The Somatic Genomic Landscape of Glioblastoma

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Items 501–600 of 1,018

1. Role of the Microenvironment in Glioma Pathogenesis
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2. Biological activity of tumor-treating fields in preclinical glioma models
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3. Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression
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4. TERT Promoter Alterations in Glioblastoma: A Systematic Review
   Nathalie Olympios, Vianney Gilard, Florent Marguet, Florian Clatot, Frédéric Di Fiore, Maxime Fontanilles · 2021 · Cancers
5. Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons
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6. USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance
   Jin‐Ku Lee, Nakho Chang, Yeup Yoon, Heekyoung Yang, Heejin Cho, Eun Hee Kim, Yongjae Shin, Wonyoung Kang, Young Taek Oh, Gyeong In Mun et al. · 2015 · Neuro-Oncology
7. Efficacy and safety results of ABT-414 in combination with radiation and temozolomide in newly diagnosed glioblastoma
   David A. Reardon, Andrew B. Lassman, Martin J. van den Bent, Priya Kumthekar, Ryan T. Merrell, Andrew Mark Scott, Lisa Fichtel, Erik P. Sulman, Erica J. Gomez, Judee S. Fischer et al. · 2016 · Neuro-Oncology
8. Aptamer-conjugated PEGylated quantum dots targeting epidermal growth factor receptor variant III for fluorescence imaging of glioma
   Jiaze Tang, Ning Huang, Xiang Zhang, Tao Zhou, Ying Ching Tan, Jiangli Pi, Li Pi, Si Cheng, Huzhi Zheng, Yuan Zeng Cheng · 2017 · International Journal of Nanomedicine · Retracted
9. Current trends in mouse models of glioblastoma
   Masafumi Miyai, Hiroyuki Tomita, Akio Soeda, Hirohito Yano, Toru Iwama, Akira Hara · 2017 · Journal of Neuro-Oncology
10. Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression
    Andrea Comba, Syed Mohd Faisal, Patrick Dunn, Anna E. Argento, Todd Charles Hollon, Wajd N. Al‐Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar Lennart Quass, Pierre F. Apostolides et al. · 2022 · Nature Communications
11. Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress
    Yingying Liu, Shanshan Fang, Qiushi Sun, Bo Liu · 2016 · Biochemical and Biophysical Research Communications
12. Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells
    Raul Bardini Bressan, Pooran Singh Dewari, Maria Kalantzaki, Ester Gangoso, Mantas Matjusaitis, Claudia Garcia-Diaz, Carla Blin, Vivien Grant, Harry J. C. J. Bulstrode, Sabine Gogolok et al. · 2017 · Development
13. Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
    Jason K. Sa, Nakho Chang, Hye Won Lee, Hee Jin Cho, Michele Ceccarelli, Luigi Cerulo, Jinlong Yin, Sung Soo Kim, Francesca Pia Caruso, Mijeong Lee et al. · 2020 · Genome biology
14. Glioblastoma Immune Landscape and the Potential of New Immunotherapies
    Thomas Daubon, Audrey Hémadou, Irati Romero Garmendia, Maya Saleh · 2020 · Frontiers in Immunology
15. Accelerating the understanding of cancer biology through the lens of genomics
    Dongfang Wang, Baolin Liu, Zemin Zhang · 2023 · Cell
16. Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma
    Shiqun Wang, Wei Yan, Lingkai Kong, Shuguang Zuo, Jingyi Wu, Chunxiao Zhu, Huaping Huang, Bohao He, Jie Dong, Jiwu Wei · 2023 · Nature Communications
17. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling
    Jianghong Man, Jocelyn D. Shoemake, Tuopu Ma, Anthony E. Rizzo, Andrew R. Godley, Qiulian Wu, Alireza Mohammad Mohammadi, Shideng Bao, Jeremy N. Rich, Jennifer S. Yu · 2015 · Cancer Research
18. NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age
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19. Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway
    Yingfeng Xia, Bingwei Ye, Jane Ding, Yajie Yu, Ahmet Alptekin, Muthusamy Thangaraju, Puttur Devi Prasad, Zhi‐Chun Ding, Eun Jeong Park, Jeong-Hyeon Choi et al. · 2019 · Cancer Research
20. The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma
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21. Cell Lineage-Based Stratification for Glioblastoma
    Zilai Wang, Daochun Sun, Yu-Jung Chen, Xuanhua Xie, Yufeng Shi, Viviane S. Tabar, Cameron Walter Brennan, Tejus Bale, Chenura D. Jayewickreme, Dan R. Laks et al. · 2020 · Cancer Cell
22. Radiomics-based machine learning model for efficiently classifying transcriptome subtypes in glioblastoma patients from MRI
    Nguyen Quoc Khanh Le, Truong Nguyen Khanh Hung, Duyen Thi Do, Luu Ho Thanh Lam, Lương Hữu Đăng, Tuan-Tu Huynh · 2021 · Computers in Biology and Medicine
23. β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
    Anne-Florence Blandin, Guillaume Renner, Maxime Lehmann, Isabelle H Lelong-Rebel, Sophie Martin, Monique Dontenwill · 2015 · Frontiers in Pharmacology
24. Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach
    Tanner Michael Johanns, Jeffrey P. Ward, Christopher A. Miller, Courtney Wilson, Dale K. Kobayashi, Diane E. Bender, Yujie Fu, Anton Alexandrov, Elaine R. Mardis, Maxim N. Artyomov et al. · 2016 · Cancer Immunology Research
25. Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients withEGFR-amplified, recurrent glioblastoma: results from an international phase I multicenter trial
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26. Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
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27. Epigenomic Reprogramming as a Driver of Malignant Glioma
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28. Nucleic acid drug vectors for diagnosis and treatment of brain diseases
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29. Phase II Study of Bevacizumab, Temozolomide, and Hypofractionated Stereotactic Radiotherapy for Newly Diagnosed Glioblastoma
    Antonio M. P. Omuro, Kathryn P. Beal, Philip H. Gutin, Sasan Karimi, Denise D. Correa, Thomas Joseph Kaley, Lisa Marie DeAngelis, Timothy An-thy Chan, Igor T. Gavrilovic, Craig P. Nolan et al. · 2014 · Clinical Cancer Research
30. Comparative Molecular Life History of Spontaneous Canine and Human Gliomas
    Samirkumar B. Amin, Kevin J. Anderson, C. Elizabeth Boudreau, Emmanuel Martínez-Ledesma, Emre Kocakavuk, Kevin C. Johnson, Floris P Barthel, Frederick S. Varn, Cynthia Kassab, Xiaoyang Ling et al. · 2020 · Cancer Cell
31. An epigenetic gateway to brain tumor cell identity
    Stephen C. Mack, Christopher G. Hubert, Tyler E. Miller, Michael D. Taylor, Jeremy N. Rich · 2015 · Nature Neuroscience
32. Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
    Liang, Wen-Wei, Lu, Rita Jui-Hsien, Jayasinghe, Reyka G., Foltz, Steven M., Porta-Pardo, Eduard, Geffen, Yifat, Wendl, Michael C., Lazcano, Rossana, Kolodziejczak, Iga, Song, Yizhe et al. · 2023 · Cancer Cell
33. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer
    Joshua J. Meidenbauer, Purna Mukherjee, Thomas N. Seyfried · 2015 · Nutrition & Metabolism
34. Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration
    Paul A. Clark, Saswati Bhattacharya, Ardem Elmayan, Soesiawati R. Darjatmoko, Bradley A. Thuro, Michael B. Yan, Paul R. van Ginkel, Arthur S. Polans, John S. Kuo · 2016 · Journal of neurosurgery
35. Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications
    Wenya Linda Bi, Michael Zhang, Winona W. Wu, Yu Mei, Ian F. Dunn · 2016 · Frontiers in Surgery
36. Glutamine Addiction In Gliomas
    Javier Márquez, Francisco José Alonso, José Manuel Matés, Juan A. Segura, Mercedes Martín‐Rufián, José Angel Campos-Sandoval · 2017 · Neurochemical Research
37. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance
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38. TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma
    Kenji Fujimoto, Hideyuki Arita, Kaishi Satomi, Kai Yamasaki, Yuko Matsushita, Taishi Nakamura, Yasuji Miyakita, Toru Umehara, Keiichi Kobayashi, Kaoru Tamura et al. · 2021 · Acta Neuropathologica
39. Targeted Therapeutics in Patients With High-Grade Gliomas: Past, Present, and Future
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40. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation
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41. Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3
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42. Major Features of the 2021 WHO Classification of CNS Tumors
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43. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM
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44. ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery
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45. Oncohistones: drivers of pediatric cancers
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46. The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain
    Rajendra P. Pangeni, Prasanna Channathodiyil, David S. Huen, Lawrence Eagles, Balraj K. Johal, Dawar Pasha, Natasa Hadjistephanou, Oliver Nevell, Claire L. Davies, Ayobami I. Adewumi et al. · 2015 · Clinical Epigenetics
47. A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma
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48. Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm
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49. Endogenous GABAA receptor activity suppresses glioma growth
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50. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
    Sejin Oh, Jeonghun Yeom, Hee Jin Cho, Ju-Hwa Kim, Seon‐Jin Yoon, Hyeon-Deok Kim, Jason K. Sa, Shinyeong Ju, Hwanho Lee, Myung Joon Oh et al. · 2020 · Nature Communications
51. Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex
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52. The white matter is a pro-differentiative niche for glioblastoma
    Lucy J. Brooks, Melanie Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael J. Ellis, Zane Jaunmuktane et al. · 2021 · Nature Communications
53. Neuronal and tumourigenic boundaries of glioblastoma plasticity
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54. MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells
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55. Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme
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56. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells
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57. Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma
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58. Primate-Specific miR-663 Functions as a Tumor Suppressor by Targeting PIK3CD and Predicts the Prognosis of Human Glioblastoma
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59. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma
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60. Targeting BET bromodomain proteins in solid tumors
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61. Single‐cell sequencing maps gene expression to mutational phylogenies in PDGF‐ and EGF‐driven gliomas
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62. Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas
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63. Emergence of ERBB2 Mutation as a Biomarker and an Actionable Target in Solid Cancers
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64. Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
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65. The Role of Hypoxia in Glioblastoma Radiotherapy Resistance
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66. Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias
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67. Anatomic position determines oncogenic specificity in melanoma
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68. The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas
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69. Molecular Heterogeneity of Glioblastoma and its Clinical Relevance
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70. Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma
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71. Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
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72. Differential response of patient-derived primary glioblastoma cells to environmental stiffness
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73. Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era
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74. EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?
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75. Identifying Epistasis in Cancer Genomes: A Delicate Affair
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76. Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition
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77. Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme
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78. N-cadherin upregulation mediates adaptive radioresistance in glioblastoma
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79. An Overview of EGFR Mechanisms and Their Implications in Targeted Therapies for Glioblastoma
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80. Stem cell signature in glioblastoma: therapeutic development for a moving target
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81. Integrative multi-omics module network inference with lemon-tree
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82. RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule
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83. Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity
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84. Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity
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85. Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities
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86. High-grade Gliomas
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87. First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma
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88. From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress
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89. Non-invasive detection of somatic mutations using next-generation sequencing in primary central nervous system lymphoma
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90. NTRK1 Fusion in Glioblastoma Multiforme
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91. Gliomatosis cerebri: no evidence for a separate brain tumor entity
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92. A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer
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93. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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94. Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment
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95. Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma
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96. Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
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97. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin
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98. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma
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99. The genetic landscape of gliomas arising after therapeutic radiation
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100. USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells
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