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Cited by 317

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

Open access
Fujiwara, Hironobu, Ferreira, Manuela, Donati, Giacomo, Marciano, Denise K., Linton, James M., Sato, Yuya, Hartner, Andrea, Sekiguchi, Kiyotoshi, Reichardt, Louis F., Watt, Fiona M.·2011·Cell
DOI 10.1016/j.cell.2011.01.014
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Abstract

Summary The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is responsible for piloerection (commonly called "goosebumps"). We show that deposition of nephronectin into the basement membrane by bulge stem cells mediates selective adhesion of α8β1 integrin-expressing mesenchymal cells, including APM progenitors. Nephronectin induces α8 integrin-positive cells to upregulate smooth muscle markers. In nephronectin-null skin, the number of APM is reduced and those that form insert above the bulge, where there is compensatory upregulation of the nephronectin family member EGFL6. Deletion of α8 integrin also abolishes the selectivity of APM anchorage to the bulge. Nephronectin is a Wnt target gene; epidermal β-catenin activation upregulates epidermal nephronectin and dermal α8 integrin expression. We conclude that by expressing nephronectin bulge stem cells provide a smooth muscle cell niche and act as tendon cells for the APM. The results also reveal a functional role for basement membrane heterogeneity in tissue patterning.

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Metadata

Authors
Fujiwara, H., Ferreira, M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., & Watt, F. M.
Venue
Cell
Publisher
Elsevier BV
Published
2011-02
Volume
144
Issue
4
Pages
577-589
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2011.01.014
OpenAlex
W2055035964
Cited by
317
References
53
FWCI
28.42
Type
journal article
Language
en
Open access
bronze

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