Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 516

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis

Open access
Li, Shengben, Liu, Lin, Zhuang, Xiaohong, Yu, Yu, Liu, Xigang, Cui, Xia, Ji, Lijuan, Pan, Zhiqiang, Cao, Xiaofeng, Mo, Beixin, Zhang, Fuchun, Raikhel, Natasha, Jiang, Liwen, Chen, Xuemei·2013·Cell
DOI 10.1016/j.cell.2013.04.005
Open this paper in CoChat — free account

Abstract

Translation inhibition is a major but poorly understood mode of action of micro(mi)RNAs in plants and animals. In particular, the subcellular location where this process takes place is unknown. Here we show that the translation inhibition but not the mRNA cleavage activity of Arabidopsis miRNAs requires ALTERED MERISTEM PROGRAM1 (AMP1). AMP1 encodes an integral membrane protein associated with endoplasmic reticulum (ER) and ARGONAUTE1, the miRNA effector and a peripheral ER membrane protein. Large differences in polysome association of miRNA target RNAs are found between wild type and the amp1 mutant for membrane-bound but not total polysomes. This, together with AMP1-independent recruitment of miRNA target transcripts to membrane fractions, shows that miRNAs inhibit the translation of target RNAs on the ER. This study demonstrates that translation inhibition is an important activity of plant miRNAs, reveals the subcellular location of this activity, and uncovers a previously unknown function of the ER.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cell.2013.04.005

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Show all 64 references

Research works printed but not linked: 5

  1. Birckbichler, 1973, Fractionation of membrane-bound polysomes, free polysomes, and nuclei from tissue-cultured cells, Eur. J. Biochem., 33, 368, 10.1111/j.1432-1033.1973.tb02692.x · doi:10.1111/j.1432-1033.1973.tb02692.x
  2. Lee, 2009, Ecotype-dependent genetic regulation of bolting time in the Arabidopsis mutants with increased number of leaves, J. Microbiol. Biotechnol., 19, 542
  3. Noll, 1974, Membrane-bound and free polysomes in transformed and untransformed fibroblast cells, J. Mol. Biol., 90, 215, 10.1016/0022-2836(74)90369-6 · doi:10.1016/0022-2836(74)90369-6
  4. Won, 2012, Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana, Silence, 3, 6, 10.1186/1758-907X-3-6 · doi:10.1186/1758-907x-3-6
  5. Wang, 2007, Protein mobilization in germinating mung bean seeds involves vacuolar sorting receptors and multivesicular bodies, Plant Physiol., 143, 1628, 10.1104/pp.107.096263 · doi:10.1104/pp.107.096263

Cited by

See all 516

Metadata

Authors
Li, S., Liu, L., Zhuang, X., Yu, Y., Liu, X., Cui, X., Ji, L., Pan, Z., Cao, X., Mo, B., Zhang, F., Raikhel, N., Jiang, L., & Chen, X.
Venue
Cell
Publisher
Elsevier BV
Published
2013-04
Volume
153
Issue
3
Pages
562-574
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.04.005
OpenAlex
W2067775919
Cited by
516
References
64
FWCI
58.34
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis. https://app.cochat.ai/papers/10.1016/j.cell.2013.04.005
The paper
Li, S., Liu, L., Zhuang, X., Yu, Y., Liu, X., Cui, X., Ji, L., Pan, Z., Cao, X., Mo, B., Zhang, F., Raikhel, N., Jiang, L., & Chen, X. (2013). MicroRNAs Inhibit the Translation of Target mRNAs on the Endoplasmic Reticulum in Arabidopsis. Cell. https://doi.org/10.1016/j.cell.2013.04.005

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.