Activation of mTORC2 by Association with the Ribosome

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D.-H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 2,986

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365

mTOR signaling at a glance

Laplante, M., & Sabatini, D. M. (2009) · Journal of Cell Science · doi:10.1242/jcs.051011 · Cited by 2,170

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,114

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,410

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D., Kaufman, R. J., Ma, D., Coen, D. M., Ron, D., et al. (2005) · Science · doi:10.1126/science.1101902 · Cited by 1,403

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000038 · Cited by 1,082

Does the ribosome translate cancer?

Ruggero, D., & Pandolfi, P. P. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1015 · Cited by 928

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

García-Martínez, J. M., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081668 · Cited by 907

Advances in protein kinase B signalling: AKTion on multiple fronts

Brazil, D. P., Yang, Z.-Z., & Hemmings, B. A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.006 · Cited by 830

How Common Are Extraribosomal Functions of Ribosomal Proteins?

Warner, J. R., & McIntosh, K. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.03.006 · Cited by 747

Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1

Kim, A. H., Khursigara, G., Sun, X., Franke, T. F., & Chao, M. V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.893-901.2001 · Cited by 709

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., & Sabatini, D. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.001 · Cited by 695

mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

Hresko, R. C., & Mueckler, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508361200 · Cited by 635

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., & Guan, K. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.119 · Cited by 610

Deregulated Akt3 Activity Promotes Development of Malignant Melanoma

Stahl, J. M., Sharma, A., Cheung, M., Zimmerman, M., Cheng, J. Q., Bosenberg, M. W., Kester, M., Sandirasegarane, L., & Robertson, G. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1399 · Cited by 594

Expanding mTOR signaling

Yang, Q., & Guan, K.-L. (2007) · Cell Research · doi:10.1038/cr.2007.64 · Cited by 535

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Yang, Q., Inoki, K., Ikenoue, T., & Guan, K.-L. (2006) · Genes & Development · doi:10.1101/gad.1461206 · Cited by 517

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A. C., Mao, Y., Miao, R. Q., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.120 · Cited by 509

Rheb fills a GAP between TSC and TOR

Manning, B. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.09.003 · Cited by 483

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Pearce, L. R., Huang, X., Boudeau, J., Pawłowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F. M., Gourlay, R., Magnuson, M. A., & Alessi, D. R. (2007) · Biochemical Journal · doi:10.1042/bj20070540 · Cited by 464

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

Wang, X., McCullough, K. D., Franke, T. F., & Holbrook, N. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14624 · Cited by 460

Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhäuser, N., Carlo Marchisio, P., & Biffo, S. (2003) · Nature · doi:10.1038/nature02160 · Cited by 438

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

Hsieh, A. C., Costa, M., Zollo, O., Davis, C., Feldman, M. E., Testa, J. R., Meyuhas, O., Shokat, K. M., & Ruggero, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.021 · Cited by 434

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Barna, M., Pusic, A., Zollo, O., Costa, M., Kondrashov, N., Rego, E., Rao, P. H., & Ruggero, D. (2008) · Nature · doi:10.1038/nature07449 · Cited by 424

Functional Specificity among Ribosomal Proteins Regulates Gene Expression

Komili, S., Farny, N. G., Roth, F. P., & Silver, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.037 · Cited by 390

Amino acid regulation of TOR complex 1

Avruch, J., Long, X., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., & Dai, N. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90645.2008 · Cited by 382

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

Guertin, D. A., Stevens, D. M., Saitoh, M., Kinkel, S., Crosby, K., Sheen, J.-H., Mullholland, D. J., Magnuson, M. A., Wu, H., & Sabatini, D. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.017 · Cited by 355

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

Oh, W. J., Wu, C. ‐., Kim, S. J., Facchinetti, V., Julien, L. ‐., Finlan, M., Roux, P. P., Su, B., & Jacinto, E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.271 · Cited by 333

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

Schmidt, A., Bickle, M., Beck, T., & Hall, M. N. (1997) · Cell · doi:10.1016/s0092-8674(00)81893-0 · Cited by 300

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

Sparks, C. A., & Guertin, D. A. (2010) · Oncogene · doi:10.1038/onc.2010.139 · Cited by 299

PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis

Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jenö, P., Arrieumerlou, C., & Hall, M. N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001217 · Cited by 296

Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis

Cnop, M., Ladriere, L., Hekerman, P., Ortis, F., Cardozo, A. K., Dogusan, Z., Flamez, D., Boyce, M., Yuan, J., & Eizirik, D. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607627200 · Cited by 289

TOR complex 2: a signaling pathway of its own

Cybulski, N., & Hall, M. N. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.004 · Cited by 265

mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

Masri, J., Bernath, A., Martin, J., Jo, O. D., Vartanian, R., Funk, A., & Gera, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2223 · Cited by 253

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J., & Alessi, D. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80088-8 · Cited by 248

Loss of PTEN promotes tumor development in malignant melanoma.

Stahl, J. M., Cheung, M., Sharma, A. K., Trivedi, N. R., Shanmugam, S., & Robertson, G. P. (2003) · PubMed · Cited by 241

Molecular Organization of Target of Rapamycin Complex 2

Wullschleger, S., Loewith, R., Oppliger, W., & Hall, M. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505553200 · Cited by 234

Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization

Kamada, Y., Fujioka, Y., Suzuki, N. N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M. N., & Ohsumi, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7239-7248.2005 · Cited by 210

TOR regulation of AGC kinases in yeast and mammals

Jacinto, E., & Lorberg, A. (2008) · Biochemical Journal · doi:10.1042/bj20071518 · Cited by 205

The Saccharomyces cerevisiae TSC10/YBR265w Gene Encoding 3-Ketosphinganine Reductase Is Identified in a Screen for Temperature-sensitive Suppressors of the Ca2+-sensitive csg2Δ Mutant

Beeler, T., Bacikova, D., Gable, K., Hopkins, L., Johnson, C., Slife, H., & Dunn, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30688 · Cited by 202

Functional and therapeutic significance of Akt deregulation in malignant melanoma

Robertson, G. P. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-1577-9 · Cited by 189

The Role of Myc-Induced Protein Synthesis in Cancer

Ruggero, D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1970 · Cited by 186

Regulation of Ceramide Biosynthesis by TOR Complex 2

Aronova, S., Wedaman, K., Aronov, P. A., Fontes, K., Ramos, K., Hammock, B. D., & Powers, T. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.015 · Cited by 184

Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer

Gulhati, P., Cai, Q., Li, J., Liu, J., Rychahou, P. G., Qiu, S., Lee, E. Y., Silva, S. R., Bowen, K. A., Gao, T., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1249 · Cited by 177

TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae

Helliwell, S. B., Howald, I., Barbet, N., & Hall, M. N. (1998) · Genetics · doi:10.1093/genetics/148.1.99 · Cited by 171

Emerging functions of ribosomal proteins in gene-specific transcription and translation

Lindström, M. S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.083 · Cited by 169

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

Drenan, R. M., Liu, X., Bertram, P. G., & Zheng, X.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305912200 · Cited by 160

TOR1 and TOR2 Have Distinct Locations in Live Cells

Sturgill, T. W., Cohen, A., Diefenbacher, M., Trautwein, M., Martin, D. E., & Hall, M. N. (2008) · Eukaryotic Cell · doi:10.1128/ec.00088-08 · Cited by 159

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

Madhunapantula, S. V., & Robertson, G. P. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00585.x · Cited by 148

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions.

Gervois, N., Guilloux, Y., Diez, E., & Jotereau, F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.2403 · Cited by 122

TOR signaling in invertebrates.

Soulard, A., Cohen, A., & Hall, M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.08.007 · Cited by 120

Endoplasmic Reticulum and Golgi Localization Sequences for Mammalian Target of Rapamycin

Liu, X., & Zheng, X.-F. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0406 · Cited by 114

Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production

Idol, R. A., Robledo, S. M., Du, H., et al. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.02.001 · Cited by 109

Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

Schroder, W. A., Buck, M., Cloonan, N., Hancock, J. F., Suhrbier, A., Sculley, T. B., & Bushell, G. R. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.01.013 · Cited by 106

Saccharomyces cerevisiae Nip7p Is Required for Efficient 60S Ribosome Subunit Biogenesis

Zanchin, N. I. T., Roberts, P., deSilva, A., Sherman, F., & Goldfarb, D. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5001 · Cited by 97

The Fate of Membrane-bound Ribosomes Following the Termination of Protein Synthesis

Seiser, R. M., & Nicchitta, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004462200 · Cited by 84

Mutual Antagonism of Target of Rapamycin and Calcineurin Signaling

Mulet, J. M., Martin, D. E., Loewith, R., & Hall, M. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604244200 · Cited by 74

PKCβII modulates translation independently from mTOR and through RACK1

Grosso, S., Volta, V., Sala, L. A., Vietri, M., Marchisio, P. C., Dorit Ron, A., & Biffo, S. (2008) · Biochemical Journal · doi:10.1042/bj20080463 · Cited by 72

High density oligonucleotide array analysis of interferon-α2a sensitivity and transcriptional response in melanoma cells

Certa, U., Seiler, M., Padovan, E., & Spagnoli, G. C. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1865 · Cited by 50

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein.

Chiocchetti, A., Gibello, L., Carando, A., Aspesi, A., Secco, P., Garelli, E., Loreni, F., Angelini, M., Biava, A., Dahl, N., et al. (2005) · PubMed · Cited by 45

Degradation of alpha‐melanocyte stimulating hormone (alpha‐MSH) by CALLA/endopeptidase 24. 11 expressed by human melanoma cells in culture

Deschodt-Lanckman, M. M., Vanneste, Y., Loir, B., Michel, A., Libert, A., Ghanem, G., & Lejeune, F. J. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910460629 · Cited by 26

Eukaryotic ribosomes host PKC activity

Grosso, S., Volta, V., Vietri, M., Gorrini, C., Marchisio, P. C., & Biffo, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.118 · Cited by 23

Concurrent blockade of the NF-κB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicity

He, H., Wang, X., Zheng, X., Sun, H., Shi, X.-W., Zhong, Y., Huang, B., Yang, L., Li, J., Liao, L., et al. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.02.011 · Cited by 14

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126

mTOR signalling and cellular metabolism are mutual determinants in cancer

Mossmann, D., Park, S., & Hall, M. N. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0074-8 · Cited by 1,088

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053