The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
Open accessAbstract
SUMMARY MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell fate determination genes to influence pluripotency, differentiation, and transformation. Lin28 is a specific, post-transcriptional inhibitor of let-7 biogenesis. We report crystal structures of mouse Lin28 in complex with sequences from let-7d, let-7-f1, and let-7g precursors. The two folded domains of Lin28 recognize two distinct regions of the RNA and are sufficient for inhibition of let-7 in vivo. We also show by NMR spectroscopy that the linker connecting the two folded domains is flexible, accommodating Lin28 binding to diverse let-7 family members. Protein-RNA complex formation imposes specific conformations on both components that could affect downstream recognition by other processing factors. Our data provide a molecular explanation for Lin28 specificity and a model for how it regulates let-7.
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Metadata
- Authors
- Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., & Sliz, P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 147
- Issue
- 5
- Pages
- 1080-1091
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1993346317
- Cited by
- 356
- References
- 65
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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