The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A Poised Chromatin Platform for TGF-β Access to Master Regulators
Open accessAbstract
Specific chromatin marks keep master regulators of differentiation silent, yet poised for activation by extracellular signals. We report that nodal TGF-β signals use the poised histone mark H3K9me3 to trigger differentiation of mammalian embryonic stem cells. Nodal receptors induce the formation of companion Smad4-Smad2/3 and TRIM33-Smad2/3 complexes. TRIM33-Smad2/3 binds the histone marks H3K9me3 and K18ac on the promoters of mesendoderm regulators Gsc and Mixl1. Binding is through the PHD-Bromo cassette of TRIM33. In the crystal structure of this cassette bound to histone H3 peptides, PHD recognizes K9me3 and Bromo an adjacent K18ac. Binding of TRIM33-Smad2/3 to H3K9me3 displaces the chromatin compacting factor HP1γ and makes nodal response elements accessible to Smad4-Smad2/3 for Pol II recruitment. In turn, Smad4 increases K18 acetylation to augment TRIM33-Smad2/3 binding. Thus, nodal cues use the H3K9me3 mark as a platform to switch master regulators of stem cell differentiation from the poised to the active state.
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Cites
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Self-citationStructure and ligand of a histone acetyltransferase bromodomain
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The polarization of immune cells in the tumour environment by TGFβ
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Vertebrate Endoderm Development and Organ Formation
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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
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FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
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Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
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Molecular mechanisms of epithelial–mesenchymal transition
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Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,163
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Self-citationContextual determinants of TGFβ action in development, immunity and cancer
David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
Self-citationPerceiving the epigenetic landscape through histone readers
Musselman, C. A., Lalonde, M.-E., Côté, J., & Kutateladze, T. G. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2436 · Cited by 833
Metadata
- Authors
- Xi, Q., Wang, Z., Zaromytidou, A.-I., Zhang, X. H.-F., Chow-Tsang, L.-F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K., Kaartinen, V., Studer, L., Mark, W., Patel, D. J., & Massagué, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 147
- Issue
- 7
- Pages
- 1511-1524
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1979646592
- Cited by
- 285
- References
- 10
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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