The Somatic Genomic Landscape of Glioblastoma

Brennan, Cameron W., Verhaak, Roel G.W., McKenna, Aaron, Campos, Benito, Noushmehr, Houtan, Salama, Sofie R., Zheng, Siyuan, Chakravarty, Debyani +292 more·2013·Cell

DOI 10.1016/j.cell.2013.09.034

Cited by (1,018)

Items 201–300 of 1,018

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A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment
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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis
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PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
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Glioblastoma Therapy: Past, Present and Future
Elena Obrador, Paz Moreno-Murciano, María Oriol‐Caballo, Rafael López‐Blanch, Begoña Pineda, Julia Gutiérrez-Arroyo, Alba Loras, Luis Germán González Bonet, Conrado Martínez‐Cadenas, José M. Estrela et al. · 2024 · International Journal of Molecular Sciences
Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development
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Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity
Korshunov, Andrey, Capper, David, Reuss, David, Schrimpf, Daniel, Ryzhova, Marina, Hovestadt, Volker, Sturm, Dominik, Meyer, Jochen, Jones, Chris, Zheludkova, Olga et al. · 2016 · Acta Neuropathologica
High Incidence of Activating TERT Promoter Mutations in Meningiomas Undergoing Malignant Progression
Stéphane Goutagny, Jean‐Charles Nault, Maxime Mallet, Dominique Hénin, Jessica Zucman‐Rossi, Michel Kalamarides · 2013 · Brain Pathology
Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications
Nicole Parker, Peter Khong, Jonathon Parkinson, Viive Maarika Howell, Helen Wheeler · 2015 · Frontiers in Oncology
Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
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Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma
Vaubel, Rachael A., Tian, Shulan, Remonde, Dioval, Schroeder, Mark A., Mladek, Ann C., Kitange, Gaspar J., Caron, Alissa, Kollmeyer, Thomas M., Grove, Rebecca, Peng, Sen et al. · 2020 · Clinical Cancer Research
A comprehensive profile of recurrent glioblastoma
Benito Campos, Lars Rønn Olsen, Thomas Haargaard Urup, Hans Skovgaard Poulsen · 2016 · Oncogene
Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma
Emily Padfield, Hayley Patricia Ellis, Kathreena Mary Kurian · 2015 · Frontiers in Oncology
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Ronan Chaligné, Federico Gaiti, Dana Silverbush, Joshua S. Schiffman, Hannah R. Weisman, Lloyd Kluegel, Simon Gritsch, Sunil D. Deochand, L. Nicolas Gonzalez Castro, Alyssa R. Richman et al. · 2021 · Nature Genetics
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma
Ryan Dz-Wei Chow, Christopher D. Guzman, Guangchuan Wang, Florian Schmidt, Mark W. Youngblood, Lupeng Ye, Youssef Errami, Matthew B. Dong, Michael A. Q. Martinez, Sensen Zhang et al. · 2017 · Nature Neuroscience
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph Dresser, Christian K. Werner, Hanshi Sun, Drew W. Pratt, Peter Sajjakulnukit, Shuang George Zhao et al. · 2020 · Nature Communications
Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment
Victor Andrés Arrieta, Crismita Dmello, Daniel James McGrail, Daniel Jay Brat, Catalina Lee-Chang, Amy B. Heimberger, Dhan Sidhartha Chand, Roger Stupp, Adam M. Sonabend · 2023 · Journal of Clinical Investigation
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective
Radhika Mathur, Qixuan Wang, Patrick G. Schupp, Ana Nikolić, Stephanie Hilz, Chibo Hong, Nadia R. Grishanina, Darwin W. Kwok, Nicholas O. Stevers, Qiushi Jin et al. · 2024 · Cell
Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma
Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek Łoś, Thomas C. Klonisch, Saeid Ghavami · 2022 · International Journal of Molecular Sciences
Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Yanming Ren, Zongyao Huang, Lingling Zhou, Peng Xiao, Junwei Song, Ping He, Chuanxing Xie, Ran Zhou, Menghan Li, Xiangqun Dong et al. · 2023 · Nature Communications
Targeting Rac and Cdc42 GTPases in Cancer
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Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells
Graham Dickson and Hugh MacLeod, Danielle Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M. Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli et al. · 2018 · Cell Reports
Macrophages and microglia: the cerberus of glioblastoma
Alice Buonfiglioli, Dolores Hambardzumyan · 2021 · Acta Neuropathologica Communications
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Melanie Jackson, Foteini Hassiotou, Anna K. Nowak · 2014 · Carcinogenesis
Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
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Immunotherapy: a promising approach for glioma treatment
Feroza Yasinjan, Yang Xing, Huayue Geng, Rui Guo, Lei Yang, Ziling Liu, Hong Wang · 2023 · Frontiers in Immunology
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The 2021 WHO Classification of Tumors of the Central Nervous System: An update on pediatric low‐grade gliomas and glioneuronal tumors
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Mani, D. R., Krug, Karsten, Zhang, Bing, Satpathy, Shankha, Clauser, Karl R., Ding, Li, Ellis, Matthew, Gillette, Michael A., Carr, Steven A. · 2022 · Nature Reviews Cancer
Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas
Taishi Nakamura, Kensuke Tateishi, T. Niwa, Yuko Matsushita, Kaoru Tamura, Manabu Kinoshita, Kazuhiro Tanaka, Shintaro Fukushima, Hirokazu Takami, Hideyuki Arita et al. · 2015 · Neuropathology and Applied Neurobiology
Combination therapy to checkmate Glioblastoma: clinical challenges and advances
Debarati Ghosh, Saikat Nandi, Sonali Bhattacharjee · 2018 · Clinical and Translational Medicine
Molecular and Genomic Alterations in Glioblastoma Multiforme
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EGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise
Manfred Westphal, Cécile L. Maire, Katrin Lamszus · 2017 · CNS Drugs
Radiogenomics to characterize regional genetic heterogeneity in glioblastoma
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The NF1 gene in tumor syndromes and melanoma
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Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis
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Glioma stem cells and their roles within the hypoxic tumor microenvironment
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Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma
Karina Biserova, Arvīds Jakovļevs, Romans Uljanovs, Ilze Štrumfa · 2021 · Cells
IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
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Recurrent Glioblastoma: From Molecular Landscape to New Treatment Perspectives
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Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
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The REMBRANDT study, a large collection of genomic data from brain cancer patients
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells
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PRMT5 inhibition disrupts splicing and stemness in glioblastoma
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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells
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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
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Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma
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Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells
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EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
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The Molecular Pathogenesis of Colorectal Cancer and Its Potential Application to Colorectal Cancer Screening
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Molecular and cellular heterogeneity: the hallmark of glioblastoma
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Advances in the Knowledge of the Molecular Biology of Glioblastoma and Its Impact in Patient Diagnosis, Stratification, and Treatment
Belén Delgado-Martín, Miguel Ángel Medina · 2020 · Advanced Science
CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis
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The genomic landscape of schwannoma
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The NF1 gene revisited - from bench to bedside
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Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells
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Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis
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DNA repair mechanisms and their clinical impact in glioblastoma
Hélène Erasimus, Matthieu Gobin, Simone P. Niclou, Eric Van Dyck · 2016 · Mutation Research/Reviews in Mutation Research
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR -Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
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A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
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PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
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Targeting histone lysine methylation in cancer
John P. McGrath, Patrick Trojer · 2015 · Pharmacology & Therapeutics
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
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A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma
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Fruit Flies in Biomedical Research
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