The Somatic Genomic Landscape of Glioblastoma

Brennan, Cameron W., Verhaak, Roel G.W., McKenna, Aaron, Campos, Benito, Noushmehr, Houtan, Salama, Sofie R., Zheng, Siyuan, Chakravarty, Debyani, Sanborn, J. Zachary, Berman, Samuel H., Beroukhim, Rameen, Bernard, Brady, Wu, Chang-Jiun, Genovese, Giannicola, Shmulevich, Ilya, Barnholtz-Sloan, Jill, Zou, Lihua, Vegesna, Rahulsimham, Shukla, Sachet A., Ciriello, Giovanni, Yung, W.K., Zhang, Wei, Sougnez, Carrie, Mikkelsen, Tom, Aldape, Kenneth, Bigner, Darell D., Van Meir, Erwin G., Prados, Michael, Sloan, Andrew, Black, Keith L., Eschbacher, Jennifer, Finocchiaro, Gaetano, Friedman, William, Andrews, David W., Guha, Abhijit, Iacocca, Mary, O’Neill, Brian P., Foltz, Greg, Myers, Jerome, Weisenberger, Daniel J., Penny, Robert, Kucherlapati, Raju, Perou, Charles M., Hayes, D. Neil, Gibbs, Richard, Marra, Marco, Mills, Gordon B., Lander, Eric, Spellman, Paul, Wilson, Richard, Sander, Chris, Weinstein, John, Meyerson, Matthew, Gabriel, Stacey, Laird, Peter W., Haussler, David, Getz, Gad, Chin, Lynda, Benz, Christopher, Barnholtz-Sloan, Jill, Barrett, Wendi, Ostrom, Quinn, Wolinsky, Yingli, Black, Keith L., Bose, Bikash, Boulos, Paul T., Boulos, Madgy, Brown, Jenn, Czerinski, Christine, Eppley, Matthew, Iacocca, Mary, Kempista, Thelma, Kitko, Teresa, Koyfman, Yakov, Rabeno, Brenda, Rastogi, Pawan, Sugarman, Michael, Swanson, Patricia, Yalamanchii, Kennedy, Otey, Ilana P., Liu, Yingchun Spring, Xiao, Yonghong, Auman, J.Todd, Chen, Peng-Chieh, Hadjipanayis, Angela, Lee, Eunjung, Lee, Semin, Park, Peter J., Seidman, Jonathan, Yang, Lixing, Kucherlapati, Raju, Kalkanis, Steven, Mikkelsen, Tom, Poisson, Laila M., Raghunathan, Aditya, Scarpace, Lisa, Bernard, Brady, Bressler, Ryan, Eakin, Andrea, Iype, Lisa, Kreisberg, Richard B., Leinonen, Kalle, Reynolds, Sheila, Rovira, Hector, Thorsson, Vesteinn, Shmulevich, Ilya, Annala, Matti J., Penny, Robert, Paulauskis, Joseph, Curley, Erin, Hatfield, Martha, Mallery, David, Morris, Scott, Shelton, Troy, Shelton, Candace, Sherman, Mark, Yena, Peggy, Cuppini, Lucia, DiMeco, Francesco, Eoli, Marica, Finocchiaro, Gaetano, Maderna, Emanuela, Pollo, Bianca, Saini, Marco, Balu, Saianand, Hoadley, Katherine A., Li, Ling, Miller, C. Ryan, Shi, Yan, Topal, Michael D., Wu, Junyuan, Dunn, Gavin, Giannini, Caterina, O'Neill, Brian P., Aksoy, B. Arman, Antipin, Yevgeniy, Borsu, Laetitia, Berman, Samuel H., Brennan, Cameron W., Cerami, Ethan, Chakravarty, Debyani, Ciriello, Giovanni, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Ladanyi, Marc, Lash, Alex, Liang, Yupu, Reva, Boris, Sander, Chris, Schultz, Nikolaus, Shen, Ronglai, Socci, Nicholas D., Viale, Agnes, Ferguson, Martin L., Chen, Qing-Rong, Demchok, John A., Dillon, Laura A.L., Shaw, Kenna R. Mills, Sheth, Margi, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Davidsen, Tanja, Guyer, Mark S., Ozenberger, Bradley A., Sofia, Heidi J., Bergsten, Julie, Eckman, John, Harr, Jodi, Myers, Jerome, Smith, Christine, Tucker, Kelly, Winemiller, Cindy, Zach, Leigh Anne, Ljubimova, Julia Y., Eley, Greg, Ayala, Brenda, Jensen, Mark A., Kahn, Ari, Pihl, Todd D., Pot, David A., Wan, Yunhu, Eschbacher, Jennifer, Foltz, Greg, Hansen, Nathan, Hothi, Parvi, Lin, Biaoyang, Shah, Nameeta, Yoon, Jae-geun, Lau, Ching, Berens, Michael, Ardlie, Kristin, Beroukhim, Rameen, Carter, Scott L., Cherniack, Andrew D., Noble, Mike, Cho, Juok, Cibulskis, Kristian, DiCara, Daniel, Frazer, Scott, Gabriel, Stacey B., Gehlenborg, Nils, Gentry, Jeff, Heiman, David, Kim, Jaegil, Jing, Rui, Lander, Eric S., Lawrence, Michael, Lin, Pei, Mallard, Will, Meyerson, Matthew, Onofrio, Robert C., Saksena, Gordon, Schumacher, Steve, Sougnez, Carrie, Stojanov, Petar, Tabak, Barbara, Voet, Doug, Zhang, Hailei, Zou, Lihua, Getz, Gad, Dees, Nathan N., Ding, Li, Fulton, Lucinda L., Fulton, Robert S., Kanchi, Krishna-Latha, Mardis, Elaine R., Wilson, Richard K., Baylin, Stephen B., Andrews, David W., Harshyne, Larry, Cohen, Mark L., Devine, Karen, Sloan, Andrew E., VandenBerg, Scott R., Berger, Mitchel S., Prados, Michael, Carlin, Daniel, Craft, Brian, Ellrott, Kyle, Goldman, Mary, Goldstein, Theodore, Grifford, Mia, Haussler, David, Ma, Singer, Ng, Sam, Salama, Sofie R., Sanborn, J. Zachary, Stuart, Joshua, Swatloski, Teresa, Waltman, Peter, Zhu, Jing, Foss, Robin, Frentzen, Barbara, Friedman, William, McTiernan, Raquel, Yachnis, Anthony, Hayes, D. Neil, Perou, Charles M., Zheng, Siyuan, Vegesna, Rahulsimham, Mao, Yong, Akbani, Rehan, Aldape, Kenneth, Bogler, Oliver, Fuller, Gregory N., Liu, Wenbin, Liu, Yuexin, Lu, Yiling, Mills, Gordon, Protopopov, Alexei, Ren, Xiaojia, Sun, Youting, Wu, Chang-Jiun, Yung, W.K. Alfred, Zhang, Wei, Zhang, Jianhua, Chen, Ken, Weinstein, John N., Chin, Lynda, Verhaak, Roel G.W., Noushmehr, Houtan, Weisenberger, Daniel J., Bootwalla, Moiz S., Lai, Phillip H., Triche, Timothy J., Van Den Berg, David J., Laird, Peter W., Gutmann, David H., Lehman, Norman L., VanMeir, Erwin G., Brat, Daniel, Olson, Jeffrey J., Mastrogianakis, Gena M., Devi, Narra S., Zhang, Zhaobin, Bigner, Darell, Lipp, Eric, McLendon, Roger·2013·Cell
DOI 10.1016/j.cell.2013.09.034

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  61. Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
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  62. Modeling Mutual Exclusivity of Cancer Mutations
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  64. Current State and Future Prospects of Immunotherapy for Glioma
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  65. Telomere-related Markers for Cancer
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  66. Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma
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  67. New hints towards a precision medicine strategy for IDH wild-type glioblastoma
    K. White, Kate Connor, James Clerkin, Brona M. Murphy, Manuela Salvucci, Alice C. O’Farrell, Markus Rehm, David O’Brien, Jochen H.M. Prehn, Simone P. Niclou et al. · 2020 · Annals of Oncology
  68. A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma
    Bin Sheng Wong, Sagar R Shah, Christopher L. Yankaskas, Vivek K. Bajpai, Pei-Hsun Wu, Deborah Chin, Brent Ifemembi, Karim ReFaey, Paula V. Schiapparelli, Xiaobin Zheng et al. · 2020 · Nature Biomedical Engineering
  69. The Landscape of Novel Therapeutics and Challenges in Glioblastoma Multiforme: Contemporary State and Future Directions
    Karam Khaddour, Tanner Michael Johanns, George Ansstas · 2020 · Pharmaceuticals
  70. In Vitro Glioblastoma Models: A Journey into the Third Dimension
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  71. Development of PI3K inhibitors: Advances in clinical trials and new strategies (Review)
    Dandan Meng, Wei A. He, Yan Zhang, Zhenguo Liang, Jinling Zheng, Xu Zhang, Xing Zheng, Peng Zhan, Hongfei Chen, Wen-Jun Li et al. · 2021 · Pharmacological Research
  72. ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance
    Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, Gabriele Sulli, Leo J.Y. Kim, Guoxin Zhang, Zhixin Qiu et al. · 2022 · Journal of Clinical Investigation
  73. Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides
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  74. The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics
    Jimena G. Perez, Nhan L. Tran, Michael G. Rosenblum, Craig S. Schneider, Nina P. Connolly, A J Kim, Graeme F. Woodworth, Jeffrey A. Winkles · 2015 · Oncogene
  75. Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase
    José Luis Izquierdo-García, Larry M. Cai, Myriam M. Chaumeil, Pia Eriksson, Aaron E. Robinson, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen · 2014 · PLoS ONE
  76. DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations
    Diego M. Marzese, Richard A. Scolyer, María Roqué, Laura María Vargas-Roig, Jamie L. Huynh, James S. Wilmott, Rajmohan Murali, Michael E. Buckland, Garni Barkhoudarian, John F. Thompson et al. · 2014 · Neuro-Oncology
  77. The three-dimensional cancer genome
    M. Ryan Corces, Victor G. Corces · 2016 · Current Opinion in Genetics & Development
  78. Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models
    Josephine Kam Tai Dermawan, Masahiro Hitomi, Daniel J. Silver, Qiulian Wu, Poorva Sandlesh, Andrew Edward Sloan, Andrei A. Purmal, Katerina V. Gurova, Jeremy N. Rich, Justin Durla Lathia et al. · 2016 · Cancer Research
  79. Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma
    Carl Johannes Koschmann, Daniel B. Zamler, Alan G. Mackay, Dan R. Robinson, Yi-Mi Wu, Robert E. Doherty, Bernard Lawrence Marini, Dustin Tran, Hugh J. L. Garton, Karin M. Muraszko et al. · 2016 · Oncotarget
  80. RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis
    Wanyeon Kim, HyeSook Youn, Sungmin Lee, EunGi Kim, Daehoon Kim, Jung Sub Lee, Jae-Myung Lee, BuHyun Youn · 2018 · Experimental & Molecular Medicine
  81. LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy
    Changhong Liu, Haijuan Fu, Xiaoping Liu, Qianqian Lei, Yan Zhang, Xiaoling She, Qiang Liu, Qing Liu, Yingnan Sun, Guiyuan Li et al. · 2018 · Molecular Therapy
  82. Targeting Resistance against the MDM2 Inhibitor RG7388 in Glioblastoma Cells by the MEK Inhibitor Trametinib
    Berberich, Anne, Kessler, Tobias, Thomé, Carina M., Pusch, Stefan, Hielscher, Thomas, Sahm, Felix, Oezen, Iris, Schmitt, Lara-Marie, Ciprut, Sara, Hucke, Nanina et al. · 2019 · Clinical Cancer Research
  83. Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma
    Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie Jonsgar Sandberg, Swapnil Potdar, Aija Kyttälä, Iver Arne Langmoen, Aki Laakso, Emília Gaál‐Paavola, Markus Perola et al. · 2019 · BMC Cancer
  84. ATRXmRNA expression combined withIDH1/2mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples
    Jinquan Cai, Pei Yang, Chuanbao Zhang, Wei Zhang, Yanwei Liu, Zhaoshi Bao, Xing Liu, Wenzhong Du, Hongjun Wang, Tao Jiang et al. · 2014 · Oncotarget
  85. Molecular Testing of Brain Tumor
    Sung‐Hye Park, Jae‐Kyung Won, Seong‐Ik Kim, Yujin Lee, Chul‐Kee Park, Seung‐Ki Kim, Seung-Hong Choi · 2017 · Journal of Pathology and Translational Medicine
  86. Global DNA Methylation Patterns in Human Gliomas and Their Interplay with Other Epigenetic Modifications
    Michał J. Dąbrowski, Bartosz Wojtaś · 2019 · International Journal of Molecular Sciences
  87. An update on the central nervous system manifestations of Li–Fraumeni syndrome
    Brent A. Orr, Michael R. Clay, Emilia Modolo Pinto, Chimene A. Kesserwan · 2019 · Acta Neuropathologica
  88. Proteogenomics of glioblastoma associates molecular patterns with survival
    Gali Arad, Paula Ofek, Eilam Yeini, Mariya Mardamshina, Artem Danilevsky, Noam Shomron, Rachel Grossman, Ronit Satchi‐Fainaro, Tamar Geiger · 2021 · Cell Reports
  89. Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy
    Jay Ramanlal Anand, Lilly F. Chiou, Carly A. Sciandra, Xingyuan Zhang, Jiyong Hong, Di Wu, Pei Zhou, Cyrus Vaziri · 2023 · NAR Cancer
  90. Dysregulated FGF signalling in neoplastic disorders
    Yasmine Tanner, Richard Philip Grose · 2015 · Seminars in Cell and Developmental Biology
  91. Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer
    Ruud H. M. Wijdeven, Baoxu Pang, Sabina Y. van der Zanden, Xiaohang Qiao, Vincent A. Blomen, Marlous Hoogstraat, Esther H. Lips, Lennert Janssen, Lodewyk F.A. Wessels, Thijn R. Brummelkamp et al. · 2015 · Cancer Research
  92. Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data
    Taosheng Xu, Thuc Duy Le, Lin Liu, Rujing Wang, Bingyu Sun, Jiuyong Li · 2016 · PLoS ONE
  93. Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma
    Alfeu Zanotto‐Filho, Rosângela Mayer Gonçalves, Karina Klafke, Priscila Oliveira de Souza, Fabiane Cristine Dillenburg, Luigi Carro, Daniel Pens Gelain, José Cláudio Fonseca Moreira · 2016 · Cancer Letters
  94. Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma
    Nichola A. Cruickshanks, Ying Zhang, Fang Yuan, Mary Pahuski, Myron Keith Gibert, Roger Abounader · 2017 · Cancers
  95. GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma
    Marta Moreno, Leire Pedrosa, Laia Paré, Estela Pineda, Leire Bejarano, Josefina Martínez, Veerakumar Balasubramaniyan, Ravesanker Ezhilarasan, Naveen Kallarackal, Sung-Hak Kim et al. · 2017 · Cell Reports
  96. Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma
    Hsiao P. J. Voon, Maheshi Udugama, Wendi Lin, Linda L. Hii, Ruby H. P. Law, David L. Steer, Partha Pratim Das, Jeff R. Mann, Lee H. Wong · 2018 · Nature Communications
  97. Practical implications of integrated glioma classification according to the World Health Organization classification of tumors of the central nervous system 2016
    Bastian Malzkorn, Guido Reifenberger · 2016 · Current Opinion in Oncology
  98. Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme
    Jing Han, Raj K. Puri · 2017 · Journal of Neuro-Oncology
  99. Origin of Gliomas
    Şevin Turcan, Daniel P. Cahill · 2018 · Seminars in Neurology
  100. Computational Characterization of Suppressive Immune Microenvironments in Glioblastoma
    Suvi Luoto, Ismaïl Hermelo, Elisa M. Vuorinen, Paavo Hannus, Juha Kesseli, Matti Nykter, Kirsi Johanna Granberg · 2018 · Cancer Research