetic Networks after High-Level Spinal Cord Injury
Noble, B. T., Brennan, F. H., Wang, Y., Guan, Z., Mo, X., Schwab, J. M., & Popovich, P. G. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2134-21.2022 · Cited by 30
Targeting of Voltage-Gated Calcium Channel α2δ-1 Subunit to Lipid Rafts Is Independent from a GPI-Anchoring Motif
Robinson, P. A., Etheridge, S., Song, L., Shah, R., Fitzgerald, E. M., & Jones, O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019802 · Cited by 30
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus
Okada‐Tsuchioka, M., Segawa, M., Kajitani, N., Hisaoka‐Nakashima, K., Shibasaki, C., Morinobu, S., & Takebayashi, M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.001 · Cited by 30
Traumatic Brain Injury and Posttraumatic Epilepsy
Prince, D. A., Parada, I., & Graber, K. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0024 · Cited by 30
Gabapentin for fibromyalgia pain in adults
Cooper, T. E., Moore, R. A., Derry, S., & Wiffen, P. J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012188 · Cited by 30
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades
Tran, M. D., Furones-Alonso, O., Sanchez‐Molano, J., & Bramlett, H. M. (2012) · Neuroreport · doi:10.1097/wnr.0b013e32835688fe · Cited by 29
Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity
Koh, S., Chen, W. J., Dejneka, N. S., Harris, I. R., Lü, B., Girman, S., Saylor, J., Wang, S., & Eroğlu, Ç. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1532-17.2018 · Cited by 29
L-Type Calcium Channels: Structure and Functions
Feng, T., Kalyaanamoorthy, S., & Barakat, K. (2018) · InTech eBooks · doi:10.5772/intechopen.77305 · Cited by 33
Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development
Testen, A., Ali, M., Sexton, H. G., Hodges, S., Dubester, K., Reissner, K. J., Swartzwelder, H. S., & Risher, M.-L. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.044 · Cited by 29
Role of High Voltage-Gated Ca2+ Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function
Tuluc, P., Theiner, T., Jacobo‐Piqueras, N., & Geisler, S. M. (2021) · Cells · doi:10.3390/cells10082004 · Cited by 34
Targets for preventing epilepsy following cortical injury
Li, H., McDonald, W. S., Parada, I., Faria, L. C., Graber, K., Takahashi, D. K., Ma, Y., & Prince, D. A. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.042 · Cited by 29
Hypothalamic Dysfunction of the Thrombospondin Receptor α2δ-1 Underlies the Overeating and Obesity Triggered by Brain-Derived Neurotrophic Factor Deficiency
Cordeira, J., Felsted, J. A., Teillon, S., Daftary, S. S., Panessiti, M., Wirth, J. R., Sena‐Esteves, M., & Rios, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1572-13.2014 · Cited by 29
Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α2δ Ligands
Thorpe, A. J., Clair, A. G., Hochman, S., & Clemens, S. (2011) · European Neurology · doi:10.1159/000328431 · Cited by 29
Plasticity Response in the Contralesional Hemisphere after Subtle Neurotrauma: Gene Expression Profiling after Partial Deafferentation of the Hippocampus
Andersson, D., Wilhelmsson, U., Nilsson, M., Kubista, M., Ståhlberg, A., Pekna, M., & Pekny, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070699 · Cited by 29
Dynamic association of calcium channel subunits at the cellular membrane
Voigt, A., Freund, R., Heck, J., Missler, M., Obermair, G. J., Thomas, U., & Heine, M. (2016) · Neurophotonics · doi:10.1117/1.nph.3.4.041809 · Cited by 30
α2δ‐1‐Linked NMDA and AMPA Receptors in Neuropathic Pain and Gabapentinoid Action
Huang, Y., Chen, S., & Pan, H. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70064 · Cited by 28
Differential Dependence of GABAergic and Glutamatergic Neurons on Glia for the Establishment of Synaptic Transmission
Turko, P., Groberman, K., Browa, F., Cobb, S., & Vida, I. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy029 · Cited by 27
Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner
Mazur, A., Bills, E., DeSchepper, K. M., Williamson, J. C., Henderson, B. J., & Risher, W. C. (2021) · eNeuro · doi:10.1523/eneuro.0014-21.2021 · Cited by 29
The Calcium Channel α2δ1 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain
Cui, W., Wu, H., Yu, X., Song, T., Xu, X., & Xu, F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.699731 · Cited by 30
Expression of voltage‐gated calcium channel α2δ4 subunits in the mouse and rat retina
Müller, L. P. D. S., Liu, J., Solomon, A. M., Rodriguez, A. R., & Brecha, N. C. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23294 · Cited by 28
Calcium channels as therapeutic targets
Belardetti, F., & Zamponi, G. W. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.38 · Cited by 27
Astrocytes and developmental plasticity in fragile X.
Cheng, C., Sourial, M., & Doering, L. C. (2012) · Neural Plasticity · doi:10.1155/2012/197491 · Cited by 28
Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor
Chen, J., Stork, T., Kang, Y., Nardone, K., Auer, F., Farrell, R. J., Jay, T. R., Heo, D., Sheehan, A. E., Paton, C., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.008 · Cited by 27
Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology
Tong, W., Maira, M., Gagnon, M., & Saragovi, H. U. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134255 · Cited by 27
Drug safety evaluation of pregabalin
Toth, C. C. (2012) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2012.677026 · Cited by 27
Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit
Offord, J., & Isom, L. L. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1173010 · Cited by 27
Proteolytic maturation of α2δ controls the probability of synaptic vesicular release
Ferron, L., Kadurin, I., & DOLPHIN, A. C. (2018) · eLife · doi:10.7554/elife.37507 · Cited by 25
Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer
Ma, Y., Yang, X., Zhao, W., Yang, Y., & Zhang, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03522-0 · Cited by 27
Astrocyte‐mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome
Reynolds, K. E., Wong, C. R., & Scott, A. L. M. (2021) · Glia · doi:10.1002/glia.23997 · Cited by 25
The gabapentinoid drugs and their abuse potential
Goins, A. E., Patel, K., & Alles, S. R. A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107926 · Cited by 27
Trigeminal nerve injury‐induced thrombospondin‐4 up‐regulation contributes to orofacial neuropathic pain states in a rat model
Li, K.-W., Kim, D., Zaucke, F., & Luo, Z. D. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00396.x · Cited by 27
Self-citation
E2F-1 Directly Regulates Thrombospondin 1 Expression
Ji, W., Zhang, W., & Xiao, W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013442 · Cited by 27
2 -1 Signaling in Nucleus Accumbens Is Necessary for Cocaine-Induced Relapse
Spencer, S. M., Brown, R. M., Quintero, G. C., Kupchik, Y. M., Thomas, C. A., Reissner, K. J., & Kalivas, P. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1204-13.2014 · Cited by 26
Epigenetic Signaling in Glia Controls Presynaptic Homeostatic Plasticity
Wang, T., Morency, D. T., Harris, N., & Davis, G. W. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.041 · Cited by 25
Assisted morphogenesis: glial control of dendrite shapes
Procko, C., & Shaham, S. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.005 · Cited by 27
Disrupted glutamate homeostasis as a target for glioma therapy
Biegański, M., & Szeliga, M. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00644-y · Cited by 27
A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic?
Bilbo, S. D., Nevison, C. D., & Parker, W. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26253 · Cited by 28
Embryonic Stem Cell-Derived Peripheral Auditory Neurons Form Neural Connections with Mouse Central Auditory Neurons In Vitro via the α2δ1 Receptor
Liu, Z., Jiang, Y., Li, X., & Hu, Z. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.05.006 · Cited by 26
Voltage‐gated calcium channels in genetic epilepsies
Lauerer, R. J., & Lerche, H. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15983 · Cited by 26
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α2δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity
Yang, Y. L., Yang, F., Yang, F., Li, C.-L., Wang, Y., Li, Z., Lü, Y.-F., Yu, Y., Han, F., He, T., et al. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-015-0008-3 · Cited by 26
The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
Thorpe, A. J., & Offord, J. (2010) · PubMed · Cited by 26
HCN2 channel‐induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling
Pai, V. P., & Levin, M. G. (2022) · Wound Repair and Regeneration · doi:10.1111/wrr.13032 · Cited by 26
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling
Chen, G., Xu, J., Luo, H., Luo, X., Singh, S. K., Ramirez, J. J., James, M. L., Mathew, J. P., Berger, M., Eroğlu, Ç., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161028 · Cited by 27
The association between Gabapentin or Pregabalin use and the risk of dementia: an analysis of the National Health Insurance Research Database in Taiwan
Huang, Y.-H., Pan, M., & Yang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1128601 · Cited by 24
Neuropathic pain in cats: mechanisms and multimodal management
Rusbridge, C. (2024) · Journal of Feline Medicine and Surgery · doi:10.1177/1098612x241246518 · Cited by 28
DrosophilaMmp2 Regulates the Matrix Molecule Faulty Attraction (Frac) to Promote Motor Axon Targeting inDrosophila
Miller, C. M., Liu, N., Page, A. W., & Broihier, H. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4811-10.2011 · Cited by 24
In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?
Forbes, T., Pauža, A. G., & Adams, J. C. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00251.2021 · Cited by 24
Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca2+ channels
Cunningham, K. L., & Littleton, J. T. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1116729 · Cited by 25
The function of astrocytes and their role in neurological diseases
Yuan, W., Huang, W., Jiang, Y., Xu, H., Duan, C., Chen, N., Liu, Y., & Fu, X. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16160 · Cited by 26
Biology-driven material design for ischaemic stroke repair
Phan, N. V., Rathbun, E. M., Ouyang, Y., Carmichael, S. T., & Segura, T. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00117-6 · Cited by 26
Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels
Rougier, J., Albesa, M., Syam, N., Halet, G., Abriel, H., & Viard, P. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1636-6 · Cited by 24
Altered expression of the voltage-gated calcium channel subunit α2δ-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain
Nieto‐Rostro, M., Sandhu, G., Bauer, C. S., Jiruška, P., Jefferys, J. G. R., & DOLPHIN, A. C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.03.013 · Cited by 24
Association of Alterations in Gray Matter Volume With Reduced Evoked‐Pain Connectivity Following Short‐Term Administration of Pregabalin in Patients With Fibromyalgia
Puiu, T., Kairys, A. E., Pauer, L., Schmidt‐Wilcke, T., Ichesco, E., Hampson, J. P., Napadow, V., Clauw, D. J., & Harris, R. E. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39600 · Cited by 24
Differential effects of voltage‐gated calcium channel blockers on calcium channel alpha‐2‐delta‐1 subunit protein‐mediated nociception
Chang, E. Y., Chen, X., Kim, M., Gong, N., Bhatia, S., & Luo, Z. D. (2014) · European Journal of Pain · doi:10.1002/ejp.585 · Cited by 24
Self-citation
Advancing glioblastoma therapy: Learning from the past and innovations for the future
Rana, M., Liou, K.-C., Thakur, A., Nepali, K., & Liou, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217601 · Cited by 28
Gabapentin Prevents Progressive Increases in Excitatory Connectivity and Epileptogenesis Following Neocortical Trauma
Takahashi, D. K., Jin, S., & Prince, D. A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx152 · Cited by 24
α2δ-1 Signaling Drives Cell Death, Synaptogenesis, Circuit Reorganization, and Gabapentin-Mediated Neuroprotection in a Model of Insult-Induced Cortical Malformation
Lau, L. A., Noubary, F., Wang, D., & Dulla, C. G. (2017) · eNeuro · doi:10.1523/eneuro.0316-17.2017 · Cited by 23
The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling
dos Santos, G. G., Jiménez‐Andrade, J. M., Woller, S. A., Muñoz‐Islas, E., Ramirez-Rosas, M. B., Ohashi, N., Catroli, G. F., Fujita, Y., Yaksh, T. L., & Corr, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-72441-5 · Cited by 23
Role of Neurons and Glia Cells in Wound Healing as a Novel Perspective Considering Platelet as a Conventional Player
Beura, S. K., Panigrahi, A. R., Yadav, P., Agrawal, S., & Singh, S. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02587-4 · Cited by 23
Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments
Nechipurenko, I. V., Doroquez, D. B., & Sengupta, P. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0246-z · Cited by 23
Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons
Guo, Y., Zhang, Z., Wu, H.-E., Luo, Z. D., Hogan, Q. H., & Pan, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.019 · Cited by 23
Self-citation
Treatment of Generalized Anxiety Disorder with Gabapentin
Markota, M., & Morgan, R. J. (2017) · Case Reports in Psychiatry · doi:10.1155/2017/6045017 · Cited by 23
Gabapentin in the Treatment of Post-Dural Puncture Headache: A Case Series
Wagner, Y., Storr, F., & Cope, S. (2012) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1204000420 · Cited by 23
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytesPreprint
Li, J., Pan, L., Godoy, M. I., Pembroke, W. G., Rexach, J. E., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y.-W., Stiles, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.17.044222 · Cited by 23
Targeting astrocytes polarization after spinal cord injury: a promising direction
Li, H., Liu, Y., Sun, Y., Guo, H., Lv, S., Guo, W., Ren, J., Wang, Y., Zu, J., Yan, J., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1478741 · Cited by 22
Novel approaches to clinical trial design in cancer neuroscience
Jones, G., Anderson, J. L., Nguyen, P. T., Gleber‐Netto, F. O., Hwang, W. L., Puduvalli, V. K., Monje, M., & Amit, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.015 · Cited by 24
Thrombospondins and synaptogenesis.
Wang, B., Guo, W., & Huang, Y. (2012) · PubMed Central · doi:10.3969/j.issn.1673-5374.2012.22.009 · Cited by 22
Infections in the Developing Brain: The Role of the Neuro-Immune Axis
Kim, J., Erice, C., Rohlwink, U. K., & Tucker, E. W. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.805786 · Cited by 28
Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues
Fernandez, P. C. R., Wright, C. S., Warden, S. J., Hum, J. M., Farach‐Carson, M. C., & Thompson, W. R. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00750-x · Cited by 23
Microglia‐derived extracellular vesicles in homeostasis and demyelination/remyelination processes
Mancini, V. S. B. W., Mattera, V. S., Pasquini, J. M., Pasquini, L. A., & Correale, J. D. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16011 · Cited by 26
Early Gabapentin Treatment during the Latency Period Increases Convulsive Threshold, Reduces Microglial Activation and Macrophage Infiltration in the Lithium-Pilocarpine Model of Epilepsy
Rossi, A., Murta, V., Auzmendi, J., & Ramos, A. J. (2017) · Pharmaceuticals · doi:10.3390/ph10040093 · Cited by 24
Pathophysiological roles of thrombospondin-4 in disease development
Genaro, K., & Luo, Z. D. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.06.007 · Cited by 23
Self-citation
Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention
Bilbo, S. D., Jones, J. P., & Parker, W. (2012) · Autism Research and Treatment · doi:10.1155/2012/910946 · Cited by 23
Tripartite synaptomics: Cell-surface proximity labeling in vivo
Takano, T., & Soderling, S. H. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.05.002 · Cited by 22
Exposure to predator odor and resulting anxiety enhances the expression of the α2δ subunit of voltage‐sensitive calcium channels in the amygdala
Nasca, C., Orlando, R., Marchiafava, M., Boldrini, P., Battaglia, G., Scaccianoce, S., Matrisciano, F., Pittaluga, A., & Nicoletti, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07895.x · Cited by 21
Selective Decline of Synaptic Protein Levels in the Frontal Cortex of Female Mice Deficient in the Extracellular Metalloproteinase ADAMTS1
Howell, M. D., Torres‐Collado, A. X., Iruela‐Arispe, M. L., & Gottschall, P. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047226 · Cited by 21
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus
Zhang, Y., Zhang, M., Zhu, W., Pan, X., Wang, Q., Gao, X. J., Wang, C., Zhang, X., Liu, Y., Li, S., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00437-x · Cited by 21
The calcium channel subunit α2δ-3 organizes synapses via an activity-dependent and autocrine BMP signaling pathway
Hoover, K. M., Gratz, S. J., Qi, N., Herrmann, K. A., Liu, Y. A., Perry-Richardson, J. J., Vanderzalm, P. J., O’Connor-Giles, K. M., & Broihier, H. T. (2019) · Nature Communications · doi:10.1038/s41467-019-13165-7 · Cited by 19

Authors: Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., Green, E. M., Lawler, J., Dolmetsch, R., Garcia, K. C., Smith, S. J., Luo, Z. D., Rosenthal, A., Mosher, D. F., & Barres, B. A.
Affiliations: Stanford Medicine (US)
Howard Hughes Medical Institute (US)
University of Wisconsin–Madison (US)
Beth Israel Deaconess Medical Center (US)
University of California, Irvine Medical Center (US)
ORCID: Allen, Nicola J.
Susman, Michael W.
Park, Chan Young
Özkan, Engin
Annis, Douglas S.
Huberman, Andrew D.
Green, Eric M.
Lawler, Jack
Dolmetsch, Ricardo
Smith, Stephen J.
Luo, Z. David
Rosenthal, Arnon
Mosher, Deane F.
Barres, Ben A.
Venue: Cell
Publisher: Elsevier BV
Published: 2009-10
Volume: 139
Issue: 2
Pages: 380-392
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.09.025
PMC: PMC2791798
OpenAlex: W1988452935
Cited by: 893
References: 49
Citations by year: 2026: 30 · 2025: 47 · 2024: 62 · 2023: 57 · 2022: 52 · 2021: 59 · 2020: 68 · 2019: 41 · 2018: 54 · 2017: 53 · 2016: 50 · 2015: 41 · 2014: 54 · 2013: 66 · 2012: 56
FWCI: 21.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1421 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL049081, HL49081)
National Institute on Drug Abuse (R01DA015043, R37DA015043, DA15043)
National Institute of Neurological Disorders and Stroke (NS-40135, R01NS040135)
National Institute of Dental and Craniofacial Research (R21DE014545, DE14545)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: thrombospondin, synaptogenesis, excitatory synapses, astrocytes, epidermal growth factor-like repeats, synaptic adhesion, postsynaptic receptors, gabapentin, central nervous system development, synaptic plasticity
MeSH terms: Gabapentin, Amines, Animals, Cyclohexanecarboxylic Acids, gamma-Aminobutyric Acid, Neuronal Plasticity, Neurons, Synapses, Calcium Channels, Rats, Sprague-Dawley, CD36 Antigens, Calcium Channels, L-Type, Mice, Rats, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks