The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube
Open accessAbstract
Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Sonic Hedgehog (Shh) acts as a morphogen to control the pattern of neuronal subtype specification. Using an in vivo reporter of Shh signaling, mouse genetics, and systems modeling, we show that a spatially and temporally changing gradient of Shh signaling is interpreted by the regulatory logic of a downstream transcriptional network. The design of the network, which links three transcription factors to Shh signaling, is responsible for differential spatial and temporal gene expression. In addition, the network renders cells insensitive to fluctuations in signaling and confers hysteresis--memory of the signal. Our findings reveal that morphogen interpretation is an emergent property of the architecture of a transcriptional network that provides robustness and reliability to tissue patterning.
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Cites
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BackgroundTeratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
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Self-citationAnterior-posterior positional information in the absence of a strong Bicoid gradient
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The mechanisms of Hedgehog signalling and its roles in development and disease
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Self-citationPhenotypic impact of genomic structural variation: insights from and for human disease
Weischenfeldt, J., Symmons, O., Spitz, F., & Korbel, J. O. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3373 · Cited by 658
Primary Cilia and Mammalian Hedgehog Signaling
Bangs, F., & Anderson, K. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028175 · Cited by 642
Establishing neuronal diversity in the spinal cord: a time and a place
Sagner, A., & Briscoe, J. (2019) · Development · doi:10.1242/dev.182154 · Cited by 281
Self-citationCoordination of progenitor specification and growth in mouse and chick spinal cord
Kicheva, A., Bollenbach, T., Ribeiro, A., Valle, H. P., Lovell-Badge, R., Episkopou, V., & Briscoe, J. (2014) · Science · doi:10.1126/science.1254927 · Cited by 180
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Metadata
- Authors
- Balaskas, N., Ribeiro, A., Panovska, J., Dessaud, E., Sasai, N., Page, K. M., Briscoe, J., & Ribes, V.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 148
- Issue
- 1-2
- Pages
- 273-284
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157103346
- Cited by
- 463
- References
- 9
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Balaskas, N., Ribeiro, A., Panovska, J., Dessaud, E., Sasai, N., Page, K. M., Briscoe, J., & Ribes, V. (2012). Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube. Cell. https://doi.org/10.1016/j.cell.2011.10.047
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