The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis
Open accessAbstract
SUMMARY Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment induced the upregulation of the brown fat cell fate determining gene Prdm16, brown fat specific markers, and genes involved in thermogenesis and β-adrenergic signaling. Moreover, pockets of cells with prototypical brown fat morphology and high UCP1 levels were observed in the white fat of enriched mice associated with resistance to diet-induced obesity. Hypothalamic overexpression of BDNF reproduced the enrichment-associated activation of the brown fat gene program and lean phenotype. Inhibition of BDNF signaling by genetic knockout or dominant negative trkB reversed this phenotype. Our genetic and pharmacologic data suggest a mechanism whereby induction of hypothalamic BDNF expression in response to environmental stimuli leads to selective sympathoneural modulation of white fat to induce “browning” and increased energy dissipation.
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Citations
Cites
Brown Adipose Tissue: Function and Physiological Significance
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PRDM16 controls a brown fat/skeletal muscle switch
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BackgroundInfluentialBile acids induce energy expenditure by promoting intracellular thyroid hormone activation
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Cited by
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
The sexual dimorphism of obesity
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Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828
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“In several rodent models, browning of WAT depots appears to be protective against diet-induced metabolic disorders, including obesity and diabetes (10,11).”
BackgroundRoberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643
Metadata
- Authors
- Cao, L., Choi, E. Y., Liu, X., Martin, A., Wang, C., Xu, X., & During, M. J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 14
- Issue
- 3
- Pages
- 324-338
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1978586367
- Cited by
- 386
- References
- 67
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cao, L., Choi, E. Y., Liu, X., Martin, A., Wang, C., Xu, X., & During, M. J. (2011). White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis. Cell Metabolism. https://doi.org/10.1016/j.cmet.2011.06.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
