The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche
Open accessAbstract
Summary The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is responsible for piloerection (commonly called "goosebumps"). We show that deposition of nephronectin into the basement membrane by bulge stem cells mediates selective adhesion of α8β1 integrin-expressing mesenchymal cells, including APM progenitors. Nephronectin induces α8 integrin-positive cells to upregulate smooth muscle markers. In nephronectin-null skin, the number of APM is reduced and those that form insert above the bulge, where there is compensatory upregulation of the nephronectin family member EGFL6. Deletion of α8 integrin also abolishes the selectivity of APM anchorage to the bulge. Nephronectin is a Wnt target gene; epidermal β-catenin activation upregulates epidermal nephronectin and dermal α8 integrin expression. We conclude that by expressing nephronectin bulge stem cells provide a smooth muscle cell niche and act as tendon cells for the APM. The results also reveal a functional role for basement membrane heterogeneity in tissue patterning.
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Cites
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Darwin, C. (1872) · J. Murray eBooks · doi:10.1037/10001-000 · Cited by 11,657
Defining the Epithelial Stem Cell Niche in Skin
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The stem-cell niche as an entity of action
Scadden, D. T. (2006) · Nature · doi:10.1038/nature04957 · Cited by 1,856
Out of Eden: Stem Cells and Their Niches
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Self-citationErez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515
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Capturing and profiling adult hair follicle stem cells
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Extracellular Matrix Degradation and Remodeling in Development and Disease
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Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,294
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
Seguin, L., Desgrosellier, J. S., Weis, S. M., & Cheresh, D. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.006 · Cited by 685
Modulating the stem cell niche for tissue regeneration
Lane, S. W., Williams, D. A., & Watt, F. M. (2014) · Nature Biotechnology · doi:10.1038/nbt.2978 · Cited by 615
Self-citationJoost, S., Zeisel, A., Jacob, T., Sun, X., La Manno, G., Lönnerberg, P., Linnarsson, S., & Kasper, M. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.010 · Cited by 429
Metadata
- Authors
- Fujiwara, H., Ferreira, M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., & Watt, F. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 144
- Issue
- 4
- Pages
- 577-589
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2055035964
- Cited by
- 317
- References
- 53
- FWCI
- 28.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fujiwara, H., Ferreira, M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., & Watt, F. M. (2011). The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche. Cell. https://doi.org/10.1016/j.cell.2011.01.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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