The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition
Open accessAbstract
Summary Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. We report here that mice living in an enriched housing environment show reduced tumor growth and increased remission. We found this effect in melanoma and colon cancer models, and that it was not caused by physical activity alone. Serum from animals held in an enriched environment (EE) inhibited cancer proliferation in vitro and was markedly lower in leptin. Hypothalamic BDNF was selectively upregulated by EE, its genetic overexpression reduced tumor burden, whereas BDNF knockdown blocked the effect of EE. Mechanistically, we show that hypothalamic BDNF downregulated leptin production in adipocytes via sympathoneural β-adrenergic signaling. These results suggest that genetic or environmental activation of this BDNF/leptin axis may have therapeutic significance for cancer.
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Self-citationNatural rewards, neuroplasticity, and non-drug addictions
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Metadata
- Authors
- Cao, L., Liu, X., Lin, E.-J. D., Wang, C., Choi, E. Y., Riban, V., Lin, B., & During, M. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 1
- Pages
- 52-64
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2166016923
- Cited by
- 369
- References
- 52
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cao, L., Liu, X., Lin, E.-J. D., Wang, C., Choi, E. Y., Riban, V., Lin, B., & During, M. J. (2010). Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition. Cell. https://doi.org/10.1016/j.cell.2010.05.029
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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