Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.·2014·Cell

DOI 10.1016/j.cell.2013.12.010

Cited by (1,027)

Items 301–400 of 1,027

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells
Oreoluwa O. Adedoyin, Ravindra Boddu, Amie Traylor, Jeremie M. Lever, Subhashini Bolisetty, James F. George, Anupam Agarwal · 2017 · American Journal of Physiology-Renal Physiology
Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes
Tae-Jun Park, Jei Hyoung Park, Ga Seul Lee, Ji-Yoon Lee, Ji Hye Shin, Min Wook Kim, Yong Sook Kim, Jeong‐Yoon Kim, Kyoung‐Jin Oh, Baek-Soo Han et al. · 2019 · Cell Death and Disease
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin, Jinbo B. Yang · 2022 · Signal Transduction and Targeted Therapy
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Florêncio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal et al. · 2024 · Nature
BID links ferroptosis to mitochondrial cell death pathways
Sandra Neitemeier, Anja Jelinek, Vincenzo Laino, Lena Hoffmann, Ina Eisenbach, Roman Eying, Goutham K. Ganjam, Amalia M. Dolga, Sina Oppermann, Carsten Culmsee · 2017 · Redox Biology
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
Özge Canli, Adele M. Nicolas, J. R. P. Gupta, Fabian Finkelmeier, Olga Goncharova, Marina Hadzi Pesic, Tobias Neumann, David A. Horst, Martin Löwer, Uğur Şahin et al. · 2017 · Cancer Cell
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
Tammo Müller, Christin Dewitz, Jessica Schmitz, Anna Sophia Schröder, Jan Hinrich Bräsen, Brent R. Stockwell, James M. Murphy, Ulrich Kunzendorf, Stefan Krautwald · 2017 · Cellular and Molecular Life Sciences
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W. et al. · 2018 · Oncogene
Ferroptosis in Cancer Cell Biology
Christina M. Bebber, Fabienne Müller, Laura Prieto Clemente, Josephine Weber, Silvia von Karstedt · 2020 · Cancers
Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis
Anja Jelinek, Lukas Heyder, Michael Daude, Matthias Plessner, Sylvia Krippner, Robert Grosse, Wibke E. Diederich, Carsten Culmsee · 2018 · Free Radical Biology and Medicine
Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer
Fan Zhang, Feng Li, Guihong Lu, Weidong Nie, Lijun Zhang, Yanlin Lv, Weier Bao, Xiaoyong Gao, Wei Wei, Kanyi Pu et al. · 2019 · ACS Nano
A Polarity‐Sensitive Ratiometric Fluorescence Probe for Monitoring Changes in Lipid Droplets and Nucleus during Ferroptosis
Kang‐Nan Wang, Liu‐Yi Liu, Duo Mao, Shidang Xu, Cai‐Ping Tan, Qian Cao, Zong‐Wan Mao, Bin Liu · 2021 · Angewandte Chemie International Edition
Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification
Yuanzhi Ye, An Chen, Li Li, Qingchun Liang, Siyi Wang, Qianqian Dong, Mingwei Fu, Zirong Lan, Yining Li, Xiaoyu Liu et al. · 2022 · Kidney International
Targeting Cancer Cell Dormancy
Recasens, Ariadna, Munoz, Lenka · 2019 · Trends in Pharmacological Sciences
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model
Matthew Jennis, Che-Pei Kung, Subhasree Basu, Anna Budina-Kolomets, Julia I-Ju Leu, Sakina Khaku, Jeremy P. Scott, Kathy Qi Cai, Michelle R. Campbell, Devin K. Porter et al. · 2016 · Genes & Development
Regulated necrosis in kidney ischemia-reperfusion injury
Pefanis, Aspasia, Ierino, Francesco L., Murphy, James M., Cowan, Peter J. · 2019 · Kidney International
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming
Sergio Gascón, Elisa Murenu, Giacomo Masserdotti, Felipe Ortega, Gianluca Luigi Russo, David Petřík, Aditi Deshpande, Christophe Heinrich, Marisa Karow, Stephen P. Robertson et al. · 2015 · Cell stem cell
Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
Pedro Norat, Sauson Soldozy, Jennifer D. Sokolowski, Catherine M. Gorick, Jeyan Sathia Kumar, Youngrok Chae, Kaan Yağmurlu, Francesco Ugo Prada, Melanie Walker, Michael R. Levitt et al. · 2020 · npj Regenerative Medicine
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
Yun Pyo Kang, Andrea Mockabee‐Macias, Chang Jiang, Aimee Falzone, Nicolas Prieto-Farigua, Everett M Stone, Isaac S. Harris, Gina M. DeNicola · 2020 · Cell Metabolism
Ferroptosis in health and disease
Carsten Berndt, Hamed Alborzinia, Vera Skafar, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayır, Christina M. Bebber, Kıvanç Birsoy, Jan P. Böttcher et al. · 2024 · Redox Biology
Targeting iron metabolism in drug discovery and delivery
Crielaard, Bart J., Lammers, Twan, Rivella, Stefano · 2017 · Nature Reviews Drug Discovery
Elucidating Compound Mechanism of Action by Network Perturbation Analysis
Woo, Jung Hoon, Shimoni, Yishai, Yang, Wan Seok, Subramaniam, Prem, Iyer, Archana, Nicoletti, Paola, Rodríguez Martínez, María, López, Gonzalo, Mattioli, Michela, Realubit, Ronald et al. · 2015 · Cell
An essential role for functional lysosomes in ferroptosis of cancer cells
Torii, Seiji, Shintoku, Ryosuke, Kubota, Chisato, Yaegashi, Makoto, Torii, Ryoko, Sasaki, Masaya, Suzuki, Toshinobu, Mori, Masanobu, Yoshimoto, Yuhei, Takeuchi, Toshiyuki et al. · 2016 · Biochemical Journal
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
Chen, Delin, Chu, Bo, Yang, Xin, Liu, Zhaoqi, Jin, Ying, Kon, Ning, Rabadan, Raul, Jiang, Xuejun, Stockwell, Brent R., Gu, Wei · 2021 · Nature Communications
Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes
Yuichi Baba, Jason K. Higa, Briana K. Shimada, Kate M. Horiuchi, Tomohiro Suhara, Motoi Kobayashi, Jonathan D. Woo, Hiroko Aoyagi, Karra S. Marh, Hiroaki Kitaoka et al. · 2017 · American Journal of Physiology-Heart and Circulatory Physiology
Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
Yongxin Zheng, Junlu Sun, Zhiting Luo, Yimin Li, Yongbo Huang · 2024 · Cell Death and Disease
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
Douglas Hanniford, Alejandro J. Ulloa-Morales, Alcida Karz, Maria Gabriela Berzoti-Coelho, Rana S. Moubarak, Beatriz Sánchez‐Sendra, Andreas Kloetgen, Verónica Dávalos, Jochen Imig, Pamela Wu et al. · 2020 · Cancer Cell
The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
Yuqing Wu, Si-Wei Zhang, Xiaoxiao Gong, Samantha Tam, Desheng Xiao, Shuang Liu, Yongguang Tao · 2020 · Molecular Cancer
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure
Naoya Yamada, Tadayoshi Karasawa, Hiroaki J. Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata et al. · 2020 · Cell Death and Disease
MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect
Binbin Ding, Pan Zheng, Fan Jiang, Yajie Zhao, Meifang Wang, Mengyu Chang, Ping’an Ma, Jun Lin · 2020 · Angewandte Chemie International Edition
Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
Michael M. Gaschler, Fanghao Hu, Huizhong Feng, Andreas Linkermann, Wei Min, Brent R. Stockwell · 2018 · ACS Chemical Biology
Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice
Qi, Jing, Kim, Jong-Won, Zhou, Zixiong, Lim, Chae-Woong, Kim, Bumseok · 2020 · The American Journal of Pathology
Cell death in pancreatic cancer: from pathogenesis to therapy
Xin Chen, Herbert J. Zeh, Rui Kang, Guido Kroemer, Daolin Tang · 2021 · Nature Reviews Gastroenterology & Hepatology
Ferroptosis and cell death mechanisms in Parkinson's disease
Stephanie J. Guiney, Paul Anthony Adlard, Ashley Ian Bush, David Isaac Finkelstein, Scott Ayton · 2017 · Neurochemistry International
The therapeutic potential of targeting regulated non-apoptotic cell death
Kamyar Hadian, Brent R. Stockwell · 2023 · Nature Reviews Drug Discovery
Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis
Michael S. Mortensen, Jimena Ruiz, Jennifer L. Watts · 2023 · Cells
Ferroptosis Accompanied by •OH Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe
Hongyu Li, Wen Sheng Shi, Xiaohua Li, Yiming Hu, Fang Yu, Huimin Ma · 2019 · Journal of the American Chemical Society
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Zhimin Tang, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Dandan Zhang, Huiqin Gao, Hao Sun, Jing Zhang, Ping Gu · 2021 · Redox Biology
Recent progress in ferroptosis: inducers and inhibitors
Yunxi Du, Zhong Guo · 2022 · Cell Death Discovery
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions
Seonghun Kim, Shin‐Wook Kang, Jeongho Joo, Seung Hyeok Han, Huiyoon Shin, Bo Young Nam, Jimin Park, Tae‐Hyun Yoo, Gyuri Kim, Pureunchowon Lee et al. · 2021 · Cell Death and Disease
Cell death pathways: intricate connections and disease implications
Matthias Kist, Domagoj Vucic · 2021 · The EMBO Journal
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B., Fisher, Oliver M., Read, Matthew, Guerra, Glen R. et al. · 2017 · Nature Communications
NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
Delin Chen, Omid Tavana, Bo Chu, Luke N. Erber, Yue Chen, Richard J. Baer, Wei Jun Gu · 2017 · Molecular Cell
Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Lv, Huanhuan, Zhen, Chenxiao, Liu, Junyu, Yang, Pengfei, Hu, Lijiang, Shang, Peng · 2019 · Oxidative Medicine and Cellular Longevity
Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator
Yujing He, Xiaoying Liu, Lei Xing, Xing Wan, Xin Yao Chang, Hu‐Lin Jiang · 2020 · Biomaterials
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics
Lohans Pedrera, Rafael Atillo Espiritu, Uris Ros, Josephine Weber, Anja Maria Schmitt, Jenny Stroh, Stephan Hailfinger, Silvia von Karstedt, Ana J. García‐Sáez · 2020 · Cell Death and Differentiation
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Haiyan Wang, Yan Cheng, Chao Mao, Shuang Liu, Desheng Xiao, Jun Xing Huang, Yongguang Tao · 2021 · Molecular Therapy
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis
Hülya Bayır, Tamil S. Anthonymuthu, Yulia Y. Tyurina, Sarju J. Patel, Andrew A. Amoscato, Andrew M. Lamade, Qin Yang, Georgy K. Vladimirov, Caroline C. Philpott, Valerian E. Kagan · 2020 · Cell chemical biology
PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway
Yilong Wang, Shu Wang Yan, Xuemei Liu, Fei Deng, Pengchao Wang, Liuye Yang, Lizhi Hu, Kai Huang, Jiangui He · 2022 · Cell Death and Differentiation
Disulfidptosis: disulfide stress–induced cell death
Xiaoguang Liu, Li Zhuang, Boyi Gan · 2023 · Trends in Cell Biology
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
Carlson, Bradley A., Tobe, Ryuta, Yefremova, Elena, Tsuji, Petra A., Hoffmann, Victoria J., Schweizer, Ulrich, Gladyshev, Vadim N., Hatfield, Dolph L., Conrad, Marcus · 2016 · Redox Biology
Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy
Tian Xu, Yuying Ma, Qinling Yuan, Hui‐Xin Hu, Xinkai Hu, Zhiyu Qian, Janiqua Kyiesha Rolle, Yueqing Gu, Siwen Li · 2020 · ACS Nano
Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer
Ali Ghoochani, En‐Chi Hsu, Merve Aslan, Meghan A. Rice, Holly M. Nguyen, James D. Brooks, Eva Corey, Ramasamy Paulmurugan, Tanya Ivanova Stoyanova · 2021 · Cancer Research
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
Yibing Chen, Yanjun Mi, Xiaofei Zhang, Qian Ma, Yucen Song, Liwei Zhang, Dandan Wang, Jinliang Xing, Benxin Hou, Haolong Li et al. · 2019 · Journal of Experimental & Clinical Cancer Research
The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis
Naiara Santana-Codina, Ajami Gikandi, Joseph Douglas Mancias · 2021 · Advances in experimental medicine and biology
Ferroptosis: bug or feature?
Dixon, Scott J. · 2017 · Immunological Reviews
Ferroptosis: principles and significance in health and disease
Fangquan Chen, Rui Kang, Daolin Tang, Jiao Liu · 2024 · Journal of Hematology & Oncology
Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors
Qingbo Xu, Guiting Zhan, Zelong Zhang, Tuying Yong, Xiangliang Yang, Lu Gan · 2020 · Theranostics
Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells
Hao, Shihui, Yu, Jiang, He, Wanming, Huang, Qiong, Zhao, Yang, Liang, Bishan, Zhang, Shuyi, Wen, Zhaowei, Dong, Shumin, Rao, Jinjun et al. · 2017 · Neoplasia
Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer
Rundi Song, Tianliang Li, Jiayi Ye, Fang Zhen Sun, Bo Hou, Madiha Saeed, Jing Gao, Yingjie Wang, Qiwen Zhu, Zhiai Xu et al. · 2021 · Advanced Materials
A guideline on the molecular ecosystem regulating ferroptosis
Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayır, Wan Seok Yang, Ana J. García‐Sáez, Maria S. Ioannou et al. · 2024 · Nature Cell Biology
A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer
Wen‐Hsuan Yang, Zhiqing Huang, Jianli Wu, Chien‐Kuang Cornelia Ding, Susan K. Murphy, Jen‐Tsan Chi · 2019 · Molecular Cancer Research
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy
Huanji Xu, Di Ye, Meiling Ren, Hongying Zhang, Feng Bi · 2021 · Trends in Molecular Medicine
Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity
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Cell Death in Liver Diseases: A Review
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Iron in Neurodegeneration – Cause or Consequence?
Alain Ndayisaba, Christine Kaindlstorfer, Gregor Karl Wenning · 2019 · Frontiers in Neuroscience
Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer
Shasha He, Yuyan Jiang, Jing Li, Kanyi Pu · 2020 · Angewandte Chemie International Edition
Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence
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Lipid droplets and cellular lipid flux
Alyssa J. Mathiowetz, James A. Olzmann · 2024 · Nature Cell Biology
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
Chuan’ai Chen, Dekun Wang, Yangyang Yu, Tianyuan Zhao, Ningning Min, Yan Wu, Lichun Kang, Yong Mei Zhao, Lingfang Du, Mianzhi Zhang et al. · 2021 · Cell Death and Disease
Extracellular histones in tissue injury and inflammation
Ramanjaneyulu Allam, Santhosh V. R. Kumar, Murthy N. Darisipudi, Hans‐Joachim Anders · 2014 · Journal of Molecular Medicine
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
Yiqun Jiang, Chao Mao, Rui Yang, Bin Yan, Ying Shi, Xiaoli Liu, Weiwei Lai, Yating Liu, Xiang Wang, Desheng Xiao et al. · 2017 · Theranostics
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He et al. · 2021 · Journal of Clinical Investigation
NUPR1 is a critical repressor of ferroptosis
Liu, Jiao, Song, Xinxin, Kuang, Feimei, Zhang, Qiuhong, Xie, Yangchun, Kang, Rui, Kroemer, Guido, Tang, Daolin · 2021 · Nature Communications
Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases
Mingzhu Tang, Zhe Chen, Di Wu, Linxi Chen · 2018 · Journal of Cellular Physiology
Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke
Rui Mao, Ningning Zong, Yujie Hu, Ying Chen, Yun Xu · 2022 · Neuroscience Bulletin
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent R. Stockwell, Guido Kroemer, Rui Kang, Daolin Tang · 2023 · Science Translational Medicine
Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Po‐Han Chen, Jianli Wu, Chien‐Kuang Cornelia Ding, Chao‐Chieh Lin, Samuel M Pan, Nathan Bossa, Yitong Xu, Wen‐Hsuan Yang, Bernard Mathey-Prévôt, Jen‐Tsan Chi · 2019 · Cell Death and Differentiation
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella · 2021 · Biomolecules
Ferroptosis in liver disease: new insights into disease mechanisms
Jing Wu, Yi Wang, Rongtao Jiang, Ran Xue, Xuehong Yin, Muchen Wu, Qinghua Meng · 2021 · Cell Death Discovery
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
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Thirty years of NRF2: advances and therapeutic challenges.
Zhang, Donna D. · 2025 · Nature Reviews Drug Discovery
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
Shrikant R. Mulay, Jyaysi Desai, Santhosh V. R. Kumar, Jonathan N. Eberhard, Dana Thomasová, Simone Romoli, Melissa Grigorescu, Onkar P. Kulkarni, Bastian Popper, Volker Vielhauer et al. · 2016 · Nature Communications
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage
Jieru Wan, Honglei Ren, Jian Wang · 2019 · Stroke and Vascular Neurology
Glutathione peroxidase 4: a new player in neurodegeneration?
Bárbara Rita Cardoso, Dominic James Hare, Ashley Ian Bush, Blaine Russell Roberts · 2016 · Molecular Psychiatry
Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wei Wu, Menghuan Li, Zhong Yuan Luo · 2021 · Advanced Science
Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function
Liangyu Chen, Xinxing Li, LIBO LIU, Bo Yu, Yixue Xue, Yunhui Liu · 2015 · Oncology Reports · Retracted
Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity
Xiaoya Li, Tianxiang Wang, Xinmei Huang, Yue Li, Tiange Sun, Shufei Zang, Kun‐Liang Guan, Yue Xiong, Jun Liu, Hai‐Xin Yuan · 2020 · Liver International
Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology
Rikki A. M. Brown, Kirsty L. Richardson, Tasnuva D. Kabir, Debbie Trinder, Ruth Ganß, Peter J. Leedman · 2020 · Frontiers in Oncology
Ferroptosis and Necroptosis in the Kidney
Alexia Belavgeni, Claudia Meyer, Julian Stumpf, Christian Hugo, Andreas Linkermann · 2020 · Cell chemical biology
ESCRT-III–dependent membrane repair blocks ferroptosis
Enyong Dai, Lingjun Meng, Rui Kang, Xiaofeng Wang, Daolin Tang · 2019 · Biochemical and Biophysical Research Communications
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Tianyu Ma, Jingtong Du, Yufeng Zhang, Yuyao Wang, Bingxuan Wang, Tianhong Zhang · 2022 · Cell Death Discovery
The induction of ferroptosis by impairing STAT3/Nrf2/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin
Qiang Liu, Kunzheng Wang · 2019 · Cell Biology International
Ferroptosis and Its Potential Role in Human Diseases
Chu Han, Yuanyuan Liu, Rongji Dai, Nafissa Ismail, Weijun Su, Bo Li · 2020 · Frontiers in Pharmacology
Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
Ioannis Poursaitidis, Xiaomeng Wang, Thomas Crighton, Christiaan F. Labuschagne, David Y. Mason, Shira L. Cramer, Kendra Triplett, Rajat Roy, Olivier E. Pardo, Michael J. Seckl et al. · 2017 · Cell Reports
Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System
Jan Lewerenz, Gamze Ates, Axel Methner, Marcus Conrad, Pamela A Maher · 2018 · Frontiers in Neuroscience
Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1
Hironari Nishizawa, Mitsuyo Matsumoto, Tomohiko Shindo, Daisuke Saigusa, Hiroki Kato, Katsushi Suzuki, Masaki Sato, Yusho Ishii, Hiroaki Shimokawa, Kazuhiko Igarashi · 2019 · Journal of Biological Chemistry
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mäßenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk et al. · 2021 · Nature Communications
The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities
Kamari Weaver, Rachid Skouta · 2022 · Biomedicines