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Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
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Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that induce their formation are not well understood. We have previously identified thrombospondin as an astrocyte-secreted protein that promotes central nervous system (CNS) synaptogenesis. Here, we identify the neuronal thrombospondin receptor involved in CNS synapse formation as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin. We show that the VWF-A domain of alpha2delta-1 interacts with the epidermal growth factor-like repeats common to all thrombospondins. alpha2delta-1 overexpression increases synaptogenesis in vitro and in vivo and is required postsynaptically for thrombospondin- and astrocyte-induced synapse formation in vitro. Gabapentin antagonizes thrombospondin binding to alpha2delta-1 and powerfully inhibits excitatory synapse formation in vitro and in vivo. These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation.
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“For example, astrocytes secrete thrombospondins, which bind their receptors ␣2␦1 on neurons to stimulate synapse formation (Christopherson et al., 2005;Eroglu et al., 2009).”
From An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014) · cites this paper as Eroglu et al., 2009
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“Beyond these PNN-associated compounds also proteins released by astrocytes influence synaptogenesis, for example thrombospondins and the gabapentin receptor55,73, Hevin and SPARC56, or Pentraxin 3 that promotes excitatory synapse formation by fostering the clustering of AMPA glutamate receptors74.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [73]
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Cites
Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Self-citationControl of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Self-citationThe Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel
GEE, N. S., Brown, J. P., Dissanayake, V. U. K., Offord, J., Thurlow, R. J., & Woodruff, G. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5768 · Cited by 1,182
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Meyer‐Franke, A., Kaplan, M. R., Pfrieger, F. W., & Barres, B. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90172-8 · Cited by 849
Self-citationWhittaker, C., & Hynes, R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-05-0259 · Cited by 788
Micheva, K. D., & Smith, S. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.014 · Cited by 787
Self-citationVGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680
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Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
“For example, astrocytes secrete thrombospondins, which bind their receptors 2 1 on neurons to stimulate synapse formation (Christopherson et al., 2005; Eroglu et al., 2009).”
Self-citationExtracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404
Self-citationReactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336
Self-citationThe Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Paşca, A. M., Sloan, S. A., Clarke, L. E., Tian, Y., Makinson, C. D., Huber, N., Kim, C. H., Park, J.-Y., O'Rourke, N. A., Nguyen, K. D., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3415 · Cited by 1,609
Self-citationGlia and pain: Is chronic pain a gliopathy?
Ji, R., Berta, T., & Nedergaard, M. (2013) · Pain · doi:10.1016/j.pain.2013.06.022 · Cited by 1,193
Zamponi, G. W., Striessnig, J., Koschak, A., & DOLPHIN, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,158
Cell Biology of Astrocyte-Synapse Interactions
Allen, N. J., & Eroglu, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.056 · Cited by 1,098
Self-citationEmerging roles of astrocytes in neural circuit development
Clarke, L. E., & Barres, B. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3484 · Cited by 975
Self-citationAstrocytes Control Synapse Formation, Function, and Elimination
Chung, W.-S., Allen, N. J., & Eroglu, C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020370 · Cited by 839
Self-citationRegulation of synaptic connectivity by glia.
Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813
Self-citationCentral mechanisms of pathological pain
Kuner, R. (2010) · Nature Medicine · doi:10.1038/nm.2231 · Cited by 795
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Allen, N. J., Bennett, M. L., Foo, L. C., Wang, G. X., Chakraborty, C., Smith, S. J., & Barres, B. A. (2012) · Nature · doi:10.1038/nature11059 · Cited by 764
Self-citationAstrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 793
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
Moore, A., Wiffen, P. J., Derry, S., & McQuay, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub2 · Cited by 729
Astrocytes and disease: a neurodevelopmental perspective
Molofsky, A. V., Krenick, R., Ullian, E., Tsai, H.-H., Deneen, B., Richardson, W. D., Barres, B. A., & Rowitch, D. H. (2012) · Genes & Development · doi:10.1101/gad.188326.112 · Cited by 682
Self-citationNeuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction
Simms, B., & Zamponi, G. W. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.016 · Cited by 712
Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
Kucukdereli, H., Allen, N. J., Lee, A. T., Feng, A., Ozlu, M. I., Conatser, L. M., Chakraborty, C., Workman, G., Weaver, M., Sage, E. H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104977108 · Cited by 642
Self-citationSloan, S. A., Darmanis, S., Huber, N., Khan, T. A., Birey, F., Caneda, C., Reimer, R., Quake, S. R., Barres, B. A., & Paşca, S. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.035 · Cited by 593
Self-citationDiabetic neuropathy: cellular mechanisms as therapeutic targets
Vincent, A. M., Callaghan, B. C., Smith, A. L., & Feldman, E. L. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.137 · Cited by 586
Glial cells in (patho)physiology
Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07664.x · Cited by 561
Gabapentin for chronic neuropathic pain in adults
Wiffen, P. J., Derry, S., Bell, R. F., Rice, A. S., Tölle, T. R., Phillips, T., & Moore, R. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007938.pub4 · Cited by 561
Astrocyte heterogeneity: an underappreciated topic in neurobiology
Zhang, Y., & Barres, B. A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.005 · Cited by 569
Self-citationExtracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506
Clarke, H., Bonin, R. P., Orser, B. A., Englesakis, M., Wijeysundera, D. N., & Katz, J. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318249d36e · Cited by 481
The ThrombospondinsPreprint
Adams, J. C., & Lawler, J. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009712 · Cited by 468
Self-citationHuman astrocytes: structure and functions in the healthy brain
Vasile, F., Dossi, E., & Rouach, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1383-5 · Cited by 428
Glioblastoma remodelling of human neural circuits decreases survival
Krishna, S., Choudhury, A., Keough, M. B., Seo, K., Ni, L., Kakaizada, S., Lee, A. J., Aabedi, A. A., Popova, G., Lipkin, B., et al. (2023) · Nature · doi:10.1038/s41586-023-06036-1 · Cited by 466
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
Farhy-Tselnicker, I., & Allen, N. J. (2018) · Neural Development · doi:10.1186/s13064-018-0104-y · Cited by 416
Self-citationEtiology and Pharmacology of Neuropathic Pain
Alles, S. R. A., & Smith, P. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014399 · Cited by 399
Revisiting the matricellular concept
Murphy-Ullrich, J. E., & Sage, E. H. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.07.005 · Cited by 401
Do glia drive synaptic and cognitive impairment in disease?
Chung, W.-S., Welsh, C. A., Barres, B. A., & Stevens, B. (2015) · Nature Neuroscience · doi:10.1038/nn.4142 · Cited by 385
Self-citationThe β Subunit of Voltage-Gated Ca 2+ Channels
Buraei, Z., & Yang, J. (2010) · Physiological Reviews · doi:10.1152/physrev.00057.2009 · Cited by 399
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
DOLPHIN, A. C. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3311 · Cited by 392
DOLPHIN, A. C. (2016) · The Journal of Physiology · doi:10.1113/jp272262 · Cited by 367
Development and critical period plasticity of the barrel cortex
Erzurumlu, R. S., & Gaspar, P. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08075.x · Cited by 360
Astrocyte regulation of synaptic behavior
Allen, N. J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013053 · Cited by 343
Self-citationL-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function
Hofmann, F. B., Flockerzi, V., KAHL, S., & Wegener, J. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00016.2013 · Cited by 359
Calcium-Permeable Ion Channels in Pain Signaling
Bourinet, E., Altier, C., Hildebrand, M. E., Trang, T., Salter, M. W., & Zamponi, G. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00023.2013 · Cited by 349
Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue
Nagai, J., Rajbhandari, A. K., Gangwani, M. R., Hachisuka, A., Coppola, G., Masmanidis, S. C., Fanselow, M. S., & Khakh, B. S. (2019) · Cell · doi:10.1016/j.cell.2019.03.019 · Cited by 328
Behaviorally consequential astrocytic regulation of neural circuits
Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M. R., Monk, K. R., Hastings, M. H., Haydon, P. G., Rowitch, D. H., Shaham, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.12.008 · Cited by 315
Neely, G. G., Heß, A., Costigan, M., Keene, A. C., Goulas, S., Langeslag, M., Griffin, R. S., Belfer, I., Dai, F., Smith, S. B., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.047 · Cited by 318
Self-citationAntiepileptic drugs for neuropathic pain and fibromyalgia
Wiffen, P. J., Derry, S., Moore, R. A., Aldington, D. J., Cole, P., Rice, A. S. C., Lunn, M. P., Hamunen, K., Haanpää, M. L., & Kalso, E. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010567.pub2 · Cited by 395
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
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White matter astrocytes in health and disease
Lundgaard, I., Osório, M. J., Kress, B. T., Sanggaard, S., & Nedergaard, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.050 · Cited by 302
Weissberg, I., Wood, L., Kamintsky, L., Vazquez, O. N., Milikovsky, D. Z., Alexander, A., Oppenheim, H., Ardizzone, C., Becker, A. J., Frigerio, F., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.029 · Cited by 291
Chen, J., Li, L., Chen, S.-R., Chen, H., Xie, J.-D., Sirrieh, R. E., MacLean, D. M., Zhang, Y., Zhou, M.-H., Jayaraman, V., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.021 · Cited by 285
Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
DOLPHIN, A. C., & Lee, A. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0278-2 · Cited by 291
How addictive are gabapentin and pregabalin? A systematic review
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Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management
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Stahl, S. M., Porreca, F., Taylor, C. P., Cheung, R. Y., Thorpe, A. J., & Clair, A. G. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.001 · Cited by 277
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Patel, R., & Dickenson, A. H. (2016) · Pharmacology Research & Perspectives · doi:10.1002/prp2.205 · Cited by 277
Molecular signals of plasticity at the tetrapartite synapse
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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse
Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271
Siddiqui, T. J., & Craig, A. M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.016 · Cited by 276
Astroglial cradle in the life of the synapse
Verkhratsky, A., & Nedergaard, M. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0595 · Cited by 266
Current understanding of the thrombospondin-1 interactome
Resovi, A., Pinessi, D., Chiorino, G., & Taraboletti, G. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.01.012 · Cited by 270
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Tedeschi, A., Dupraz, S., Laskowski, C. J., Xue, J., Ulas, T., Beyer, M., Schultze, J. L., & Bradke, F. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.026 · Cited by 259
Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
Ippolito, D. M., & Eroğlu, Ç. (2010) · Journal of Visualized Experiments · doi:10.3791/2270 · Cited by 254
Harris, R. E., Napadow, V., Huggins, J. P., Pauer, L., Kim, J., Hampson, J. P., Sundgren, P. C., Foerster, B. R., Petrou, M., Schmidt‐Wilcke, T., et al. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000017 · Cited by 253
Targeting the neural extracellular matrix in neurological disorders
Soleman, S., Filippov, M. A., Dityatev, A., & Fawcett, J. W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.050 · Cited by 244
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
Heyes, S., Pratt, W. S., Rees, E., Dahimène, S., Ferron, L., Owen, M. J., & DOLPHIN, A. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.002 · Cited by 240
Neuroinflammation: An astrocyte perspective
Lee, H., Lee, J.-H., Flausino, L. E., & Quintana, F. J. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi7828 · Cited by 253
Diniz, L. P., Almeida, J. C., Tortelli, V., Lopes, C. V., Setti-Perdigão, P., Stipursky, J., Kahn, S. A., Romão, L. F., Miranda, J. D., Alves‐Leon, S. V., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380824 · Cited by 237
Dityatev, A. E., Seidenbecher, C. I., & Schachner, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.08.003 · Cited by 235
Stratification of astrocytes in healthy and diseased brain
Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236
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Lindsay, N. M., Chen, C., Gilam, G., Mackey, S., & Scherrer, G. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7360 · Cited by 246
Davies, A., Kadurin, I., Alvarez‐Laviada, A., Douglas, L. R., Nieto‐Rostro, M., Bauer, C. S., Pratt, W. S., & DOLPHIN, A. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908735107 · Cited by 231
Astrocyte-immune cell interactions in physiology and pathology
Han, R. T., Kim, R. D., Molofsky, A. V., & Liddelow, S. A. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.013 · Cited by 223
Early somatostatin interneuron connectivity mediates the maturation of deep layer cortical circuits
Tuncdemir, S. N., Wamsley, B., Stam, F. J., Osakada, F., Goulding, M., Callaway, E. M., Rudy, B., & Fishell, G. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.020 · Cited by 224
Role of astrocyte–synapse interactions in CNS disorders
Blanco‐Suárez, E., Caldwell, A. L. M., & Allen, N. J. (2016) · The Journal of Physiology · doi:10.1113/jp270988 · Cited by 234
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Chincholkar, M. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.02.066 · Cited by 220
Molecular mechanisms of astrocyte-induced synaptogenesis
Baldwin, K. T., & Eroğlu, Ç. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.006 · Cited by 219
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Shen, K., & Scheiffele, P. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135302 · Cited by 218
Glutamatergic medications for the treatment of drug and behavioral addictions
Olive, M. F., Cleva, R. M., Kalivas, P. W., & Malcolm, R. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.015 · Cited by 211
The α2δ subunits of voltage-gated calcium channels
DOLPHIN, A. C. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.11.019 · Cited by 210
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207
Blanco‐Suárez, E., Liu, T., Kopelevich, A., & Allen, N. J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.043 · Cited by 217
Self-citationCortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., Inada, H., Roh, S. E., Kim, S. J., Lee, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82859 · Cited by 202
Kim, Y. H., Park, J., & Choi, Y. K. (2019) · Antioxidants · doi:10.3390/antiox8050121 · Cited by 211
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Toth, C. C. (2013) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098613505614 · Cited by 199
Farhy-Tselnicker, I., van Casteren, A. C. M., Lee, A., Chang, V. T., Aricescu, A. R., & Allen, N. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.053 · Cited by 199
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Metadata
- Authors
- Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., Green, E. M., Lawler, J., Dolmetsch, R., Garcia, K. C., Smith, S. J., Luo, Z. D., Rosenthal, A., Mosher, D. F., & Barres, B. A.
- Affiliations
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- University of Wisconsin–Madison (US)
- Beth Israel Deaconess Medical Center (US)
- University of California, Irvine Medical Center (US)
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 139
- Issue
- 2
- Pages
- 380-392
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2791798
- OpenAlex
- W1988452935
- Cited by
- 893
- References
- 49
- Citations by year
- 2026: 30 · 2025: 47 · 2024: 62 · 2023: 57 · 2022: 52 · 2021: 59 · 2020: 68 · 2019: 41 · 2018: 54 · 2017: 53 · 2016: 50 · 2015: 41 · 2014: 54 · 2013: 66 · 2012: 56
- FWCI
- 21.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1421 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL049081, HL49081)
- National Institute on Drug Abuse (R01DA015043, R37DA015043, DA15043)
- National Institute of Neurological Disorders and Stroke (NS-40135, R01NS040135)
- National Institute of Dental and Craniofacial Research (R21DE014545, DE14545)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- thrombospondin, synaptogenesis, excitatory synapses, astrocytes, epidermal growth factor-like repeats, synaptic adhesion, postsynaptic receptors, gabapentin, central nervous system development, synaptic plasticity
- MeSH terms
- Gabapentin, Amines, Animals, Cyclohexanecarboxylic Acids, gamma-Aminobutyric Acid, Neuronal Plasticity, Neurons, Synapses, Calcium Channels, Rats, Sprague-Dawley, CD36 Antigens, Calcium Channels, L-Type, Mice, Rats, Neurogenesis
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