Molecular Signals of Epigenetic States
Open accessAbstract
Epigenetic signals are responsible for the establishment, maintenance, and reversal of metastable transcriptional states that are fundamental for the cell’s ability to “remember” past events, such as changes in the external environment or developmental cues. Complex epigenetic states are orchestrated by several converging and reinforcing signals, including transcription factors, noncoding RNAs, DNA methylation, and histone modifications. Although all of these pathways modulate transcription from chromatin in vivo, the mechanisms by which epigenetic information is transmitted through cell division remain unclear. Because epigenetic states are metastable and change in response to the appropriate signals, a deeper understanding of their molecular framework will allow us to tackle the dysregulation of epigenetics in disease.
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- Authors
- Bonasio, R., Tu, S., & Reinberg, D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bonasio, Roberto
- Tu, Shengjiang
- Reinberg, Danny
- Venue
- Science
- Published
- 2010-10-29
- Volume
- 330
- Issue
- 6004
- Pages
- 612-616
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3772643
- OpenAlex
- W2074174832
- Cited by
- 912
- References
- 86
- Citations by year
- 2026: 22 · 2025: 25 · 2024: 37 · 2023: 37 · 2022: 48 · 2021: 49 · 2020: 33 · 2019: 51 · 2018: 56 · 2017: 65 · 2016: 55 · 2015: 83 · 2014: 78 · 2013: 86 · 2012: 91
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (GM037120, R01GM037120, R37GM037120, GM064844, R01GM064844)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- epigenetic states, epigenetic memory, transcription factors, non-coding RNA, DNA methylation, histone modifications, chromatin regulation
- MeSH terms
- Animals, Cell Division, Chromatin, Histones, Humans, Protein Processing, Post-Translational, Transcription Factors, Transcription, Genetic, DNA Methylation, RNA, Untranslated, Epigenesis, Genetic
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